Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL1627325 207068 0 None -1 8 Human 10.3 pEC50 = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm900604g
2098 3638 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
36511 3638 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3805 3638 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3835 3638 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL235363 3638 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL384518 210581 9 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
2098 3638 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
36511 3638 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3805 3638 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3835 3638 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
CHEMBL235363 3638 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
2098 3638 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
36511 3638 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3805 3638 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3835 3638 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3638 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
2098 3638 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3638 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3638 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3638 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3638 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
73356363 89074 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89074 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355648 96676 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 96676 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21588 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21588 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297675 100153 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100153 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10259515 156595 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 156595 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL263185 208816 4 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
2089 2725 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3795 2725 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2725 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2725 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL415159 211427 4 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44297866 101574 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 101574 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL441061 212131 16 None 2 2 Guinea pig 8.7 pEC50 = 8.7 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
73348740 89076 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89076 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355678 23286 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23286 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10350201 116659 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 116659 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10327810 116236 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116236 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10055612 95978 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 95978 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
14860666 104940 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL311917 104940 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
2098 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
15931130 101511 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 101511 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
5311135 21523 10 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21523 10 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
44355179 24144 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24144 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 206987 0 None -1 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
2098 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
36511 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3805 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3835 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3638 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
10395375 116157 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116157 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
10462850 24059 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24059 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
15931129 193308 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 193308 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL81919 214109 0 None -676 2 Guinea pig 6.2 pEC50 = 6.2 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL335054 209734 0 None -20 3 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
44297852 98550 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 98550 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2090 2726 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2726 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2726 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
11765601 95977 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 95977 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355368 25437 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25437 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10009596 115010 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 115010 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
73356365 89077 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
CHEMBL2372954 89077 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
108167 2813 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
2107 2813 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
CHEMBL1178725 2813 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
135434109 4217 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL100636 4217 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
9967131 205772 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
CHEMBL94461 205772 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
10363809 111638 17 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL329007 111638 17 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44328454 168173 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL437075 168173 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10111225 205744 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL94328 205744 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10477054 4426 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102032 4426 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10458573 4299 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL101148 4299 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
135488049 206474 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL98524 206474 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
2102 1166 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
5311057 1166 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
CHEMBL441225 1166 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
10480465 206673 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL99792 206673 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10272852 107407 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319301 107407 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9821217 107244 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319118 107244 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL3215877 107244 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9871754 5337 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5337 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
2098 3638 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
36511 3638 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3805 3638 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3835 3638 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
CHEMBL235363 3638 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
44433394 146125 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL392368 146125 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433394 146125 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL392368 146125 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
9960689 11900 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183286 11900 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288600 11900 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
9871754 5337 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5337 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
9945487 206017 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95852 206017 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10268178 205925 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95315 205925 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
2102 1166 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
5311057 1166 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL441225 1166 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
104943 55099 34 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
CHEMBL16192 55099 34 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
22879211 206402 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL98125 206402 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44433393 167086 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL430170 167086 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433393 167086 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL430170 167086 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
2098 3638 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
36511 3638 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3805 3638 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3835 3638 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
CHEMBL235363 3638 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
132846 96998 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL1256740 96998 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL27006 96998 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
9968267 108069 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL320220 108069 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10089212 4439 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102157 4439 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10047566 164689 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
CHEMBL422931 164689 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
10650495 106935 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 106935 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
11801327 9266 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9266 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
9871754 5337 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5337 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
135413536 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
230 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
3490 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
6918365 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
CHEMBL1471 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
DB00673 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
9832207 11894 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11894 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11894 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10817013 9166 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9166 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44327794 110934 1 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL327357 110934 1 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL2369600 207889 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
44286165 157849 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1794935 157849 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL40900 157849 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5074991 212578 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10039383 85052 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
CHEMBL22680 85052 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
15542673 205830 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL94834 205830 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44327909 111866 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL329450 111866 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304126 207735 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
9832306 112227 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330367 112227 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330462 112227 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
10123138 108039 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL317524 108039 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL320002 108039 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10190842 106740 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL316705 106740 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44286051 11901 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183288 11901 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288840 11901 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44285793 99826 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1201933 99826 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289091 99826 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44331794 4135 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL100178 4135 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL2369697 207905 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10769060 5957 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 5957 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
44285794 141269 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38624 141269 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44213067 11906 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183307 11906 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289727 11906 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10626666 108708 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 108708 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
10602943 106934 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 106934 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
10168749 205887 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95127 205887 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10745241 110042 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110042 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369696 207904 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10234086 111144 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL328511 111144 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
10258866 16425 5 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL124066 16425 5 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
136035319 162747 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL418800 162747 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10027061 14783 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL120844 14783 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL2304029 207731 0 None - 1 Rat 4.6 pIC50 = 4.6 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10122529 109068 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL322194 109068 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44349304 16797 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL125385 16797 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10212645 13178 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL1191766 13178 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL542908 13178 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542881 112095 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330172 112095 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10233656 206115 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL96442 206115 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10283825 96245 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL264007 96245 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
153996 112171 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112171 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112171 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10507650 162778 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 162778 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986134 163281 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL4206396 163281 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
9918576 205606 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL93556 205606 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
44286200 141321 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38652 141321 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10147107 205886 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431850 205886 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95125 205886 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304032 207732 0 None - 1 Rat 4.5 pIC50 = 4.5 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10212223 206399 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431458 206399 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL98079 206399 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
9832207 11894 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11894 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11894 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5083565 213099 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10121390 112242 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330499 112242 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10123040 160548 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL411691 160548 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL537027 160548 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542879 112326 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330719 112326 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349364 116331 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL337987 116331 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10578261 9093 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9093 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
10360490 88311 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL23617 88311 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
44286038 11106 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL1178749 11106 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL39595 11106 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL2304118 207734 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00157a009
10190413 205598 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL410270 205598 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL93519 205598 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
10417124 117976 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL341365 117976 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
44349370 116769 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL339488 116769 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
15542871 206119 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
CHEMBL96466 206119 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
10530375 5553 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5553 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
10917690 205871 0 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95051 205871 0 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
44328187 206398 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL98076 206398 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
135556923 106916 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL317979 106916 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
9832306 112227 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330367 112227 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330462 112227 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL2304130 207737 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O 10.1021/jm00157a009
10917690 205871 0 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 205871 0 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
44285795 96053 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL262540 96053 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44349303 116716 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL339444 116716 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL2304129 207736 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10620143 98805 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL281828 98805 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10327313 16698 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL124979 16698 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
15831290 146073 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39232 146073 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
10603544 110075 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110075 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
10190056 110950 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL327497 110950 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
44285857 11094 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1178703 11094 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38030 11094 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10190638 205808 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94726 205808 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283825 96245 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL264007 96245 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283765 107601 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
CHEMBL319535 107601 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
15542874 111677 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL329055 111677 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10769059 108130 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108130 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
10123138 108039 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL317524 108039 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320002 108039 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542673 205830 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94834 205830 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333379 205841 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL94906 205841 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10305069 206114 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96441 206114 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL2304115 207733 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10190056 110950 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL327497 110950 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
10212725 97717 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL273915 97717 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
15542679 108040 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320003 108040 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9918576 205606 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL93556 205606 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
10190413 205598 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL410270 205598 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL93519 205598 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
44328188 111038 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL327888 111038 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542879 112326 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330719 112326 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10121390 112242 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330499 112242 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10123040 160548 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL411691 160548 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL537027 160548 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10190770 206275 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330430 206275 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97357 206275 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10212223 206399 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431458 206399 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL98079 206399 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147107 205886 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431850 205886 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95125 205886 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333241 206058 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL96141 206058 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10233656 206115 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96442 206115 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147218 106980 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL318369 106980 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542881 112095 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330172 112095 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328321 167225 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL430471 167225 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10122529 109068 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL322194 109068 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10169609 205911 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95243 205911 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
10234086 111144 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL328511 111144 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
15542880 205773 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94480 205773 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10168749 205887 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95127 205887 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10305888 205821 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94788 205821 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328320 205867 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL95029 205867 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10284042 206247 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97240 206247 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542869 205875 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95076 205875 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9892984 143733 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39049 143733 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
11801586 5392 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5392 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986135 162849 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL419500 162849 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL5078626 212800 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44331786 107331 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL319212 107331 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
44331715 4666 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL103657 4666 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
44331792 106699 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL316486 106699 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
44349375 114560 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL334304 114560 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10063954 98279 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL277918 98279 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10190770 206275 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330430 206275 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL97357 206275 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349369 16719 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
CHEMBL125093 16719 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
44407908 140027 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140027 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44408039 75151 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75151 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408088 139295 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139295 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408089 139656 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 139656 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408045 75254 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75254 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
104943 55099 34 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
3086681 2240 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2240 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2240 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44370529 48794 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 48794 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
44408040 74070 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74070 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407998 75147 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75147 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407971 140223 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140223 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44370713 50759 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 50759 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
44305816 162469 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 162469 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
44408051 140696 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 140696 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
21041073 138320 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138320 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
9829083 119634 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 119634 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2102 1166 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
5311057 1166 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
CHEMBL441225 1166 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
44407906 74359 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74359 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74424 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74424 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407907 75345 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75345 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408025 75562 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75562 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407917 96110 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96110 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44407903 140191 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140191 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44407902 75073 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75073 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44408046 140213 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140213 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
104943 55099 34 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55099 34 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44407972 140225 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140225 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44370530 48858 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 48858 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
44307819 102123 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102123 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 168698 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168698 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 196998 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196998 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307757 201842 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201842 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202075 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57394644 68023 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68023 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10032981 106270 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106270 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10055415 106274 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
118718516 114862 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 114862 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9939040 4941 5 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4941 5 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44307679 201823 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201823 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 201940 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201940 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68024 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68024 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10395494 106272 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106272 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
9832198 106273 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384380 59511 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL172794 59511 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44383617 155161 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL405167 155161 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10395612 106265 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106265 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9801487 205270 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 205270 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
52937467 62194 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62194 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44307898 199788 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199788 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10418001 106271 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106271 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL439284 212083 18 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
44307758 201862 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201862 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391133 68025 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68025 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
10350454 106249 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106275 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44383164 165157 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL424567 165157 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL3349620 209700 8 None - 0 Guinea pig 5.7 pKd = 5.7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718517 114863 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 114863 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44407901 139914 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 139914 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
52937271 62192 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62192 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
132837 2207 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2207 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2207 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
52937273 62190 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62190 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
10145229 9083 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9083 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
10349900 106267 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10350528 106251 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384379 129125 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL367312 129125 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL170299 207100 0 None - 0 Guinea pig 6.4 pKd = 6.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44408048 140028 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140028 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
10259370 106266 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106266 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10506928 119713 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 119713 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44383616 167998 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL435717 167998 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10325464 119629 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 119629 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44307821 101644 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101644 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44337201 108125 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108125 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
107686 3327 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3327 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3327 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
52937270 62191 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62191 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44408033 74423 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74423 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44408047 96320 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96320 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
15887537 108559 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 108559 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
21121353 101003 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
57392804 67642 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67642 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67642 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57403249 71165 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911968 71165 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1962728 71165 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67641 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67641 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
52933155 67645 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911970 67645 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67642 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67642 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67642 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67641 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67641 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67642 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67642 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67642 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57398076 67644 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911969 67644 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67641 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67641 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67641 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67641 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
2096 3587 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2096 3587 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3587 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
25078100 3587 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3588 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
16131028 3588 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3588 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2097 3588 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3588 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3588 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2096 3587 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3587 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
135413536 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
30699 215969 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
10328936 1517 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2086 1517 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2955 1517 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL373569 1517 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
135413538 1649 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
4470 1649 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
7623 1649 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1199324 1649 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB06717 1649 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
2096 3587 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
25078100 3587 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
2088 2146 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
45749 2146 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2101 3641 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
155817436 2753 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2092 2753 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
107686 3327 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
3522 3327 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
CHEMBL131171 3327 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
10328936 1517 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2086 1517 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2955 1517 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
CHEMBL373569 1517 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3849 3145 0 None - 1 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9243521
135413538 1649 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
4470 1649 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
7623 1649 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1199324 1649 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB06717 1649 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
108167 2813 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
2107 2813 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
CHEMBL1178725 2813 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
17268 3068 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2094 3068 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
10349 2220 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
9809077 2220 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
CHEMBL4303434 2220 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
3850 3430 0 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3086681 2240 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
3510 2240 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
CHEMBL42407 2240 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
2110 2922 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
219077 2922 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
3480 2922 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
CHEMBL346178 2922 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
DB04872 2922 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
2100 3640 0 None - 1 Human 6.4 pIC50 None 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2091 2755 0 None -223 2 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2099 3639 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2103 1613 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
6437864 1613 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
132629 2206 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
2104 2206 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
CHEMBL24999 2206 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
168489 3067 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2093 3067 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2109 4073 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
9852253 4073 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
CHEMBL129683 4073 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
132837 2207 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2207 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2207 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
2098 3638 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
36511 3638 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3805 3638 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3835 3638 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3638 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL384518 210581 9 None - 0 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
CHEMBL428532 211707 6 None - 0 Guinea pig 8.8 pEC50 = 8.8 Binding
Compound was evaluated for effective dose against Muscular receptor in guinea pig ileumCompound was evaluated for effective dose against Muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
44337561 96290 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL264395 96290 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308430 101793 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL303222 101793 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 208382 0 None - 0 Guinea pig 5.9 pEC50 = 5.9 Binding
Compound was evaluated for effective dose against neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
CHEMBL263185 208816 4 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
CHEMBL415159 211427 4 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44337560 109262 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL323028 109262 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337787 9077 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL110177 9077 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308431 163970 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL421485 163970 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 208382 0 None - 0 Guinea pig 8.7 pEC50 = 8.7 Binding
Compound was evaluated for effective dose against muscular receptor in guinea pig ileumCompound was evaluated for effective dose against muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
132629 2206 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
2104 2206 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL24999 2206 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL422779 211565 0 None - 0 Guinea pig 8.5 pEC50 = 8.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
CHEMBL106184 206728 0 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
108147 3526 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
2127 3526 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL106124 3526 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL428532 211707 6 None - 0 Guinea pig 8.4 pEC50 = 8.4 Binding
Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against Neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
10843656 96374 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
CHEMBL265115 96374 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
44337775 162855 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL419558 162855 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337797 108527 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL321228 108527 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308550 101648 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL302349 101648 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
162673403 182467 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4794099 182467 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
44337530 167334 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL431243 167334 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
162651127 179701 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4750714 179701 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
11238415 98797 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL281797 98797 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
11352855 96669 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL26761 96669 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9821217 107244 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL319118 107244 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3215877 107244 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
49863731 15157 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15157 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
25129133 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
25129133 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188300 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
46884430 8236 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8236 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11852872 68285 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68285 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
25027805 70678 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951813 70678 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
44178113 60935 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60935 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
57391771 70676 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 70676 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395695 71278 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917866 71278 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963416 71278 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
87318292 125931 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 125931 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
67232184 125925 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 125925 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
73265457 125930 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 125930 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11248796 161100 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL413027 161100 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
122182823 121547 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596448 121547 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433804 146262 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146262 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
73265450 125921 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 125921 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
73265453 125926 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 125926 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
57402264 70616 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951626 70616 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57403992 70623 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951633 70623 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
73265456 125929 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 125929 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
9828716 71289 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917853 71289 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963487 71289 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
127944 120412 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL356062 120412 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL555572 120412 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
46881682 8013 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8013 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46883879 7688 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7688 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57398784 70621 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951631 70621 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
57400919 71275 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917856 71275 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963413 71275 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57397000 70677 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951811 70677 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
11621512 70620 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951630 70620 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57397022 70622 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951632 70622 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265454 125927 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 125927 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
57400917 71303 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917852 71303 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963577 71303 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
135539114 206561 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
CHEMBL99055 206561 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
122182821 121545 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596446 121545 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
122182822 121546 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596447 121546 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433798 145153 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145153 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433797 145603 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 145603 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6465 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6465 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135539114 206561 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
CHEMBL99055 206561 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
57398783 70619 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951629 70619 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
57391771 70676 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 70676 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395688 68283 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917851 68283 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57390405 71277 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917865 71277 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963415 71277 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57397483 71276 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917859 71276 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963414 71276 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400921 71264 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917860 71264 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963300 71264 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57395693 71265 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917862 71265 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963301 71265 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456802 97001 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270090 97001 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
16663280 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272649 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
23653789 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
46881727 5518 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5518 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8365 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8365 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8824 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8824 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8824 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8824 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52949827 17160 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17160 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
25028925 90934 2 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 90934 2 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
16663280 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
16663280 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97512 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
23653789 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
44444666 153850 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL398720 153850 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
127944 120412 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL356062 120412 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL555572 120412 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
46947062 17278 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57391807 70617 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951627 70617 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
24889113 7866 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7866 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7866 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52943848 17238 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17238 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
73265455 125928 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 125928 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2098 3638 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3638 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3638 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3638 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3638 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
135406581 31711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
CHEMBL140745 31711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
44433800 146256 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146256 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433803 146261 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146261 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6465 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6465 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881820 7480 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7480 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881729 7857 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7857 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8365 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8365 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444634 93667 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249145 93667 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
24180495 154144 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399668 154144 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444643 154362 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400848 154362 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
135406581 31711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
CHEMBL140745 31711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
73265452 125924 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 125924 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11852872 68285 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68285 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402266 70624 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951634 70624 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265451 125923 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 125923 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
11409185 98964 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 98964 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
57402690 68282 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917850 68282 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
9917079 60837 33 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 60837 33 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
5752 3942 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
6918331 3942 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
CHEMBL522302 3942 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
DB12436 3942 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
71456209 78247 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL2112366 78247 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
46881729 7857 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7857 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750888 8366 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8366 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752434 9045 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9045 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52941351 17196 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17196 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57395691 71304 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917858 71304 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963578 71304 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400923 71279 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917867 71279 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963417 71279 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10407571 167394 8 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL431690 167394 8 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
57397481 71310 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917855 71310 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963613 71310 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
11983278 165547 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
CHEMBL425956 165547 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
11983278 165547 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
CHEMBL425956 165547 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
135449286 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
135485796 35024 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL143587 35024 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
135449286 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
CHEMBL52330 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
44407331 140682 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382848 140682 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
135413536 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
230 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
3490 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
6918365 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
CHEMBL1471 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
DB00673 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
44433799 88240 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88240 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
135449286 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL52330 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
24888943 7865 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7865 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46881682 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8013 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947645 17061 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17061 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17125 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17125 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993313 186448 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 186448 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444631 93666 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249144 93666 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
44444637 94065 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251577 94065 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444685 154234 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154234 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
135547943 34204 21 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
CHEMBL142819 34204 21 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
135449286 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
CHEMBL52330 192586 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
42611207 124266 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124266 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
57399171 68284 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917857 68284 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57398782 70611 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951621 70611 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
135413536 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
230 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
3490 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
6918365 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
CHEMBL1471 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
DB00673 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
135539114 206561 2 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL99055 206561 2 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
135419433 31580 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL140626 31580 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
44407427 140649 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL382803 140649 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44318589 162791 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL419119 162791 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094861 204095 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83250 204095 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094863 106651 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL316141 106651 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
57393955 71253 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917863 71253 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963216 71253 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46830287 7908 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7908 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993314 170472 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 170472 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44444664 94042 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251387 94042 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
73265449 123893 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 123893 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
10051762 81817 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21709 81817 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44407513 73948 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202417 73948 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
10004377 110920 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327250 110920 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44325058 111960 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329828 111960 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL1651026 207083 19 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cellsDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL1651026 207083 19 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting methodDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.11.014
57398785 70625 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951635 70625 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
24889113 7866 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7866 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7866 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884518 7896 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7896 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884467 7909 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7909 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 7931 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884519 8009 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 8009 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
52943994 17650 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17650 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993955 183723 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 183723 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444681 93937 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 93937 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444688 154465 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL401415 154465 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444658 166511 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL428933 166511 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
45271306 193999 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193999 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2098 3638 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
36511 3638 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3805 3638 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3835 3638 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
CHEMBL235363 3638 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
2098 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
36511 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3805 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3835 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
CHEMBL235363 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
2098 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274207 78163 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
CHEMBL21122 78163 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
10053419 82208 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21792 82208 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44412226 168271 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL437878 168271 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44433789 145601 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145601 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44444646 93587 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248748 93587 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444693 94061 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251557 94061 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444650 154363 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
CHEMBL400849 154363 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
2098 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
36511 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3805 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3835 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
CHEMBL235363 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
2098 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
36511 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3805 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3835 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL235363 3638 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL389652 210683 0 None 2 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44334114 4478 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
CHEMBL102382 4478 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
44295002 155421 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL406136 155421 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44407325 73017 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
CHEMBL201362 73017 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
57390403 71311 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917861 71311 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963614 71311 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46881728 5519 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5519 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881821 5524 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5524 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884516 7744 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7744 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
42639650 187612 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 187612 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444684 93848 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL250390 93848 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
44444695 94101 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251768 94101 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44274251 82749 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21831 82749 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10053174 99048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL283318 99048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412207 139802 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380680 139802 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
9821217 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL319118 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL3215877 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
9821217 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL319118 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL3215877 107244 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
57403991 70615 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951625 70615 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
44456522 158338 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL409520 158338 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
22885694 140915 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384177 140915 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24888772 7934 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 7934 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752434 9045 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9045 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947646 17063 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17063 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52942803 17064 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17064 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44444669 153881 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL398919 153881 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
10186401 98470 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
CHEMBL279442 98470 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
24889114 7669 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7669 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46884515 7743 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7743 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884472 7913 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7913 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993312 178773 10 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 178773 10 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444638 155117 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL404855 155117 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
3086681 2240 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2240 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2240 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44333730 107186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL319046 107186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
10098209 98632 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL280662 98632 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
57400915 71274 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917844 71274 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963412 71274 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44416078 139608 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL380210 139608 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
16006943 140912 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384171 140912 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884473 7707 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7707 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883823 8347 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8347 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52948931 17067 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17067 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
44444660 154109 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399466 154109 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444685 154234 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154234 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
44444692 154936 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL404001 154936 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44593632 178192 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
CHEMBL468830 178192 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
44177570 60931 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60931 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10460917 163197 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL420543 163197 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
2102 1166 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
5311057 1166 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
CHEMBL441225 1166 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
73352606 92541 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441368 92541 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
10460917 163197 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163197 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
57402689 68280 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917845 68280 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
23146876 70613 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951623 70613 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44433802 146258 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146258 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44433804 146262 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146262 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
22885615 79770 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213538 79770 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
52947645 17061 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17061 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52947647 17065 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17065 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44233185 193154 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193154 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
57397021 70614 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951624 70614 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
46884471 7667 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7667 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7687 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7687 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24888942 7864 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7864 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883824 8348 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8348 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44444640 93546 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248545 93546 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444694 154287 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL400393 154287 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9850771 119373 2 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119373 2 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
15253734 164797 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL423623 164797 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
46227362 200897 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200897 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274166 79841 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL21385 79841 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
44412236 77785 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210365 77785 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
22885699 80608 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215373 80608 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885703 140894 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL384112 140894 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44357006 13613 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL1195055 13613 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL553778 13613 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
44356378 25538 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL135263 25538 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10480465 206673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99792 206673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9892852 83960 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL22194 83960 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
24785717 121591 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 121591 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
18669097 98943 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL282725 98943 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
57402692 71266 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917869 71266 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963302 71266 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402221 70679 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951814 70679 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
22885697 141140 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385463 141140 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44433394 146125 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL392368 146125 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
2102 1166 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
5311057 1166 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
CHEMBL441225 1166 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
9892852 83960 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL22194 83960 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10553959 187287 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL49638 187287 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
104943 55099 34 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
CHEMBL16192 55099 34 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
9796216 101773 13 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
CHEMBL303118 101773 13 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
44294293 187869 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50270 187869 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10098209 98632 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL280662 98632 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
57402265 70618 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951628 70618 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
44433797 145603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 145603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
52948868 17066 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17066 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
46883879 7688 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7688 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44593636 181038 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181038 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
11814040 78399 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112743 78399 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
9871891 5386 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107482 5386 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
9871891 5386 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
CHEMBL107482 5386 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
11318556 93501 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93501 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9871414 98540 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
CHEMBL279977 98540 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
44274253 171711 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL447473 171711 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
10099787 103037 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085129 103037 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10480465 206673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99792 206673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412245 77603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL209657 77603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44444689 93790 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 93790 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
24755076 91152 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
CHEMBL240706 91152 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
44412445 77566 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
CHEMBL209456 77566 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
135405092 138753 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL379137 138753 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
3086681 2240 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
3510 2240 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
CHEMBL42407 2240 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
10257218 24635 2 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL134500 24635 2 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10460917 163197 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163197 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5337 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5337 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10101238 34618 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143156 34618 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 207083 19 None - 1 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2013.03.016
44407370 74102 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL202775 74102 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
22885698 138815 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL379289 138815 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44444629 93665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249143 93665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9871754 5337 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5337 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
5757 3923 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
9832383 3923 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
CHEMBL522987 3923 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
DB11949 3923 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
58993578 121592 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596493 121592 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
9891865 79647 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212991 79647 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
22885692 79768 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213515 79768 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44415869 80281 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215147 80281 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885691 80904 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL215889 80904 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
10951720 78397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112741 78397 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10369373 161411 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL415705 161411 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
24992986 183722 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 183722 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44294659 103039 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085131 103039 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9869697 64310 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817895 64310 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
10341570 120561 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 120561 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3638 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
36511 3638 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3805 3638 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3835 3638 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL235363 3638 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44274153 77527 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL20937 77527 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
135529973 120996 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL358343 120996 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
44407459 140580 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382720 140580 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44456524 97489 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272569 97489 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44416008 80091 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214748 80091 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884470 7912 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7912 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752568 8824 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8824 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
18407037 161709 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL416372 161709 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
18407037 161709 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL416372 161709 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412173 77858 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210630 77858 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44456700 95463 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL259251 95463 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415789 141133 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385414 141133 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10144275 18705 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128369 18705 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
22293490 100840 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL296583 100840 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
24785717 121591 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 121591 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
44356404 23005 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
CHEMBL133140 23005 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
18669091 4617 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103367 4617 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10008129 60752 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL176500 60752 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9938284 100945 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL297344 100945 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11755227 201387 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63793 201387 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
71450870 78249 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL2112368 78249 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
22885695 138594 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378689 138594 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
46881600 7027 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7027 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44444689 93790 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 93790 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444671 154218 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400060 154218 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
57402688 71262 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917843 71262 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963298 71262 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
52941489 17549 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17549 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10768417 165050 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL424291 165050 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 207083 19 None - 1 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
58993533 121584 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596485 121584 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
19797422 96215 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL263795 96215 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
104943 55099 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL16192 55099 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
10346229 82609 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21813 82609 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
21955317 103038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085130 103038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44412374 77441 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
CHEMBL209240 77441 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
11678857 138777 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL379224 138777 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44456865 97454 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272469 97454 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
14986135 162849 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
CHEMBL419500 162849 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
44334275 5003 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL105420 5003 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
9871754 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10415870 103035 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085127 103035 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10483816 190604 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL51893 190604 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
10483816 79220 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115007 79220 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10415870 140078 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL381390 140078 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
53379508 66128 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817891 66128 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852123 66128 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
22885696 138399 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378416 138399 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44444654 93623 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248943 93623 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15516313 178140 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL468350 178140 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
44593636 181038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181038 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
9871754 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
10698096 55583 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL162337 55583 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9871754 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5337 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
44334149 4531 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102730 4531 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10393962 103040 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085132 103040 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
22293475 186545 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186545 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
18782542 110977 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL327606 110977 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
11146618 78398 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
CHEMBL2112742 78398 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
104943 55099 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44346234 14478 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL120523 14478 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
10415534 165653 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL426577 165653 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2098 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
36511 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3805 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3835 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL235363 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
22885704 81113 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL216018 81113 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24752568 8824 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8824 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752568 8824 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8824 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444659 93738 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249568 93738 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9855000 20421 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20421 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
18669080 4939 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105047 4939 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10210026 100890 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296979 100890 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
58993465 121593 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596494 121593 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
22885702 80096 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214761 80096 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884434 7843 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7843 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44346438 114252 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL333882 114252 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
10098987 59666 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59666 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
CHEMBL16192 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
104943 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
CHEMBL16192 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
44410317 76797 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207794 76797 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415921 141215 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385925 141215 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889458 8345 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8345 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46947062 17278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
9821217 107244 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL319118 107244 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL3215877 107244 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 181860 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 181860 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44577989 188840 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL513351 188840 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
9984665 5270 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL106864 5270 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
104943 55099 34 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2098 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
36511 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3805 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3835 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
CHEMBL235363 3638 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
44412493 77541 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
CHEMBL209407 77541 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
44415909 79476 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212349 79476 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
49863732 15158 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15158 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
135430679 45785 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
CHEMBL153310 45785 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
44294660 103041 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085133 103041 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
53379509 66123 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817892 66123 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852099 66123 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
44433789 145601 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145601 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24750888 8366 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8366 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135430775 45089 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152685 45089 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44412235 139645 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380388 139645 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44415808 81049 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215975 81049 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
11756257 167220 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43044 167220 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
18669059 98315 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL278149 98315 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412373 138570 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
CHEMBL378663 138570 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
21955285 188407 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50867 188407 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
104943 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55099 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
24785978 121582 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 121582 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
9329 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9894349 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
CHEMBL339486 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9329 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
10392469 193186 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 193186 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44177669 60932 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60932 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10325507 60121 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL175224 60121 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44444674 93889 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250596 93889 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44408291 140349 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL381984 140349 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408177 140444 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL382331 140444 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408290 140718 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL383048 140718 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
10007758 178403 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL47070 178403 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227363 197984 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197984 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44412453 161140 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL413279 161140 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
21955222 101313 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL300014 101313 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10392469 193186 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL539928 193186 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
2102 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
5311057 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
CHEMBL441225 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
10098987 59666 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59666 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10720240 34870 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143375 34870 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
2102 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
5311057 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL441225 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
2102 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
5311057 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
CHEMBL441225 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
2102 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
5311057 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
CHEMBL441225 1166 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
105083 25247 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL135022 25247 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
44410278 140333 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381965 140333 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44408176 73974 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL202439 73974 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44593634 182207 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL479049 182207 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
10099939 4918 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4918 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 106863 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 106863 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4918 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4918 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
10814682 205980 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL95626 205980 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44433798 145153 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145153 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
46884468 7910 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7910 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
104943 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL16192 55099 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44415896 138385 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378331 138385 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44299271 194374 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL56038 194374 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
42639649 170178 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170178 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44334107 4339 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL101421 4339 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44299271 194374 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56038 194374 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10814682 205980 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL95626 205980 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412159 140390 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL382255 140390 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
46884430 8236 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8236 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
22901329 98622 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL28055 98622 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
9805809 102613 6 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
CHEMBL307488 102613 6 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
44334127 4566 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102937 4566 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44415554 138520 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378609 138520 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
136094860 204391 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85792 204391 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44433796 89761 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL238220 89761 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44444677 154444 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL401281 154444 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44312057 202747 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL72234 202747 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
24785978 121582 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 121582 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10392925 14312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120081 14312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10076669 59902 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174016 59902 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11800025 120767 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL357887 120767 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
18669082 165163 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL424586 165163 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669082 165163 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL424586 165163 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL2115376 207523 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
2102 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
5311057 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL441225 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44410191 140161 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381555 140161 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415947 79893 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214118 79893 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24750734 7931 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 7931 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 7931 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
2102 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
5311057 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL441225 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
44305288 201190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62649 201190 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10392925 14312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120081 14312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
18686789 92542 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441369 92542 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
136094778 138731 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
CHEMBL379010 138731 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
10357939 117576 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL340559 117576 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
44294291 100720 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL295685 100720 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408158 139649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL380408 139649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
56662745 64312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64312 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10258336 100812 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296397 100812 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44307416 201319 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63240 201319 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10258336 100812 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296397 100812 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44456703 157809 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408960 157809 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
2102 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
5311057 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
CHEMBL441225 1166 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
2098 3638 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
36511 3638 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3805 3638 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3835 3638 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3638 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
44412225 139179 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL379816 139179 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44407431 72882 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
CHEMBL201192 72882 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
10076383 100756 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL296013 100756 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
104943 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL16192 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
44408313 74153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL202884 74153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
52941550 17622 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17622 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
104943 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL16192 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44433784 89759 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238210 89759 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44416136 79397 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212025 79397 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
9855000 20421 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20421 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
10347274 128151 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL366818 128151 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
CHEMBL16192 55099 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
21955298 79219 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115006 79219 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL396426 210749 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44415967 138172 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL377917 138172 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46947062 17278 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10502796 32098 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL141034 32098 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44578024 178117 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL468163 178117 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
10372941 119003 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
CHEMBL345520 119003 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
10885893 102439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL306089 102439 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10553959 187287 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL49638 187287 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44305221 100559 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL294545 100559 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10553959 187287 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL49638 187287 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44313273 203261 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL76501 203261 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44433793 147852 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393746 147852 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL396426 210749 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
22293505 188938 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL51417 188938 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
25028925 90934 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 90934 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
44358731 30126 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139167 30126 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10077113 121029 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121029 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55099 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55099 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
22293475 186545 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186545 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415444 79812 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213726 79812 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
52949827 17160 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17160 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 7931 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL229280 207713 0 None 23 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44333607 4906 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL104883 4906 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10142159 81132 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21607 81132 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
44274180 162640 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL418186 162640 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
44433787 88104 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235219 88104 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
11800024 206516 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98811 206516 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
136180340 119104 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL346447 119104 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10053205 116085 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116085 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11800024 206516 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98811 206516 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44408123 140057 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL381362 140057 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
46881682 8013 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8013 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
104943 55099 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55099 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10578351 119723 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL352176 119723 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
71449072 78168 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78168 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
56668401 66110 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817890 66110 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852009 66110 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415404 79631 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212931 79631 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10721713 119532 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350381 119532 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
18709649 164454 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42259 164454 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44415550 165583 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL426145 165583 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881820 7480 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7480 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44433792 147850 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393745 147850 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
22901329 98622 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28055 98622 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
22901329 98622 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL28055 98622 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44294689 101142 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL298858 101142 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11016806 203249 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL76455 203249 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
9829083 119634 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 119634 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10816374 18707 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128384 18707 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
132846 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL1256740 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL27006 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
132846 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL1256740 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL27006 96998 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135547943 34204 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL142819 34204 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
44456828 97131 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270751 97131 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44358610 29270 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138463 29270 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 119846 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119846 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
18669087 98277 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL277880 98277 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669087 98277 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL277880 98277 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44325035 111661 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329018 111661 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44415400 79683 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213134 79683 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
9938657 59906 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59906 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
10502796 32098 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL141034 32098 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
11799022 4401 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL101763 4401 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881727 5518 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5518 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
15549737 178238 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL469176 178238 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 181860 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 181860 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44578056 189165 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL515935 189165 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
19797472 118257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
CHEMBL341863 118257 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
10341570 120561 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 120561 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3638 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3638 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3638 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3638 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3638 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
58993655 121585 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596486 121585 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
24752434 9045 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9045 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL2370435 208104 0 None 48 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
15639110 167579 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL433020 167579 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44274544 81114 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21602 81114 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44328469 111748 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL329090 111748 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
24782914 121581 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596482 121581 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884431 7972 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 7972 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10578269 34920 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143464 34920 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
4898 2724 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
5742 2724 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149 2724 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
CHEMBL206253 2724 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
DB09048 2724 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
10047566 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL422931 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10047566 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL422931 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415840 79556 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212663 79556 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10049890 79602 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 79602 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10047566 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL422931 164689 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL389652 210683 0 None 2 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11813209 203389 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL77684 203389 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
18669072 82904 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21909 82904 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
10576865 206386 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98022 206386 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44433810 89449 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237796 89449 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
9959724 164303 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42191 164303 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10531050 119846 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119846 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
489662 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL21815 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
44297605 193020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL53312 193020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
9805809 102613 6 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL307488 102613 6 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
44338517 6258 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108200 6258 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9938657 59906 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59906 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
44346206 113162 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL332284 113162 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
10047567 205489 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL92701 205489 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
9890435 96994 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL27003 96994 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
2102 1166 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
5311057 1166 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL441225 1166 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
44458328 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL283356 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
11799022 4401 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL101763 4401 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44346206 113162 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL332284 113162 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576865 206386 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98022 206386 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10648551 206685 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99873 206685 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL1256740 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL27006 96998 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
489662 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21815 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
489662 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21815 82614 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10648551 206685 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99873 206685 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
24799545 86993 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333621 86993 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44407321 74058 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202568 74058 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410193 139804 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL380684 139804 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
44297605 193020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
CHEMBL53312 193020 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
44456580 154747 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL402895 154747 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24889111 7842 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7842 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17061 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17061 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17125 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17125 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943994 17650 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17650 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10047566 164689 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL422931 164689 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44458328 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL283356 99054 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
46227361 200896 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200896 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL389652 210683 0 None -2 4 Rat 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44335318 5036 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5036 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44312285 102484 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 102484 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10047566 164689 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL422931 164689 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
71450941 79109 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79109 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44305248 201198 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 201198 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
9805809 102613 6 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 102613 6 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
2098 3638 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
36511 3638 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3805 3638 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3835 3638 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL235363 3638 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
10837742 185283 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL48680 185283 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
44318685 204284 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84881 204284 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44408124 75050 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL203961 75050 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
58993471 121583 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596484 121583 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
58993453 121587 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
CHEMBL3596488 121587 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
56662745 64312 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64312 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64312 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415415 78567 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211304 78567 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884469 7911 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7911 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
46881779 8365 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8365 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306210 101917 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303896 101917 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335372 4706 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4706 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10414428 4784 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
CHEMBL104301 4784 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
44358603 118540 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342662 118540 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9959330 193884 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL554713 193884 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2098 3638 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3638 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3638 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3638 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3638 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
10578969 56930 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL165007 56930 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10626048 118065 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341599 118065 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
490428 119071 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119071 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44294535 103036 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL3085128 103036 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
24801458 86996 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333624 86996 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
44407422 140832 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL383743 140832 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410281 75217 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL204573 75217 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993670 121588 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
CHEMBL3596489 121588 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
57399170 71309 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917842 71309 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963612 71309 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456650 154956 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL404089 154956 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
52941570 17062 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17062 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943848 17238 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17238 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10052312 106906 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL317896 106906 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44338545 9245 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111176 9245 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9916428 112348 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL330888 112348 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
10793838 119581 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350846 119581 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9892852 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9890435 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL27003 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
44333692 4489 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102434 4489 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44270505 12260 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1185492 12260 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL417263 12260 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
9890435 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
CHEMBL27003 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
9890435 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL27003 96994 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318605 204151 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83772 204151 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44456894 159991 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL411242 159991 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10049890 79602 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 79602 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
22885690 141251 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL386151 141251 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
52942803 17064 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17064 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
11756839 5127 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL106087 5127 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9892852 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL22194 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
44358676 29797 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138890 29797 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9850771 119373 2 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119373 2 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9892852 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL22194 83960 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44368171 45143 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152742 45143 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10460917 163197 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163197 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5337 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5337 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11568372 204306 3 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 204306 3 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44318672 204370 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85626 204370 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
57390401 71263 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963299 71263 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3216988 71263 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44415986 79974 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214472 79974 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889113 7866 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7866 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7866 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881728 5519 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5519 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44335319 107024 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107024 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44370448 119254 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL347891 119254 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358604 28309 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL137609 28309 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44358732 31036 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140124 31036 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358428 118504 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342607 118504 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9871754 5337 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5337 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
2098 3638 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
36511 3638 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3805 3638 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3835 3638 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3638 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2098 3638 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
36511 3638 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3805 3638 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3835 3638 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
CHEMBL235363 3638 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
136180339 120591 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL357303 120591 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10027219 99121 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99121 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44274412 75685 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
CHEMBL20572 75685 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
44410283 137774 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL377091 137774 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
22293475 186545 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186545 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408295 139795 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL380651 139795 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
2098 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
36511 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3805 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3835 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
CHEMBL235363 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
56662745 64312 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64312 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64312 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
2098 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
36511 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3805 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3835 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
CHEMBL235363 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
44456625 168368 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL438759 168368 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415403 138166 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL377881 138166 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
52941489 17549 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17549 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941506 17585 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17585 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17278 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
71699792 124265 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124265 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
19797432 37522 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37522 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10438671 27141 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136764 27141 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358707 31242 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL140299 31242 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
9850771 119373 2 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119373 2 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10076881 162366 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 162366 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10627355 119505 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119505 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44338518 7641 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108889 7641 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338359 162877 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL419742 162877 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
132629 2206 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
2104 2206 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
CHEMBL24999 2206 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
21050485 167402 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL431732 167402 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799366 86990 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333618 86990 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
10648288 101430 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL300856 101430 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
24785977 121555 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596456 121555 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
10414293 37220 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37220 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
44396853 66937 7 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL188166 66937 7 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
21994307 26608 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136305 26608 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358471 29953 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139015 29953 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
132837 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
9461 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
CHEMBL22870 2207 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
10394703 193297 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54540 193297 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
135480369 33489 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
CHEMBL142216 33489 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
44274269 76678 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20717 76678 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
22293476 79218 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115005 79218 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
24889283 8346 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8346 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
52948931 17067 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17067 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
52941351 17196 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17196 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44306310 101850 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303548 101850 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306023 101916 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303890 101916 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10100236 28601 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137887 28601 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358470 29714 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138825 29714 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358561 30262 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139286 30262 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
2098 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
36511 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3805 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3835 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3638 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
10075595 60028 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174526 60028 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10554361 30645 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139719 30645 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10529338 31202 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL140263 31202 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10840066 116220 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL337358 116220 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541574 86983 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333611 86983 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44307181 202023 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67667 202023 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
58993542 121594 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596495 121594 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884432 7840 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7840 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947647 17065 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17065 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6465 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6465 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7931 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7931 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306218 162024 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL416864 162024 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44370973 46502 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL153976 46502 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44370354 120703 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
CHEMBL357757 120703 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
10462250 120879 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL358173 120879 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358720 28288 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137580 28288 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358657 30190 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139226 30190 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10816935 117604 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340732 117604 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
46881821 5524 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5524 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
71541373 86997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333625 86997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800231 87009 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333637 87009 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785712 121590 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
CHEMBL3596491 121590 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
57393953 71271 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917849 71271 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963369 71271 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44415443 77581 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209531 77581 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415485 79500 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212439 79500 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415502 79627 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212919 79627 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884517 8008 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 8008 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7687 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7687 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17061 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17061 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17278 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17278 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6465 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6465 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
19797432 37522 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37522 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10650469 57138 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165498 57138 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44328374 206248 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL97241 206248 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
11755361 116068 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL336439 116068 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
15639149 112410 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL331059 112410 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10413173 29445 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
CHEMBL138620 29445 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
44346149 15342 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL121742 15342 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346551 15406 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL122119 15406 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10359664 113503 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
CHEMBL332644 113503 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
54581461 60934 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60934 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
10254526 100030 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291025 100030 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44368083 44705 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152339 44705 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10457416 14717 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14717 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10098987 59666 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59666 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
14986135 162849 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 162849 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44402934 70728 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 70728 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
44359091 31033 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
CHEMBL140123 31033 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
44346420 14190 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14190 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44318657 204203 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84090 204203 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL2371978 208427 0 None 30 3 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55099 34 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55099 34 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
18391045 99930 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290043 99930 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44288896 168421 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168421 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
19098237 36890 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36890 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44312056 203016 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 203016 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358585 31051 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL140134 31051 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
18709652 167723 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL434012 167723 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44306230 100288 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292799 100288 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44319057 204129 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 204129 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
19049350 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281940 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
19049350 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL281940 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19049350 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL281940 98823 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
44346694 114312 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334072 114312 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44289443 168506 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43970 168506 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
44297749 192931 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52892 192931 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333579 4316 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101288 4316 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
44338510 8546 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL109514 8546 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44338531 9268 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111304 9268 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
44322648 204595 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87194 204595 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322525 204847 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88810 204847 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10095174 204937 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89385 204937 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44415470 165291 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424883 165291 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7841 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7841 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44294395 186612 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972677 186612 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL49233 186612 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15755315 162631 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
CHEMBL418124 162631 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
15755303 198664 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59768 198664 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755300 201288 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL63059 201288 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44337428 7155 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
CHEMBL108575 7155 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
10793341 108353 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
CHEMBL320989 108353 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
44411742 77900 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 77900 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
44344435 12975 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL119025 12975 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
2125 2981 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 2981 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 2981 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
44291515 100669 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 100669 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44291788 100942 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 100942 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44346650 113940 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
CHEMBL333308 113940 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
15755305 100516 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294288 100516 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755312 100591 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL294737 100591 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
15755330 201129 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62349 201129 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755295 201576 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64631 201576 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1190873 206851 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
CHEMBL541800 206851 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
10840399 9285 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL111384 9285 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
15755333 100111 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
CHEMBL291602 100111 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
15755331 100381 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293445 100381 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755294 201623 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64829 201623 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64601 214078 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10744888 108180 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
CHEMBL320762 108180 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
44337578 167524 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432620 167524 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
15485361 96781 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 96781 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10362340 89839 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23851 89839 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44274545 82099 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21775 82099 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44362598 36593 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145022 36593 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10362340 89839 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
CHEMBL23851 89839 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
44312026 102378 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL305608 102378 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44289232 169305 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL444043 169305 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106267 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL2369600 207889 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10477952 98531 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL279916 98531 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
19797474 37238 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145552 37238 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44384902 59632 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59632 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44362586 37518 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
CHEMBL145799 37518 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
44276673 96908 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 96908 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
44324705 111865 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329445 111865 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
44359056 118945 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL345069 118945 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
10039383 85052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
CHEMBL22680 85052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
44297603 162578 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417760 162578 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11683136 105323 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126963 105323 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44333708 162824 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL419352 162824 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
11489471 94439 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25398 94439 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10389968 59579 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173014 59579 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
21753663 194980 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56442 194980 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
71541576 86985 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333613 86985 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800927 87011 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333639 87011 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
44433783 89758 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238209 89758 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883823 8347 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8347 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11705241 87807 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347857 87807 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
24993314 170472 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 170472 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44306115 201795 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL66151 201795 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324814 205476 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL92621 205476 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
44288901 162731 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL418697 162731 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11318556 93501 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93501 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10840688 119696 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351940 119696 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44299464 198083 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59380 198083 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44306211 101866 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303680 101866 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
46884467 7909 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7909 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10202046 120548 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 120548 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10407571 167394 8 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
CHEMBL431690 167394 8 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
44307162 201669 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL65153 201669 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
71583096 87792 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347694 87792 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
15755296 101813 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303337 101813 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755297 102186 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304472 102186 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10256518 96945 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL269781 96945 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
10363425 164056 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL421591 164056 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288846 167773 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43432 167773 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10317821 36558 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL144996 36558 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44358472 116295 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL337803 116295 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44294321 11945 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
54093758 11945 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL1183502 11945 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL301168 11945 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
15037921 119120 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346626 119120 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
68928842 124278 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124278 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44312218 202439 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 202439 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10506929 56285 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56285 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
44328416 206203 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL96956 206203 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
10039383 85052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL22680 85052 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
19797452 121015 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL358529 121015 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44287503 99743 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL288340 99743 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44299829 197398 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL58774 197398 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44287541 159110 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41038 159110 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL449091 212210 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10692651 100620 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 100620 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
19003165 101704 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL302719 101704 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
3198 203802 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203802 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203802 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44297683 167627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL433285 167627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
9869033 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL290364 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
71541468 87005 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333633 87005 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801626 87012 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333640 87012 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
57403990 70610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951620 70610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
44335410 4931 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 4931 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44288885 99820 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
CHEMBL289026 99820 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
44396809 165814 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
CHEMBL427514 165814 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
44358709 29576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL138715 29576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44358679 29642 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138770 29642 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358680 116104 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336715 116104 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358683 118865 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
CHEMBL344434 118865 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
9869033 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL290364 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
9869033 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL290364 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
9910357 11874 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183052 11874 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL277524 11874 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44338638 5647 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107829 5647 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338546 108121 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL320535 108121 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
9917079 60837 33 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 60837 33 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
44346334 15076 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121094 15076 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10837362 30534 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL139558 30534 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44299969 195520 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56814 195520 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44359117 118828 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
CHEMBL344217 118828 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
44297491 193680 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55180 193680 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
76325557 105319 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126959 105319 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
76325558 105328 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126968 105328 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
490428 119071 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119071 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
22293473 79222 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115009 79222 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24783682 121558 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596459 121558 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
11724403 167980 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL435564 167980 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
9852911 98924 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL282618 98924 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL2372525 208525 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
15118534 105709 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
CHEMBL3138259 105709 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
11445389 187807 10 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
CHEMBL501675 187807 10 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
44287211 159988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41124 159988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
16755229 173355 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL454087 173355 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
10435750 98799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
CHEMBL281804 98799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
10506124 100790 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL296228 100790 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10435750 98799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
CHEMBL281804 98799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
44312952 104916 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL311688 104916 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44322649 162819 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL419312 162819 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322524 204876 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL88998 204876 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44322704 204995 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89847 204995 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346399 161120 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL413108 161120 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
44322678 204835 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88731 204835 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346333 12945 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL1190061 12945 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL540060 12945 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10530444 119695 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL351922 119695 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44212284 59673 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 59673 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
19797443 165059 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL424307 165059 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10439730 106275 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44346302 112602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL331392 112602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
11724403 167980 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 167980 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
44333821 4708 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL103984 4708 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44297293 170261 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL445357 170261 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44368118 118979 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL345315 118979 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
22859115 205501 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL92818 205501 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44334143 4506 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102569 4506 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
22859115 205501 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92818 205501 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
2090 2726 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2726 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2726 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
132961 141570 14 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 141570 14 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
24801795 87001 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333629 87001 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44318405 105102 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL312202 105102 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
24784192 121570 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596471 121570 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44297912 193021 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL53314 193021 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44433786 146377 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392567 146377 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883824 8348 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8348 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941570 17062 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17062 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941550 17622 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17622 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10251123 4769 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104225 4769 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44370893 119338 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL348594 119338 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
9869033 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 99958 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71449177 79252 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL2115161 79252 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
71456198 78165 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 78165 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44299583 101200 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL299275 101200 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19968650 168799 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
CHEMBL442028 168799 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
44319222 105663 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 105663 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44326280 97627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
CHEMBL273302 97627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
49799942 10446 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL1169534 10446 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44294194 176256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
CHEMBL46103 176256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
24783421 121562 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596463 121562 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
22850669 201297 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL63109 201297 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
22850669 201297 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL63109 201297 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44289169 101018 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101018 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358649 28576 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137868 28576 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358611 28897 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
CHEMBL138130 28897 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
44358673 31248 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140303 31248 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44289169 101018 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL297883 101018 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297728 100296 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292874 100296 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294416 183385 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
74972686 183385 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48173 183385 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406442 210861 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44458825 11885 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
54428149 11885 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1183194 11885 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL283990 11885 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
132961 141570 14 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
CHEMBL38824 141570 14 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
10364942 92922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
CHEMBL24549 92922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
71456210 78248 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
CHEMBL2112367 78248 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
10364942 92922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
CHEMBL24549 92922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
49863733 15159 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15159 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326290 205670 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL93909 205670 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44288789 100906 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297134 100906 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44386105 131408 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 131408 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
10429546 98600 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL280422 98600 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
46227361 200896 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200896 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44289257 99886 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL289573 99886 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44289257 99886 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL289573 99886 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
44288789 100906 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL297134 100906 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL2369603 207891 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44306341 202050 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
CHEMBL67843 202050 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
10389745 100037 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291074 100037 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
76318227 105324 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126964 105324 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11612528 105335 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126974 105335 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44334112 4971 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105201 4971 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
44333950 107755 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
CHEMBL319700 107755 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
44276728 167479 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL432279 167479 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44299875 193120 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53846 193120 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274167 83037 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21991 83037 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
44276728 167479 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL432279 167479 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
56678621 66112 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817883 66112 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852017 66112 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44306004 13223 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL1192152 13223 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL543338 13223 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44306694 100337 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL293164 100337 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306354 201320 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
CHEMBL63249 201320 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
44312257 102437 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 102437 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358602 27102 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136734 27102 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358596 29053 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138269 29053 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
22293565 79294 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115449 79294 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
44303850 100600 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294798 100600 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44303793 198437 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59615 198437 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
68932793 124276 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 124276 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44337795 108088 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL320308 108088 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9978999 5410 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL107618 5410 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44324710 111857 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329416 111857 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
44358435 28506 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137792 28506 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44381056 57305 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL166816 57305 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44294376 11947 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
53927094 11947 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183513 11947 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL301946 11947 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
44294476 185626 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL48731 185626 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
132961 141570 14 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 141570 14 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL264353 208873 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44346199 14132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL119947 14132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2369630 207900 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44358834 30367 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
CHEMBL139375 30367 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
44346199 14132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL119947 14132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
44433782 144934 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL391441 144934 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
9832198 106273 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
16214865 172701 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL452531 172701 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44346259 113618 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL332796 113618 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44346259 113618 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL332796 113618 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10767359 56208 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL163481 56208 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44368082 44679 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL152316 44679 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
44287609 99897 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 99897 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44274316 164863 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL423836 164863 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
56666212 64311 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817896 64311 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
52941489 17549 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17549 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL2112243 207486 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
21994365 25255 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL135028 25255 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358708 29575 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
CHEMBL138714 29575 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
44345148 10385 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL116535 10385 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44458598 98392 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL278849 98392 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
9954221 15358 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
CHEMBL121852 15358 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
44359025 28923 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL138150 28923 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44306435 96341 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL264821 96341 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44368326 172057 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL449347 172057 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44299750 193996 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55651 193996 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
10483816 190604 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL51893 190604 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10407571 167394 8 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL431690 167394 8 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
19797480 121032 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL358589 121032 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10409595 4721 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104075 4721 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44358473 31249 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
CHEMBL140304 31249 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
44358801 118464 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
CHEMBL342386 118464 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
14986146 44334 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152011 44334 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
44297488 193438 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54996 193438 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44297487 193608 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55129 193608 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10073370 59604 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL173120 59604 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10045010 89760 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23822 89760 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299854 100197 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL292237 100197 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
10041814 98418 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
CHEMBL279050 98418 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
10064734 122448 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
CHEMBL360815 122448 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
10041814 98418 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
CHEMBL279050 98418 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
1016 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3690 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
44297424 190393 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51863 190393 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
2247 502 77 None -117 41 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -117 41 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -117 41 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -117 41 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -117 41 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
44358981 161123 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL413122 161123 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
44346319 112957 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL331925 112957 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
12096357 55908 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL162636 55908 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
44368158 121253 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL358932 121253 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11518191 105333 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126972 105333 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
76314660 105338 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126977 105338 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11489240 94846 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25639 94846 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10407571 167394 8 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL431690 167394 8 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321456 204965 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL89652 204965 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
104943 55099 34 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55099 34 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
71541469 87006 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333634 87006 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44318658 104304 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL310896 104304 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44415540 141272 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL386258 141272 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71583094 87790 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347692 87790 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71452663 78133 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 78133 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
11743207 4746 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104165 4746 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10342371 4875 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104737 4875 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44358710 30000 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139057 30000 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 119846 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119846 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
118722856 115690 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358420 115690 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44321408 106539 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL315435 106539 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321408 106539 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL315435 106539 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15037920 45473 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45473 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10531291 6495 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108304 6495 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44380707 120061 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL354564 120061 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
136056467 188612 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
49824386 188612 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL51135 188612 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44348660 117543 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL340394 117543 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
2812 4711 96 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4711 96 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44404006 132235 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 132235 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
10439730 106275 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44297705 190289 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL51849 190289 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
71450949 79139 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 79139 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10055415 106274 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10344874 119645 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 119645 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
44386231 61051 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 61051 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
15639102 114030 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL333566 114030 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
11433531 90697 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL23982 90697 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9933653 98551 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28003 98551 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
44299444 195513 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56811 195513 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
58993503 121574 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596475 121574 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44297858 155224 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL405820 155224 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
24992986 183722 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 183722 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
18654565 167366 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL431459 167366 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
10370818 162101 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL416983 162101 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44297708 193300 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54578 193300 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10834930 120987 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL358305 120987 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44213477 204030 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82692 204030 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
10369316 87796 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347702 87796 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44328401 112170 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL330362 112170 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
10835447 24531 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL134415 24531 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
71583093 87801 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347851 87801 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
15755313 101729 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL302844 101729 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
19797425 37184 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL145500 37184 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL64037 214075 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
46227360 200895 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200895 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44297680 100177 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292156 100177 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL265155 208893 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
122182824 121577 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596478 121577 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
56681948 66137 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817882 66137 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852159 66137 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44335466 4985 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 4985 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44358783 30454 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
CHEMBL139471 30454 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
11192771 93900 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25065 93900 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9985523 98704 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL281200 98704 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
24799546 86994 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333622 86994 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
58993452 121549 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596450 121549 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44458786 11049 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178356 11049 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23096 11049 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
44349033 16610 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124532 16610 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
22869971 164716 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42306 164716 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
9981979 98701 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
CHEMBL281194 98701 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
44318349 204345 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL85414 204345 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44277742 100307 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL29293 100307 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44321457 167631 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL433336 167631 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
11633082 105322 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126962 105322 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10650263 25882 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 25882 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10501444 101407 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101407 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135890952 204377 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
CHEMBL85674 204377 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
11225834 98752 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL281491 98752 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
10364638 14489 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL120546 14489 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10094248 4718 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL104060 4718 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10006814 5171 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL106326 5171 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
44288548 100788 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL296213 100788 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44288790 169786 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL44474 169786 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
21994270 26887 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL136544 26887 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44312953 202852 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL72951 202852 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44359088 118279 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
CHEMBL342044 118279 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
178025 118648 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL342924 118648 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44305927 100146 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
CHEMBL291868 100146 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
44359111 118386 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL342260 118386 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
10364638 14489 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120546 14489 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346320 112958 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL331926 112958 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
44321442 204530 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL86806 204530 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44334098 5047 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105631 5047 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44321457 167631 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL433336 167631 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
9892852 83960 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 83960 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99054 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
44458983 99144 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL283989 99144 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
44458351 98931 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 98931 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44277478 166853 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
CHEMBL429610 166853 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
19797429 169883 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL444872 169883 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10745241 110042 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110042 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369606 207894 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44338530 9267 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111303 9267 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322429 204541 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL86890 204541 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322610 204919 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89245 204919 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346330 14398 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL120441 14398 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
18669055 4542 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102811 4542 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
136180338 164634 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL422862 164634 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11757401 59631 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59631 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9892852 83960 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 83960 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44458328 99054 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99054 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL281971 209102 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
44287803 99747 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 99747 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
25176461 86975 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333604 86975 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
25176462 86976 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333605 86976 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
58993541 121595 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596496 121595 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
136043848 77597 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209627 77597 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7841 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7841 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57565074 87794 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347696 87794 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2112240 207483 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44358495 115648 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL335788 115648 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10722491 119530 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
CHEMBL350366 119530 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
104943 55099 34 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL16192 55099 34 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL439019 212070 0 None 3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44294519 103034 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085126 103034 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44407467 73615 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL202141 73615 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44415471 139030 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379707 139030 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46830287 7908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881729 7857 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7857 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8824 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8824 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1651026 207083 19 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human tachykinin NK1 receptorInhibition of human tachykinin NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2010.07.034
44358727 26631 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136323 26631 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44359071 165120 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL424480 165120 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
44177670 60933 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60933 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44334108 4581 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103085 4581 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
135767968 45114 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
CHEMBL152716 45114 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
10457416 14717 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14717 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
490428 119071 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL346154 119071 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44299273 193146 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53901 193146 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
24782911 121575 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596476 121575 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
16663280 97512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
16663280 97512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10744602 56087 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163133 56087 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274277 80663 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21548 80663 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
56681950 66132 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817887 66132 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852130 66132 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415484 168372 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168372 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884472 7913 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7913 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947646 17063 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17063 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948868 17066 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17066 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
21994340 27812 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137255 27812 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
11800372 117763 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340931 117763 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL2370874 208194 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/S0960-894X(01)80229-8
44359094 33378 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
CHEMBL142121 33378 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
9927183 193932 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
CHEMBL55591 193932 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
136180337 121005 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL358437 121005 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
10834119 35403 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL143974 35403 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL405422 210814 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
44294224 103032 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085124 103032 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9887525 189233 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL51648 189233 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44415392 140890 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384102 140890 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24889113 7866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44358467 167678 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL433683 167678 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328394 205966 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95561 205966 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44319084 13585 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 13585 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 13585 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319321 13592 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 13592 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 13592 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
132837 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
9461 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL22870 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL405209 210802 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
22293565 79217 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115004 79217 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
46881682 8013 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 8013 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11654898 87802 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347852 87802 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10369341 5677 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107848 5677 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9980171 9146 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL110679 9146 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
10506929 56285 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56285 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
18407045 81705 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21662 81705 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL263852 208848 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
23025481 64309 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817893 64309 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
57400460 70607 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951616 70607 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
57398780 70608 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951618 70608 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
46881779 8365 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8365 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11561036 87803 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347853 87803 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
11539564 87804 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347854 87804 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL389651 210682 0 None 6 3 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
10369844 98879 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL282290 98879 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
24800578 86995 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333623 86995 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
44307417 201384 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63762 201384 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
57397020 70612 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951622 70612 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44456847 97003 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270114 97003 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415436 79549 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212644 79549 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415530 79721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213316 79721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415448 140908 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384157 140908 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881729 7857 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7857 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10414293 37220 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37220 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
71449143 79110 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 79110 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10603019 5173 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL106334 5173 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10369653 96352 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
CHEMBL264997 96352 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
10624372 202013 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67612 202013 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318640 204141 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83716 204141 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44410155 138759 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL379152 138759 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
24782912 121573 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596474 121573 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
44433800 146256 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146256 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
21994327 26723 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136411 26723 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10815815 119556 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL350582 119556 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL387670 210664 0 None 109 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
44333964 5073 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105763 5073 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10837611 32025 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL140982 32025 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10669293 33225 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL141994 33225 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44274362 168625 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL440649 168625 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL2372518 208522 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2102 1166 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
5311057 1166 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
CHEMBL441225 1166 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
44358767 26903 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136559 26903 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358741 30866 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139967 30866 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL2371977 208426 0 None 17 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11705830 105334 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126973 105334 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10318976 205560 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL93216 205560 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
44326306 111844 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL329325 111844 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44321442 204530 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL86806 204530 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
24800743 86989 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333617 86989 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
44433802 146258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44335376 4477 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 4477 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44370369 48640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL155976 48640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44288951 100016 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290926 100016 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797419 164708 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL423019 164708 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44380708 57270 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL166610 57270 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
9329 3684 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3684 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3684 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
44277726 98653 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL280849 98653 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL413827 211340 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44177145 194055 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 194055 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44410321 140713 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL382988 140713 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993596 121551 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596452 121551 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
44324706 205535 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93038 205535 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
44348756 15392 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
CHEMBL122020 15392 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
10627355 119505 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119505 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44297520 194409 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56069 194409 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294355 11138 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
49824390 11138 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178897 11138 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48454 11138 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
12225557 120664 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 120664 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
156500036 185862 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
CHEMBL4876457 185862 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
136046099 11050 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
49824391 11050 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178358 11050 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23181 11050 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
10456618 131713 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369692 131713 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10698161 5124 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106083 5124 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11363490 93622 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL24894 93622 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44359054 31610 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
CHEMBL140659 31610 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
10556941 98757 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
CHEMBL281530 98757 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
44333561 4602 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103221 4602 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
21753665 197996 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59310 197996 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10811257 101357 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101357 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
16755279 174521 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL456875 174521 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL413827 211340 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44277726 98653 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL280849 98653 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
10350454 106249 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312951 102727 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL308363 102727 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
9831641 79287 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 79287 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
10071124 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL278351 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10506376 55567 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162330 55567 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44304144 13325 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1192961 13325 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL544284 13325 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44288772 155065 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL40455 155065 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358416 27103 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL136735 27103 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44383969 128524 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128524 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
10412224 86295 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL23184 86295 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
44324845 168727 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL441458 168727 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
104943 55099 34 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55099 34 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10071124 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL278351 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
10004190 129565 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 129565 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10071124 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL278351 98337 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
44294481 103033 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085125 103033 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799711 87004 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333632 87004 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
42639650 187612 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 187612 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44358552 118680 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
CHEMBL343150 118680 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
44270411 11878 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183074 11878 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278487 11878 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44359096 28918 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138146 28918 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
46227363 197984 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197984 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44212281 130094 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 130094 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44346420 14190 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
CHEMBL119990 14190 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
10393324 120296 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL355643 120296 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
56675185 66114 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817834 66114 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852026 66114 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
68870199 124274 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 124274 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44348605 112598 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
CHEMBL331346 112598 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
44288892 101035 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297970 101035 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44289168 168515 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL43977 168515 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL2112246 207489 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
71461705 79208 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 79208 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9914897 178480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 178480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
21994362 29514 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
CHEMBL138666 29514 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
9914897 178480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 178480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44212688 154507 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40164 154507 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44212684 162429 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417519 162429 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44287557 168131 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
CHEMBL436698 168131 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
15037919 119122 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119122 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44307409 101787 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL303181 101787 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10458783 98164 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL277004 98164 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44312219 101911 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 101911 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15639130 113016 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL332106 113016 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44346524 113022 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL332140 113022 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
10484232 193758 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55229 193758 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
22859118 167650 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL433539 167650 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
44346420 14190 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14190 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
58993475 121561 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596462 121561 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
46884434 7843 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7843 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306252 101739 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
CHEMBL302892 101739 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
44306226 101772 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL303116 101772 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10005824 5826 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
CHEMBL107959 5826 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
9868622 6120 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108126 6120 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
9888665 121467 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121467 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44312256 202874 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 202874 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44312888 96288 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL264384 96288 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
44319340 204197 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 204197 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319250 106524 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 106524 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
158365 188137 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
CHEMBL504788 188137 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
44346524 113022 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL332140 113022 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
44328407 106823 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL317289 106823 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL406812 210874 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44344209 114051 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL333726 114051 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44375297 56498 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL164361 56498 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
19003143 202160 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68670 202160 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
10448006 202199 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68934 202199 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
44321047 204461 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL86378 204461 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
44346550 14519 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
CHEMBL120589 14519 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
44346476 113627 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
CHEMBL332843 113627 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
44287210 99903 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL289728 99903 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
54582278 60825 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765497 60825 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
16755278 189393 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL517102 189393 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL302668 209168 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1 10.1021/jm00089a011
44297648 191980 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52139 191980 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44318406 169138 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL443799 169138 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
24782915 121565 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596466 121565 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44433795 88343 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL236304 88343 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
18709628 166255 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42845 166255 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
9873546 77683 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL209899 77683 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 113829 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113829 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113829 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44288926 101013 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297833 101013 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
104943 55099 34 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
25129133 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44303794 100363 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293355 100363 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699790 124263 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 124263 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44381059 57529 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL167066 57529 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2112246 207489 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
CHEMBL2372444 208500 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
10478708 205839 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL94883 205839 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
21994346 30011 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139071 30011 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44312324 202978 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 202978 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15295988 60747 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176471 60747 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10477953 98478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL279500 98478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
19797451 36576 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145008 36576 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44307118 201321 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63257 201321 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24782656 121568 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596469 121568 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44338639 5649 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107831 5649 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338532 7549 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108822 7549 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322735 105497 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL313070 105497 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322728 204942 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89425 204942 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
9801487 205270 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 205270 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
25129133 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44306034 102254 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304897 102254 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL2369763 207936 8 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
10027061 14783 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120844 14783 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
44346175 12285 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
CHEMBL118565 12285 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
22293526 79297 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115452 79297 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
68932391 124268 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 124268 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
10459262 4813 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104435 4813 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44370954 167769 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL434272 167769 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
1122655 122582 22 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
CHEMBL361031 122582 22 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
21994363 118852 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL344370 118852 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL2112245 207488 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44308931 202635 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71553 202635 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL2372517 208521 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44298065 194028 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL55691 194028 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL62581 214068 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/jm00089a011
10769264 9126 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110508 9126 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129135 172028 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172028 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44384678 61042 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 61042 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
19797431 37202 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145514 37202 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44299814 167399 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
CHEMBL431725 167399 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
11409185 98964 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL282853 98964 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11329897 91466 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24136 91466 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10004190 129565 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 129565 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44287443 99808 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 99808 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
16755255 188542 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL510547 188542 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
11642147 87788 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347690 87788 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44288927 168213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43744 168213 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44359109 31754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL140768 31754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
44297563 193287 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54435 193287 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44415393 79968 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL214435 79968 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
15755298 197039 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL58245 197039 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699789 124262 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 124262 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL2112245 207488 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44294394 11148 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53838756 11148 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178980 11148 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52448 11148 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44297753 162129 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL417026 162129 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
10318912 97042 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27026 97042 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
10249652 129211 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367423 129211 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
15295989 59368 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL172238 59368 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44324746 205567 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93251 205567 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
44334185 4500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102525 4500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44346664 16376 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL123764 16376 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
44334185 4500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
CHEMBL102525 4500 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
44297466 101436 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300896 101436 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333727 108731 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL321710 108731 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
10627789 100112 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
CHEMBL29161 100112 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
24889458 8345 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8345 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
10790827 119406 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
CHEMBL349273 119406 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
44306309 100525 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294342 100525 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10840510 164738 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423254 164738 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
54581251 60823 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765495 60823 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
56681832 66145 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817833 66145 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852229 66145 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
21994308 30230 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139256 30230 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10506124 100790 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL296228 100790 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44344995 96009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL262301 96009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44290659 101063 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 101063 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL264341 208869 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL269584 209054 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
44337703 110198 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL326001 110198 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL2369630 207900 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212285 123300 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 123300 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
44276738 96742 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 96742 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
10045837 61048 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL176919 61048 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL2369605 207893 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
16755280 176224 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL460683 176224 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
54584234 60833 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765503 60833 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL2114443 207511 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
9851741 79783 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL213601 79783 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL2112242 207485 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10456592 5227 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL106609 5227 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
56657842 62912 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
CHEMBL1790897 62912 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
44359260 114986 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL335106 114986 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
10407571 167394 8 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL431690 167394 8 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10047989 92065 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
CHEMBL24314 92065 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
56671766 66111 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817828 66111 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852010 66111 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44303835 101296 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
CHEMBL299887 101296 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
21256636 30013 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139072 30013 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10047989 92065 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL24314 92065 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL216813 207596 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44321430 106503 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL315176 106503 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
10811257 101357 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101357 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44277705 101497 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30139 101497 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44306217 201353 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL63471 201353 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44334111 109319 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL323317 109319 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL2372521 208524 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
24801797 86999 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333627 86999 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541470 87007 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333635 87007 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801101 87014 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL2333642 87014 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL306072 209231 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
67233125 125922 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651888 125922 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
71541575 86984 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333612 86984 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44277705 101497 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL30139 101497 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
10649948 6610 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108349 6610 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
18654560 111818 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329168 111818 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
44349003 17807 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126221 17807 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
10350454 106249 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44458353 99143 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99143 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
10520658 98194 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL277260 98194 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
44337500 106705 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL316515 106705 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44458328 99054 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99054 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44286798 166878 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL42972 166878 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10075002 4693 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103851 4693 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
10027219 99121 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99121 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24799364 86992 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333620 86992 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9910432 133000 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
CHEMBL370816 133000 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
22724580 139638 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL380351 139638 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44358719 29635 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138764 29635 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358742 30748 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139854 30748 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10603097 56198 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163310 56198 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10674548 57142 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165510 57142 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44305544 201385 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 201385 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10457416 14717 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120781 14717 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
10457416 14717 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14717 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11225834 98752 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL281491 98752 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10696382 121469 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL359214 121469 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL2115375 207522 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
56668399 66134 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817886 66134 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852139 66134 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10530699 119633 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351253 119633 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
9831309 134741 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 134741 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
153996 112171 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 112171 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 112171 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 112171 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 112171 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 112171 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44338583 5719 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
CHEMBL107875 5719 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
44338346 5794 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107941 5794 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338587 7358 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108667 7358 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44359083 29186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL138390 29186 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
57398781 70609 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951619 70609 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
24888943 7865 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7865 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941489 17549 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17549 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
18709650 164695 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42295 164695 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
9888665 121467 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121467 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10721128 55993 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162977 55993 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10769745 57193 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165949 57193 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
132837 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
9461 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
CHEMBL22870 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
44297434 193304 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54602 193304 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132837 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2207 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
44273822 75153 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20430 75153 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL2372516 208520 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44289862 99887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL289600 99887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
21994258 118898 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL344646 118898 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328423 106887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317761 106887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL426363 211597 0 None 26 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55099 34 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55099 34 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993517 121579 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596480 121579 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44433794 166892 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL429798 166892 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
9927183 193932 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
CHEMBL55591 193932 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
15214194 5046 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL105629 5046 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
10096063 107938 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL319874 107938 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
11757401 59631 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59631 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2089 2725 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2725 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2725 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2725 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44415513 165215 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424709 165215 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44306327 12924 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL1189912 12924 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL539762 12924 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44306196 100267 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292715 100267 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306107 102362 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305547 102362 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
18709663 165549 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42597 165549 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44370340 119042 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL345866 119042 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
19797460 120499 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 120499 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305467 102339 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL305375 102339 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
71720664 87010 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333638 87010 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
24784193 121580 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596481 121580 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44456651 95006 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL257112 95006 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
73348949 90391 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90391 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
44335354 4865 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 4865 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
71458131 79274 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 79274 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44276882 95778 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
CHEMBL26086 95778 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
71541687 86987 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333615 86987 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
57395687 68281 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917846 68281 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44433790 89014 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237100 89014 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
11114226 202845 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL72895 202845 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10075851 59707 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173564 59707 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55099 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55099 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993461 121578 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596479 121578 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44370449 119392 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL349113 119392 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
46884470 7912 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7912 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
19098237 36890 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36890 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319086 13600 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 13600 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 13600 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
25129135 172028 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172028 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44334113 5194 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL106440 5194 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44326281 205459 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92524 205459 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44459032 90456 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23926 90456 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44318413 203970 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82220 203970 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
24783424 121572 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596473 121572 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10476776 108073 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL320231 108073 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288758 100642 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 100642 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
107686 3327 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3327 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3327 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44344231 113017 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL332111 113017 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44346159 14353 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
CHEMBL120190 14353 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
44177669 60932 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60932 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44319571 106557 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL315532 106557 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44415437 79567 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212697 79567 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
19797420 36629 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145051 36629 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10553958 100899 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL297068 100899 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
9915428 173061 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 173061 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
44287895 100737 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 100737 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44304123 198893 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL59913 198893 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
10405990 206383 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL98011 206383 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
9915428 173061 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 173061 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44287409 158503 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40969 158503 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287368 154682 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40262 154682 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287461 162144 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41705 162144 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44357469 161206 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
CHEMBL413904 161206 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
10367419 4338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
CHEMBL101420 4338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
11661655 105321 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126961 105321 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10480944 59578 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173013 59578 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
2089 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274341 81137 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21611 81137 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
56681830 66129 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817830 66129 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852124 66129 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10841047 57168 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165727 57168 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9918576 205606 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL93556 205606 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL2370873 208193 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(N)=O 10.1016/S0960-894X(01)80229-8
44322406 164582 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL422773 164582 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322515 204989 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89818 204989 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10367419 4338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101420 4338 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
10460069 165785 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL427295 165785 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44383815 59982 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
CHEMBL174365 59982 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
12736776 11052 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
53641783 11052 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178362 11052 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23360 11052 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
44459024 11057 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL1178380 11057 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL24818 11057 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
16755254 185592 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487259 185592 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
44386230 61034 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 61034 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
10350528 106251 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44322511 106616 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL315937 106616 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346557 113021 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL332139 113021 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
15295990 131585 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369580 131585 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
54587143 60822 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765494 60822 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
11547090 87806 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347856 87806 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44306398 201854 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
CHEMBL66592 201854 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
10432488 4827 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL104513 4827 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
10026002 109196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL322714 109196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
44358442 29592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138727 29592 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
107686 3327 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3327 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3327 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
104943 55099 34 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2089 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3795 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311311 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL217406 2725 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL263185 208816 4 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm070577s
44270482 11877 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183073 11877 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278455 11877 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
12736777 11051 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
54433543 11051 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178360 11051 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23287 11051 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
44348666 112993 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331978 112993 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44348801 112969 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331934 112969 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44337421 108041 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
CHEMBL320029 108041 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
44287388 155466 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40620 155466 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44297492 192890 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL52717 192890 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
131871 119023 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119023 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44306416 100116 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL291634 100116 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370769 49747 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL156933 49747 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
19797413 36627 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145050 36627 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10552574 119474 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
CHEMBL349882 119474 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
44359259 24916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
CHEMBL134737 24916 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
44275987 98885 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL282331 98885 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
9892852 83960 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 83960 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44297939 101206 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299312 101206 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
71699788 124261 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 124261 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
44289256 100065 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL291298 100065 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44270549 11035 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1178214 11035 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL15970 11035 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44312145 203010 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 203010 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
10793140 57114 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
CHEMBL165308 57114 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
44297604 101165 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299016 101165 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44276732 99543 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL286747 99543 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24801102 87019 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333647 87019 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
46884468 7910 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7910 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
44289441 100639 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL295107 100639 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10453364 5328 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107145 5328 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10433381 5509 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107689 5509 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10350528 106251 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44305511 201277 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 201277 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
9823811 59600 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL173110 59600 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44358814 30877 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139977 30877 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
44352062 18745 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18745 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
131954513 161529 31 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 161529 31 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
21121353 101003 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
54587142 60821 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765493 60821 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
44321519 205001 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL89897 205001 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321519 205001 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL89897 205001 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44307089 201324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63278 201324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL2112244 207487 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cn2ccc3ccccc32)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
76318226 105318 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126958 105318 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44294338 11944 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
54307293 11944 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183499 11944 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL300854 11944 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
11568372 204306 3 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 204306 3 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44380745 119792 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL352697 119792 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
10245452 100718 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL295680 100718 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
9888665 121467 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121467 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10506928 119713 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 119713 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44297498 101532 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301630 101532 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10552836 4123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL100141 4123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
58993657 121553 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
CHEMBL3596454 121553 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
16755228 173132 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL453581 173132 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
19797456 34246 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142855 34246 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44319249 204352 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 204352 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
44304176 201131 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62357 201131 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154442 14051 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
53703341 14051 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL1198573 14051 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL23147 14051 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
10071902 108914 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL321979 108914 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL2369630 207900 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44346480 114364 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334189 114364 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL2369767 207939 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
44299298 194575 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56176 194575 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
15037918 44600 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44600 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
19797436 36606 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145030 36606 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797448 37011 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145360 37011 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44358500 31297 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
CHEMBL140360 31297 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
44287861 161190 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161190 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
19797446 34322 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142919 34322 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
10793492 110814 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL326649 110814 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44358426 30669 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139753 30669 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10336036 111854 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
CHEMBL32940 111854 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
44359055 32116 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL141050 32116 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
10501444 101407 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101407 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44287555 158254 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40944 158254 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
23294214 168594 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 168594 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
76332769 105327 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126967 105327 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
10646925 30767 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL139868 30767 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44287895 100737 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 100737 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
16755230 172406 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL451773 172406 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
24801459 87003 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333631 87003 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
15755301 100601 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294814 100601 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44345010 14332 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL120126 14332 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10041813 96506 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL26623 96506 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10041813 96506 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL26623 96506 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
44297822 193354 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL54931 193354 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44321099 204503 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86659 204503 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15755334 96114 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
CHEMBL263013 96114 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
44177670 60933 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60933 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
71541471 87008 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333636 87008 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
71452815 79302 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2115528 79302 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
44328405 105717 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL313863 105717 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44338646 9066 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL110086 9066 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
10552836 4123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL100141 4123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576866 111003 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL327736 111003 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44294398 11139 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
54220048 11139 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL1178902 11139 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL48734 11139 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
16755206 186057 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL488045 186057 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
44303938 201458 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64166 201458 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154438 11056 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
53968534 11056 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178371 11056 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23682 11056 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
44288936 157623 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL40875 157623 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11409185 98964 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 98964 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
44287390 155232 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40587 155232 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44338557 9258 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111244 9258 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
132837 2207 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2207 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2207 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
11757401 59631 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59631 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
56671913 66135 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817888 66135 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852140 66135 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
46884473 7707 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7707 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10817203 57226 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
CHEMBL166240 57226 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
44305271 101774 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 101774 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44319323 13635 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 13635 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 13635 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL394671 210731 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
CHEMBL394671 210731 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44433788 88105 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235220 88105 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44328425 168904 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL442962 168904 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44233184 193100 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193100 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9871754 5337 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5337 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
104943 55099 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL16192 55099 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44410162 76776 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207698 76776 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44294261 79223 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115010 79223 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
10086982 115692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358422 115692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
10072926 109198 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL322718 109198 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
9871754 5337 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5337 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
134138503 153903 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3932836 153903 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3990081 153903 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
49863734 15160 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15160 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326362 205566 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
CHEMBL93243 205566 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
16755231 188405 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL508659 188405 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44306219 102256 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304901 102256 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44358703 115564 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL335624 115564 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9853506 12978 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 12978 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 12978 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9799676 194146 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55823 194146 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44456748 168614 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL440587 168614 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10071073 5279 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL106904 5279 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
44233410 193921 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 193921 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44433789 145601 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145601 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
10792813 57212 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166144 57212 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44319224 106593 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 106593 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10360490 88311 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL23617 88311 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL238168 208646 9 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
10007035 79115 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2114031 79115 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10460415 116039 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336261 116039 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10745307 164854 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL423824 164854 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL238168 208646 9 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
11547594 105336 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126975 105336 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
136043853 138386 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378340 138386 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
58993634 121586 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596487 121586 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
10438407 100187 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL292190 100187 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
57395686 71273 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917841 71273 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963411 71273 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
53249015 60830 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765500 60830 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
9939040 4941 5 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 4941 5 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44358864 30132 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139176 30132 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44319306 106613 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 106613 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274183 82052 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21760 82052 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
56661423 66121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817832 66121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852069 66121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
136043849 138171 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
CHEMBL377916 138171 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
44306108 102363 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305548 102363 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
22293578 186544 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL49175 186544 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44415424 140923 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384244 140923 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
11498370 100707 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 100707 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
15295987 130830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL368804 130830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
15755316 201204 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
CHEMBL62711 201204 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
44299298 194575 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL56176 194575 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
16755256 172529 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452027 172529 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL2369599 207888 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
14986135 162849 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL419500 162849 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44287606 100045 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100045 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10228092 76952 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20826 76952 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
58993510 121540 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596200 121540 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
54580277 60832 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765502 60832 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
9830535 205089 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90416 205089 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
9830535 205089 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL90416 205089 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
44294324 12256 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
54414362 12256 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1185473 12256 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL416468 12256 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
71583095 87791 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347693 87791 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71699791 124264 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 124264 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44337667 108370 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321021 108370 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10744740 109175 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL322508 109175 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
15154446 11048 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
53746881 11048 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178355 11048 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23073 11048 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
10318477 166756 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL429395 166756 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10318477 166756 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL429395 166756 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
107686 3327 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
3522 3327 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL131171 3327 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797466 34375 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142961 34375 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44297701 101221 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299388 101221 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11489240 94846 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL25639 94846 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44274520 82171 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21788 82171 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
44358861 118132 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL341681 118132 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
15755299 100421 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293726 100421 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10325464 119629 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 119629 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44458828 11055 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178368 11055 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23533 11055 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
44281769 109172 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL32248 109172 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
19098237 36890 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36890 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10428330 169655 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
CHEMBL444552 169655 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
44297562 193367 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54940 193367 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10576866 111003 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL327736 111003 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881600 7027 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7027 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44302017 197651 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 197651 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
71541370 87013 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333641 87013 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
10404051 85620 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23077 85620 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
10027661 59387 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
CHEMBL172308 59387 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
54585203 60831 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765501 60831 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
10053205 116085 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116085 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
46884469 7911 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7911 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL2369630 207900 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44344195 162808 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 162808 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL307433 209234 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44328357 111049 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL327943 111049 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44287556 99749 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL288382 99749 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
11641636 105337 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126976 105337 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
24801457 87015 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333643 87015 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44415472 139071 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379744 139071 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44433781 89497 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL237992 89497 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
44303900 162354 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL417390 162354 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
15154449 11875 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
54080603 11875 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1183064 11875 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL278135 11875 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
44297724 101453 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301008 101453 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44286772 167276 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43085 167276 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
56668295 66140 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817836 66140 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852171 66140 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
10393390 97825 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 97825 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10317867 4795 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104345 4795 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44287511 144205 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL39089 144205 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24785190 121556 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596457 121556 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
52941506 17585 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17585 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
76314659 105332 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126971 105332 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44287819 100926 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL297244 100926 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
10386984 5341 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107220 5341 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10625208 55571 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
CHEMBL162332 55571 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
76332768 105326 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126966 105326 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
44288896 168421 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168421 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL2372519 208523 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
44277452 100613 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL29487 100613 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
44348667 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44212283 59546 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 59546 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
71541371 87018 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333646 87018 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10253192 4854 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104654 4854 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44312028 102379 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 102379 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10627355 119505 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119505 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44328395 107026 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL318629 107026 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
19003169 102315 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL305274 102315 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44321047 204461 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
CHEMBL86378 204461 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
44326328 205376 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92032 205376 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44346420 14190 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14190 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
107686 3327 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3327 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3327 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
18782568 205551 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL93184 205551 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
24784955 121566 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596467 121566 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL311405 209353 15 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44305865 100217 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL292346 100217 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL2092883 207458 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10258592 98750 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 98750 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44368172 121001 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL358409 121001 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
10097954 131599 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL369601 131599 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44287609 99897 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 99897 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
24783681 121567 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596468 121567 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415458 79939 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL214317 79939 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415539 138450 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378537 138450 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44305864 201803 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
CHEMBL66193 201803 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
44358519 30542 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139569 30542 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44338584 8073 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109183 8073 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
22353151 9043 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109937 9043 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338618 108838 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL321892 108838 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44346558 15215 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121459 15215 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
24889114 7669 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7669 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
11743365 106904 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL317870 106904 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
44178113 60935 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60935 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44274530 98476 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279488 98476 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
24782655 121569 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596470 121569 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415486 80502 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL215315 80502 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
44358469 30928 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
CHEMBL140023 30928 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
10623791 30689 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139784 30689 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541572 86979 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333608 86979 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541573 86980 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333609 86980 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
22293463 100846 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296629 100846 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415412 78316 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211257 78316 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10553136 164772 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423464 164772 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
46884516 7744 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7744 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306036 13656 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL1195366 13656 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL554413 13656 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306318 202088 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL68225 202088 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44358545 27232 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136832 27232 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9976640 194953 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
CHEMBL56427 194953 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
9976640 194953 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56427 194953 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274170 76719 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20736 76719 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
44274199 98303 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL278088 98303 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
10392469 193186 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 193186 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44370928 47492 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL154803 47492 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
10603392 57152 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165566 57152 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274118 98497 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL279674 98497 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
57397019 71190 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951617 71190 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1962935 71190 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
46884519 8009 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 8009 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
24752434 9045 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9045 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10743826 118081 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341656 118081 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
44415484 168372 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168372 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44326361 111005 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL327765 111005 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44326361 111005 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL327765 111005 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
9874168 203991 3 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 203991 3 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
23025461 66119 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852063 66119 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL3216952 66119 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
9805809 102613 6 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 102613 6 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
11844212 98196 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL277279 98196 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113829 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44338652 108123 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL320544 108123 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44322736 205273 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL91436 205273 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44233185 193154 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193154 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL5083565 213099 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44458789 141281 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
CHEMBL386306 141281 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
44458351 98931 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 98931 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL410808 211096 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
15755314 101728 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
CHEMBL302843 101728 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
44458789 141281 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
CHEMBL386306 141281 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
18655106 198785 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
CHEMBL59854 198785 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
44287443 99808 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 99808 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10697072 55524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162288 55524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
22901331 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
22901331 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
54435601 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
59922977 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL1183068 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL278294 11876 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
44318310 203945 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL81986 203945 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
44333682 4554 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102887 4554 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
11490127 91652 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24194 91652 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
12225557 120664 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 120664 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
24801792 87016 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333644 87016 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
54582296 60826 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765498 60826 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
10473960 85855 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
CHEMBL23129 85855 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
44177570 60931 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60931 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
68932301 124272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 124272 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44288795 167709 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43394 167709 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10917690 205871 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
CHEMBL95051 205871 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
44286718 167166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43027 167166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44383969 128524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
44383969 128524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128524 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
54585202 60827 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765499 60827 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
54585205 60836 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765506 60836 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
46884432 7840 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7840 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44297602 193572 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL55098 193572 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL2114442 207510 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
24783683 121564 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596465 121564 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
24889111 7842 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7842 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10370593 6186 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL108164 6186 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44288976 162680 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL418438 162680 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106267 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312887 102464 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL306267 102464 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
24782658 121559 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596460 121559 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
22851562 165900 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL42778 165900 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44297451 100193 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292211 100193 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
16755232 173016 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL453314 173016 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
21308488 101033 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL297957 101033 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL2369601 207890 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm960281e
10043484 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
CHEMBL23715 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
44334006 107130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL318989 107130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44297513 101134 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL298772 101134 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
10499624 116134 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL336931 116134 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44308930 202624 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71498 202624 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44308930 202624 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL71498 202624 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44299916 194129 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55796 194129 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
9869033 99958 3 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 99958 3 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
56675290 66116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1817884 66116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1852032 66116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
16755257 172814 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452794 172814 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
44324532 205116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90547 205116 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
15755319 100214 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL292320 100214 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10410206 79174 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL2114308 79174 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
10410322 98944 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
CHEMBL282728 98944 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
10043484 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
CHEMBL23715 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
10043484 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
CHEMBL23715 89035 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
44297931 192112 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL52198 192112 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44287191 157139 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40817 157139 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44275987 98885 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL282331 98885 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
19797477 38428 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL146552 38428 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
9984184 202943 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 202943 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44383681 165716 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL426939 165716 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
10411026 61027 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176772 61027 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
44319341 204174 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83885 204174 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44297493 162599 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL417914 162599 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
10620143 98805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL281828 98805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
54582297 60834 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765504 60834 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
71583092 87797 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
CHEMBL2347703 87797 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
44324527 106056 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
CHEMBL314084 106056 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
10620143 98805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL281828 98805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44274242 98694 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL281149 98694 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
10553958 100899 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL297068 100899 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL5076397 212664 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of tachykinin NK1 receptor (unknown origin)Inhibition of tachykinin NK1 receptor (unknown origin)
ChEMBL None None None O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 10.1021/acs.jmedchem.1c01968
10553958 100899 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL297068 100899 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44297469 101311 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300005 101311 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44328545 205918 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95270 205918 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL1196922 206854 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
CHEMBL558620 206854 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10692651 100620 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 100620 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44294261 79298 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115454 79298 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2112241 207484 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1 10.1021/jm960281e
44375315 56213 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56213 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
10530317 5157 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL106239 5157 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44286754 162594 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL417881 162594 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
104974 3419 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 3419 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 3419 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 3419 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 3419 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL2369604 207892 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44324531 205028 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90035 205028 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
44433803 146261 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146261 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
44289934 100789 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL296216 100789 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44358672 118853 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
CHEMBL344378 118853 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
21121353 101003 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
71452678 78167 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 78167 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
9868530 76979 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL20837 76979 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24800398 86982 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333610 86982 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
56678486 66136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817837 66136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852157 66136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
9874168 203991 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 203991 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44408144 74917 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL203700 74917 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
44415411 138256 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378076 138256 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
2755911 75088 48 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75088 48 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44274104 80148 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21489 80148 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
18669089 98482 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279523 98482 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24799187 86998 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333626 86998 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
22293526 79221 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115008 79221 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24785443 121554 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596455 121554 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
44338586 6807 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL108422 6807 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
71541577 86986 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333614 86986 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
46884518 7896 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7896 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306436 100533 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294370 100533 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335360 4796 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 4796 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
44358427 30798 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139903 30798 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44325096 111044 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327928 111044 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
58993609 121563 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596464 121563 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
40727876 115693 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358423 115693 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
44297642 193779 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55240 193779 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
53379507 66120 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817829 66120 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852067 66120 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10390130 98784 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281717 98784 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
11619202 87795 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347697 87795 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
107686 3327 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3327 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3327 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44299943 193889 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55476 193889 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10602065 35170 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143775 35170 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44358670 29758 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL138853 29758 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44297463 162569 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417731 162569 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10327540 162953 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL420221 162953 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
44289219 161753 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL416436 161753 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
118722857 115691 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358421 115691 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44333606 5080 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105800 5080 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
10342797 90458 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
CHEMBL23927 90458 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
24800925 87017 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333645 87017 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL405795 210834 6 None - 0 Guinea pig 6.2 pIC50 = 6.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
10458786 5351 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107283 5351 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288934 154552 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL40189 154552 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10087358 60021 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
CHEMBL174465 60021 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
21308490 101177 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299089 101177 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
44346675 113756 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
CHEMBL333039 113756 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
44337704 167571 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432979 167571 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44297859 101247 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
CHEMBL299528 101247 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
21994329 28708 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137972 28708 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL2112246 207489 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
11724403 167980 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 167980 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10389807 96162 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL26336 96162 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL411230 211127 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44433785 146376 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392566 146376 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
68870858 124271 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 124271 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
18391053 166026 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42800 166026 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797458 34003 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142638 34003 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
19797415 38007 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
CHEMBL146223 38007 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
44287481 162432 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417522 162432 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10650263 25882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 25882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44345147 110811 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL326613 110811 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297649 188126 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL50455 188126 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10052114 165530 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL425848 165530 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10837320 35219 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143813 35219 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL265573 208909 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44384901 169337 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 169337 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44384986 129252 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 129252 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
44411637 138750 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 138750 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
44344195 162808 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 162808 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
10055415 106274 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL418757 211491 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
58993550 121552 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596453 121552 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44384677 130936 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 130936 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
44413144 138689 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
CHEMBL378784 138689 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
54582277 60819 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765491 60819 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
28558057 162499 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41762 162499 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24801627 86988 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333616 86988 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10695397 189014 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL51477 189014 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
46884517 8008 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 8008 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10026200 4779 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104277 4779 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44385575 59484 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 59484 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
71583203 87793 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347695 87793 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
10473960 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
CHEMBL23129 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
10473960 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23129 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44415423 138724 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378984 138724 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71699787 124260 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 124260 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797468 37523 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145801 37523 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19003156 66805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
CHEMBL187554 66805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
10473960 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
CHEMBL23129 85855 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
15639109 163482 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL420876 163482 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44321046 204499 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86643 204499 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321046 204499 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86643 204499 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44321493 204516 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
CHEMBL86746 204516 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
10451098 11701 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
CHEMBL118194 11701 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
44307137 101641 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL302315 101641 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24783930 121560 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596461 121560 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
10030004 110857 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL326889 110857 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
15391369 102355 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 102355 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44328389 106753 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL316842 106753 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
4189 205195 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10405461 60020 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
CHEMBL174464 60020 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
2090 2726 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2726 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2726 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44384987 61025 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 61025 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44289169 101018 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101018 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
54585204 60835 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765505 60835 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
10031310 4642 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103510 4642 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
10339539 109280 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109280 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
44276788 96049 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
CHEMBL26251 96049 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
44319329 204254 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL84588 204254 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44306045 100200 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292256 100200 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
9871754 5337 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5337 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
21994328 30993 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140086 30993 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
24784190 121571 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596472 121571 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
9855000 20421 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20421 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44328400 107625 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL319559 107625 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44415435 79731 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213359 79731 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415469 166876 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL429715 166876 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
11546759 87805 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347855 87805 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
21994352 118776 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
CHEMBL343797 118776 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
10626865 57219 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166178 57219 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44328424 106824 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317297 106824 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227360 200895 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200895 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
10839068 118219 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL341745 118219 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
24993312 178773 10 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 178773 10 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
10436850 79236 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2115107 79236 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
11546190 105320 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126960 105320 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
19098236 33811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL142477 33811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319082 167464 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 167464 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
18669085 82963 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21939 82963 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44306693 101878 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
CHEMBL303750 101878 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
44358476 30149 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL139190 30149 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
44297629 189916 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51794 189916 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
46884515 7743 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7743 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44456866 157427 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408484 157427 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24993955 183723 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 183723 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL276294 209083 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
44415447 141020 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384796 141020 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44338640 167526 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL432627 167526 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44321099 204503 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86659 204503 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44368159 47930 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL155218 47930 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44346420 14190 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14190 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44288758 100642 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 100642 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
24785191 121557 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596458 121557 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
44294423 11934 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53817703 11934 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183414 11934 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295686 11934 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15037919 119122 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119122 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
71541376 87002 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333630 87002 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785445 121550 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596451 121550 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
10668476 98989 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL282996 98989 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
9957036 163606 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL42103 163606 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10668476 98989 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL282996 98989 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44380709 119888 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL353416 119888 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44297359 191749 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL52070 191749 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
44345156 113608 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL332759 113608 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10674743 109729 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL323762 109729 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
100951644 169067 11 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
CHEMBL4437106 169067 11 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
24889283 8346 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8346 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
44289218 163157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42050 163157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44233184 193100 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193100 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
15037920 45473 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45473 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44363017 37071 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
CHEMBL145407 37071 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
44358982 30450 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139464 30450 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
42639649 170178 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170178 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44370352 51219 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL158255 51219 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44212282 60958 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 60958 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
19960248 169517 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL444339 169517 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
10452352 128003 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
CHEMBL366753 128003 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
76336391 105325 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126965 105325 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
71541372 87020 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333648 87020 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
11634999 87789 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347691 87789 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
131871 119023 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119023 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44359010 29785 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138883 29785 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
23294208 96700 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 96700 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44299310 96287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL264376 96287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL436706 211938 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(N)=O 10.1016/S0960-894X(01)80229-8
44346497 14374 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL120286 14374 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10407632 101354 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30029 101354 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10736544 102282 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL305094 102282 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
10520658 98194 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98194 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10025594 90459 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL23928 90459 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
24799365 86991 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333619 86991 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9852376 98645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 98645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44385121 60840 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
CHEMBL176557 60840 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
44299753 193969 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55635 193969 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44287861 161190 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161190 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL415600 211446 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
56661421 66115 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817831 66115 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852028 66115 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
44312000 202973 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 202973 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
14999557 102152 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304246 102152 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
68870105 124267 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 124267 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
16755281 176225 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
CHEMBL460684 176225 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
44297698 193320 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54717 193320 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
68932311 124273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 124273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44322724 204574 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87066 204574 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
24800577 87000 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333628 87000 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
15755302 101849 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303543 101849 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44458869 11881 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL1183106 11881 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL280339 11881 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
44375286 119605 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351059 119605 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
9827668 111780 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL329105 111780 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11647974 105331 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126970 105331 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
9938657 59906 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59906 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
9827668 111780 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL329105 111780 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44458598 98392 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL278849 98392 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
107686 3327 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3327 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3327 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44274331 82048 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
CHEMBL21759 82048 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
44433799 88240 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88240 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44306000 100416 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL293675 100416 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370925 119108 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL346485 119108 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
132837 2207 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2207 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2207 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
58993629 121589 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596490 121589 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
24888772 7934 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 7934 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44319307 106065 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 106065 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415399 79644 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL212978 79644 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415449 79855 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213908 79855 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44290030 172966 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL45316 172966 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
19797439 36655 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36655 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
10577745 56849 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164563 56849 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
24782913 121576 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596477 121576 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
57402686 71261 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963297 71261 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3217199 71261 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10053175 4800 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104370 4800 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44319223 106621 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 106621 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
10202046 120548 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 120548 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
46884471 7667 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7667 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44352062 18745 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18745 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44319355 105043 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 105043 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71541473 86978 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333607 86978 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
107686 3327 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3327 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3327 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44319308 105897 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 105897 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274181 77857 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21062 77857 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
44358475 30147 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139189 30147 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10063954 98279 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL277918 98279 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44297484 194329 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56003 194329 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
18986937 167594 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL433107 167594 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
68930433 124269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 124269 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797417 37084 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145414 37084 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10099318 56891 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164912 56891 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
14986135 162849 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 162849 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44337620 109251 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL322976 109251 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9979913 107985 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL319932 107985 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
104974 3419 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 3419 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 3419 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 3419 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 3419 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL334721 209653 1 None - 3 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
44358520 30157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139198 30157 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44346693 15229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL121480 15229 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44366601 42181 9 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL149905 42181 9 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
104943 55099 34 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55099 34 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
44346200 14296 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL120038 14296 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
44299876 162627 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL418114 162627 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44274392 77737 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21018 77737 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
22293476 79295 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115450 79295 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44337569 9130 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL110558 9130 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10520658 98194 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98194 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL2369630 207900 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
9851211 5128 28 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL106092 5128 28 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44287606 100045 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100045 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10344874 119645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 119645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
10907460 9735 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9735 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10548166 34874 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
CHEMBL143377 34874 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
68928720 124277 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 124277 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
10454303 5411 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL107619 5411 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
44458353 99143 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99143 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
44307090 100243 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL292496 100243 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
21955298 79296 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115451 79296 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2369607 207895 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10840161 167706 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL433906 167706 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9832198 106273 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44294408 11146 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178974 11146 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52114 11146 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44294305 11935 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972643 11935 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183417 11935 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295781 11935 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
21994241 29554 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138695 29554 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
71458099 79181 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 79181 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44348676 17767 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126009 17767 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
19797445 118933 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL344970 118933 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44383265 120009 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
CHEMBL354542 120009 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
10408564 5906 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108010 5906 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10474902 88257 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23597 88257 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299830 195002 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL56458 195002 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44274326 81140 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21612 81140 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
58993640 121548 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596449 121548 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
2090 2726 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311312 2726 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL437797 2726 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
44297523 100226 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292404 100226 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44288770 159265 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
CHEMBL41057 159265 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
10408912 95962 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL26193 95962 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
44274534 98502 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279726 98502 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
46884431 7972 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 7972 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
54581461 60934 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60934 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
44276792 98674 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 98674 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44297685 100609 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL294843 100609 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44334072 5026 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105560 5026 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
11295303 94619 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25521 94619 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
44305557 201125 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 201125 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44287803 99747 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 99747 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44410194 76530 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL206983 76530 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
16755253 185607 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487276 185607 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
118722858 115694 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358424 115694 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
44306757 100485 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
CHEMBL294114 100485 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
44306092 201733 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL65703 201733 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324793 205274 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL91438 205274 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44324775 205583 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93401 205583 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44289197 100685 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL295425 100685 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
104943 55099 34 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55099 34 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797460 120499 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 120499 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305557 201125 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 201125 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10063954 98279 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL277918 98279 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
71541472 86977 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333606 86977 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44346536 16129 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
CHEMBL122580 16129 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
44306106 102334 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305368 102334 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10531588 119849 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
CHEMBL353116 119849 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
44346536 16129 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL122580 16129 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
19049319 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL417784 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
19049319 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417784 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797439 36655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
19049319 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
CHEMBL417784 162584 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
56658036 66130 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817885 66130 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852128 66130 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
23653789 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
23653789 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3530 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
10698085 19207 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL129354 19207 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
24888942 7864 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7864 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44299463 194869 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56372 194869 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44290080 193188 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL539937 193188 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44319356 103892 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 103892 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415529 139497 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL380017 139497 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24993313 186448 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 186448 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
10499846 31008 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
CHEMBL140101 31008 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
130847 198896 13 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59915 198896 13 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
43815 186337 58 None - 24 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL1708 186337 58 None - 24 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL490 186337 58 None - 24 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL2112245 207488 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
54581252 60824 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765496 60824 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11248796 161100 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL413027 161100 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44289102 167944 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL435367 167944 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
76311027 105329 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126969 105329 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
18986942 202217 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL69051 202217 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
44299898 162579 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417766 162579 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797414 36948 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145308 36948 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44324681 111973 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329840 111973 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
44281769 109172 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
CHEMBL32248 109172 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
44345938 11898 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 11898 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
10339539 109280 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109280 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL2092730 207457 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
45271306 193999 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193999 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
46227362 200897 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200897 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274254 79796 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21366 79796 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
11661466 36685 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145103 36685 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL2112246 207489 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44274444 82166 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21787 82166 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
11801586 5392 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5392 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL2112245 207488 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
CHEMBL2369766 207938 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
56671764 66109 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817821 66109 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852008 66109 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
56671762 66127 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817820 66127 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852121 66127 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
23025476 66142 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1817817 66142 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1852184 66142 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
2090 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
5311312 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL437797 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44358847 29956 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
CHEMBL139017 29956 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
54586136 60820 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765492 60820 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
2090 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
5311312 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 2726 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
44375315 56213 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56213 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44318671 105643 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL313432 105643 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
15037918 44600 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44600 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
5757 3923 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3923 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3923 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3923 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10907397 43636 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151177 43636 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366788 43904 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
CHEMBL151585 43904 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
22901331 11876 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
18964186 202601 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
CHEMBL71397 202601 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
2102 1166 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1166 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1166 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
21836542 42057 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL149794 42057 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11005795 41941 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
CHEMBL149690 41941 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
21699577 43102 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150709 43102 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10918128 119346 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL348653 119346 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10973497 42991 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150619 42991 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
23224631 43667 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151231 43667 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11071954 164786 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL423584 164786 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
22901331 11876 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10864234 43733 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151317 43733 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10929285 66376 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL185572 66376 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
21836537 41123 5 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL148998 41123 5 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366712 43257 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL150842 43257 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11028028 43424 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150997 43424 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11060266 43894 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL151570 43894 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
22901331 11876 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10984417 43533 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151088 43533 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44366743 43715 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL151289 43715 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
11813113 42890 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150537 42890 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11827396 42961 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150585 42961 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836550 118978 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345309 118978 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11071343 121003 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL358418 121003 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366283 39302 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147301 39302 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103819 118974 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL345288 118974 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836558 120772 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357946 120772 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11123982 43934 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
CHEMBL151621 43934 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
44300138 100430 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293804 100430 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
21836503 41708 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL149469 41708 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
44300056 100369 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293374 100369 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555235 100369 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300032 197416 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58873 197416 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
52937467 62194 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62194 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
21836538 39250 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147241 39250 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
10864203 43451 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151026 43451 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44300037 191335 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL52004 191335 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
104943 55099 34 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55099 34 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
71452185 83122 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83122 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300106 196602 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL57584 196602 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11135103 121060 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
CHEMBL358600 121060 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
11113999 43619 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151155 43619 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11763019 119185 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
CHEMBL347284 119185 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
44241710 83118 0 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83118 0 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300497 100291 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL292816 100291 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
22901331 11876 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
11071001 42725 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
CHEMBL150381 42725 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
44366988 43757 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151356 43757 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366559 119026 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345733 119026 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366577 120598 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357357 120598 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
52937271 62192 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62192 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 117654 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 117654 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
6604943 101270 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL299701 101270 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555236 101270 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300034 196828 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
CHEMBL57778 196828 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
71457524 83120 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83120 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10864032 43454 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151028 43454 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836496 120379 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL355973 120379 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
104943 55099 34 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55099 34 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
118730934 117655 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 117655 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44300055 100536 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL294452 100536 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11813288 43028 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
CHEMBL150644 43028 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
44366742 43714 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151288 43714 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103197 78004 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL2111193 78004 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
132927 4021 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
138398059 4021 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
677 4021 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL294453 4021 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL551291 4021 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
9847362 121175 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL358694 121175 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
135413536 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
44300139 197365 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58598 197365 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
118730932 117653 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 117653 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
25129133 188300 0 None 102 5 Human 11.2 pKi = 11.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188300 0 None 102 5 Human 11.2 pKi = 11.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
10288987 18030 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
CHEMBL1270066 18030 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
122187724 122550 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 122550 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10216430 79495 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212428 79495 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
5752 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
6918331 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
CHEMBL522302 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
DB12436 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
5752 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
6918331 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL522302 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
DB12436 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL3609617 210084 0 None 501 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10714695 41791 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL149557 41791 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 77839 13 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 77839 13 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419537 208693 0 None 32 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44264764 13076 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1191008 13076 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL542044 13076 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
22880695 13475 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1194085 13475 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL545594 13475 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
127944 120412 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL356062 120412 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL555572 120412 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL3608939 210081 0 None 1 3 Rat 10.4 pKi = 10.4 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL261390 208773 0 None 34 3 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44177770 122486 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 122486 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10500669 38840 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146885 38840 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10809458 118882 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL344536 118882 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
127944 120412 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356062 120412 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL555572 120412 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5752 3942 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
6918331 3942 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
CHEMBL522302 3942 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
DB12436 3942 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
44264847 12713 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1188354 12713 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL536103 12713 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44264766 13444 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193883 13444 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL545360 13444 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
45271306 193999 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193999 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
11793012 120534 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356786 120534 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10499614 121464 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359188 121464 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 77839 13 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 77839 13 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
22880684 13384 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193478 13384 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544891 13384 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
24969015 92545 3 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441373 92545 3 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419538 208694 0 None 75 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
44177570 60931 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60931 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44233185 193154 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193154 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
10641076 167853 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL434884 167853 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10152974 57562 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672044 57562 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
15463537 13884 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1197007 13884 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL558990 13884 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
51002938 57565 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672047 57565 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL389652 210683 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 210683 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419542 208698 0 None 6 3 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419541 208697 0 None 3 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419543 208699 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
9871118 145599 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3919618 145599 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2109 4073 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 4073 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 4073 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
10173872 138743 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379072 138743 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46227362 200897 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200897 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
51002993 57571 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672053 57571 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL3609616 210083 0 None 1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL2419539 208695 0 None 25 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
2109 4073 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 4073 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 4073 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10546738 165056 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL424301 165056 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
23725089 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 791 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
72203985 92543 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441371 92543 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1651026 207083 19 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
9961315 117421 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 117421 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
51003118 57569 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672051 57569 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL3609616 210083 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10288987 18030 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270066 18030 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10495476 39671 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147776 39671 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10643148 121030 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL358575 121030 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10784942 121476 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359255 121476 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
51002996 57575 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672058 57575 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
2102 1166 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1166 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1166 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
105083 25247 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
CHEMBL135022 25247 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
2102 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
2102 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1166 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
9809876 19202 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 19202 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
51003056 57566 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672048 57566 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
49863732 15158 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15158 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
10217362 18110 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270565 18110 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10547681 120565 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL357029 120565 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
21041073 138320 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138320 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
51003119 57570 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672052 57570 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
53320128 57573 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672056 57573 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
10290124 92544 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441372 92544 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
10289148 146579 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3927453 146579 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3609618 210085 0 None 16 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44560810 172704 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL452534 172704 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
9958115 172927 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453054 172927 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560811 188406 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL508661 188406 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
11327981 181696 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL478392 181696 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL229280 207713 0 None 23 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
51003053 57576 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672059 57576 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
44177669 60932 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60932 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10217361 18109 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270564 18109 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
5757 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
9832383 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
CHEMBL522987 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
DB11949 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
5757 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3923 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10289302 18050 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270175 18050 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
9872808 57563 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672045 57563 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
46227363 197984 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197984 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
2102 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5311057 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL441225 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5757 3923 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
9832383 3923 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
CHEMBL522987 3923 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
DB11949 3923 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
2102 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
5311057 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL441225 1166 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
10598278 13811 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196442 13811 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556981 13811 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
52943331 18065 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270271 18065 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52947014 18122 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270664 18122 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
2102 1166 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1166 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1166 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
9852904 116536 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 116536 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
51002992 57568 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672050 57568 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
122187724 122550 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 122550 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52940937 18093 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270465 18093 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10152358 18049 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270174 18049 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL389652 210683 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL389652 210683 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419541 208697 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 210683 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
153996 112171 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 112171 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 112171 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
9831546 203464 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 203464 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2397481 208671 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
11712457 18166 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270970 18166 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL2397481 208671 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2018.06.009
10128086 79416 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212112 79416 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128366 79854 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213906 79854 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128322 172403 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL451765 172403 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10311126 172628 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452270 172628 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44560775 172702 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452532 172702 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
104943 55099 34 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55099 34 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
44241723 83119 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83119 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10603544 110075 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110075 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
51002995 57574 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672057 57574 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
52945787 18092 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270464 18092 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
23725089 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 791 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
122187205 122487 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 122487 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52942011 18152 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270868 18152 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52943450 18031 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270067 18031 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
52946917 18137 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270766 18137 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10174642 146015 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3922759 146015 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2102 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
5311057 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
CHEMBL441225 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
2102 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
5311057 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
CHEMBL441225 1166 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
44408025 75562 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75562 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
10363623 84455 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL22360 84455 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
15463538 13794 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196327 13794 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556562 13794 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
102023780 120235 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 120235 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 120235 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 120235 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9852630 203145 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 203145 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
22960738 74934 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
CHEMBL203716 74934 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
10164354 165448 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL425406 165448 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
18403344 140383 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL382242 140383 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
52942012 18153 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270869 18153 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10173872 138744 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379073 138744 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
10128086 138994 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL379520 138994 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
44560832 176239 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL460890 176239 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560834 189404 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL517121 189404 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
104943 55099 34 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55099 34 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
11490769 83123 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83123 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
9874473 41564 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44307758 201862 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201862 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10311483 144340 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3909899 144340 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL2370435 208104 0 None 48 2 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
44140365 186456 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490926 186456 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10173890 77860 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210641 77860 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
51003178 57572 3 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672055 57572 3 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
9873032 75032 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203867 75032 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL3609615 210082 0 None -2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
2102 1166 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1166 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1166 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
44380081 57801 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 57801 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9810434 103904 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 103904 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44407938 139916 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL380931 139916 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
52937467 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937467 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
52937467 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62194 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
135416054 79814 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213735 79814 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 79910 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214194 79910 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
44560809 172928 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453055 172928 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560833 176278 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL461299 176278 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44241723 83119 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83119 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10698493 109291 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL323224 109291 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
10522676 118656 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL342966 118656 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10761962 118721 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343404 118721 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
24969353 197468 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
CHEMBL589371 197468 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
46224928 197721 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 197721 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
46889695 6851 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084436 6851 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
104974 3419 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
2111 3419 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
3481 3419 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
CHEMBL308148 3419 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
DB06660 3419 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
46227361 200896 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200896 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
11261795 197025 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL492117 197025 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL581391 197025 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
52943348 18123 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270665 18123 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10462 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
9808518 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
CHEMBL206488 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
122187205 122487 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 122487 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10311496 18077 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270370 18077 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380448 119774 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 119774 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315483 96151 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 96151 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 155080 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 155080 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 155080 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 203739 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 203739 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10296442 75155 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204306 75155 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
24768355 168329 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168329 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10296442 75155 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL204306 75155 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560773 172400 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451763 172400 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
10194796 191259 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL519914 191259 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL439019 212070 0 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
52940879 18144 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270786 18144 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
44307773 101890 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 101890 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 201842 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201842 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889696 6852 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084437 6852 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
24768355 168329 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168329 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71458106 79189 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
CHEMBL2114439 79189 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
51003117 57567 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672049 57567 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
10311306 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5027 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5749 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
CHEMBL3707331 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
DB09291 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
104943 55099 34 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55099 34 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10128131 18066 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270272 18066 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380337 57134 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 57134 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380396 57415 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 57415 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380082 57807 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 57807 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380091 120209 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 120209 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380473 120271 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 120271 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9896757 203273 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 203273 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44241710 83118 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83118 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44314480 102466 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL306311 102466 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
10127439 172528 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452022 172528 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44241710 83118 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83118 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71452185 83122 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83122 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10817360 5122 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106078 5122 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10769059 108130 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108130 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
44307898 199788 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199788 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL387670 210664 0 None 109 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2207 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
10128485 148055 7 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3939059 148055 7 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11296094 6353 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082415 6353 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
2102 1166 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1166 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1166 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
10621261 36300 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL144793 36300 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9929728 39524 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147619 39524 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408039 75151 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75151 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408047 96320 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96320 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
46224962 197723 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 197723 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
10476340 94567 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL25492 94567 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
44380206 57467 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 57467 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380132 95980 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 95980 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380290 99628 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 99628 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9961955 172204 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 172204 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9810544 203084 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 203084 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44408107 74944 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203740 74944 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL389651 210682 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
10817013 9166 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9166 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44307821 101644 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101644 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307819 102123 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102123 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 168698 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168698 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307820 201940 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201940 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
11734825 13116 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 13116 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
122187725 122551 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 122551 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
46889690 6873 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084522 6873 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL2371977 208426 0 None 17 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL2419540 208696 0 None 4 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10530375 5553 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5553 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
44380131 57308 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 57308 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380415 119809 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 119809 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9831674 103932 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 103932 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
9917970 203245 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 203245 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337201 108125 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108125 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44299271 194374 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL56038 194374 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
10231172 138735 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
CHEMBL379038 138735 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
44560755 172629 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452271 172629 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
52946919 18143 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270785 18143 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
46889697 6853 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084438 6853 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
51003055 57564 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672046 57564 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
4898 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
5742 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
6451149 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
CHEMBL206253 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
DB09048 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
54581461 60934 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60934 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
127032533 138258 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
CHEMBL3780776 138258 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
71716116 85934 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313630 85934 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380062 120251 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 120251 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9961936 102615 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 102615 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315370 203131 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 203131 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 203442 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 203442 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
5759 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
6450815 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
CHEMBL204694 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
44338517 6258 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108200 6258 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358516 168010 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL435796 168010 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44346206 113162 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL332284 113162 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
145948847 166919 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 166919 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10173890 77850 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210591 77850 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 79955 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214388 79955 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46889693 6874 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084523 6874 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44177670 60933 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60933 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL426363 211597 0 None 26 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11801327 9266 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9266 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44307953 168628 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 168628 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 168628 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9875181 170777 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 170777 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 201881 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 201881 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202075 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10762277 13370 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193282 13370 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544660 13370 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44281977 108906 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 108906 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52949509 18078 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270371 18078 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
2098 3638 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
36511 3638 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3805 3638 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3835 3638 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
CHEMBL235363 3638 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
44315298 102637 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 102637 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2372071 208433 11 None - 1 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1016/s0960-894x(98)00219-4
9808347 140231 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381832 140231 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127030411 138263 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
CHEMBL3780820 138263 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
52946726 17975 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269638 17975 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL2419537 208693 0 None -32 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44241710 83118 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83118 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
104943 55099 34 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55099 34 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10650495 106935 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 106935 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
10626666 108708 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 108708 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
44307741 202090 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 202090 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10303099 7196 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1086003 7196 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
52940877 18138 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270767 18138 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
44216236 6429 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1082737 6429 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380279 57514 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 57514 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380414 57847 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 57847 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315421 105248 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 105248 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
15508105 203123 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 203123 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033167 138224 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780408 138224 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
9874206 202075 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874473 41564 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44407998 75147 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75147 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408046 140213 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140213 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407971 140223 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140223 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358335 26657 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136347 26657 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10437488 29712 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138824 29712 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599018 197722 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 197722 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
9826304 186432 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490755 186432 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
2106 3490 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 3490 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 3490 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
44315390 203333 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 203333 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315576 203534 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 203534 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10304406 139810 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380705 139810 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
155551678 174859 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 174859 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
10218122 137855 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL377242 137855 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10239346 138214 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL378027 138214 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
71452185 83122 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83122 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71453994 83121 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83121 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44307679 201823 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201823 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889667 6795 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084165 6795 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
9872249 76197 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206171 76197 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127031644 138305 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138305 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
127033173 138315 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138315 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
145948797 166915 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 166915 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768356 155321 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155321 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
52943089 17976 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
CHEMBL1269639 17976 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
11490769 83123 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83123 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71457524 83120 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83120 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71455736 83124 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83124 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380526 58020 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 58020 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315369 102545 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 102545 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44305818 14626 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14626 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14626 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
85169 6837 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6837 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
85169 6837 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6837 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
10204249 75213 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204554 75213 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
85169 6837 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL108438 6837 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
85169 6837 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL108438 6837 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
44233410 193921 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 193921 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2102 1166 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
5311057 1166 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
CHEMBL441225 1166 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
44307678 196998 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196998 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889694 6498 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083052 6498 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
46889698 6854 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084439 6854 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44407902 75073 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75073 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44338518 7641 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108889 7641 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
22353151 9043 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109937 9043 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358612 30986 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL140080 30986 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358249 116050 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL336305 116050 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
44338359 162877 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL419742 162877 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44380338 119970 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 119970 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315297 203159 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 203159 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL589979 214024 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None None 10.1021/jm400209h
2098 3638 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
36511 3638 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3805 3638 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3835 3638 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL235363 3638 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
22960739 75258 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204714 75258 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
44177770 122486 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 122486 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL589979 214024 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589979 214024 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
24768354 97517 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL272665 97517 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL2419543 208699 0 None -16 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL261390 208773 0 None -34 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71461646 78499 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 78499 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380289 119749 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 119749 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44407939 75008 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203753 75008 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
9850565 75841 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL205829 75841 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44408838 140735 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL383125 140735 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
71455736 83124 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83124 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10745532 9141 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
CHEMBL110656 9141 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
10555763 107556 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL319476 107556 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
9874473 41564 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
46889668 6497 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083051 6497 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380080 12136 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 12136 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 12136 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10145229 9083 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9083 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337370 106932 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 106932 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
101658885 160941 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
CHEMBL4127872 160941 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
44233184 193100 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193100 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44380092 119855 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 119855 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315589 203130 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 203130 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 203318 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 203318 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033168 138245 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138245 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
44315589 203130 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 203130 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
49863734 15160 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15160 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
11793946 37994 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146210 37994 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408045 75254 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75254 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44358318 30032 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139088 30032 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
22353158 30667 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139750 30667 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358456 118388 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342266 118388 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10741553 13385 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193479 13385 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL544892 13385 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
9892922 100436 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
CHEMBL293844 100436 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
44215305 118749 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 118749 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44407907 75345 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75345 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407917 96110 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96110 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44408088 139295 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139295 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44358568 30480 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139499 30480 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
10302076 30517 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139531 30517 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
9892922 100436 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL293844 100436 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
44281685 99569 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 99569 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281538 109824 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 109824 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
3082491 197637 15 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL590518 197637 15 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL58178 214002 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL591489 214025 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 10.1021/jm901352b
44380277 58933 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 58933 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
73212439 104128 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104782 104128 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44338531 9268 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111304 9268 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
44358346 26581 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
CHEMBL136279 26581 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
46224962 197723 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 197723 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL261608 208774 0 None -3 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44281332 112411 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 112411 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44304397 201595 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64698 201595 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44304302 201631 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL64862 201631 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
45379600 197498 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
CHEMBL589543 197498 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
57391133 68025 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68025 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
11799987 5246 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
CHEMBL106754 5246 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
118731115 117668 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408732 117668 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44380107 119595 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350952 119595 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
86274487 159542 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 159542 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
44318455 104198 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL310521 104198 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
44334501 4940 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL105055 4940 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337207 7748 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 7748 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44177669 60932 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60932 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
46889691 6849 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084434 6849 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL589082 214021 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611293 90642 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397493 90642 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44337078 106711 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL316552 106711 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL2372070 208432 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
19610193 106748 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 106748 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
44364001 39664 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 39664 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314865 203403 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 203403 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281505 116390 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 116390 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281334 118889 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 118889 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 35671 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 35671 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44281587 53276 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 53276 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104130 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104130 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44408089 139656 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 139656 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408051 140696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 140696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44338546 108121 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL320535 108121 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
71717930 85935 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
CHEMBL2313631 85935 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
73350089 88978 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 88978 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
73354570 88980 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 88980 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
44314866 102432 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306039 102432 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314454 105138 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 105138 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644614 112212 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288158 112212 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304470 112212 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644604 112247 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288153 112247 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305011 112247 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358589 28806 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL138056 28806 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
9853827 84797 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 84797 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9872676 77826 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 77826 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
53472113 118353 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 118353 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
2132 3687 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 3687 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 3687 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
71533722 118355 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 118355 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 118363 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 118363 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
10813332 7692 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108933 7692 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
71533722 118355 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 118355 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
10745123 10443 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169522 10443 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44337200 9163 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL110766 9163 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363984 35440 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 35440 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
44215306 36943 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 36943 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44215303 118457 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 118457 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 120498 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 120498 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
118730933 117654 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 117654 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 117654 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 117654 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
56665366 65577 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835843 65577 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177570 60931 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60931 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44314873 203082 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 203082 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10395141 203117 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 203117 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44282002 124986 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 124986 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104130 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104130 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
10651193 7372 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108676 7372 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11273015 57957 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 57957 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
2110 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
2110 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
219077 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
3480 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
CHEMBL346178 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
DB04872 2922 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
44318665 105670 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
CHEMBL313590 105670 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
132837 2207 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2207 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2207 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
44337514 5213 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106555 5213 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
15887536 5356 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107309 5356 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
54397413 90635 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397486 90635 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
44314453 96637 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL267333 96637 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314732 203385 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 203385 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318694 105546 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL313297 105546 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
44408864 76168 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206016 76168 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44363990 16136 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 16136 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363982 35438 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 35438 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363442 37707 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 37707 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
24768353 97299 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
CHEMBL271619 97299 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
44233185 193154 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193154 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
10394952 104270 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 104270 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314486 105176 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 105176 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9987474 203125 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 203125 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44177670 60933 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60933 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44281345 109991 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 109991 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337353 5355 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 5355 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL388265 210668 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm901352b
44318677 203981 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82278 203981 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
44337080 110109 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL325547 110109 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44380313 57785 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 57785 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380095 120343 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 120343 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337174 7801 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 7801 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
9566253 75159 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204327 75159 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL3609617 210084 0 None -501 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
73212437 104132 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104786 104132 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
90644632 111454 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288168 111454 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644628 112237 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288165 112237 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3304854 112237 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10141196 26595 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136291 26595 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
135530616 29578 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
CHEMBL138716 29578 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
10230370 30379 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139382 30379 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358408 30755 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139859 30755 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358597 31245 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL140302 31245 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
9852911 98924 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
CHEMBL282618 98924 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
10085946 164788 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL423597 164788 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
25222441 195465 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 195465 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
118730936 117657 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408522 117657 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
10552479 108516 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321215 108516 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44315267 105026 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 105026 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44358421 29539 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138682 29539 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44363962 35701 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 35701 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44363949 120429 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 120429 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314502 203089 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 203089 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10531434 7378 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108683 7378 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
51351504 60285 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 60285 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
118731119 117672 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
CHEMBL3408736 117672 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
44351946 116866 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 116866 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44281784 112994 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 112994 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44318865 204420 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
CHEMBL86053 204420 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
44380094 58436 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 58436 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
141952732 119959 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 119959 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 119959 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44337467 109726 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 109726 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363936 19835 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 19835 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9868422 169712 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL444624 169712 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507771 109250 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL322975 109250 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
73353537 90639 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397490 90639 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
10790280 108132 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL320583 108132 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
10649307 109879 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
CHEMBL324177 109879 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
10531273 9109 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
CHEMBL110393 9109 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
71549913 118351 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 118351 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44408725 165515 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL425768 165515 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
7088456 197846 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL592133 197846 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44363908 35555 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 35555 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363756 39597 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 39597 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44138558 192436 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL522292 192436 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10189341 10024 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 10024 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10746177 6945 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL108481 6945 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
11100291 177103 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL464178 177103 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
10649931 7793 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108990 7793 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL2371916 208407 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
20906619 60344 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 60344 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
73353047 88976 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 88976 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314547 102402 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 102402 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
25221995 195176 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 195176 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
46228976 197465 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL589329 197465 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
15487997 90631 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397482 90631 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363925 39823 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 39823 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314871 105213 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 105213 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644630 111452 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288166 111452 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
90644620 112294 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288161 112294 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305870 112294 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44407901 139914 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 139914 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358409 118837 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL344265 118837 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
46224928 197721 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 197721 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
54583959 60345 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 60345 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
90644606 112293 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288154 112293 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305869 112293 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338530 9267 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111303 9267 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
11239751 84747 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 84747 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44322610 204919 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
CHEMBL89245 204919 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
86274490 159339 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 159339 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
44315210 102445 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 102445 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44409023 139688 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380510 139688 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44560754 172626 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452269 172626 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10359664 113503 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
CHEMBL332644 113503 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
9896563 103304 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103304 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9810288 201996 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 201996 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44281633 99525 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 99525 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281649 108533 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 108533 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 108718 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 108718 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281650 113298 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 113298 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 113313 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 113313 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52943090 17977 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269640 17977 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
71453994 83121 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83121 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380413 96148 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 96148 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380249 119838 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 119838 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
127034831 135990 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
CHEMBL3736287 135990 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
72734611 90553 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90553 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
72734611 90553 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90553 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
127032846 138262 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138262 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
145948744 166914 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 166914 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
72734611 90553 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2396664 90553 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
72734611 90553 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2396664 90553 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10769060 5957 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 5957 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
11353915 6875 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084525 6875 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
46889692 6850 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084435 6850 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315209 203203 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 203203 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44178113 60935 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60935 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10793340 5648 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
CHEMBL107830 5648 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
10817098 110039 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL325106 110039 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44380090 120208 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 120208 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44315422 102664 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 102664 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315591 203266 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 203266 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315299 203302 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 203302 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 14477 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14477 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14477 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10237920 79432 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212173 79432 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
9927183 193932 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
CHEMBL55591 193932 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
44315572 102508 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 102508 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
145948965 166927 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 166927 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
11794060 118693 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343219 118693 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
86302473 112251 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288169 112251 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305156 112251 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408040 74070 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74070 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74424 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74424 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407908 140027 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140027 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44358317 116037 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL336251 116037 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358425 164894 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL423913 164894 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
145948839 166918 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 166918 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44560774 172401 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451764 172401 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
73348949 90391 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90391 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
10816496 5132 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
CHEMBL106100 5132 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
46889669 6933 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084771 6933 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315231 104920 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 104920 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44408062 140026 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL381151 140026 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
10600310 85932 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313628 85932 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380248 57855 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 57855 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71457524 83120 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83120 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL3609619 210086 0 None 34 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
145948981 166930 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 166930 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
9874473 41564 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44380732 58683 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 58683 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 35487 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 35487 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363979 120470 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 120470 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 202849 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 202849 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL2370435 208104 0 None -48 2 Guinea pig 7.7 pKi = 7.7 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm00073a022
44314578 203438 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 203438 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
13821356 106238 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
CHEMBL3144091 106238 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
44318578 203979 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82274 203979 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
2110 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
2110 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
219077 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
3480 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
CHEMBL346178 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
DB04872 2922 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
44337330 5260 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 5260 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
86275688 147775 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 147775 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
18393120 5188 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 5188 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44408736 140355 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL382043 140355 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
44314503 203285 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 203285 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5083565 213099 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10839138 85933 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313629 85933 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
51351496 60284 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 60284 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
86274732 122479 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
CHEMBL3608741 122479 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
86274727 160236 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 160236 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
18546500 76354 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206490 76354 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
46228975 199947 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL605906 199947 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
44334665 167434 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL432007 167434 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337308 5373 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 5373 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2372065 208430 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N1C2CC3CCC2(CS1(=O)=O)C3(C)C)[C@@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
44233184 193100 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193100 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44314504 102443 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 102443 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281357 111241 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32872 111241 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL3609618 210085 0 None -1148 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44334664 4472 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
CHEMBL102356 4472 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
86274488 160170 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
CHEMBL4113741 160170 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
44380093 120224 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 120224 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10010039 39665 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 39665 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44305793 100378 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 100378 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314577 159333 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 159333 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
44314299 203435 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 203435 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318269 204272 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL84761 204272 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
44380474 58475 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 58475 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10417108 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287454 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314482 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380795 204412 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 204412 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337313 108116 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 108116 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314482 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363963 120764 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 120764 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10417108 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL287454 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 103332 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 99638 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44338532 7549 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108822 7549 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
9801487 205270 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
CHEMBL91418 205270 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
10603383 110859 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
CHEMBL326893 110859 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
73345476 88981 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370514 88981 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
45379601 199057 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL600224 199057 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
73212518 104121 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104774 104121 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
73212440 104126 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
CHEMBL3104780 104126 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
90644624 112264 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288163 112264 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305323 112264 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358385 27256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL136850 27256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
73212593 104123 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104776 104123 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212592 104127 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104781 104127 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
145948981 166930 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 166930 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
73353535 90634 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397485 90634 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44281778 109208 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 109208 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10794699 9147 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110688 9147 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10530592 10444 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169523 10444 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44334591 106937 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
CHEMBL318093 106937 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
10627789 100112 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
CHEMBL29161 100112 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
52937271 62192 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62192 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937271 62192 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62192 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948797 166915 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 166915 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10603365 9199 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL110913 9199 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL261608 208774 0 None -9 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44337023 108187 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320770 108187 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44462338 204082 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83156 204082 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
145948847 166919 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 166919 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10722607 5134 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL106106 5134 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
10698708 109302 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
CHEMBL323274 109302 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
10697884 163915 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL421408 163915 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44408625 168157 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL436951 168157 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44315590 167245 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 167245 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL2371978 208427 0 None 30 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
9918520 102278 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102278 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889466 7197 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1086004 7197 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
104943 55099 34 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
CHEMBL16192 55099 34 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
44408100 140155 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL381524 140155 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
44407972 140225 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140225 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44338583 5719 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
CHEMBL107875 5719 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
44358280 26672 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136360 26672 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358334 26832 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136504 26832 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358569 116292 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL337789 116292 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358323 118474 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342443 118474 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44315573 103319 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 103319 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337371 5219 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 5219 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
25129135 172028 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172028 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
9918479 57307 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 57307 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
22000062 76205 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206268 76205 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948809 166917 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 166917 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44611294 90643 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397494 90643 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10239000 79371 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL211888 79371 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
11467400 6428 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082735 6428 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
9869764 140012 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381058 140012 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948955 166926 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 166926 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44409008 74766 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203605 74766 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10530741 9103 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
CHEMBL110355 9103 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
10115747 140625 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL382771 140625 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL2419540 208696 0 None -4 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
46227360 200895 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200895 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44138555 192569 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL523156 192569 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44408766 96476 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL265986 96476 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507650 162778 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 162778 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
90644635 112209 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288170 112209 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304460 112209 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408033 74423 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74423 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44337414 9125 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 9125 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
46227362 200897 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200897 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44314154 203358 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 203358 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44334845 108420 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
CHEMBL321098 108420 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
3668 1531 36 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1531 36 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1531 36 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1531 36 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
44334666 4559 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
CHEMBL102917 4559 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
90663661 106229 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
CHEMBL3143946 106229 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
118730935 117656 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408521 117656 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44334708 4565 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL102932 4565 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
118731117 117670 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408734 117670 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
56682292 65579 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835845 65579 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
90644631 111453 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288167 111453 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358248 26468 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL136187 26468 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
20599018 197722 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 197722 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
44304398 102213 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL304638 102213 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
16655023 106955 1 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 106955 1 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
44408911 140033 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL381179 140033 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
73212517 104122 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104775 104122 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212516 104124 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104777 104124 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
90644626 112256 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288164 112256 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305163 112256 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304340 201182 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL62597 201182 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44337270 108115 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 108115 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337007 109919 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL324416 109919 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
52937273 62190 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62190 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
44281572 109903 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 109903 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 113753 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 113753 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
54581461 60934 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60934 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
86275687 143109 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
CHEMBL3899877 143109 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
10007108 163413 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
CHEMBL420787 163413 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
44380475 58476 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168770 58476 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 104603 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 104603 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
24768355 168329 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168329 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768355 168329 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168329 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44281713 99202 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 99202 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281788 99524 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 99524 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73353536 90636 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397487 90636 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
2110 2922 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 2922 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 2922 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 2922 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 2922 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
10600014 167307 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL431070 167307 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
10007326 106383 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL314499 106383 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
44314481 203228 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 203228 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
145948839 166918 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 166918 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
145948968 166928 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 166928 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
45271306 193999 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193999 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
118730934 117655 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 117655 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
51003494 58014 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 58014 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
44337355 5274 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 5274 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
118731114 117667 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408731 117667 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44363948 36148 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 36148 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 118252 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 118252 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10507772 109265 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL323044 109265 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44336987 108462 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL321154 108462 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
9809308 204011 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82552 204011 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
4189 205195 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44408628 139833 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380827 139833 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380764 120216 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 120216 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363978 40249 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 40249 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
11801041 109965 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL324667 109965 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44334654 107715 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL319653 107715 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
52937270 62191 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62191 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948809 166917 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 166917 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314945 203287 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 203287 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44281392 99496 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 99496 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44323563 205286 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
CHEMBL91475 205286 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
90644629 111168 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3286415 111168 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10300825 29729 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL138839 29729 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44304301 201626 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64839 201626 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
90644616 112239 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288159 112239 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304856 112239 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644610 112252 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288156 112252 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305158 112252 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
2110 2922 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 2922 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 2922 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 2922 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 2922 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44338557 9258 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111244 9258 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44363926 38833 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 38833 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314867 156785 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 156785 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44408755 74688 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203481 74688 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10032693 109274 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 109274 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
107686 3327 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3327 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3327 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
9939040 4941 5 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4941 5 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL2419544 208700 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10602943 106934 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 106934 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
9824321 75091 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204206 75091 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9846661 76222 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206294 76222 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380457 57808 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 57808 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9939307 201793 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 201793 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10531666 9101 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110340 9101 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL3609615 210082 0 None -24 4 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44318312 104387 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL311027 104387 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
86275451 159546 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 159546 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
57396389 68026 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
CHEMBL1916636 68026 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
44407890 74824 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL203655 74824 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44337208 5168 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 5168 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44282003 99649 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 99649 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334500 4468 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
CHEMBL102332 4468 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
44281744 112975 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 112975 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363877 38913 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 38913 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44409004 74090 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL202720 74090 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
46227361 200896 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200896 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44318565 204213 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL84161 204213 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL2372339 208477 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
44318497 204282 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL84873 204282 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
145948965 166927 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 166927 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314872 96424 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 96424 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337202 7893 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 7893 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337079 106712 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL316553 106712 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44337024 108189 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL320771 108189 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
145948744 166914 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 166914 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10769914 110662 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL326429 110662 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL2112592 207496 0 None -1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44380596 59040 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 59040 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44408726 76207 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL206274 76207 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
10091563 39472 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL147543 39472 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
44314861 167217 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL430416 167217 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
11801965 5149 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106217 5149 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10603279 7940 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
CHEMBL109080 7940 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
9939307 201793 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 201793 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44282001 99347 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 99347 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 109900 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 109900 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 110085 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 110085 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10321715 26500 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136213 26500 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44338618 108838 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL321892 108838 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
10393853 109224 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL322885 109224 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
2755911 75088 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75088 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75088 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75088 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75088 48 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2042018 75088 48 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
15887537 108559 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 108559 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
145948968 166928 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 166928 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44364030 36417 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 36417 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44282004 121247 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 121247 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
90644608 112210 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288155 112210 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304468 112210 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338652 108123 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL320544 108123 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
46224897 197433 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
CHEMBL589130 197433 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
73350555 90637 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397488 90637 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
2098 3638 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
36511 3638 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3805 3638 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3835 3638 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL235363 3638 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
44334581 5162 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL106273 5162 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
2090 2726 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 2726 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 2726 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
445694 119524 75 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL350320 119524 75 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
11305162 74421 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203109 74421 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44334489 106814 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL317209 106814 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
44337354 5384 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 5384 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44314834 203439 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 203439 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281771 99179 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 99179 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
7088460 197600 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590275 197600 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
70689371 77976 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
CHEMBL2110361 77976 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
46227360 200895 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200895 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
18546495 140182 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL381744 140182 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44380680 57283 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166759 57283 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44318593 167431 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL431974 167431 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
44281787 162648 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 162648 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
49863733 15159 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15159 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
118730932 117653 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 117653 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44364003 118490 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 118490 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10295489 139812 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL380716 139812 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
44281957 99355 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 99355 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10010096 99428 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 99428 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
24768356 155321 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155321 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
10675169 108172 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL320758 108172 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44408846 140015 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381081 140015 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
14991605 90641 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397492 90641 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10229773 75150 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204296 75150 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
44407906 74359 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74359 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408048 140028 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140028 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44407903 140191 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140191 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44338586 6807 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL108422 6807 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44338584 8073 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109183 8073 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10187704 118919 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL344847 118919 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 197686 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 197686 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
118730933 117654 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 117654 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
10578261 9093 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9093 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
127033168 138245 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138245 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
56668794 65578 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835844 65578 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177145 194055 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 194055 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9874473 41564 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
71549635 160327 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 160327 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
145948955 166926 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 166926 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314597 103872 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 103872 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
118731113 117666 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408730 117666 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44314298 203432 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 203432 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10001148 51170 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL158212 51170 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
90644622 112248 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288162 112248 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305013 112248 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358413 26701 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136389 26701 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358551 29121 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138335 29121 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 197686 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 197686 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
2089 2725 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3795 2725 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
5311311 2725 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL217406 2725 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
90644612 112223 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288157 112223 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304538 112223 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644618 112266 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288160 112266 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305331 112266 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304381 101615 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
CHEMBL302163 101615 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
7037588 197601 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590276 197601 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44318874 203953 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82065 203953 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
3198 203802 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203802 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203802 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
131954513 161529 31 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 161529 31 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
11683187 198250 35 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL594828 198250 35 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
8867347 60279 6 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 60279 6 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44408821 75041 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203928 75041 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
73352066 90640 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397491 90640 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363435 36957 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 36957 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380733 58308 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 58308 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363983 17982 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 17982 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281958 109199 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 109199 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337289 107552 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 107552 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
46227363 197984 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197984 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
10651575 5085 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL105847 5085 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129133 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44380069 57312 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 57312 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
127031644 138305 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138305 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
44337288 7963 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 7963 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
52937467 62194 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62194 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL2419538 208694 0 None -117 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
10140125 27073 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136709 27073 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
20811360 30112 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139150 30112 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358247 118502 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342602 118502 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44338640 167526 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL432627 167526 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44337324 6633 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 6633 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314548 102436 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 102436 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281516 99420 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 99420 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73352065 90632 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397483 90632 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44550460 195361 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 195361 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
25129135 172028 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172028 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
73347011 88979 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 88979 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44409000 168375 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL438801 168375 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
118731118 117671 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
CHEMBL3408735 117671 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
44318486 104942 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
CHEMBL311946 104942 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
118731116 117669 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408733 117669 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44281743 99178 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 99178 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334630 109167 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL322453 109167 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
10721590 7582 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108847 7582 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10746828 6864 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL108448 6864 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL2372068 208431 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(Cc2ccccc2)[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
73212515 104125 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104778 104125 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44338510 8546 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL109514 8546 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
57394644 68023 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68023 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44334582 161144 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL413383 161144 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
73212519 104120 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104773 104120 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44304323 100118 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
CHEMBL291650 100118 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
90417914 118360 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 118360 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
9887650 16472 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16472 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44380794 119777 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352614 119777 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10078301 118727 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 118727 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 120535 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 120535 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
127033173 138315 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138315 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
9872295 12513 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL1187084 12513 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL489924 12513 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44334499 106816 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
CHEMBL317238 106816 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
127032846 138262 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138262 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
85169 6837 6 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL108438 6837 6 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
9846662 75559 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL204958 75559 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
3668 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
3668 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
5311081 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL333357 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL589982 1531 36 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
10299289 192015 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL521605 192015 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10232846 113617 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 113617 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10767720 78282 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
CHEMBL2112476 78282 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
73351579 88975 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 88975 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
10792994 7433 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108725 7433 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44380763 119528 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 119528 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281476 99469 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286235 99469 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314533 105199 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 105199 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314946 203354 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 203354 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1016 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3690 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2247 502 77 None -117 41 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -117 41 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -117 41 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -117 41 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -117 41 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2812 4711 96 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4711 96 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44407932 75544 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204918 75544 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9940831 14477 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14477 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14477 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10032406 39714 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 39714 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314868 155157 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 155157 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314487 102440 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 102440 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281672 113025 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 113025 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL387816 210665 0 None 23 2 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611292 90633 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397484 90633 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44305818 14626 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14626 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14626 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL2419539 208695 0 None -81 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44337173 6611 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 6611 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
122187725 122551 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 122551 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44281358 97811 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 97811 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337266 5226 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 5226 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44407896 138132 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL377712 138132 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44408697 75080 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204165 75080 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
73355028 90638 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397489 90638 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2111789 207475 0 None -3 2 Human 4.0 pKi = 4.0 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44408910 140761 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL383289 140761 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
10409484 189069 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
CHEMBL515179 189069 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
44281753 99356 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 99356 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
43815 186337 58 None - 24 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL1708 186337 58 None - 24 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL490 186337 58 None - 24 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
132837 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2207 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9329 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
9894349 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
CHEMBL339486 3684 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
23653789 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
9280 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
CHEMBL447955 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
DB12973 3530 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
2098 3638 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
36511 3638 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3805 3638 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3835 3638 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
CHEMBL235363 3638 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
9278 3789 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
9916461 3789 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
CHEMBL3544984 3789 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
DB12580 3789 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
2098 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3638 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
None 214433 0 125I-Bolton Hunter 2 5 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
135413536 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
202 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 201377 82 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 201377 82 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 201437 51 UNDEFINED -1 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 201437 51 UNDEFINED -1 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 215594 0 3H-SP -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 1811 41 3H-SUBSTANCE P -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 1811 41 3H-SUBSTANCE P -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 1811 41 3H-SUBSTANCE P -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 1975 106 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 1975 106 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 1975 106 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 1975 106 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 1975 106 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 3153 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 3153 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 3153 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 3153 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 3153 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 91403 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 91403 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
133090 97971 18 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 97971 18 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
44208932 140176 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140176 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
1973 201790 12 125I-[SAR9, Met(O2)11]-SP -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 201790 12 125I-[SAR9, Met(O2)11]-SP -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 201790 12 125I-[SAR9, Met(O2)11]-SP -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5079497 214303 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 214358 0 3H-Leu,4,5 Substance P -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 214359 0 3H-Leu,4,5 Substance P -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 214752 0 3H-SUBSTANCE P -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
None 214304 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 3H-SUBSTANCE P -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
2098 3638 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
None 214304 0 125I-Bolton Hunter -1202 8 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214433 0 125I-Bolton Hunter -1412 5 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 214434 0 125I-Bolton Hunter -2 6 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 195566 21 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214304 0 125I-Bolton Hunter -354 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214434 0 125I-Bolton Hunter -2 6 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 195566 21 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214304 0 3H-Sar9,Met(O2)11-Substance P -354 8 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214433 0 125I-Bolton Hunter -2 5 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 214304 0 125I-Bolton Hunter -354 8 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 125I-Bolton Hunter -354 8 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
9850582 195566 21 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
2812 4711 96 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 4711 96 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
2247 502 77 None -117 41 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 502 77 None -117 41 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 502 77 None -117 41 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 502 77 None -117 41 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 502 77 None -117 41 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
1016 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 3690 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3198 203802 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 203802 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 203802 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 205195 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 205195 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 205195 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
None 214301 0 125I-[MePhe7]-NKB -676 4 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
9850582 195566 21 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214304 0 125I-Bolton Hunter -354 8 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214302 0 125I-[MePhe7]-NKB -851 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214304 0 125I-[MePhe7]-NKB -354 8 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
4898 2724 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
5742 2724 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
6451149 2724 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
CHEMBL206253 2724 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
DB09048 2724 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
71544786 216030 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
10311306 3315 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5027 3315 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5749 3315 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
CHEMBL3707331 3315 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
DB09291 3315 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
23725089 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
4401 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
5758 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
9917021 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
CHEMBL1672054 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
DB06634 791 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
None 214434 0 125I-Bolton Hunter 2 6 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
10158788 3671 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5746 3671 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5752 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
6918331 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
CHEMBL522302 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
DB12436 3942 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
2087 1889 0 None 31 4 Human 10.8 pKi = 10.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2095 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2095 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL1885865 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL1885865 3528 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5759 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
6450815 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
CHEMBL204694 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
4898 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
5742 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
6451149 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
CHEMBL206253 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
DB09048 2724 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
107967 1616 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
2114 1616 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
CHEMBL1416993 1616 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
10311306 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5027 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5749 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
CHEMBL3707331 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
DB09291 3315 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
10462 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
9808518 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
CHEMBL206488 1985 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
5754 3215 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
9917716 3215 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
5757 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
5757 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
9832383 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
9832383 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
CHEMBL522987 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
CHEMBL522987 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
DB11949 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
DB11949 3923 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
23725089 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
23725089 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
4401 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
4401 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
5758 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
5758 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
9917021 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
9917021 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
CHEMBL1672054 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
CHEMBL1672054 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
DB06634 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
DB06634 791 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
2102 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
2102 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
5311057 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
5311057 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
CHEMBL441225 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
CHEMBL441225 1166 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
188927 1585 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
5751 1585 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
CHEMBL515966 1585 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
3086681 2240 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
3510 2240 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
CHEMBL42407 2240 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
2090 2726 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 2726 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 2726 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2110 2922 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 2922 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 2922 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 2922 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 2922 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
104974 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 3419 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2105 3225 0 None - 1 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12206858
2089 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
2089 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2089 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
3795 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
3795 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
5311311 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5311311 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
CHEMBL217406 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL217406 2725 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 3490 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 3490 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 3490 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
2098 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
36511 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3805 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3835 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
CHEMBL235363 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 3638 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501