Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Assay
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

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 DOI
CHEMBL1627325 211270 None 0 Human Functional pEC50 = 10.3 10.3 -1 8
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm900604g
2098 3694 None 31 Human Functional pEC50 = 10.2 10.2 -1 11
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
36511 3694 None 31 Human Functional pEC50 = 10.2 10.2 -1 11
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3805 3694 None 31 Human Functional pEC50 = 10.2 10.2 -1 11
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3835 3694 None 31 Human Functional pEC50 = 10.2 10.2 -1 11
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL235363 3694 None 31 Human Functional pEC50 = 10.2 10.2 -1 11
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL384518 214788 None 8 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
2098 3694 None 31 Human Functional pEC50 = 9.2 9.2 -1 11
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
36511 3694 None 31 Human Functional pEC50 = 9.2 9.2 -1 11
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3805 3694 None 31 Human Functional pEC50 = 9.2 9.2 -1 11
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3835 3694 None 31 Human Functional pEC50 = 9.2 9.2 -1 11
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
CHEMBL235363 3694 None 31 Human Functional pEC50 = 9.2 9.2 -1 11
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
2098 3694 None 31 Human Functional pEC50 = 9 9.0 -1 11
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
36511 3694 None 31 Human Functional pEC50 = 9 9.0 -1 11
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3805 3694 None 31 Human Functional pEC50 = 9 9.0 -1 11
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3835 3694 None 31 Human Functional pEC50 = 9 9.0 -1 11
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3694 None 31 Human Functional pEC50 = 9 9.0 -1 11
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
2098 3694 None 31 Guinea pig Functional pEC50 = 9 9.0 -2 11
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 None 31 Guinea pig Functional pEC50 = 9 9.0 -2 11
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 None 31 Guinea pig Functional pEC50 = 9 9.0 -2 11
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 None 31 Guinea pig Functional pEC50 = 9 9.0 -2 11
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 None 31 Guinea pig Functional pEC50 = 9 9.0 -2 11
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
73356363 89538 None 0 Guinea pig Functional pEC50 = 8.9 8.9 9 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89538 None 0 Guinea pig Functional pEC50 = 8.9 8.9 9 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355648 97177 None 0 Guinea pig Functional pEC50 = 6.0 6.0 -22 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 97177 None 0 Guinea pig Functional pEC50 = 6.0 6.0 -22 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21795 None 0 Guinea pig Functional pEC50 = 6.0 6.0 -19 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21795 None 0 Guinea pig Functional pEC50 = 6.0 6.0 -19 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297675 100674 None 0 Guinea pig Functional pEC50 = 6.9 6.9 -47 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100674 None 0 Guinea pig Functional pEC50 = 6.9 6.9 -47 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10259515 157229 None 0 Guinea pig Functional pEC50 = 7.9 7.9 954 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 157229 None 0 Guinea pig Functional pEC50 = 7.9 7.9 954 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL263185 213020 None 5 Human Functional pEC50 = 7.9 7.9 2 2
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
2089 2766 None 25 Guinea pig Functional pEC50 = 7.9 7.9 -6 8
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3795 2766 None 25 Guinea pig Functional pEC50 = 7.9 7.9 -6 8
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2766 None 25 Guinea pig Functional pEC50 = 7.9 7.9 -6 8
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2766 None 25 Guinea pig Functional pEC50 = 7.9 7.9 -6 8
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL415159 215635 None 4 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44297866 102099 None 0 Guinea pig Functional pEC50 = 7.8 7.8 -38 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 102099 None 0 Guinea pig Functional pEC50 = 7.8 7.8 -38 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL441061 216340 None 15 Guinea pig Functional pEC50 = 8.7 8.7 2 2
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
73348740 89540 None 0 Guinea pig Functional pEC50 = 8.4 8.4 51 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89540 None 0 Guinea pig Functional pEC50 = 8.4 8.4 51 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355678 23497 None 0 Guinea pig Functional pEC50 = 6.5 6.5 4 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23497 None 0 Guinea pig Functional pEC50 = 6.5 6.5 4 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10350201 117225 None 0 Guinea pig Functional pEC50 = 5.4 5.4 -6 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 117225 None 0 Guinea pig Functional pEC50 = 5.4 5.4 -6 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10327810 116800 None 0 Guinea pig Functional pEC50 = 4.4 4.4 -31 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116800 None 0 Guinea pig Functional pEC50 = 4.4 4.4 -31 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10055612 96478 None 0 Guinea pig Functional pEC50 = 7.4 7.4 31 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 96478 None 0 Guinea pig Functional pEC50 = 7.4 7.4 31 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
14860666 105475 None 0 Guinea pig Functional pEC50 = 7.4 7.4 -3 2
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL311917 105475 None 0 Guinea pig Functional pEC50 = 7.4 7.4 -3 2
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
2098 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
15931130 102036 None 0 Guinea pig Functional pEC50 = 6.4 6.4 -1000 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 102036 None 0 Guinea pig Functional pEC50 = 6.4 6.4 -1000 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
5311135 21730 None 12 Guinea pig Functional pEC50 = 5.4 5.4 -1148 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21730 None 12 Guinea pig Functional pEC50 = 5.4 5.4 -1148 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
44355179 24356 None 0 Guinea pig Functional pEC50 = 7.4 7.4 -33 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24356 None 0 Guinea pig Functional pEC50 = 7.4 7.4 -33 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 211188 None 0 Guinea pig Functional pEC50 = 7.4 7.4 -1 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
2098 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
36511 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3805 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3835 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3694 None 31 Guinea pig Functional pEC50 = 8.3 8.3 -2 11
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
10395375 116721 None 0 Guinea pig Functional pEC50 = 5.3 5.3 -2 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116721 None 0 Guinea pig Functional pEC50 = 5.3 5.3 -2 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
10462850 24271 None 0 Guinea pig Functional pEC50 = 6.3 6.3 -36 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24271 None 0 Guinea pig Functional pEC50 = 6.3 6.3 -36 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
15931129 197222 None 0 Guinea pig Functional pEC50 = 8.2 8.2 1 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 197222 None 0 Guinea pig Functional pEC50 = 8.2 8.2 1 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL81919 218376 None 0 Guinea pig Functional pEC50 = 6.2 6.2 -676 2
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL335054 213939 None 0 Guinea pig Functional pEC50 = 7.2 7.2 -20 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
44297852 99061 None 0 Guinea pig Functional pEC50 = 7.2 7.2 -7 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 99061 None 0 Guinea pig Functional pEC50 = 7.2 7.2 -7 2
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2090 2767 None 27 Guinea pig Functional pEC50 = 7.2 7.2 -6 9
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2767 None 27 Guinea pig Functional pEC50 = 7.2 7.2 -6 9
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2767 None 27 Guinea pig Functional pEC50 = 7.2 7.2 -6 9
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
11765601 96477 None 0 Guinea pig Functional pEC50 = 6.1 6.1 -9 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 96477 None 0 Guinea pig Functional pEC50 = 6.1 6.1 -9 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355368 25649 None 0 Guinea pig Functional pEC50 = 7.1 7.1 -1 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25649 None 0 Guinea pig Functional pEC50 = 7.1 7.1 -1 3
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10009596 115573 None 0 Guinea pig Functional pEC50 = 7.1 7.1 1 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 115573 None 0 Guinea pig Functional pEC50 = 7.1 7.1 1 2
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
73356365 89541 None 0 Guinea pig Functional pEC50 = 6.1 6.1 - 1
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
CHEMBL2372954 89541 None 0 Guinea pig Functional pEC50 = 6.1 6.1 - 1
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
108167 2856 None 6 Guinea pig Functional pIC50 = 10.7 10.7 58 2
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
2107 2856 None 6 Guinea pig Functional pIC50 = 10.7 10.7 58 2
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
CHEMBL1178725 2856 None 6 Guinea pig Functional pIC50 = 10.7 10.7 58 2
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
135434109 4283 None 0 Rat Functional pIC50 = 10.1 10.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL100636 4283 None 0 Rat Functional pIC50 = 10.1 10.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
9967131 209964 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
CHEMBL94461 209964 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
10363809 112193 None 17 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL329007 112193 None 17 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44328454 168841 None 0 Human Functional pIC50 = 9.9 9.9 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL437075 168841 None 0 Human Functional pIC50 = 9.9 9.9 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10111225 209936 None 0 Human Functional pIC50 = 9.9 9.9 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL94328 209936 None 0 Human Functional pIC50 = 9.9 9.9 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10477054 4495 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102032 4495 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10458573 4366 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL101148 4366 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
135488049 210674 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL98524 210674 None 0 Rat Functional pIC50 = 9.8 9.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
2102 1189 None 17 Human Functional pIC50 = 9.8 9.8 6 2
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
5311057 1189 None 17 Human Functional pIC50 = 9.8 9.8 6 2
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
CHEMBL441225 1189 None 17 Human Functional pIC50 = 9.8 9.8 6 2
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
10480465 210874 None 0 Rat Functional pIC50 = 9.7 9.7 1 2
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL99792 210874 None 0 Rat Functional pIC50 = 9.7 9.7 1 2
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10272852 107949 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319301 107949 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9821217 107786 None 17 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319118 107786 None 17 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL3215877 107786 None 17 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9871754 5411 None 0 Human Functional pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5411 None 0 Human Functional pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
2098 3694 None 31 Human Functional pIC50 = 9.6 9.6 -1 11
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
36511 3694 None 31 Human Functional pIC50 = 9.6 9.6 -1 11
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3805 3694 None 31 Human Functional pIC50 = 9.6 9.6 -1 11
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3835 3694 None 31 Human Functional pIC50 = 9.6 9.6 -1 11
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
CHEMBL235363 3694 None 31 Human Functional pIC50 = 9.6 9.6 -1 11
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
44433394 146746 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL392368 146746 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433394 146746 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL392368 146746 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
9960689 12009 None 1 Guinea pig Functional pIC50 = 9.5 9.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183286 12009 None 1 Guinea pig Functional pIC50 = 9.5 9.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288600 12009 None 1 Guinea pig Functional pIC50 = 9.5 9.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
9871754 5411 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5411 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
9945487 210210 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95852 210210 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10268178 210118 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95315 210118 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
2102 1189 None 17 Human Functional pIC50 = 9.3 9.3 6 2
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
5311057 1189 None 17 Human Functional pIC50 = 9.3 9.3 6 2
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL441225 1189 None 17 Human Functional pIC50 = 9.3 9.3 6 2
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
104943 55402 None 31 Guinea pig Functional pIC50 = 9.3 9.3 4 5
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
CHEMBL16192 55402 None 31 Guinea pig Functional pIC50 = 9.3 9.3 4 5
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
22879211 210602 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL98125 210602 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44433393 167747 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL430170 167747 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433393 167747 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL430170 167747 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
2098 3694 None 31 Human Functional pIC50 = 9.2 9.2 -1 11
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
36511 3694 None 31 Human Functional pIC50 = 9.2 9.2 -1 11
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3805 3694 None 31 Human Functional pIC50 = 9.2 9.2 -1 11
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3835 3694 None 31 Human Functional pIC50 = 9.2 9.2 -1 11
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
CHEMBL235363 3694 None 31 Human Functional pIC50 = 9.2 9.2 -1 11
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
132846 2238 None 16 Rat Functional pIC50 = 9.1 9.1 1 4
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
13432 2238 None 16 Rat Functional pIC50 = 9.1 9.1 1 4
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
CHEMBL27006 2238 None 16 Rat Functional pIC50 = 9.1 9.1 1 4
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(97)10118-4
9968267 108612 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL320220 108612 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10089212 4508 None 0 Rat Functional pIC50 = 9.0 9.0 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102157 4508 None 0 Rat Functional pIC50 = 9.0 9.0 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10047566 165336 None 2 Human Functional pIC50 = 9.0 9.0 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
CHEMBL422931 165336 None 2 Human Functional pIC50 = 9.0 9.0 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
10650495 107475 None 0 Guinea pig Functional pIC50 = 9 9.0 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 107475 None 0 Guinea pig Functional pIC50 = 9 9.0 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
11801327 9358 None 0 Guinea pig Functional pIC50 = 8.9 8.9 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9358 None 0 Guinea pig Functional pIC50 = 8.9 8.9 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
9871754 5411 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5411 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
135413536 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
230 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
3490 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
6918365 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
CHEMBL1471 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
DB00673 448 None 58 Human Functional pIC50 = 8.9 8.9 3 7
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
9832207 12003 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 12003 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 12003 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10817013 9258 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9258 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44327794 111485 None 2 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL327357 111485 None 2 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL2369600 212093 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
44286165 158487 None 0 Guinea pig Functional pIC50 = 7.0 7.0 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1794935 158487 None 0 Guinea pig Functional pIC50 = 7.0 7.0 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL40900 158487 None 0 Guinea pig Functional pIC50 = 7.0 7.0 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5074991 216837 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10039383 85511 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
CHEMBL22680 85511 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
15542673 210023 None 0 Guinea pig Functional pIC50 = 6.9 6.9 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL94834 210023 None 0 Guinea pig Functional pIC50 = 6.9 6.9 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44327909 112421 None 0 Guinea pig Functional pIC50 = 7.9 7.9 37 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL329450 112421 None 0 Guinea pig Functional pIC50 = 7.9 7.9 37 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304126 211939 None 0 Rat Functional pIC50 = 4.9 4.9 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
9832306 112787 None 0 Guinea pig Functional pIC50 = 5.9 5.9 -2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330367 112787 None 0 Guinea pig Functional pIC50 = 5.9 5.9 -2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330462 112787 None 0 Guinea pig Functional pIC50 = 5.9 5.9 -2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
10123138 108582 None 0 Guinea pig Functional pIC50 = 6.8 6.8 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL317524 108582 None 0 Guinea pig Functional pIC50 = 6.8 6.8 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL320002 108582 None 0 Guinea pig Functional pIC50 = 6.8 6.8 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10190842 107280 None 0 Guinea pig Functional pIC50 = 7.8 7.8 63 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL316705 107280 None 0 Guinea pig Functional pIC50 = 7.8 7.8 63 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44286051 12010 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183288 12010 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288840 12010 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44285793 100344 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1201933 100344 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289091 100344 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44331794 4200 None 0 Rat Functional pIC50 = 6.8 6.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL100178 4200 None 0 Rat Functional pIC50 = 6.8 6.8 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL2369697 212109 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10769060 6036 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 6036 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
44285794 141888 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38624 141888 None 0 Guinea pig Functional pIC50 = 7.8 7.8 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44213067 12015 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183307 12015 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289727 12015 None 0 Guinea pig Functional pIC50 = 8.7 8.7 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10626666 109251 None 0 Guinea pig Functional pIC50 = 8.6 8.6 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 109251 None 0 Guinea pig Functional pIC50 = 8.6 8.6 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
10602943 107474 None 0 Guinea pig Functional pIC50 = 8.6 8.6 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 107474 None 0 Guinea pig Functional pIC50 = 8.6 8.6 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
10168749 210080 None 0 Guinea pig Functional pIC50 = 7.7 7.7 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95127 210080 None 0 Guinea pig Functional pIC50 = 7.7 7.7 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10745241 110594 None 0 Guinea pig Functional pIC50 = 4.7 4.7 -1 2
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110594 None 0 Guinea pig Functional pIC50 = 4.7 4.7 -1 2
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369696 212108 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10234086 111697 None 0 Guinea pig Functional pIC50 = 7.6 7.6 6 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL328511 111697 None 0 Guinea pig Functional pIC50 = 7.6 7.6 6 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
10258866 16609 None 5 Human Functional pIC50 = 6.6 6.6 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL124066 16609 None 5 Human Functional pIC50 = 6.6 6.6 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
136035319 163393 None 0 Rat Functional pIC50 = 7.6 7.6 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL418800 163393 None 0 Rat Functional pIC50 = 7.6 7.6 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10027061 14958 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL120844 14958 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL2304029 211935 None 0 Rat Functional pIC50 = 4.6 4.6 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10122529 109612 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL322194 109612 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44349304 16985 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL125385 16985 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10212645 13294 None 0 Guinea pig Functional pIC50 = 7.6 7.6 346 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL1191766 13294 None 0 Guinea pig Functional pIC50 = 7.6 7.6 346 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL542908 13294 None 0 Guinea pig Functional pIC50 = 7.6 7.6 346 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542881 112654 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330172 112654 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10233656 210310 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL96442 210310 None 0 Guinea pig Functional pIC50 = 7.6 7.6 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10283825 96746 None 0 Guinea pig Functional pIC50 = 6.5 6.5 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL264007 96746 None 0 Guinea pig Functional pIC50 = 6.5 6.5 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
153996 112731 None 0 Human Functional pIC50 = 8.5 8.5 1 6
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112731 None 0 Human Functional pIC50 = 8.5 8.5 1 6
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112731 None 0 Human Functional pIC50 = 8.5 8.5 1 6
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10507650 163425 None 0 Guinea pig Functional pIC50 = 8.5 8.5 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 163425 None 0 Guinea pig Functional pIC50 = 8.5 8.5 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986134 163928 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL4206396 163928 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
9918576 209796 None 0 Guinea pig Functional pIC50 = 7.5 7.5 2 3
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL93556 209796 None 0 Guinea pig Functional pIC50 = 7.5 7.5 2 3
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
44286200 141940 None 0 Guinea pig Functional pIC50 = 7.5 7.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38652 141940 None 0 Guinea pig Functional pIC50 = 7.5 7.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10147107 210079 None 0 Guinea pig Functional pIC50 = 7.5 7.5 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431850 210079 None 0 Guinea pig Functional pIC50 = 7.5 7.5 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95125 210079 None 0 Guinea pig Functional pIC50 = 7.5 7.5 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304032 211936 None 0 Rat Functional pIC50 = 4.5 4.5 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10212223 210599 None 0 Guinea pig Functional pIC50 = 7.5 7.5 2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431458 210599 None 0 Guinea pig Functional pIC50 = 7.5 7.5 2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL98079 210599 None 0 Guinea pig Functional pIC50 = 7.5 7.5 2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
9832207 12003 None 0 Guinea pig Functional pIC50 = 7.5 7.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 12003 None 0 Guinea pig Functional pIC50 = 7.5 7.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 12003 None 0 Guinea pig Functional pIC50 = 7.5 7.5 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5083565 217360 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10121390 112802 None 0 Guinea pig Functional pIC50 = 7.4 7.4 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330499 112802 None 0 Guinea pig Functional pIC50 = 7.4 7.4 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10123040 161189 None 0 Guinea pig Functional pIC50 = 7.4 7.4 7 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL411691 161189 None 0 Guinea pig Functional pIC50 = 7.4 7.4 7 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL537027 161189 None 0 Guinea pig Functional pIC50 = 7.4 7.4 7 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542879 112887 None 0 Guinea pig Functional pIC50 = 7.4 7.4 2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330719 112887 None 0 Guinea pig Functional pIC50 = 7.4 7.4 2 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349364 116895 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL337987 116895 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10578261 9185 None 0 Guinea pig Functional pIC50 = 8.4 8.4 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9185 None 0 Guinea pig Functional pIC50 = 8.4 8.4 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
10360490 88773 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL23617 88773 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
44286038 11214 None 0 Guinea pig Functional pIC50 = 8.3 8.3 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL1178749 11214 None 0 Guinea pig Functional pIC50 = 8.3 8.3 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL39595 11214 None 0 Guinea pig Functional pIC50 = 8.3 8.3 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL2304118 211938 None 0 Rat Functional pIC50 = 5.4 5.4 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00157a009
10190413 209788 None 0 Guinea pig Functional pIC50 = 7.4 7.4 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL410270 209788 None 0 Guinea pig Functional pIC50 = 7.4 7.4 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL93519 209788 None 0 Guinea pig Functional pIC50 = 7.4 7.4 3 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
10417124 118544 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL341365 118544 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
44349370 117336 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL339488 117336 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
15542871 210314 None 0 Guinea pig Functional pIC50 = 8.3 8.3 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
CHEMBL96466 210314 None 0 Guinea pig Functional pIC50 = 8.3 8.3 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
10530375 5631 None 0 Guinea pig Functional pIC50 = 8.3 8.3 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5631 None 0 Guinea pig Functional pIC50 = 8.3 8.3 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
10917690 210064 None 1 Guinea pig Functional pIC50 = 8.3 8.3 3 4
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95051 210064 None 1 Guinea pig Functional pIC50 = 8.3 8.3 3 4
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
44328187 210598 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL98076 210598 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
135556923 107456 None 0 Rat Functional pIC50 = 8.2 8.2 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL317979 107456 None 0 Rat Functional pIC50 = 8.2 8.2 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
9832306 112787 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330367 112787 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330462 112787 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL2304130 211941 None 0 Rat Functional pIC50 = 6.3 6.3 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O 10.1021/jm00157a009
10917690 210064 None 1 Human Functional pIC50 = 5.3 5.3 -999 4
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 210064 None 1 Human Functional pIC50 = 5.3 5.3 -999 4
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
44285795 96553 None 0 Guinea pig Functional pIC50 = 7.3 7.3 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL262540 96553 None 0 Guinea pig Functional pIC50 = 7.3 7.3 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44349303 117283 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL339444 117283 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL2304129 211940 None 0 Rat Functional pIC50 = 4.3 4.3 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10620143 99316 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL281828 99316 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10327313 16884 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL124979 16884 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
15831290 146694 None 0 Guinea pig Functional pIC50 = 7.2 7.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39232 146694 None 0 Guinea pig Functional pIC50 = 7.2 7.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
10603544 110627 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110627 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
10190056 111501 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL327497 111501 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
44285857 11202 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1178703 11202 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38030 11202 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10190638 210001 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94726 210001 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283825 96746 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL264007 96746 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283765 108143 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
CHEMBL319535 108143 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
15542874 112232 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL329055 112232 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10769059 108673 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108673 None 0 Guinea pig Functional pIC50 = 8.2 8.2 - 1
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
10123138 108582 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL317524 108582 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320002 108582 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542673 210023 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94834 210023 None 0 Guinea pig Functional pIC50 = 8.2 8.2 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333379 210034 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL94906 210034 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10305069 210309 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96441 210309 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL2304115 211937 None 0 Rat Functional pIC50 = 6.2 6.2 - 1
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10190056 111501 None 0 Guinea pig Functional pIC50 = 6.2 6.2 -1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL327497 111501 None 0 Guinea pig Functional pIC50 = 6.2 6.2 -1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
10212725 98222 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL273915 98222 None 0 Guinea pig Functional pIC50 = 8.2 8.2 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
15542679 108583 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320003 108583 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9918576 209796 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 3
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL93556 209796 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 3
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
10190413 209788 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL410270 209788 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL93519 209788 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
44328188 111589 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL327888 111589 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542879 112887 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330719 112887 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10121390 112802 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330499 112802 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10123040 161189 None 0 Guinea pig Functional pIC50 = 8.1 8.1 7 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL411691 161189 None 0 Guinea pig Functional pIC50 = 8.1 8.1 7 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL537027 161189 None 0 Guinea pig Functional pIC50 = 8.1 8.1 7 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10190770 210474 None 0 Guinea pig Functional pIC50 = 8.1 8.1 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330430 210474 None 0 Guinea pig Functional pIC50 = 8.1 8.1 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97357 210474 None 0 Guinea pig Functional pIC50 = 8.1 8.1 1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10212223 210599 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431458 210599 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL98079 210599 None 0 Guinea pig Functional pIC50 = 8.1 8.1 2 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147107 210079 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431850 210079 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95125 210079 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333241 210252 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL96141 210252 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10233656 210310 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96442 210310 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147218 107522 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL318369 107522 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542881 112654 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330172 112654 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328321 167891 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL430471 167891 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10122529 109612 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL322194 109612 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10169609 210104 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95243 210104 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
10234086 111697 None 0 Guinea pig Functional pIC50 = 8.1 8.1 6 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL328511 111697 None 0 Guinea pig Functional pIC50 = 8.1 8.1 6 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
15542880 209965 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94480 209965 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10168749 210080 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95127 210080 None 0 Guinea pig Functional pIC50 = 8.1 8.1 3 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10305888 210014 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94788 210014 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328320 210060 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL95029 210060 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10284042 210445 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97240 210445 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542869 210068 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95076 210068 None 0 Guinea pig Functional pIC50 = 8.1 8.1 -1 2
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9892984 144353 None 1 Guinea pig Functional pIC50 = 6.2 6.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39049 144353 None 1 Guinea pig Functional pIC50 = 6.2 6.2 - 1
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
11801586 5468 None 0 Guinea pig Functional pIC50 = 5.1 5.1 1 2
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5468 None 0 Guinea pig Functional pIC50 = 5.1 5.1 1 2
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986135 163496 None 0 Human Functional pIC50 = 4.1 4.1 -10 3
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL419500 163496 None 0 Human Functional pIC50 = 4.1 4.1 -10 3
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL5078626 217060 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44331786 107873 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL319212 107873 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
44331715 4736 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL103657 4736 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
44331792 107239 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL316486 107239 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
44349375 115122 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL334304 115122 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10063954 98786 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL277918 98786 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10190770 210474 None 0 Guinea pig Functional pIC50 = 7.0 7.0 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330430 210474 None 0 Guinea pig Functional pIC50 = 7.0 7.0 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL97357 210474 None 0 Guinea pig Functional pIC50 = 7.0 7.0 1 2
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349369 16906 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
CHEMBL125093 16906 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
44407908 140644 None 0 Human Functional pKd = 10 10.0 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140644 None 0 Human Functional pKd = 10 10.0 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44408039 75529 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75529 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408088 139912 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139912 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408089 140273 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 140273 None 0 Human Functional pKd = 9.8 9.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408045 75633 None 0 Human Functional pKd = 9.5 9.5 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75633 None 0 Human Functional pKd = 9.5 9.5 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
104943 55402 None 31 Human Functional pKd = 9.5 9.5 -4 5
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55402 None 31 Human Functional pKd = 9.5 9.5 -4 5
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
3086681 2272 None 18 Human Functional pKd = 9.4 9.4 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2272 None 18 Human Functional pKd = 9.4 9.4 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2272 None 18 Human Functional pKd = 9.4 9.4 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44370529 49073 None 0 Guinea pig Functional pKd = 9.3 9.3 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 49073 None 0 Guinea pig Functional pKd = 9.3 9.3 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
44408040 74445 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74445 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407998 75525 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75525 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407971 140841 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140841 None 0 Human Functional pKd = 9.2 9.2 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44370713 51047 None 0 Guinea pig Functional pKd = 9.1 9.1 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 51047 None 0 Guinea pig Functional pKd = 9.1 9.1 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
44305816 163114 None 0 Human Functional pKd = 9.1 9.1 - 0
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 163114 None 0 Human Functional pKd = 9.1 9.1 - 0
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
44408051 141314 None 0 Human Functional pKd = 9.1 9.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 141314 None 0 Human Functional pKd = 9.1 9.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
21041073 138936 None 0 Human Functional pKd = 9 9.0 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138936 None 0 Human Functional pKd = 9 9.0 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
9829083 120203 None 0 Human Functional pKd = 9 9.0 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 120203 None 0 Human Functional pKd = 9 9.0 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2102 1189 None 17 Human Functional pKd = 8.9 8.9 6 2
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
5311057 1189 None 17 Human Functional pKd = 8.9 8.9 6 2
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
CHEMBL441225 1189 None 17 Human Functional pKd = 8.9 8.9 6 2
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
44407906 74734 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74734 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74799 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74799 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407907 75724 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75724 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408025 75942 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75942 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407917 96611 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96611 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44407903 140809 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140809 None 0 Human Functional pKd = 8.9 8.9 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44407902 75451 None 0 Human Functional pKd = 8.8 8.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75451 None 0 Human Functional pKd = 8.8 8.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44408046 140831 None 0 Human Functional pKd = 8.8 8.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140831 None 0 Human Functional pKd = 8.8 8.8 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
104943 55402 None 31 Human Functional pKd = 8.7 8.7 -4 5
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55402 None 31 Human Functional pKd = 8.7 8.7 -4 5
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44407972 140843 None 0 Human Functional pKd = 8.7 8.7 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140843 None 0 Human Functional pKd = 8.7 8.7 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44370530 49137 None 0 Guinea pig Functional pKd = 8 8.0 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 49137 None 0 Guinea pig Functional pKd = 8 8.0 - 0
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
44307819 102651 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102651 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 169367 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 169367 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 201131 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 201131 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307757 205994 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 205994 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 206229 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 206229 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57394644 68387 None 0 Human Functional pKd = 7 7.0 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68387 None 0 Human Functional pKd = 7 7.0 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10032981 106808 None 0 Human Functional pKd = 7 7.0 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106808 None 0 Human Functional pKd = 7 7.0 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10055415 106812 None 0 Human Functional pKd = 7 7.0 -2 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106812 None 0 Human Functional pKd = 7 7.0 -2 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
118718516 115425 None 0 Guinea pig Functional pKd = 7 7.0 - 0
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 115425 None 0 Guinea pig Functional pKd = 7 7.0 - 0
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9939040 5012 None 7 Guinea pig Functional pKd = 7.9 7.9 - 2
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 5012 None 7 Guinea pig Functional pKd = 7.9 7.9 - 2
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44307679 205975 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 205975 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 206093 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 206093 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68388 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68388 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10395494 106810 None 0 Human Functional pKd = 6.9 6.9 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106810 None 0 Human Functional pKd = 6.9 6.9 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
9832198 106811 None 0 Human Functional pKd = 6.9 6.9 1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106811 None 0 Human Functional pKd = 6.9 6.9 1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384380 59844 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL172794 59844 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44383617 155792 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL405167 155792 None 0 Guinea pig Functional pKd = 5.9 5.9 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10395612 106803 None 0 Human Functional pKd = 4.9 4.9 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106803 None 0 Human Functional pKd = 4.9 4.9 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9801487 209456 None 0 Guinea pig Functional pKd = 6.9 6.9 - 1
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 209456 None 0 Guinea pig Functional pKd = 6.9 6.9 - 1
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
52937467 62543 None 0 Human Functional pKd = 7.8 7.8 - 1
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62543 None 0 Human Functional pKd = 7.8 7.8 - 1
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44307898 203930 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 203930 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10418001 106809 None 0 Human Functional pKd = 6.8 6.8 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106809 None 0 Human Functional pKd = 6.8 6.8 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL439284 216292 None 19 Human Functional pKd = 6.8 6.8 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
44307758 206014 None 0 Guinea pig Functional pKd = 7.7 7.7 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 206014 None 0 Guinea pig Functional pKd = 7.7 7.7 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391133 68389 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68389 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
10350454 106787 None 0 Human Functional pKd = 6.7 6.7 2 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106787 None 0 Human Functional pKd = 6.7 6.7 2 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106813 None 0 Human Functional pKd = 6.7 6.7 -1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106813 None 0 Human Functional pKd = 6.7 6.7 -1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44383164 165805 None 0 Guinea pig Functional pKd = 6.7 6.7 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL424567 165805 None 0 Guinea pig Functional pKd = 6.7 6.7 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL3349620 213905 None 8 Guinea pig Functional pKd = 5.7 5.7 - 0
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718517 115426 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 115426 None 0 Guinea pig Functional pKd = 6.6 6.6 - 0
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44407901 140531 None 0 Human Functional pKd = 8.5 8.5 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 140531 None 0 Human Functional pKd = 8.5 8.5 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
52937271 62541 None 0 Human Functional pKd = 8.4 8.4 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62541 None 0 Human Functional pKd = 8.4 8.4 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
132837 2237 None 40 Human Functional pKd = 8.4 8.4 77 4
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2237 None 40 Human Functional pKd = 8.4 8.4 77 4
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2237 None 40 Human Functional pKd = 8.4 8.4 77 4
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
52937273 62539 None 0 Human Functional pKd = 7.5 7.5 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62539 None 0 Human Functional pKd = 7.5 7.5 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
10145229 9175 None 0 Guinea pig Functional pKd = 6.5 6.5 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9175 None 0 Guinea pig Functional pKd = 6.5 6.5 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
10349900 106805 None 0 Human Functional pKd = 6.5 6.5 -3 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106805 None 0 Human Functional pKd = 6.5 6.5 -3 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10350528 106789 None 0 Human Functional pKd = 7.4 7.4 1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106789 None 0 Human Functional pKd = 7.4 7.4 1 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384379 129715 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL367312 129715 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL170299 211302 None 0 Guinea pig Functional pKd = 6.4 6.4 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44408048 140645 None 0 Human Functional pKd = 8.3 8.3 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140645 None 0 Human Functional pKd = 8.3 8.3 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
10259370 106804 None 0 Human Functional pKd = 7.3 7.3 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106804 None 0 Human Functional pKd = 7.3 7.3 - 0
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10506928 120282 None 0 Human Functional pKd = 6.3 6.3 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 120282 None 0 Human Functional pKd = 6.3 6.3 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44383616 168666 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL435717 168666 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10325464 120198 None 0 Human Functional pKd = 5.3 5.3 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 120198 None 0 Human Functional pKd = 5.3 5.3 - 1
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44307821 102169 None 0 Guinea pig Functional pKd = 8.2 8.2 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 102169 None 0 Guinea pig Functional pKd = 8.2 8.2 - 0
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44337201 108668 None 0 Guinea pig Functional pKd = 8.2 8.2 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108668 None 0 Guinea pig Functional pKd = 8.2 8.2 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
107686 3379 None 28 Guinea pig Functional pKd = 7.2 7.2 -3 5
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3379 None 28 Guinea pig Functional pKd = 7.2 7.2 -3 5
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3379 None 28 Guinea pig Functional pKd = 7.2 7.2 -3 5
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
52937270 62540 None 0 Human Functional pKd = 6.2 6.2 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62540 None 0 Human Functional pKd = 6.2 6.2 - 0
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44408033 74798 None 0 Human Functional pKd = 8.1 8.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74798 None 0 Human Functional pKd = 8.1 8.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44408047 96821 None 0 Human Functional pKd = 8.1 8.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96821 None 0 Human Functional pKd = 8.1 8.1 - 0
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
15887537 109102 None 0 Guinea pig Functional pKd = 7.1 7.1 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 109102 None 0 Guinea pig Functional pKd = 7.1 7.1 - 0
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
21121353 101528 None 0 Human Functional pKd = 7.1 7.1 16 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101528 None 0 Human Functional pKd = 7.1 7.1 16 4
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
57392804 68006 None 0 Human Functional pKi = 10.3 10.3 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 68006 None 0 Human Functional pKi = 10.3 10.3 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 68006 None 0 Human Functional pKi = 10.3 10.3 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57403249 71533 None 0 Human Functional pKi = 10.2 10.2 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911968 71533 None 0 Human Functional pKi = 10.2 10.2 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1962728 71533 None 0 Human Functional pKi = 10.2 10.2 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 68005 None 0 Human Functional pKi = 10.1 10.1 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 68005 None 0 Human Functional pKi = 10.1 10.1 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
52933155 68009 None 0 Human Functional pKi = 10 10.0 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911970 68009 None 0 Human Functional pKi = 10 10.0 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 68006 None 0 Human Functional pKi = 9.8 9.8 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 68006 None 0 Human Functional pKi = 9.8 9.8 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 68006 None 0 Human Functional pKi = 9.8 9.8 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 68005 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 68005 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 68006 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 68006 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 68006 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57398076 68008 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911969 68008 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 68005 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 68005 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 68005 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 68005 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
2096 3644 None 0 Guinea pig Functional pA2 = 7.1 7.1 25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2096 3644 None 0 Guinea pig Functional pA2 = 7.1 7.1 25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3644 None 0 Guinea pig Functional pA2 = 7.1 7.1 25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
25078100 3644 None 0 Guinea pig Functional pA2 = 7.1 7.1 25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3645 None 0 Guinea pig Functional pA2 = 7.6 7.6 112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
16131028 3645 None 0 Guinea pig Functional pA2 = 7.6 7.6 112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3645 None 0 Guinea pig Functional pA2 = 7.6 7.6 112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2097 3645 None 0 Guinea pig Functional pA2 = 7.6 7.6 112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3645 None 0 Rat Functional pEC50 = 5.5 5.5 -112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3645 None 0 Rat Functional pEC50 = 5.5 5.5 -112 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2096 3644 None 0 Rat Functional pEC50 = 5.6 5.6 -25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3644 None 0 Rat Functional pEC50 = 5.6 5.6 -25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
135413536 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 448 None 58 Mongolian jird Functional pIC50 = 8 8.0 -3 7
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
30699 220190 None 0 Human Functional pIC50 = 8.3 8.3 -1 14
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
10328936 1546 None 23 Human Functional pIC50 = 8.1 8.1 2 2
NoneNone
Drug Central None None None None None
2086 1546 None 23 Human Functional pIC50 = 8.1 8.1 2 2
NoneNone
Drug Central None None None None None
2955 1546 None 23 Human Functional pIC50 = 8.1 8.1 2 2
NoneNone
Drug Central None None None None None
CHEMBL373569 1546 None 23 Human Functional pIC50 = 8.1 8.1 2 2
NoneNone
Drug Central None None None None None
135413538 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
135413538.0 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
4470 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
7623 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1199324 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB06717 1679 None 0 Human Functional pIC50 = 8.1 8.1 - 1
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
2096 3644 None 0 Rat Functional pIC50 = 5.7 5.7 -25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
25078100 3644 None 0 Rat Functional pIC50 = 5.7 5.7 -25 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
2088 2177 None 0 Human Functional pIC50 = 6.9 6.9 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
45749 2177 None 0 Human Functional pIC50 = 6.9 6.9 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2101 3697 None 0 Human Functional pIC50 = 7.5 7.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
155817436 2793 None 0 Human Functional pIC50 = 7.6 7.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2092 2793 None 0 Human Functional pIC50 = 7.6 7.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
107686 3379 None 28 Human Functional pIC50 = 7.7 7.7 -3 5
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
3522 3379 None 28 Human Functional pIC50 = 7.7 7.7 -3 5
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
CHEMBL131171 3379 None 28 Human Functional pIC50 = 7.7 7.7 -3 5
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
10328936 1546 None 23 Human Functional pIC50 = 8.6 8.6 2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2086 1546 None 23 Human Functional pIC50 = 8.6 8.6 2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2955 1546 None 23 Human Functional pIC50 = 8.6 8.6 2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
CHEMBL373569 1546 None 23 Human Functional pIC50 = 8.6 8.6 2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3849 3194 None 0 Rat Functional pIC50 = 8.6 8.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9243521
135413538 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
135413538.0 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
4470 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
7623 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1199324 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB06717 1679 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
108167 2856 None 6 Human Functional pIC50 = 9.0 9.0 -58 2
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
2107 2856 None 6 Human Functional pIC50 = 9.0 9.0 -58 2
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
CHEMBL1178725 2856 None 6 Human Functional pIC50 = 9.0 9.0 -58 2
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
17268 3117 None 0 Human Functional pIC50 = 9.2 9.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2094 3117 None 0 Human Functional pIC50 = 9.2 9.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
10349 2251 None 0 Human Functional pIC50 = 9.7 9.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
9809077 2251 None 0 Human Functional pIC50 = 9.7 9.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
CHEMBL4303434 2251 None 0 Human Functional pIC50 = 9.7 9.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
3850 3486 None 0 Human Functional pIC50 = 9.8 9.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3086681 2272 None 18 Human Functional pIC50 = 9.8 9.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
3510 2272 None 18 Human Functional pIC50 = 9.8 9.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
CHEMBL42407 2272 None 18 Human Functional pIC50 = 9.8 9.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
2110 2969 None 33 Human Functional pIC50 None 5.6 5.6 -2041 3
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
219077 2969 None 33 Human Functional pIC50 None 5.6 5.6 -2041 3
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
3480 2969 None 33 Human Functional pIC50 None 5.6 5.6 -2041 3
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
CHEMBL346178 2969 None 33 Human Functional pIC50 None 5.6 5.6 -2041 3
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
DB04872 2969 None 33 Human Functional pIC50 None 5.6 5.6 -2041 3
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
2100 3696 None 0 Human Functional pIC50 None 6.4 6.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2091 2795 None 0 Human Functional pIC50 None 6.5 6.5 -223 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2099 3695 None 0 Human Functional pIC50 None 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2103 1643 None 0 Human Functional pIC50 None 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
6437864 1643 None 0 Human Functional pIC50 None 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
132629 2236 None 13 Human Functional pIC50 None 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
2104 2236 None 13 Human Functional pIC50 None 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
CHEMBL24999 2236 None 13 Human Functional pIC50 None 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
168489 3116 None 0 Human Functional pIC50 None 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2093 3116 None 0 Human Functional pIC50 None 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2109 4137 None 6 Human Functional pIC50 None 9.9 9.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
9852253 4137 None 6 Human Functional pIC50 None 9.9 9.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
CHEMBL129683 4137 None 6 Human Functional pIC50 None 9.9 9.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
132837 2237 None 40 Rat Functional pIC50 ~ 6.3 6.3 -83 4
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2237 None 40 Rat Functional pIC50 ~ 6.3 6.3 -83 4
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2237 None 40 Rat Functional pIC50 ~ 6.3 6.3 -83 4
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
392622 56328 None 57 Human Binding pAC50 = 5.9 5.9 - 4
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56328 None 57 Human Binding pAC50 = 5.9 5.9 - 4
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
3793 205667 None 50 Human Binding pAC50 = 5.8 5.8 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
45039617 205667 None 50 Human Binding pAC50 = 5.8 5.8 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
CHEMBL64391 205667 None 50 Human Binding pAC50 = 5.8 5.8 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
3883 183641 None 69 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 183641 None 69 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
43815 187026 None 38 Human Binding pAC50 = 6.7 6.7 - 24
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 187026 None 38 Human Binding pAC50 = 6.7 6.7 - 24
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 187026 None 38 Human Binding pAC50 = 6.7 6.7 - 24
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
1890 2759 None 31 Human Binding pAC50 = 5.6 5.6 - 26
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 2759 None 31 Human Binding pAC50 = 5.6 5.6 - 26
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 2759 None 31 Human Binding pAC50 = 5.6 5.6 - 26
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 2759 None 31 Human Binding pAC50 = 5.6 5.6 - 26
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 2759 None 31 Human Binding pAC50 = 5.6 5.6 - 26
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
191 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170.0 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 403 None 60 Human Binding pAC50 = 5.6 5.6 - 28
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
212 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651.0 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 3806 None 35 Human Binding pAC50 = 5.4 5.4 - 25
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2247 505 None 55 Human Binding pAC50 = 5.3 5.3 -117 41
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 505 None 55 Human Binding pAC50 = 5.3 5.3 -117 41
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 505 None 55 Human Binding pAC50 = 5.3 5.3 -117 41
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 505 None 55 Human Binding pAC50 = 5.3 5.3 -117 41
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 505 None 55 Human Binding pAC50 = 5.3 5.3 -117 41
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2585 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2585.0 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 None 59 Human Binding pAC50 = 6.3 6.3 - 22
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
11434515 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
11434515.0 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
11519741 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
4484 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
7449 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL1194325 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
DB08897 261 None 6 Human Binding pAC50 = 6.3 6.3 - 5
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
213 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
2717 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
5533 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
5533.0 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL621 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00656 3853 None 34 Human Binding pAC50 = 5.3 5.3 - 43
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
10034073 17168 None 30 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 17168 None 30 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
2600 3779 None 53 Human Binding pAC50 = 5.2 5.2 - 13
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2608 3779 None 53 Human Binding pAC50 = 5.2 5.2 - 13
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5405 3779 None 53 Human Binding pAC50 = 5.2 5.2 - 13
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL17157 3779 None 53 Human Binding pAC50 = 5.2 5.2 - 13
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
DB00342 3779 None 53 Human Binding pAC50 = 5.2 5.2 - 13
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
644241 95239 None 68 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 95239 None 68 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
5360696 1406 None 18 Human Binding pAC50 = 5.2 5.2 - 3
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
6953 1406 None 18 Human Binding pAC50 = 5.2 5.2 - 3
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
842 1406 None 18 Human Binding pAC50 = 5.2 5.2 - 3
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
CHEMBL52440 1406 None 18 Human Binding pAC50 = 5.2 5.2 - 3
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
DB00514 1406 None 18 Human Binding pAC50 = 5.2 5.2 - 3
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
5328940 100270 None 65 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL288441 100270 None 65 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
3157 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
3157.0 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 1470 None 44 Human Binding pAC50 = 5.1 5.1 - 11
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
1353 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559.0 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1911 None 63 Human Binding pAC50 = 5.1 5.1 - 85
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
242 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795.0 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 70 Human Binding pAC50 = 5.1 5.1 - 51
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
1024 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
162639143 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
5284373 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
760 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL160 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00091 1289 None 44 Human Binding pAC50 = 6 6.0 - 1
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
2098 3694 None 31 Human Binding pEC50 = 9.2 9.2 1 6
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
36511 3694 None 31 Human Binding pEC50 = 9.2 9.2 1 6
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3805 3694 None 31 Human Binding pEC50 = 9.2 9.2 1 6
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3835 3694 None 31 Human Binding pEC50 = 9.2 9.2 1 6
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3694 None 31 Human Binding pEC50 = 9.2 9.2 1 6
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL384518 214788 None 8 Human Binding pEC50 = 9.2 9.2 - 0
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
CHEMBL428532 215916 None 5 Guinea pig Binding pEC50 = 8.8 8.8 - 0
Compound was evaluated for effective dose against Muscular receptor in guinea pig ileumCompound was evaluated for effective dose against Muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
44337561 96791 None 0 Guinea pig Binding pEC50 = 8.0 8.0 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL264395 96791 None 0 Guinea pig Binding pEC50 = 8.0 8.0 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308430 102318 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL303222 102318 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 212586 None 0 Guinea pig Binding pEC50 = 5.9 5.9 - 0
Compound was evaluated for effective dose against neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
CHEMBL263185 213020 None 5 Human Binding pEC50 = 7.9 7.9 - 0
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
CHEMBL415159 215635 None 4 Human Binding pEC50 = 7.9 7.9 - 0
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44337560 109806 None 0 Guinea pig Binding pEC50 = 6.8 6.8 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL323028 109806 None 0 Guinea pig Binding pEC50 = 6.8 6.8 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337787 9169 None 0 Guinea pig Binding pEC50 = 6.8 6.8 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL110177 9169 None 0 Guinea pig Binding pEC50 = 6.8 6.8 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308431 164617 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL421485 164617 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 212586 None 0 Guinea pig Binding pEC50 = 8.7 8.7 - 0
Compound was evaluated for effective dose against muscular receptor in guinea pig ileumCompound was evaluated for effective dose against muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
132629 2236 None 13 Human Binding pEC50 = 7.6 7.6 - 0
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
2104 2236 None 13 Human Binding pEC50 = 7.6 7.6 - 0
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL24999 2236 None 13 Human Binding pEC50 = 7.6 7.6 - 0
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL422779 215773 None 0 Guinea pig Binding pEC50 = 8.5 8.5 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
CHEMBL106184 210929 None 0 Guinea pig Binding pEC50 = 6.5 6.5 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
108147 3583 None 32 Guinea pig Binding pEC50 = 4.5 4.5 - 3
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
2127 3583 None 32 Guinea pig Binding pEC50 = 4.5 4.5 - 3
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL106124 3583 None 32 Guinea pig Binding pEC50 = 4.5 4.5 - 3
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL428532 215916 None 5 Guinea pig Binding pEC50 = 8.4 8.4 - 0
Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against Neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
10843656 96875 None 0 Guinea pig Binding pEC50 = 6.4 6.4 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
CHEMBL265115 96875 None 0 Guinea pig Binding pEC50 = 6.4 6.4 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
44337775 163502 None 0 Guinea pig Binding pEC50 = 5.4 5.4 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL419558 163502 None 0 Guinea pig Binding pEC50 = 5.4 5.4 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337797 109070 None 0 Guinea pig Binding pEC50 = 8.3 8.3 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL321228 109070 None 0 Guinea pig Binding pEC50 = 8.3 8.3 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308550 102173 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL302349 102173 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
162673403 183155 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4794099 183155 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
44337530 168000 None 0 Guinea pig Binding pEC50 = 7.2 7.2 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL431243 168000 None 0 Guinea pig Binding pEC50 = 7.2 7.2 - 0
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
162651127 180387 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4750714 180387 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
11238415 99308 None 0 Human Binding pIC50 = 11 11.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL281797 99308 None 0 Human Binding pIC50 = 11 11.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
11352855 97169 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL26761 97169 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9821217 107786 None 17 Human Binding pIC50 = 10.9 10.9 - 5
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL319118 107786 None 17 Human Binding pIC50 = 10.9 10.9 - 5
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3215877 107786 None 17 Human Binding pIC50 = 10.9 10.9 - 5
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
49863731 15336 None 0 Human Binding pIC50 = 10.9 10.9 - 3
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15336 None 0 Human Binding pIC50 = 10.9 10.9 - 3
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
25129133 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
25129133 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188995 None 0 Human Binding pIC50 = 10.9 10.9 - 4
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
46884430 8322 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8322 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11852872 68649 None 0 Human Binding pIC50 = 10.8 10.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68649 None 0 Human Binding pIC50 = 10.8 10.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
25027805 71046 None 0 Human Binding pIC50 = 10.8 10.8 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951813 71046 None 0 Human Binding pIC50 = 10.8 10.8 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
44178113 61284 None 0 Human Binding pIC50 = 10.7 10.7 - 3
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 61284 None 0 Human Binding pIC50 = 10.7 10.7 - 3
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
57391771 71044 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 71044 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395695 71646 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917866 71646 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963416 71646 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
87318292 126520 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 126520 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
67232184 126514 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 126514 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
73265457 126519 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 126519 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11248796 161743 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL413027 161743 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
122182823 122127 None 0 Mongolian jird Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596448 122127 None 0 Mongolian jird Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433804 146883 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146883 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
73265450 126510 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 126510 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
73265453 126515 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 126515 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
57402264 70984 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951626 70984 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57403992 70991 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951633 70991 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
73265456 126518 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 126518 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
9828716 71657 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917853 71657 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963487 71657 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
127944 120989 None 2 Human Binding pIC50 = 10.4 10.4 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL356062 120989 None 2 Human Binding pIC50 = 10.4 10.4 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL555572 120989 None 2 Human Binding pIC50 = 10.4 10.4 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
46881682 8099 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8099 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46883879 7772 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7772 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57398784 70989 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951631 70989 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
57400919 71643 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917856 71643 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963413 71643 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57397000 71045 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951811 71045 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
11621512 70988 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951630 70988 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57397022 70990 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951632 70990 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265454 126516 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 126516 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
57400917 71671 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917852 71671 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963577 71671 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
135539114 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
CHEMBL99055 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
135539114 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL99055 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
122182821 122125 None 0 Mongolian jird Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596446 122125 None 0 Mongolian jird Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
122182822 122126 None 0 Mongolian jird Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596447 122126 None 0 Mongolian jird Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433798 145774 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145774 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433797 146224 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 146224 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6545 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6545 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135539114 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
CHEMBL99055 210761 None 4 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
57398783 70987 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951629 70987 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
57391771 71044 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 71044 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395688 68647 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917851 68647 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57390405 71645 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917865 71645 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963415 71645 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57397483 71644 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917859 71644 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963414 71644 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400921 71632 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917860 71632 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963300 71632 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57395693 71633 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917862 71633 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963301 71633 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456802 97503 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270090 97503 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
16663280 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272649 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
23653789 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
46881727 5596 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5596 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8452 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8452 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8914 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8914 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8914 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8914 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52949827 17349 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17349 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
25028925 91399 None 3 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 91399 None 3 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
16663280 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
16663280 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 98014 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
23653789 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3587 None 25 Human Binding pIC50 = 10.2 10.2 - 2
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
44444666 154473 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL398720 154473 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
127944 120989 None 2 Human Binding pIC50 = 10.2 10.2 - 1
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL356062 120989 None 2 Human Binding pIC50 = 10.2 10.2 - 1
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL555572 120989 None 2 Human Binding pIC50 = 10.2 10.2 - 1
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
46947062 17467 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57391807 70985 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951627 70985 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
24889113 7950 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7950 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7950 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52943848 17427 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17427 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
135406581 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
CHEMBL140745 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
73265455 126517 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 126517 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2098 3694 None 31 Guinea pig Binding pIC50 = 10.2 10.2 -2 6
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3694 None 31 Guinea pig Binding pIC50 = 10.2 10.2 -2 6
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3694 None 31 Guinea pig Binding pIC50 = 10.2 10.2 -2 6
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3694 None 31 Guinea pig Binding pIC50 = 10.2 10.2 -2 6
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3694 None 31 Guinea pig Binding pIC50 = 10.2 10.2 -2 6
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
135406581 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
CHEMBL140745 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
44433800 146877 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146877 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433803 146882 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146882 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6545 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6545 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881820 7563 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7563 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881729 7941 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7941 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8452 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8452 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444634 94154 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249145 94154 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
24180495 154772 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399668 154772 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444643 154991 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400848 154991 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
135406581 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
CHEMBL140745 31935 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
73265452 126513 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 126513 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11852872 68649 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68649 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402266 70992 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951634 70992 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265451 126512 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 126512 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
11409185 99477 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 99477 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
57402690 68646 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917850 68646 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
9917079 61185 None 32 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 61185 None 32 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
5752 4005 None 23 Human Binding pIC50 = 10.1 10.1 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
6918331 4005 None 23 Human Binding pIC50 = 10.1 10.1 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
CHEMBL522302 4005 None 23 Human Binding pIC50 = 10.1 10.1 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
DB12436 4005 None 23 Human Binding pIC50 = 10.1 10.1 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
71456209 78688 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL2112366 78688 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
46881729 7941 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7941 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750888 8453 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8453 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752434 9135 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9135 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52941351 17385 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17385 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57395691 71672 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917858 71672 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963578 71672 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400923 71647 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917867 71647 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963417 71647 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10407571 168060 None 9 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL431690 168060 None 9 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
57397481 71678 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917855 71678 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963613 71678 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
11983278 166195 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
CHEMBL425956 166195 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
11983278 166195 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
CHEMBL425956 166195 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
135449286 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL52330 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
135449286 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
135485796 35259 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL143587 35259 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
135449286 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
CHEMBL52330 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
44407331 141300 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382848 141300 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
135413536 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
230 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
3490 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
6918365 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
CHEMBL1471 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
DB00673 448 None 58 Mongolian jird Binding pIC50 = 10.1 10.1 - 2
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
44433799 88702 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88702 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
135449286 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL52330 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
24888943 7949 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7949 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46881682 8099 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8099 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947645 17250 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17250 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17314 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17314 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993313 187137 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 187137 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444631 94153 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249144 94153 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
44444637 94554 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251577 94554 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444685 154862 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154862 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
135547943 34436 None 23 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
CHEMBL142819 34436 None 23 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
135449286 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
CHEMBL52330 193298 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
135413536 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
230 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
3490 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
6918365 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
CHEMBL1471 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
DB00673 448 None 58 Human Binding pIC50 = 10.1 10.1 50 2
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
42611207 124853 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124853 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
57399171 68648 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917857 68648 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57398782 70979 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951621 70979 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
135413536 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
230 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
3490 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
6918365 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
CHEMBL1471 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
DB00673 448 None 58 Human Binding pIC50 = 10 10.0 50 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
135539114 210761 None 4 Human Binding pIC50 = 10 10.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL99055 210761 None 4 Human Binding pIC50 = 10 10.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
171358581 194608 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 479 4 1 8 3.4 COc1cccc(-n2nnnc2C(F)(F)F)c1[C@H]1CO[C@@]2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
CHEMBL5290533 194608 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 479 4 1 8 3.4 COc1cccc(-n2nnnc2C(F)(F)F)c1[C@H]1CO[C@@]2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
135419433 31804 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL140626 31804 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
44407427 141267 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL382803 141267 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44318589 163438 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL419119 163438 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094861 208267 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83250 208267 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094863 107191 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL316141 107191 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
57393955 71621 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917863 71621 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963216 71621 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46830287 7992 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7992 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993314 171142 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 171142 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44444664 94531 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251387 94531 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
73265449 124479 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 124479 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
10051762 82261 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21709 82261 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44407513 74323 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202417 74323 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
10004377 111471 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327250 111471 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44325058 112515 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329828 112515 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL1651026 211285 None 21 Human Binding pIC50 = 10.0 10.0 - 1
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cellsDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL1651026 211285 None 21 Human Binding pIC50 = 10.0 10.0 - 1
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting methodDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.11.014
57398785 70993 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951635 70993 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
24889113 7950 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7950 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7950 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884518 7980 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7980 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884467 7993 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7993 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 8015 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884519 8095 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 8095 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
52943994 17839 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17839 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993955 184411 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 184411 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444681 94426 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 94426 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444688 155094 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL401415 155094 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444658 167160 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL428933 167160 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
45271306 198128 None 0 Human Binding pIC50 = 9.9 9.9 14 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 198128 None 0 Human Binding pIC50 = 9.9 9.9 14 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2098 3694 None 31 Human Binding pIC50 = 9.9 9.9 1 6
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
36511 3694 None 31 Human Binding pIC50 = 9.9 9.9 1 6
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3805 3694 None 31 Human Binding pIC50 = 9.9 9.9 1 6
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3835 3694 None 31 Human Binding pIC50 = 9.9 9.9 1 6
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
CHEMBL235363 3694 None 31 Human Binding pIC50 = 9.9 9.9 1 6
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
2098 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
36511 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3805 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3835 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
2098 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274207 78604 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
CHEMBL21122 78604 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
10053419 82652 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21792 82652 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44412226 168940 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL437878 168940 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44433789 146222 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 146222 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44444646 94074 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248748 94074 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444693 94550 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251557 94550 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444650 154992 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
CHEMBL400849 154992 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
2098 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
36511 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3805 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3835 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
2098 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
36511 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3805 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3835 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.9 9.9 -1 6
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL389652 214890 None 0 Human Binding pIC50 = 9.9 9.9 2 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44334114 4548 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
CHEMBL102382 4548 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
44295002 156053 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL406136 156053 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44407325 73389 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
CHEMBL201362 73389 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
57390403 71679 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917861 71679 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963614 71679 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46881728 5597 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5597 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881821 5602 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5602 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884516 7828 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7828 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
42639650 188301 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 188301 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444684 94337 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL250390 94337 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
44444695 94590 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251768 94590 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44274251 83194 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21831 83194 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10053174 99562 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL283318 99562 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412207 140419 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380680 140419 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
9821217 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL319118 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL3215877 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
9821217 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL319118 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL3215877 107786 None 17 Human Binding pIC50 = 9.9 9.9 - 5
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
57403991 70983 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951625 70983 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
44456522 158976 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL409520 158976 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
22885694 141534 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384177 141534 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24888772 8018 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 8018 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752434 9135 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9135 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947646 17252 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17252 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52942803 17253 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17253 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44444669 154504 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL398919 154504 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
10186401 98981 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
CHEMBL279442 98981 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
24889114 7753 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7753 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46884515 7827 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7827 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884472 7997 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7997 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993312 179459 None 8 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 179459 None 8 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444638 155748 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL404855 155748 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
3086681 2272 None 18 Human Binding pIC50 = 9.8 9.8 89125 3
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2272 None 18 Human Binding pIC50 = 9.8 9.8 89125 3
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2272 None 18 Human Binding pIC50 = 9.8 9.8 89125 3
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44333730 107728 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL319046 107728 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
10098209 99143 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL280662 99143 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
57400915 71642 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917844 71642 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963412 71642 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44416078 140225 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL380210 140225 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
16006943 141531 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384171 141531 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884473 7791 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7791 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883823 8434 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8434 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52948931 17256 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17256 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
44444660 154736 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399466 154736 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444685 154862 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154862 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
44444692 155564 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL404001 155564 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44593632 178874 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
CHEMBL468830 178874 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
44177570 61280 None 0 Human Binding pIC50 = 9.8 9.8 15 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 61280 None 0 Human Binding pIC50 = 9.8 9.8 15 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10460917 163844 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL420543 163844 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
2102 1189 None 17 Human Binding pIC50 = 9.8 9.8 -2 2
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
5311057 1189 None 17 Human Binding pIC50 = 9.8 9.8 -2 2
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.8 9.8 -2 2
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
73352606 93026 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441368 93026 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
10460917 163844 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163844 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
57402689 68644 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917845 68644 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
23146876 70981 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951623 70981 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44433802 146879 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146879 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44433804 146883 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146883 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
22885615 80211 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213538 80211 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
52947645 17250 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17250 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52947647 17254 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17254 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44233185 194934 None 0 Human Binding pIC50 = 9.8 9.8 47 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 194934 None 0 Human Binding pIC50 = 9.8 9.8 47 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
57397021 70982 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951624 70982 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
46884471 7751 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7751 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7771 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7771 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24888942 7948 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7948 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883824 8435 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8435 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44444640 94033 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248545 94033 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444694 154915 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL400393 154915 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9850771 119942 None 3 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119942 None 3 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
15253734 165444 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL423623 165444 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
46227362 205041 None 0 Human Binding pIC50 = 9.7 9.7 12 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 205041 None 0 Human Binding pIC50 = 9.7 9.7 12 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274166 80282 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL21385 80282 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
44412236 78168 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210365 78168 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
22885699 81051 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215373 81051 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885703 141513 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL384112 141513 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44357006 13730 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL1195055 13730 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL553778 13730 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
44356378 25750 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL135263 25750 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10480465 210874 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99792 210874 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9892852 84414 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL22194 84414 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
24785717 122171 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 122171 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
18669097 99456 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL282725 99456 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
57402692 71634 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917869 71634 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963302 71634 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402221 71047 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951814 71047 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
22885697 141759 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385463 141759 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44433394 146746 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL392368 146746 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
2102 1189 None 17 Human Binding pIC50 = 9.7 9.7 -2 2
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
5311057 1189 None 17 Human Binding pIC50 = 9.7 9.7 -2 2
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.7 9.7 -2 2
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
9892852 84414 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL22194 84414 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10553959 187976 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL49638 187976 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
104943 55402 None 31 Human Binding pIC50 = 9.7 9.7 1862 4
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.7 9.7 1862 4
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
9796216 102298 None 13 Human Binding pIC50 = 9.7 9.7 - 0
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
CHEMBL303118 102298 None 13 Human Binding pIC50 = 9.7 9.7 - 0
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
44294293 188560 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50270 188560 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10098209 99143 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL280662 99143 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
57402265 70986 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951628 70986 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
44433797 146224 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 146224 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
52948868 17255 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17255 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
46883879 7772 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7772 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44593636 181726 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181726 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
11814040 78840 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112743 78840 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
9871891 5461 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107482 5461 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
9871891 5461 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
CHEMBL107482 5461 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
11318556 93988 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93988 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9871414 99051 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
CHEMBL279977 99051 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
44274253 172380 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL447473 172380 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
10099787 103567 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085129 103567 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10480465 210874 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99792 210874 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412245 77986 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL209657 77986 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44444689 94278 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 94278 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
24755076 91617 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
CHEMBL240706 91617 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
44412445 77948 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
CHEMBL209456 77948 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
135405092 139370 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL379137 139370 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
3086681 2272 None 18 Human Binding pIC50 = 9.6 9.6 89125 3
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
3510 2272 None 18 Human Binding pIC50 = 9.6 9.6 89125 3
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
CHEMBL42407 2272 None 18 Human Binding pIC50 = 9.6 9.6 89125 3
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
10257218 24847 None 4 Human Binding pIC50 = 9.6 9.6 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL134500 24847 None 4 Human Binding pIC50 = 9.6 9.6 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10460917 163844 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163844 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5411 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5411 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10101238 34851 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143156 34851 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 211285 None 21 Human Binding pIC50 = 9.6 9.6 - 1
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2013.03.016
44407370 74477 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL202775 74477 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
22885698 139432 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL379289 139432 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44444629 94152 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249143 94152 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9871754 5411 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5411 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
5757 3986 None 14 Human Binding pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
9832383 3986 None 14 Human Binding pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
CHEMBL522987 3986 None 14 Human Binding pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
DB11949 3986 None 14 Human Binding pIC50 = 9.6 9.6 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
58993578 122172 None 0 Mongolian jird Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596493 122172 None 0 Mongolian jird Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
9891865 80088 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212991 80088 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
22885692 80209 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213515 80209 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44415869 80724 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215147 80724 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885691 81347 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL215889 81347 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
10951720 78838 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112741 78838 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10369373 162054 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL415705 162054 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
24992986 184410 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 184410 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44294659 103569 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085131 103569 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9869697 64662 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817895 64662 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
10341570 121138 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 121138 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3694 None 31 Human Binding pIC50 = 9.6 9.6 1 6
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
36511 3694 None 31 Human Binding pIC50 = 9.6 9.6 1 6
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3805 3694 None 31 Human Binding pIC50 = 9.6 9.6 1 6
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3835 3694 None 31 Human Binding pIC50 = 9.6 9.6 1 6
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL235363 3694 None 31 Human Binding pIC50 = 9.6 9.6 1 6
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44274153 77909 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL20937 77909 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
135529973 121574 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL358343 121574 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
44407459 141198 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382720 141198 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44456524 97991 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272569 97991 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44416008 80533 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214748 80533 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884470 7996 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7996 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752568 8914 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8914 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
18407037 162353 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL416372 162353 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
18407037 162353 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL416372 162353 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412173 78270 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210630 78270 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44456700 95962 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL259251 95962 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415789 141752 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385414 141752 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10144275 18900 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128369 18900 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
22293490 101365 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL296583 101365 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
24785717 122171 None 0 Mongolian jird Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 122171 None 0 Mongolian jird Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
44356404 23216 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
CHEMBL133140 23216 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
18669091 4687 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103367 4687 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10008129 61098 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL176500 61098 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9938284 101470 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL297344 101470 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11755227 205534 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63793 205534 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
71450870 78690 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL2112368 78690 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
22885695 139211 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378689 139211 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
46881600 7108 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7108 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44444689 94278 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 94278 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444671 154846 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400060 154846 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
57402688 71630 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917843 71630 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963298 71630 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
52941489 17738 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17738 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10768417 165697 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL424291 165697 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 211285 None 21 Human Binding pIC50 = 9.5 9.5 - 1
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
58993533 122164 None 0 Mongolian jird Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596485 122164 None 0 Mongolian jird Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
19797422 96716 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL263795 96716 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
104943 55402 None 31 Human Binding pIC50 = 9.5 9.5 1862 4
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.5 9.5 1862 4
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
10346229 83054 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21813 83054 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
21955317 103568 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085130 103568 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44412374 77823 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
CHEMBL209240 77823 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
11678857 139394 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL379224 139394 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44456865 97956 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272469 97956 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
14986135 163496 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
CHEMBL419500 163496 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
44334275 5074 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL105420 5074 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
9871754 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10415870 103565 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085127 103565 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10483816 191307 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL51893 191307 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
10483816 79661 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115007 79661 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10415870 140696 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL381390 140696 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
53379508 66482 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817891 66482 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852123 66482 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
22885696 139015 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378416 139015 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44444654 94110 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248943 94110 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15516313 178822 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL468350 178822 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
44593636 181726 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181726 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
9871754 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
10698096 55889 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL162337 55889 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9871754 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5411 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
44334149 4601 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102730 4601 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10393962 103570 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085132 103570 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
22293475 187234 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187234 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
18782542 111528 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL327606 111528 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
11146618 78839 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
CHEMBL2112742 78839 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
104943 55402 None 31 Human Binding pIC50 = 9.5 9.5 1862 4
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.5 9.5 1862 4
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44346234 14653 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL120523 14653 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
10415534 166301 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL426577 166301 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2098 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
36511 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3805 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3835 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
22885704 81556 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL216018 81556 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24752568 8914 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8914 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752568 8914 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8914 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444659 94225 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249568 94225 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9855000 20628 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20628 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
18669080 5010 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105047 5010 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10210026 101415 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296979 101415 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
58993465 122173 None 0 Mongolian jird Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596494 122173 None 0 Mongolian jird Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
22885702 80538 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214761 80538 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884434 7927 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7927 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44346438 114814 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL333882 114814 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
10098987 60001 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 60001 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
104943 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
44410317 77179 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207794 77179 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415921 141834 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385925 141834 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889458 8432 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8432 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46947062 17467 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17467 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
9821217 107786 None 17 Human Binding pIC50 = 9.4 9.4 - 5
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL319118 107786 None 17 Human Binding pIC50 = 9.4 9.4 - 5
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL3215877 107786 None 17 Human Binding pIC50 = 9.4 9.4 - 5
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 182548 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 182548 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44577989 189539 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL513351 189539 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
9984665 5344 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL106864 5344 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
104943 55402 None 31 Guinea pig Binding pIC50 = 9.4 9.4 - 4
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55402 None 31 Guinea pig Binding pIC50 = 9.4 9.4 - 4
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2098 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
36511 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3805 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3835 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.4 9.4 -1 6
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
44412493 77923 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
CHEMBL209407 77923 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
44415909 79917 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212349 79917 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
49863732 15337 None 0 Human Binding pIC50 = 9.4 9.4 24 4
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15337 None 0 Human Binding pIC50 = 9.4 9.4 24 4
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
135430679 46059 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
CHEMBL153310 46059 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
44294660 103571 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085133 103571 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
53379509 66477 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817892 66477 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852099 66477 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
44433789 146222 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 146222 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24750888 8453 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8453 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135430775 45359 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152685 45359 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44412235 140262 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380388 140262 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44415808 81492 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215975 81492 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
11756257 167886 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43044 167886 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
18669059 98824 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL278149 98824 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412373 139187 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
CHEMBL378663 139187 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
21955285 189102 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50867 189102 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
104943 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.4 9.4 1862 4
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
24785978 122162 None 0 Mongolian jird Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 122162 None 0 Mongolian jird Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
9329 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9894349 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
CHEMBL339486 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9329 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3741 None 5 Human Binding pIC50 = 9.4 9.4 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
10392469 195237 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 195237 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44177669 61281 None 0 Human Binding pIC50 = 9.3 9.3 2 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 61281 None 0 Human Binding pIC50 = 9.3 9.3 2 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10325507 60462 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL175224 60462 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44444674 94378 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250596 94378 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44408291 140967 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL381984 140967 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408177 141062 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL382331 141062 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408290 141336 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL383048 141336 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
10007758 179087 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL47070 179087 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227363 202121 None 0 Human Binding pIC50 = 9.3 9.3 28 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 202121 None 0 Human Binding pIC50 = 9.3 9.3 28 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44412453 161783 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL413279 161783 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
21955222 101838 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL300014 101838 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10392469 195237 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL539928 195237 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
2102 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
5311057 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
10098987 60001 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 60001 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10720240 35105 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143375 35105 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
2102 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
5311057 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
2102 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
5311057 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
2102 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
5311057 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.3 9.3 -2 2
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
105083 25459 None 1 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL135022 25459 None 1 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
44410278 140951 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381965 140951 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44408176 74349 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL202439 74349 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44593634 182895 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL479049 182895 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
10099939 4989 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4989 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 107403 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 107403 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4989 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4989 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
10814682 210173 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL95626 210173 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44433798 145774 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145774 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
46884468 7994 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7994 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
104943 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.3 9.3 1862 4
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44415896 139001 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378331 139001 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44299271 198504 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL56038 198504 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
42639649 170848 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170848 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44334107 4406 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL101421 4406 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44299271 198504 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56038 198504 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10814682 210173 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL95626 210173 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412159 141008 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL382255 141008 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
46884430 8322 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8322 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
22901329 99133 None 1 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL28055 99133 None 1 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
9805809 103142 None 6 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
CHEMBL307488 103142 None 6 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
44334127 4636 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102937 4636 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44415554 139136 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378609 139136 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
136094860 208569 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85792 208569 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44433796 90226 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL238220 90226 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44444677 155073 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL401281 155073 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44312057 206910 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL72234 206910 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
24785978 122162 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 122162 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10392925 14444 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120081 14444 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10076669 60238 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174016 60238 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11800025 121344 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL357887 121344 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
18669082 165811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL424586 165811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669082 165811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL424586 165811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL2115376 211726 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
2102 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
5311057 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44410191 140779 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381555 140779 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415947 80334 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214118 80334 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24750734 8015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 8015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
2102 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
5311057 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
44305288 205337 None 0 Human Binding pIC50 = 9.2 9.2 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62649 205337 None 0 Human Binding pIC50 = 9.2 9.2 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10392925 14444 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120081 14444 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
18686789 93027 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441369 93027 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
136094778 139348 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
CHEMBL379010 139348 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
10357939 118143 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL340559 118143 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
44294291 101244 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL295685 101244 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408158 140266 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL380408 140266 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
56662745 64664 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64664 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64664 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10258336 101336 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296397 101336 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44307416 205466 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63240 205466 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10258336 101336 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296397 101336 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44456703 158446 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408960 158446 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
2102 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
5311057 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9.2 9.2 -2 2
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
2098 3694 None 31 Rat Binding pIC50 = 9.2 9.2 -1 6
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
36511 3694 None 31 Rat Binding pIC50 = 9.2 9.2 -1 6
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3805 3694 None 31 Rat Binding pIC50 = 9.2 9.2 -1 6
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3835 3694 None 31 Rat Binding pIC50 = 9.2 9.2 -1 6
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.2 9.2 -1 6
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
44412225 139796 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL379816 139796 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
171343740 193721 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1252 41 16 16 -2.3 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
CHEMBL5269970 193721 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1252 41 16 16 -2.3 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
44407431 73254 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
CHEMBL201192 73254 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
10076383 101280 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL296013 101280 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
104943 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
44408313 74528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL202884 74528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
52941550 17811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17811 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
104943 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44433784 90224 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238210 90224 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44416136 79838 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212025 79838 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
9855000 20628 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20628 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
10347274 128740 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL366818 128740 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.2 9.2 1862 4
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
21955298 79660 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115006 79660 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL396426 214956 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44415967 138788 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL377917 138788 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46947062 17467 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10502796 32322 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL141034 32322 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44578024 178799 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL468163 178799 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
10372941 119572 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
CHEMBL345520 119572 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
10885893 102967 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL306089 102967 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10553959 187976 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL49638 187976 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44305221 101082 None 0 Human Binding pIC50 = 9.2 9.2 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL294545 101082 None 0 Human Binding pIC50 = 9.2 9.2 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10553959 187976 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL49638 187976 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44313273 207427 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL76501 207427 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44433793 148472 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393746 148472 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL396426 214956 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
22293505 189638 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL51417 189638 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
25028925 91399 None 3 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 91399 None 3 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
44358731 30348 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139167 30348 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10077113 121607 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121607 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55402 None 31 Human Binding pIC50 = 9.1 9.1 1862 4
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.1 9.1 1862 4
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
22293475 187234 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187234 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415444 80253 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213726 80253 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
52949827 17349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 8015 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL229280 211917 None 0 Human Binding pIC50 = 9.1 9.1 23 3
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44333607 4977 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL104883 4977 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10142159 81575 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21607 81575 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
44274180 163286 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL418186 163286 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
44433787 88566 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235219 88566 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
11800024 210716 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98811 210716 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
136180340 119673 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL346447 119673 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10053205 116649 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116649 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11800024 210716 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98811 210716 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44408123 140674 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL381362 140674 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
46881682 8099 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8099 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
104943 55402 None 31 Human Binding pIC50 = 9.1 9.1 1862 4
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55402 None 31 Human Binding pIC50 = 9.1 9.1 1862 4
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10578351 120292 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL352176 120292 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
71449072 78609 None 0 Human Binding pIC50 = 9.1 9.1 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78609 None 0 Human Binding pIC50 = 9.1 9.1 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
56668401 66464 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817890 66464 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852009 66464 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415404 80072 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212931 80072 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10721713 120101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350381 120101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
18709649 165101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42259 165101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44415550 166231 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL426145 166231 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881820 7563 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7563 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44433792 148470 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393745 148470 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
22901329 99133 None 1 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28055 99133 None 1 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
22901329 99133 None 1 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL28055 99133 None 1 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44294689 101668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL298858 101668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11016806 207415 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL76455 207415 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
9829083 120203 None 0 Human Binding pIC50 = 9.1 9.1 - 1
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 120203 None 0 Human Binding pIC50 = 9.1 9.1 - 1
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10816374 18902 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128384 18902 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
132846 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
13432 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00009-I
132846 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
13432 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/acs.jmedchem.1c00790
132846 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
13432 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm950654w
135547943 34436 None 23 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL142819 34436 None 23 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
44456828 97633 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270751 97633 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44358610 29491 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138463 29491 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 120416 None 0 Guinea pig Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 120416 None 0 Guinea pig Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
18669087 98784 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL277880 98784 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669087 98784 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL277880 98784 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44325035 112216 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329018 112216 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44415400 80124 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213134 80124 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
9938657 60242 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 60242 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
10502796 32322 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL141034 32322 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
11799022 4469 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL101763 4469 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881727 5596 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5596 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
15549737 178921 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL469176 178921 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 182548 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 182548 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44578056 189866 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL515935 189866 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
19797472 118826 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
CHEMBL341863 118826 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
10341570 121138 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 121138 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3694 None 31 Human Binding pIC50 = 9.1 9.1 1 6
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 None 31 Human Binding pIC50 = 9.1 9.1 1 6
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 None 31 Human Binding pIC50 = 9.1 9.1 1 6
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 None 31 Human Binding pIC50 = 9.1 9.1 1 6
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 None 31 Human Binding pIC50 = 9.1 9.1 1 6
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
58993655 122165 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596486 122165 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
24752434 9135 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9135 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL2370435 212308 None 0 Human Binding pIC50 = 9.0 9.0 48 2
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
15639110 168245 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL433020 168245 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44274544 81557 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21602 81557 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44328469 112303 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL329090 112303 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
24782914 122161 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596482 122161 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884431 8057 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 8057 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10578269 35155 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143464 35155 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
4898 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
5742 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149.0 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
CHEMBL206253 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
DB09048 2765 None 62 Human Binding pIC50 = 9.0 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
10047566 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL422931 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10047566 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL422931 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415840 79997 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212663 79997 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10049890 80043 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 80043 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10047566 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL422931 165336 None 2 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL389652 214890 None 0 Human Binding pIC50 = 9.0 9.0 2 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11813209 207557 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL77684 207557 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
18669072 83349 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21909 83349 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
10576865 210586 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98022 210586 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44433810 89913 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237796 89913 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
9959724 164950 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42191 164950 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10531050 120416 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 120416 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
489662 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL21815 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/s0960-894x(98)00320-5
44297605 194799 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL53312 194799 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/j.bmc.2013.09.001
9805809 103142 None 6 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL307488 103142 None 6 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
44338517 6337 None 0 Human Binding pIC50 = 9 9.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108200 6337 None 0 Human Binding pIC50 = 9 9.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9938657 60242 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 60242 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm980376b
44346206 113725 None 2 Human Binding pIC50 = 9 9.0 - 1
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL332284 113725 None 2 Human Binding pIC50 = 9 9.0 - 1
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80585-0
10047567 209677 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL92701 209677 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/0960-894X(95)00220-N
9890435 97497 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL27003 97497 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
2102 1189 None 17 Human Binding pIC50 = 9 9.0 -2 2
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
5311057 1189 None 17 Human Binding pIC50 = 9 9.0 -2 2
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL441225 1189 None 17 Human Binding pIC50 = 9 9.0 -2 2
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
44458328 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL283356 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1021/jm9700171
11799022 4469 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL101763 4469 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44346206 113725 None 2 Human Binding pIC50 = 9 9.0 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL332284 113725 None 2 Human Binding pIC50 = 9 9.0 - 1
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576865 210586 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98022 210586 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10648551 210886 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99873 210886 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
13432 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
CHEMBL27006 2238 None 16 Human Binding pIC50 = 9 9.0 - 1
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F 10.1016/S0960-894X(01)80280-8
489662 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21815 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
489662 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21815 83059 None 0 Human Binding pIC50 = 9 9.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10648551 210886 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99873 210886 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
24799545 87455 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333621 87455 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44407321 74433 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202568 74433 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410193 140421 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL380684 140421 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
44297605 194799 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
CHEMBL53312 194799 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
44456580 155376 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL402895 155376 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24889111 7926 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7926 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17250 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17250 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17314 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17314 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943994 17839 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17839 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10047566 165336 None 2 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL422931 165336 None 2 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44458328 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL283356 99569 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
46227361 205040 None 0 Human Binding pIC50 = 9 9.0 14 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 205040 None 0 Human Binding pIC50 = 9 9.0 14 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL389652 214890 None 0 Rat Binding pIC50 = 9 9.0 -2 4
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44335318 5107 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5107 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44312285 103012 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 103012 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10047566 165336 None 2 Human Binding pIC50 = 9 9.0 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL422931 165336 None 2 Human Binding pIC50 = 9 9.0 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
71450941 79550 None 0 Human Binding pIC50 = 9 9.0 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79550 None 0 Human Binding pIC50 = 9 9.0 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44305248 205345 None 0 Human Binding pIC50 = 9 9.0 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 205345 None 0 Human Binding pIC50 = 9 9.0 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
9805809 103142 None 6 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 103142 None 6 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
2098 3694 None 31 Rat Binding pIC50 = 9.0 9.0 -1 6
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
36511 3694 None 31 Rat Binding pIC50 = 9.0 9.0 -1 6
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3805 3694 None 31 Rat Binding pIC50 = 9.0 9.0 -1 6
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3835 3694 None 31 Rat Binding pIC50 = 9.0 9.0 -1 6
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 9.0 9.0 -1 6
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
101194030 194376 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3C(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
CHEMBL5284869 194376 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3C(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
10837742 185971 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL48680 185971 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
44318685 208460 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84881 208460 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44408124 75426 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL203961 75426 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
58993471 122163 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596484 122163 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
58993453 122167 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
CHEMBL3596488 122167 None 0 Mongolian jird Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
56662745 64664 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64664 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64664 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415415 79008 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211304 79008 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884469 7995 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7995 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
46881779 8452 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8452 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306210 102442 None 0 Guinea pig Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303896 102442 None 0 Guinea pig Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335372 4776 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4776 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10414428 4855 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
CHEMBL104301 4855 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
44358603 119109 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342662 119109 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9959330 198013 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL554713 198013 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2098 3694 None 31 Human Binding pIC50 = 9.0 9.0 1 6
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 None 31 Human Binding pIC50 = 9.0 9.0 1 6
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 None 31 Human Binding pIC50 = 9.0 9.0 1 6
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 None 31 Human Binding pIC50 = 9.0 9.0 1 6
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 None 31 Human Binding pIC50 = 9.0 9.0 1 6
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
10578969 57242 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL165007 57242 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10626048 118634 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341599 118634 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
490428 119640 None 3 Guinea pig Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119640 None 3 Guinea pig Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44294535 103566 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL3085128 103566 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
24801458 87458 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333624 87458 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
44407422 141451 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL383743 141451 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410281 75595 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL204573 75595 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993670 122168 None 0 Mongolian jird Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
CHEMBL3596489 122168 None 0 Mongolian jird Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
57399170 71677 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917842 71677 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963612 71677 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456650 155584 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL404089 155584 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
52941570 17251 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17251 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943848 17427 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17427 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10052312 107446 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL317896 107446 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44338545 9337 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111176 9337 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9916428 112909 None 2 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL330888 112909 None 2 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
10793838 120150 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350846 120150 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9892852 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9890435 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL27003 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
44333692 4559 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102434 4559 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44270505 12370 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1185492 12370 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL417263 12370 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
9890435 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
CHEMBL27003 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
9890435 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL27003 97497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318605 208324 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83772 208324 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44456894 160632 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL411242 160632 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10049890 80043 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 80043 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
22885690 141870 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL386151 141870 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
52942803 17253 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17253 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
11756839 5200 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL106087 5200 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9892852 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL22194 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
44358676 30019 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138890 30019 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9850771 119942 None 3 Mouse Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119942 None 3 Mouse Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9892852 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL22194 84414 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44368171 45413 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152742 45413 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10460917 163844 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163844 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5411 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5411 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11568372 208483 None 3 Human Binding pIC50 = 8.9 8.9 - 0
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 208483 None 3 Human Binding pIC50 = 8.9 8.9 - 0
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
101194031 194400 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3OC(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
CHEMBL5285318 194400 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3OC(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
44318672 208548 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85626 208548 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
57390401 71631 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963299 71631 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3216988 71631 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44415986 80415 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214472 80415 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889113 7950 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7950 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7950 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881728 5597 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5597 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44335319 107566 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107566 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44370448 119823 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL347891 119823 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358604 28529 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL137609 28529 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44358732 31259 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140124 31259 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358428 119073 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342607 119073 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9871754 5411 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5411 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
2098 3694 None 31 Human Binding pIC50 = 8.9 8.9 1 6
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
36511 3694 None 31 Human Binding pIC50 = 8.9 8.9 1 6
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3805 3694 None 31 Human Binding pIC50 = 8.9 8.9 1 6
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3835 3694 None 31 Human Binding pIC50 = 8.9 8.9 1 6
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 None 31 Human Binding pIC50 = 8.9 8.9 1 6
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2098 3694 None 31 Rat Binding pIC50 = 8.8 8.8 -1 6
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
36511 3694 None 31 Rat Binding pIC50 = 8.8 8.8 -1 6
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3805 3694 None 31 Rat Binding pIC50 = 8.8 8.8 -1 6
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3835 3694 None 31 Rat Binding pIC50 = 8.8 8.8 -1 6
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 8.8 8.8 -1 6
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
136180339 121168 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL357303 121168 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10027219 99636 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99636 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44274412 76065 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
CHEMBL20572 76065 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
44410283 138389 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL377091 138389 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
22293475 187234 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 187234 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408295 140412 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL380651 140412 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
2098 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
36511 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3805 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3835 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
CHEMBL235363 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
56662745 64664 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64664 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64664 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
2098 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
36511 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3805 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3835 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
CHEMBL235363 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
44456625 169037 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL438759 169037 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415403 138782 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL377881 138782 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
52941489 17738 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17738 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941506 17774 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17774 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17467 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
71699792 124852 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124852 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
19797432 37766 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37766 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10438671 27356 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136764 27356 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358707 31465 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL140299 31465 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
9850771 119942 None 3 Rat Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119942 None 3 Rat Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10076881 163011 None 0 Human Binding pIC50 = 8.8 8.8 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 163011 None 0 Human Binding pIC50 = 8.8 8.8 - 0
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10627355 120074 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 120074 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44338518 7724 None 0 Human Binding pIC50 = 8.8 8.8 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108889 7724 None 0 Human Binding pIC50 = 8.8 8.8 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338359 163524 None 0 Human Binding pIC50 = 8.8 8.8 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL419742 163524 None 0 Human Binding pIC50 = 8.8 8.8 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
132629 2236 None 13 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
2104 2236 None 13 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
CHEMBL24999 2236 None 13 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
21050485 168068 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL431732 168068 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799366 87452 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333618 87452 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
10648288 101955 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL300856 101955 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
24785977 122135 None 0 Mongolian jird Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596456 122135 None 0 Mongolian jird Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
10414293 37464 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37464 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
44396853 67294 None 5 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL188166 67294 None 5 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
21994307 26822 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136305 26822 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358471 30175 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139015 30175 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
132837 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
9461 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
CHEMBL22870 2237 None 40 Human Binding pIC50 = 8.8 8.8 18 5
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
10394703 197211 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54540 197211 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
135480369 33719 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
CHEMBL142216 33719 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
44274269 77059 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20717 77059 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
22293476 79659 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115005 79659 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
24889283 8433 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8433 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
52948931 17256 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17256 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
52941351 17385 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17385 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44306310 102375 None 0 Guinea pig Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303548 102375 None 0 Guinea pig Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306023 102441 None 0 Guinea pig Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303890 102441 None 0 Guinea pig Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10100236 28822 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137887 28822 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358470 29936 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138825 29936 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358561 30484 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139286 30484 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
2098 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
36511 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3805 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3835 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3694 None 31 Human Binding pIC50 = 8.8 8.8 1 6
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
10075595 60367 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174526 60367 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10554361 30869 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139719 30869 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10529338 31425 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL140263 31425 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10840066 116784 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL337358 116784 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541574 87445 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333611 87445 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44307181 206176 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67667 206176 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
58993542 122174 None 0 Mongolian jird Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596495 122174 None 0 Mongolian jird Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884432 7924 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7924 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947647 17254 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17254 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6545 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6545 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 8015 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 8015 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306218 162669 None 0 Guinea pig Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL416864 162669 None 0 Guinea pig Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44370973 46779 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL153976 46779 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44370354 121280 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
CHEMBL357757 121280 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
10462250 121457 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL358173 121457 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358720 28508 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137580 28508 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358657 30412 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139226 30412 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10816935 118171 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340732 118171 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
46881821 5602 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5602 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
71541373 87459 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333625 87459 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800231 87471 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333637 87471 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785712 122170 None 0 Mongolian jird Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
CHEMBL3596491 122170 None 0 Mongolian jird Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
57393953 71639 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917849 71639 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963369 71639 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44415443 77964 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209531 77964 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415485 79941 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212439 79941 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415502 80068 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212919 80068 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884517 8094 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 8094 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7771 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7771 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17250 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17250 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17467 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17467 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6545 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6545 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
19797432 37766 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37766 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10650469 57456 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165498 57456 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44328374 210446 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL97241 210446 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
11755361 116632 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL336439 116632 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
15639149 112972 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL331059 112972 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10413173 29666 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
CHEMBL138620 29666 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
44346149 15524 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL121742 15524 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346551 15589 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL122119 15589 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10359664 114066 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
CHEMBL332644 114066 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
54581461 61283 None 0 Human Binding pIC50 = 8.7 8.7 -6 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 61283 None 0 Human Binding pIC50 = 8.7 8.7 -6 4
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
10254526 100550 None 0 Human Binding pIC50 = 8 8.0 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291025 100550 None 0 Human Binding pIC50 = 8 8.0 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44368083 44973 None 0 Human Binding pIC50 = 8 8.0 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152339 44973 None 0 Human Binding pIC50 = 8 8.0 - 0
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10457416 14892 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14892 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10098987 60001 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 60001 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
14986135 163496 None 0 Guinea pig Binding pIC50 = 8 8.0 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 163496 None 0 Guinea pig Binding pIC50 = 8 8.0 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44402934 71096 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 71096 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
44359091 31256 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
CHEMBL140123 31256 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
44346420 14310 None 0 Rat Binding pIC50 = 8 8.0 - 0
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14310 None 0 Rat Binding pIC50 = 8 8.0 - 0
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44318657 208377 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84090 208377 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL2371978 212631 None 0 Human Binding pIC50 = 8 8.0 30 3
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55402 None 31 Human Binding pIC50 = 8 8.0 1862 4
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55402 None 31 Human Binding pIC50 = 8 8.0 1862 4
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
18391045 100450 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290043 100450 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44288896 169090 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 169090 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
19098237 37132 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 37132 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44312056 207181 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 207181 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358585 31274 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL140134 31274 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
18709652 168389 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL434012 168389 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44306230 100810 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292799 100810 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44319057 208302 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 208302 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
19049350 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281940 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
19049350 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL281940 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19049350 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL281940 99334 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
44346694 114874 None 1 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334072 114874 None 1 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44289443 169175 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43970 169175 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
44297749 194570 None 0 Human Binding pIC50 = 7 7.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52892 194570 None 0 Human Binding pIC50 = 7 7.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333579 4383 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101288 4383 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
44338510 8635 None 0 Human Binding pIC50 = 7 7.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL109514 8635 None 0 Human Binding pIC50 = 7 7.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44338531 9360 None 0 Human Binding pIC50 = 7 7.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111304 9360 None 0 Human Binding pIC50 = 7 7.0 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
44322648 208776 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87194 208776 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322525 209031 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88810 209031 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10095174 209121 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89385 209121 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44415470 165939 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424883 165939 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7925 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7925 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44294395 187301 None 0 Rat Binding pIC50 = 6 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972677 187301 None 0 Rat Binding pIC50 = 6 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL49233 187301 None 0 Rat Binding pIC50 = 6 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15755315 163276 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
CHEMBL418124 163276 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
15755303 202804 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59768 202804 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755300 205435 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL63059 205435 None 0 Guinea pig Binding pIC50 = 6 6.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44337428 7237 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
CHEMBL108575 7237 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
10793341 108896 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
CHEMBL320989 108896 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
44411742 78334 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 78334 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
44344435 13091 None 0 Human Binding pIC50 = 6 6.0 - 0
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL119025 13091 None 0 Human Binding pIC50 = 6 6.0 - 0
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
2125 3030 None 0 Human Binding pIC50 = 5 5.0 - 1
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 3030 None 0 Human Binding pIC50 = 5 5.0 - 1
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 3030 None 0 Human Binding pIC50 = 5 5.0 - 1
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
44291515 101192 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 101192 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44291788 101467 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 101467 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44346650 114503 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
CHEMBL333308 114503 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
15755305 101039 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294288 101039 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755312 101114 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL294737 101114 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
15755330 205275 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62349 205275 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755295 205725 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64631 205725 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1190873 211052 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
CHEMBL541800 211052 None 0 Guinea pig Binding pIC50 = 5 5.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
10840399 9377 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL111384 9377 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
15755333 100631 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
CHEMBL291602 100631 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
15755331 100902 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293445 100902 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755294 205772 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64829 205772 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64601 218345 None 0 Guinea pig Binding pIC50 = 4 4.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10744888 108723 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
CHEMBL320762 108723 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
44337578 168190 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432620 168190 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
15485361 97283 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 97283 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10362340 90304 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23851 90304 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44274545 82543 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21775 82543 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44362598 36834 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145022 36834 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10362340 90304 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
CHEMBL23851 90304 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
44312026 102906 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL305608 102906 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44289232 169975 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL444043 169975 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106805 None 0 Rat Binding pIC50 = 5.0 5.0 - 3
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106805 None 0 Rat Binding pIC50 = 5.0 5.0 - 3
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL2369600 212093 None 0 Human Binding pIC50 = 6.0 6.0 - 1
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10477952 99042 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL279916 99042 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
19797474 37482 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145552 37482 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44384902 59967 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59967 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44362586 37762 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
CHEMBL145799 37762 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
44276673 97410 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 97410 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
44324705 112420 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329445 112420 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
44359056 119514 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL345069 119514 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
10039383 85511 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
CHEMBL22680 85511 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
44297603 163223 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417760 163223 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11683136 105859 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126963 105859 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44333708 163471 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL419352 163471 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
11489471 94933 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25398 94933 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10389968 59913 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173014 59913 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
21753663 199111 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56442 199111 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
71541576 87447 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333613 87447 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800927 87473 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333639 87473 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
44433783 90223 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238209 90223 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883823 8434 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8434 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11705241 88269 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347857 88269 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
24993314 171142 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 171142 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44306115 205947 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL66151 205947 None 0 Guinea pig Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324814 209663 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL92621 209663 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
44288901 163377 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL418697 163377 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11318556 93988 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93988 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10840688 120265 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351940 120265 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44299464 202221 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59380 202221 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44306211 102391 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303680 102391 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
46884467 7993 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7993 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10202046 121125 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 121125 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10407571 168060 None 9 Human Binding pIC50 = 7.0 7.0 - 0
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
CHEMBL431690 168060 None 9 Human Binding pIC50 = 7.0 7.0 - 0
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
44307162 205818 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL65153 205818 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
71583096 88254 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347694 88254 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
15755296 102338 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303337 102338 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755297 102714 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304472 102714 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10256518 97448 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL269781 97448 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
10363425 164703 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL421591 164703 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288846 168439 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43432 168439 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10317821 36799 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL144996 36799 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44358472 116859 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL337803 116859 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44294321 12054 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
54093758 12054 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL1183502 12054 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL301168 12054 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
15037921 119689 None 0 Guinea pig Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346626 119689 None 0 Guinea pig Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
68928842 124865 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124865 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44312218 206598 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 206598 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10506929 56595 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56595 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
44328416 210400 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL96956 210400 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
10039383 85511 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL22680 85511 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
19797452 121593 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL358529 121593 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44287503 100260 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL288340 100260 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44299829 201532 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL58774 201532 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44287541 159751 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41038 159751 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL449091 216422 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10692651 101143 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 101143 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
19003165 102229 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL302719 102229 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
3198 207971 None 50 Human Binding pIC50 = 4.9 4.9 -37 34
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 207971 None 50 Human Binding pIC50 = 4.9 4.9 -37 34
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 207971 None 50 Human Binding pIC50 = 4.9 4.9 -37 34
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44297683 168293 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL433285 168293 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
9869033 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL290364 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
71541468 87467 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333633 87467 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801626 87474 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333640 87474 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
57403990 70978 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951620 70978 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
44335410 5002 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 5002 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44288885 100338 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
CHEMBL289026 100338 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
44396809 166462 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
CHEMBL427514 166462 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
44358709 29798 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL138715 29798 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44358679 29864 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138770 29864 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358680 116668 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336715 116668 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358683 119434 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
CHEMBL344434 119434 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
9869033 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL290364 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
9869033 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL290364 100478 None 5 Human Binding pIC50 = 7.9 7.9 - 0
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
9910357 11983 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183052 11983 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL277524 11983 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44338638 5726 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107829 5726 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338546 108664 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL320535 108664 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
9917079 61185 None 32 Mongolian jird Binding pIC50 = 7.9 7.9 - 0
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 61185 None 32 Mongolian jird Binding pIC50 = 7.9 7.9 - 0
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
44346334 15251 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121094 15251 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10837362 30758 None 1 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL139558 30758 None 1 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44299969 199652 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56814 199652 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44359117 119397 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
CHEMBL344217 119397 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
44297491 197806 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55180 197806 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
76325557 105855 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126959 105855 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
76325558 105864 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126968 105864 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
490428 119640 None 3 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119640 None 3 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
22293473 79663 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115009 79663 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24783682 122138 None 0 Mongolian jird Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596459 122138 None 0 Mongolian jird Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
11724403 168648 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007