Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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2168 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
2810 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077.0 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL373742 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB00067 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
2168 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
2810 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077.0 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL373742 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB00067 3976 None 29 Rat Functional pEC50 = 10.2 10.2 12 6
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1819441 211473 None 0 Rat Functional pEC50 = 10.2 10.2 1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819441 211473 None 0 Rat Functional pEC50 = 10.1 10.1 1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817706 211447 None 0 Rat Functional pEC50 = 10 10.0 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817706 211447 None 0 Rat Functional pEC50 = 10.0 10.0 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819542 211476 None 6 Rat Functional pEC50 = 9.9 9.9 2 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819542 211476 None 6 Rat Functional pEC50 = 9.9 9.9 2 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817704 211445 None 0 Rat Functional pEC50 = 9.9 9.9 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
90285421 115046 None 0 Human Functional pEC50 = 9.9 9.9 9 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 334 4 1 5 2.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL3342789 115046 None 0 Human Functional pEC50 = 9.9 9.9 9 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 334 4 1 5 2.7 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 10.1016/j.ejmech.2017.05.013
3601935 162457 None 0 Human Functional pEC50 = 9.9 9.9 -1 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 271 3 1 4 1.9 Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL4165132 162457 None 0 Human Functional pEC50 = 9.9 9.9 -1 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 271 3 1 4 1.9 Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL1817704 211445 None 0 Rat Functional pEC50 = 9.9 9.9 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819540 211474 None 0 Human Functional pEC50 = 9.9 9.9 64 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819540 211474 None 0 Human Functional pEC50 = 9.9 9.9 64 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819441 211473 None 0 Human Functional pEC50 = 9.8 9.8 -1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819441 211473 None 0 Human Functional pEC50 = 9.8 9.8 -1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
76685194 115047 None 0 Human Functional pEC50 = 9.8 9.8 5 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 368 4 1 5 3.1 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL3342790 115047 None 0 Human Functional pEC50 = 9.8 9.8 5 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 368 4 1 5 3.1 O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2017.05.013
5014150 162950 None 0 Human Functional pEC50 = 9.8 9.8 -1 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 305 3 1 4 2.2 Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL4173036 162950 None 0 Human Functional pEC50 = 9.8 9.8 -1 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay
ChEMBL 305 3 1 4 2.2 Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2017.05.013
CHEMBL1817707 211448 None 0 Rat Functional pEC50 = 9.8 9.8 3 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817707 211448 None 0 Rat Functional pEC50 = 9.8 9.8 3 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
2042 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
2174 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
2176 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
439302 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
439302.0 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
CHEMBL395429 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
DB00107 2983 None 40 Human Functional pEC50 = 9.7 9.7 -3 5
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
ChEMBL None None None None 10.1016/j.bmc.2019.06.018
CHEMBL1817706 211447 None 0 Human Functional pEC50 = 9.7 9.7 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817706 211447 None 0 Human Functional pEC50 = 9.7 9.7 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819541 211475 None 0 Human Functional pEC50 = 9.6 9.6 14 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
2168 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
2810 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077.0 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL373742 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB00067 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1819541 211475 None 0 Human Functional pEC50 = 9.6 9.6 14 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
2168 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
2810 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
644077.0 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL373742 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB00067 3976 None 29 Human Functional pEC50 = 9.6 9.6 -15 6
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1819555 211488 None 0 Human Functional pEC50 = 9.6 9.6 8 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819555 211488 None 0 Human Functional pEC50 = 9.6 9.6 8 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817705 211446 None 0 Human Functional pEC50 = 9.6 9.6 1 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817705 211446 None 0 Human Functional pEC50 = 9.6 9.6 1 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819542 211476 None 6 Human Functional pEC50 = 9.6 9.6 -2 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819542 211476 None 6 Human Functional pEC50 = 9.6 9.6 -2 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817705 211446 None 0 Rat Functional pEC50 = 9.5 9.5 -1 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817705 211446 None 0 Rat Functional pEC50 = 9.5 9.5 -1 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817761 211460 None 0 Rat Functional pEC50 = 9.5 9.5 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817761 211460 None 0 Rat Functional pEC50 = 9.5 9.5 2 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817702 211443 None 0 Rat Functional pEC50 = 9.5 9.5 2 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817702 211443 None 0 Rat Functional pEC50 = 9.5 9.5 2 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819440 211472 None 20 Rat Functional pEC50 = 9.5 9.5 1 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819440 211472 None 20 Rat Functional pEC50 = 9.5 9.5 1 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817704 211445 None 0 Human Functional pEC50 = 9.4 9.4 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817704 211445 None 0 Human Functional pEC50 = 9.4 9.4 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819543 211477 None 0 Human Functional pEC50 = 9.3 9.3 18 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819543 211477 None 0 Human Functional pEC50 = 9.3 9.3 18 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819548 211482 None 0 Human Functional pEC50 = 9.3 9.3 53 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
56672274 64799 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1063 20 13 16 -5.1 CCC(N)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819439 64799 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1063 20 13 16 -5.1 CCC(N)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819548 211482 None 0 Human Functional pEC50 = 9.3 9.3 53 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
56672274 64799 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1063 20 13 16 -5.1 CCC(N)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819439 64799 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1063 20 13 16 -5.1 CCC(N)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
11454 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
53330936 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817709 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB12495 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
11454 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
53330936 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817709 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB12495 3577 None 12 Rat Functional pEC50 = 9.3 9.3 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817707 211448 None 0 Human Functional pEC50 = 9.2 9.2 -3 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817707 211448 None 0 Human Functional pEC50 = 9.2 9.2 -3 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819549 211483 None 0 Human Functional pEC50 = 9.2 9.2 47 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819549 211483 None 0 Human Functional pEC50 = 9.2 9.2 47 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817756 211455 None 0 Rat Functional pEC50 = 9.2 9.2 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817756 211455 None 0 Rat Functional pEC50 = 9.2 9.2 4 5
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
2168 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
2810 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
644077 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
644077.0 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
CHEMBL373742 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
DB00067 3976 None 29 Human Functional pEC50 = 9.2 9.2 -15 6
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.3c01415
CHEMBL1817761 211460 None 0 Human Functional pEC50 = 9.2 9.2 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819440 211472 None 20 Human Functional pEC50 = 9.2 9.2 -1 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817761 211460 None 0 Human Functional pEC50 = 9.2 9.2 -2 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819440 211472 None 20 Human Functional pEC50 = 9.2 9.2 -1 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1819554 211487 None 0 Human Functional pEC50 = 9.1 9.1 5 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819554 211487 None 0 Human Functional pEC50 = 9.1 9.1 5 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817708 211449 None 0 Human Functional pEC50 = 9.1 9.1 53 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817708 211449 None 0 Human Functional pEC50 = 9.1 9.1 53 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817702 211443 None 0 Human Functional pEC50 = 9.1 9.1 -2 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817702 211443 None 0 Human Functional pEC50 = 9.1 9.1 -2 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819556 211489 None 0 Human Functional pEC50 = 9.0 9.0 67 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819556 211489 None 0 Human Functional pEC50 = 9.0 9.0 67 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817754 211453 None 0 Human Functional pEC50 = 9 9.0 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817754 211453 None 0 Human Functional pEC50 = 9 9.0 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
53362258 64645 None 0 Rat Functional pEC50 = 9 9.0 1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
CHEMBL1817695 64645 None 0 Rat Functional pEC50 = 9 9.0 1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
53362155 64824 None 0 Human Functional pEC50 = 9.0 9.0 25 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 12 16 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NOC)NC1=O 10.1021/jm200278m
CHEMBL1819560 64824 None 0 Human Functional pEC50 = 9.0 9.0 25 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 12 16 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NOC)NC1=O 10.1021/jm200278m
53362155 64824 None 0 Human Functional pEC50 = 8.9 8.9 25 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 12 16 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NOC)NC1=O 10.1021/jm200278m
CHEMBL1819560 64824 None 0 Human Functional pEC50 = 8.9 8.9 25 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 12 16 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NOC)NC1=O 10.1021/jm200278m
CHEMBL1817752 211451 None 0 Human Functional pEC50 = 8.9 8.9 77 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817692 211442 None 0 Human Functional pEC50 = 8.9 8.9 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817752 211451 None 0 Human Functional pEC50 = 8.9 8.9 77 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817770 211469 None 0 Human Functional pEC50 = 8.9 8.9 40 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817770 211469 None 0 Human Functional pEC50 = 8.9 8.9 40 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817692 211442 None 0 Human Functional pEC50 = 8.8 8.8 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817755 211454 None 0 Human Functional pEC50 = 8.8 8.8 20 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817755 211454 None 0 Human Functional pEC50 = 8.8 8.8 20 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817772 211471 None 0 Human Functional pEC50 = 8.8 8.8 11 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817772 211471 None 0 Human Functional pEC50 = 8.8 8.8 11 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362258 64645 None 0 Human Functional pEC50 = 8.8 8.8 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
CHEMBL1817695 64645 None 0 Human Functional pEC50 = 8.8 8.8 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
53362258 64645 None 0 Human Functional pEC50 = 8.8 8.8 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
CHEMBL1817695 64645 None 0 Human Functional pEC50 = 8.8 8.8 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 17 11 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)N(C)C)NC1=O 10.1021/jm200278m
CHEMBL1817749 211450 None 0 Rat Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817757 211456 None 0 Human Functional pEC50 = 8 8.0 52 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817769 211468 None 0 Human Functional pEC50 = 8.0 8.0 7 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819552 211485 None 0 Human Functional pEC50 = 8.0 8.0 3 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
2369069 179390 None 3 Human Functional pEC50 = 5.0 5.0 -1 3
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 346 3 0 5 4.0 CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1 nan
CHEMBL473106 179390 None 3 Human Functional pEC50 = 5.0 5.0 -1 3
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 346 3 0 5 4.0 CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1 nan
CHEMBL1817769 211468 None 0 Human Functional pEC50 = 8.0 8.0 7 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819552 211485 None 0 Human Functional pEC50 = 8.0 8.0 3 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817762 211461 None 0 Human Functional pEC50 = 7.9 7.9 43 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362202 64642 None 0 Human Functional pEC50 = 7.9 7.9 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1007 18 13 16 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1817691 64642 None 0 Human Functional pEC50 = 7.9 7.9 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1007 18 13 16 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NO)NC1=O 10.1021/jm200278m
25161471 55055 None 12 Human Functional pEC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 265 4 2 2 3.5 Oc1ccc(Cl)cc1CNCc1ccc(F)cc1 nan
CHEMBL1356933 55055 None 12 Human Functional pEC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 265 4 2 2 3.5 Oc1ccc(Cl)cc1CNCc1ccc(F)cc1 nan
CHEMBL1616435 55055 None 12 Human Functional pEC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 265 4 2 2 3.5 Oc1ccc(Cl)cc1CNCc1ccc(F)cc1 nan
53362202 64642 None 0 Human Functional pEC50 = 7.9 7.9 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1007 18 13 16 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1817691 64642 None 0 Human Functional pEC50 = 7.9 7.9 5 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1007 18 13 16 -4.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1817762 211461 None 0 Human Functional pEC50 = 7.9 7.9 43 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817767 211466 None 0 Human Functional pEC50 = 7.9 7.9 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817767 211466 None 0 Human Functional pEC50 = 7.9 7.9 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819553 211486 None 0 Human Functional pEC50 = 7.9 7.9 19 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
5329098 98628 None 55 Human Functional pEC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 238 1 2 1 3.1 Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1 nan
CHEMBL276711 98628 None 55 Human Functional pEC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 238 1 2 1 3.1 Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1 nan
2919564 30210 None 14 Human Functional pEC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 404 9 2 5 4.0 COc1ccc(CCNCC(O)Cn2c3ccccc3c3ccccc32)cc1OC nan
CHEMBL1390471 30210 None 14 Human Functional pEC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 404 9 2 5 4.0 COc1ccc(CCNCC(O)Cn2c3ccccc3c3ccccc32)cc1OC nan
CHEMBL1819553 211486 None 0 Human Functional pEC50 = 7.9 7.9 19 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817763 211462 None 0 Human Functional pEC50 = 7.9 7.9 19 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817759 211458 None 0 Human Functional pEC50 = 7.9 7.9 31 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817763 211462 None 0 Human Functional pEC50 = 7.9 7.9 19 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817759 211458 None 0 Human Functional pEC50 = 7.8 7.8 31 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817760 211459 None 0 Human Functional pEC50 = 7.8 7.8 14 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
172455511 196334 None 0 Human Functional pEC50 = 5.8 5.8 -72 2
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL 1187 21 14 18 -3.0 NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N\c3ccccc3)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.3c01415
CHEMBL5421609 196334 None 0 Human Functional pEC50 = 5.8 5.8 -72 2
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL 1187 21 14 18 -3.0 NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N\c3ccccc3)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.3c01415
CHEMBL1817758 211457 None 0 Human Functional pEC50 = 7.8 7.8 63 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817760 211459 None 0 Human Functional pEC50 = 7.8 7.8 14 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817758 211457 None 0 Human Functional pEC50 = 7.8 7.8 63 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
1112934 56110 None 5 Human Functional pEC50 = 4.8 4.8 -1 3
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 425 5 1 5 4.7 N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1 nan
CHEMBL1587205 56110 None 5 Human Functional pEC50 = 4.8 4.8 -1 3
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 425 5 1 5 4.7 N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1 nan
CHEMBL1625302 56110 None 5 Human Functional pEC50 = 4.8 4.8 -1 3
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 425 5 1 5 4.7 N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1 nan
53362312 64649 None 0 Human Functional pEC50 = 7.8 7.8 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1051 20 14 17 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC(CO)CO)NC1=O 10.1021/jm200278m
CHEMBL1817699 64649 None 0 Human Functional pEC50 = 7.8 7.8 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1051 20 14 17 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC(CO)CO)NC1=O 10.1021/jm200278m
53362312 64649 None 0 Human Functional pEC50 = 7.8 7.8 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1051 20 14 17 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC(CO)CO)NC1=O 10.1021/jm200278m
CHEMBL1817699 64649 None 0 Human Functional pEC50 = 7.8 7.8 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1051 20 14 17 -6.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC(CO)CO)NC1=O 10.1021/jm200278m
42601352 35412 None 0 Human Functional pEC50 = 4.8 4.8 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 282 4 2 3 3.4 Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1 nan
CHEMBL1437791 35412 None 0 Human Functional pEC50 = 4.8 4.8 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 282 4 2 3 3.4 Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1 nan
CHEMBL3211384 35412 None 0 Human Functional pEC50 = 4.8 4.8 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 282 4 2 3 3.4 Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1 nan
CHEMBL1817671 211441 None 0 Human Functional pEC50 = 7.8 7.8 53 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817671 211441 None 0 Human Functional pEC50 = 7.7 7.7 53 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819547 211481 None 0 Human Functional pEC50 = 7.7 7.7 22 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
6174589 107642 None 5 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 379 6 2 6 2.0 CCN(CC)c1ccc2cc(C(N)=O)/c(=N\NC(=O)c3ccncc3)oc2c1 nan
CHEMBL3189462 107642 None 5 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 379 6 2 6 2.0 CCN(CC)c1ccc2cc(C(N)=O)/c(=N\NC(=O)c3ccncc3)oc2c1 nan
CHEMBL1819547 211481 None 0 Human Functional pEC50 = 7.7 7.7 22 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817749 211450 None 0 Rat Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362311 64648 None 0 Human Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1817698 64648 None 0 Human Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1819555 211488 None 0 Rat Functional pEC50 = 8.7 8.7 -8 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
53362311 64648 None 0 Human Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1817698 64648 None 0 Human Functional pEC50 = 8.7 8.7 1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1819555 211488 None 0 Rat Functional pEC50 = 8.7 8.7 -8 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819550 211484 None 0 Human Functional pEC50 = 8.7 8.7 47 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819550 211484 None 0 Human Functional pEC50 = 8.7 8.7 47 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
11454 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
53330936 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817709 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB12495 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817753 211452 None 0 Human Functional pEC50 = 8.6 8.6 26 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
11454 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
53330936 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817709 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
DB12495 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm200278m
CHEMBL1817753 211452 None 0 Human Functional pEC50 = 8.6 8.6 26 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817756 211455 None 0 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817756 211455 None 0 Human Functional pEC50 = 8.6 8.6 -4 5
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
53362548 64654 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817751 64654 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362548 64654 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817751 64654 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362311 64648 None 0 Rat Functional pEC50 = 8.6 8.6 -1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1817698 64648 None 0 Rat Functional pEC50 = 8.6 8.6 -1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
53362311 64648 None 0 Rat Functional pEC50 = 8.6 8.6 -1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1817698 64648 None 0 Rat Functional pEC50 = 8.6 8.6 -1 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 20 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCCO)NC1=O 10.1021/jm200278m
CHEMBL1817749 211450 None 0 Human Functional pEC50 = 8.5 8.5 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817749 211450 None 0 Human Functional pEC50 = 8.5 8.5 -1 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362154 64823 None 0 Human Functional pEC50 = 7.7 7.7 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1047 20 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NCC(C)C)NC1=O 10.1021/jm200278m
CHEMBL1819559 64823 None 0 Human Functional pEC50 = 7.7 7.7 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1047 20 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NCC(C)C)NC1=O 10.1021/jm200278m
3650228 56001 None 6 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 402 5 2 3 5.1 COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1 nan
CHEMBL1549574 56001 None 6 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 402 5 2 3 5.1 COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1 nan
CHEMBL1624349 56001 None 6 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 402 5 2 3 5.1 COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1 nan
53362154 64823 None 0 Human Functional pEC50 = 7.7 7.7 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1047 20 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NCC(C)C)NC1=O 10.1021/jm200278m
CHEMBL1819559 64823 None 0 Human Functional pEC50 = 7.7 7.7 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1047 20 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NCC(C)C)NC1=O 10.1021/jm200278m
215028 55288 None 1 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 330 1 1 3 4.0 Clc1ccc2c(c1)C(N1CCNCC1)Cc1ccccc1S2 nan
CHEMBL1339676 55288 None 1 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 330 1 1 3 4.0 Clc1ccc2c(c1)C(N1CCNCC1)Cc1ccccc1S2 nan
CHEMBL1618211 55288 None 1 Human Functional pEC50 = 4.7 4.7 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 330 1 1 3 4.0 Clc1ccc2c(c1)C(N1CCNCC1)Cc1ccccc1S2 nan
23983726 48861 None 3 Human Functional pEC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 472 1 3 3 6.2 CC1(C)CC[C@@]2(C(=O)O)C(C1)C1=CCC3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O nan
CHEMBL1559201 48861 None 3 Human Functional pEC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 472 1 3 3 6.2 CC1(C)CC[C@@]2(C(=O)O)C(C1)C1=CCC3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O nan
2042 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
2174 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
2176 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
439302 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
439302.0 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
CHEMBL395429 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
DB00107 2983 None 40 Human Functional pEC50 = 6.6 6.6 -3 5
Agonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assayAgonist activity at human V1a receptor expressed in HEK293FT cells assessed as stimulation of calcium release by Aequorin based assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00697
CHEMBL1817703 211444 None 0 Human Functional pEC50 = 7.5 7.5 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819545 211479 None 0 Human Functional pEC50 = 7.5 7.5 6 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccnc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817771 211470 None 0 Human Functional pEC50 = 8.5 8.5 44 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817771 211470 None 0 Human Functional pEC50 = 8.5 8.5 44 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362204 64643 None 0 Human Functional pEC50 = 8.5 8.5 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1817693 64643 None 0 Human Functional pEC50 = 8.5 8.5 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
53362204 64643 None 0 Human Functional pEC50 = 8.4 8.4 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1817693 64643 None 0 Human Functional pEC50 = 8.4 8.4 10 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
53362547 64653 None 0 Human Functional pEC50 = 8.4 8.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 977 16 12 15 -5.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1817750 64653 None 0 Human Functional pEC50 = 8.4 8.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 977 16 12 15 -5.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
53362547 64653 None 0 Human Functional pEC50 = 8.4 8.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 977 16 12 15 -5.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1817750 64653 None 0 Human Functional pEC50 = 8.4 8.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 977 16 12 15 -5.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1817703 211444 None 0 Human Functional pEC50 = 7.5 7.5 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819545 211479 None 0 Human Functional pEC50 = 7.5 7.5 6 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccnc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
53363017 64822 None 0 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1019 19 12 15 -4.0 CCNC(=O)CC[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819558 64822 None 0 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1019 19 12 15 -4.0 CCNC(=O)CC[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53363017 64822 None 0 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1019 19 12 15 -4.0 CCNC(=O)CC[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819558 64822 None 0 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1019 19 12 15 -4.0 CCNC(=O)CC[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362259 64646 None 0 Human Functional pEC50 = 8.4 8.4 13 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 993 17 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1817696 64646 None 0 Human Functional pEC50 = 8.4 8.4 13 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 993 17 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NO)NC1=O 10.1021/jm200278m
53362259 64646 None 0 Human Functional pEC50 = 8.4 8.4 13 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 993 17 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1817696 64646 None 0 Human Functional pEC50 = 8.4 8.4 13 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 993 17 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NO)NC1=O 10.1021/jm200278m
CHEMBL1819554 211487 None 0 Rat Functional pEC50 = 8.4 8.4 -5 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819554 211487 None 0 Rat Functional pEC50 = 8.4 8.4 -5 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
53362369 64652 None 0 Human Functional pEC50 = 8.3 8.3 8 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1065 22 13 17 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCOCCO)NC1=O 10.1021/jm200278m
CHEMBL1817701 64652 None 0 Human Functional pEC50 = 8.3 8.3 8 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1065 22 13 17 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCOCCO)NC1=O 10.1021/jm200278m
53362548 64654 None 0 Rat Functional pEC50 = 8.3 8.3 -1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817751 64654 None 0 Rat Functional pEC50 = 8.3 8.3 -1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362369 64652 None 0 Human Functional pEC50 = 8.3 8.3 8 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1065 22 13 17 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCOCCO)NC1=O 10.1021/jm200278m
CHEMBL1817701 64652 None 0 Human Functional pEC50 = 8.3 8.3 8 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1065 22 13 17 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCOCCO)NC1=O 10.1021/jm200278m
53362548 64654 None 0 Rat Functional pEC50 = 8.3 8.3 -1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817751 64654 None 0 Rat Functional pEC50 = 8.3 8.3 -1 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 991 17 12 15 -4.8 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
449224 169078 None 10 Human Functional pEC50 = 7.4 7.4 -208 4
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL 991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmcl.2017.12.027
CHEMBL439044 169078 None 10 Human Functional pEC50 = 7.4 7.4 -208 4
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL 991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmcl.2017.12.027
3385342 40159 None 4 Human Functional pEC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 384 6 2 5 3.2 CC(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(c1ccccc1)N1CCOCC1 nan
CHEMBL1479813 40159 None 4 Human Functional pEC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 384 6 2 5 3.2 CC(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(c1ccccc1)N1CCOCC1 nan
2871994 41703 None 10 Human Functional pEC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 324 3 1 4 2.4 O=C1c2cccc3c(N4CCCCC4)ccc(c23)C(=O)N1CCO nan
CHEMBL1492232 41703 None 10 Human Functional pEC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 324 3 1 4 2.4 O=C1c2cccc3c(N4CCCCC4)ccc(c23)C(=O)N1CCO nan
53362368 64651 None 0 Human Functional pEC50 = 8.3 8.3 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCC(C)O)NC1=O 10.1021/jm200278m
CHEMBL1817700 64651 None 0 Human Functional pEC50 = 8.3 8.3 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCC(C)O)NC1=O 10.1021/jm200278m
53362368 64651 None 0 Human Functional pEC50 = 8.3 8.3 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCC(C)O)NC1=O 10.1021/jm200278m
CHEMBL1817700 64651 None 0 Human Functional pEC50 = 8.3 8.3 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 13 16 -5.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCC(C)O)NC1=O 10.1021/jm200278m
53362257 64644 None 0 Human Functional pEC50 = 8.2 8.2 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817694 64644 None 0 Human Functional pEC50 = 8.2 8.2 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362257 64644 None 0 Human Functional pEC50 = 8.2 8.2 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817694 64644 None 0 Human Functional pEC50 = 8.2 8.2 5 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CCNC(=O)C[C@@H]1NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819544 211478 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1819544 211478 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817770 211469 None 0 Rat Functional pEC50 = 7.2 7.2 -40 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817770 211469 None 0 Rat Functional pEC50 = 7.2 7.2 -40 4
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53363016 64821 None 0 Human Functional pEC50 = 8.2 8.2 9 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1819557 64821 None 0 Human Functional pEC50 = 8.2 8.2 9 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O 10.1021/jm200278m
53363016 64821 None 0 Human Functional pEC50 = 8.2 8.2 9 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O 10.1021/jm200278m
CHEMBL1819557 64821 None 0 Human Functional pEC50 = 8.2 8.2 9 4
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1005 18 12 15 -4.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O 10.1021/jm200278m
3484134 51769 None 4 Human Functional pEC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 407 5 2 3 4.6 CC(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(c1ccccc1)N1CCOCC1 nan
CHEMBL1584768 51769 None 4 Human Functional pEC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 407 5 2 3 4.6 CC(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(c1ccccc1)N1CCOCC1 nan
1471100 24425 None 12 Human Functional pEC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 350 1 1 4 3.7 O=c1c2cc(Br)ccc2nc(-c2cccc(Cl)c2)n1O nan
CHEMBL1341433 24425 None 12 Human Functional pEC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 350 1 1 4 3.7 O=c1c2cc(Br)ccc2nc(-c2cccc(Cl)c2)n1O nan
53362156 64641 None 0 Human Functional pEC50 = 7.2 7.2 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 11 16 -4.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)N(C)OC)NC1=O 10.1021/jm200278m
CHEMBL1817690 64641 None 0 Human Functional pEC50 = 7.2 7.2 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 11 16 -4.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)N(C)OC)NC1=O 10.1021/jm200278m
53362156 64641 None 0 Human Functional pEC50 = 7.2 7.2 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 11 16 -4.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)N(C)OC)NC1=O 10.1021/jm200278m
CHEMBL1817690 64641 None 0 Human Functional pEC50 = 7.2 7.2 7 3
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1035 19 11 16 -4.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)N(C)OC)NC1=O 10.1021/jm200278m
CHEMBL1817764 211463 None 0 Human Functional pEC50 = 8.1 8.1 47 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817764 211463 None 0 Human Functional pEC50 = 8.1 8.1 47 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817765 211464 None 0 Human Functional pEC50 = 8.1 8.1 51 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817765 211464 None 0 Human Functional pEC50 = 8.1 8.1 51 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817768 211467 None 0 Human Functional pEC50 = 8.1 8.1 15 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
2042 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
2174 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
2176 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
439302 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
439302.0 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
CHEMBL395429 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
DB00107 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at vasopressin 1a receptor (unknown origin)Agonist activity at vasopressin 1a receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2017.12.027
CHEMBL1817768 211467 None 0 Human Functional pEC50 = 8.1 8.1 15 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2CCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817766 211465 None 0 Human Functional pEC50 = 8.1 8.1 13 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
53362310 64647 None 0 Human Functional pEC50 = 8.1 8.1 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 13 16 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCO)NC1=O 10.1021/jm200278m
CHEMBL1817697 64647 None 0 Human Functional pEC50 = 8.1 8.1 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 13 16 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCO)NC1=O 10.1021/jm200278m
CHEMBL1817766 211465 None 0 Human Functional pEC50 = 8.1 8.1 13 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817754 211453 None 0 Rat Functional pEC50 = 8.1 8.1 -7 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
172455511 196347 None 0 Human Functional pEC50 = 6.1 6.1 -6 2
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL 1187 21 14 18 -3.0 NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.3c01415
CHEMBL5421960 196347 None 0 Human Functional pEC50 = 6.1 6.1 -6 2
Agonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assayAgonist activity at human V1a receptor transfected in HEK293 cells incubated for 1 hr by IP-one HTRF assay
ChEMBL 1187 21 14 18 -3.0 NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.3c01415
53362310 64647 None 0 Human Functional pEC50 = 8.1 8.1 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 13 16 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCO)NC1=O 10.1021/jm200278m
CHEMBL1817697 64647 None 0 Human Functional pEC50 = 8.1 8.1 3 2
Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL 1021 19 13 16 -5.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)NCCO)NC1=O 10.1021/jm200278m
CHEMBL1817754 211453 None 0 Rat Functional pEC50 = 8.1 8.1 -7 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/jm200278m
CHEMBL1817692 211442 None 0 Rat Functional pEC50 = 8.1 8.1 -5 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
CHEMBL1817692 211442 None 0 Rat Functional pEC50 = 8.1 8.1 -5 3
Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm200278m
25163004 72942 None 0 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 1317 54 6 22 6.4 C#CCOCCOCCOCCNc1nc(N2CCN(C(=O)CCCCCCCCCCNC(=O)[C@H](CCCCN)n3cc(C[C@@H](C)CC)nn3)CC2)nc(N2CCN(C(=O)CCCCCCCCCCNC(=O)[C@@H](CCC(=O)O)n3cc(CCCCCN)nn3)CC2)n1 nan
CHEMBL2004487 72942 None 0 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response screening assay for agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434964 (Confirmation screen (V1R agonists in triplicate)), 434969 (Counterscreen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))]
ChEMBL 1317 54 6 22 6.4 C#CCOCCOCCOCCNc1nc(N2CCN(C(=O)CCCCCCCCCCNC(=O)[C@H](CCCCN)n3cc(C[C@@H](C)CC)nn3)CC2)nc(N2CCN(C(=O)CCCCCCCCCCNC(=O)[C@@H](CCC(=O)O)n3cc(CCCCCN)nn3)CC2)n1 nan
2042 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
2174 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
2176 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
439302 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
439302.0 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
CHEMBL395429 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
DB00107 2983 None 40 Human Functional pEC50 = 8.1 8.1 -3 5
Agonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assayAgonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL None None None None 10.1016/j.bmc.2018.03.019
9935206 66083 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 487 4 0 7 2.8 CN(C)S(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837039 66083 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 487 4 0 7 2.8 CN(C)S(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
162676461 183618 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
CHEMBL4799793 183618 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
162676461 183618 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4799793 183618 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL5070261 216717 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL None None None OC1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
CHEMBL5074709 216815 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL None None None O[C@H]1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
10456892 66086 None 0 Human Functional pIC50 = 8.9 8.9 74 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 458 3 0 7 3.0 CS(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837041 66086 None 0 Human Functional pIC50 = 8.9 8.9 74 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 458 3 0 7 3.0 CS(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
162676448 183589 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 438 3 0 5 5.0 Brc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4799412 183589 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 438 3 0 5 5.0 Brc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
162655262 180852 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 426 2 0 5 5.3 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Br)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4756031 180852 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 426 2 0 5 5.3 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Br)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL5070075 216714 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL None None None O[C@@H]1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
CHEMBL5081323 217231 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL None None None Cc1ccc2c(c1)CC(O)Cc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
162669344 182792 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 438 2 0 3 4.1 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4789306 182792 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 438 2 0 3 4.1 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
10444 2326 None 17 Human Functional pIC50 = 7 7.0 -61 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
139030525 2326 None 17 Human Functional pIC50 = 7 7.0 -61 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
145711714 2326 None 17 Human Functional pIC50 = 7 7.0 -61 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4204210 2326 None 17 Human Functional pIC50 = 7 7.0 -61 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
162649115 179975 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 368 2 0 5 4.8 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4745524 179975 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 368 2 0 5 4.8 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CC4)CC2)no1 10.1016/j.bmcl.2020.127417
162668040 182624 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 371 1 1 4 3.3 C[C@H]1CN(C(=O)N2CCNc3cc(Cl)ccc32)CCN1c1ccccn1 10.1016/j.bmcl.2020.127416
CHEMBL4787124 182624 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 371 1 1 4 3.3 C[C@H]1CN(C(=O)N2CCNc3cc(Cl)ccc32)CCN1c1ccccn1 10.1016/j.bmcl.2020.127416
135192889 174153 None 0 Human Functional pIC50 = 5.0 5.0 -25 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 425 5 0 6 4.1 COc1ccc(-n2c(C3CC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4543809 174153 None 0 Human Functional pIC50 = 5.0 5.0 -25 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 425 5 0 6 4.1 COc1ccc(-n2c(C3CC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
162658180 181167 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 466 2 0 3 4.9 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4759676 181167 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 466 2 0 3 4.9 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162662884 182018 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 440 2 0 3 4.4 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C(C)C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4779447 182018 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 440 2 0 3 4.4 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C(C)C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
11326488 66079 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 380 2 1 6 3.3 Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
CHEMBL1837035 66079 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 380 2 1 6 3.3 Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
145965794 164468 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 462 5 3 7 2.6 COC(=O)CNC(=O)NCc1ccc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)cc1C 10.1021/acs.jmedchem.8b00697
CHEMBL4212928 164468 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 462 5 3 7 2.6 COC(=O)CNC(=O)NCc1ccc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)cc1C 10.1021/acs.jmedchem.8b00697
137212772 138027 None 0 Human Functional pIC50 = 6.0 6.0 3 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
CHEMBL3763951 138027 None 0 Human Functional pIC50 = 6.0 6.0 3 2
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
137212772 138027 None 0 Human Functional pIC50 = 6.0 6.0 3 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 10.1016/j.ejmech.2017.10.059
CHEMBL3763951 138027 None 0 Human Functional pIC50 = 6.0 6.0 3 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 609 7 2 8 4.7 COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 10.1016/j.ejmech.2017.10.059
23598597 94150 None 0 Human Functional pIC50 = 4.9 4.9 -91 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 528 5 2 4 5.8 COc1cc(NC(=O)c2cc(F)ccc2C)ccc1C(=O)N1CCC2(C=C(C(=O)O)CC2)Cc2ccccc21 10.1016/j.bmcl.2007.09.059
CHEMBL249133 94150 None 0 Human Functional pIC50 = 4.9 4.9 -91 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 528 5 2 4 5.8 COc1cc(NC(=O)c2cc(F)ccc2C)ccc1C(=O)N1CCC2(C=C(C(=O)O)CC2)Cc2ccccc21 10.1016/j.bmcl.2007.09.059
10359487 66062 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 4 0 5 3.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837018 66062 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 4 0 5 3.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
162661138 181615 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 345 2 0 5 3.5 c1ccc(N2CCC(c3nnc4n3-c3ccccc3CCC4)CC2)nc1 10.1016/j.bmcl.2020.127417
CHEMBL4764976 181615 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 345 2 0 5 3.5 c1ccc(N2CCC(c3nnc4n3-c3ccccc3CCC4)CC2)nc1 10.1016/j.bmcl.2020.127417
9829108 5238 None 1 Human Functional pIC50 = 6.9 6.9 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL106293 5238 None 1 Human Functional pIC50 = 6.9 6.9 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
2200 3311 None 35 Human Functional pIC50 = 7.9 7.9 371 3
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1016/j.bmcl.2011.08.038
3482 3311 None 35 Human Functional pIC50 = 7.9 7.9 371 3
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1016/j.bmcl.2011.08.038
60943 3311 None 35 Human Functional pIC50 = 7.9 7.9 371 3
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1016/j.bmcl.2011.08.038
CHEMBL419667 3311 None 35 Human Functional pIC50 = 7.9 7.9 371 3
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1016/j.bmcl.2011.08.038
DB13929 3311 None 35 Human Functional pIC50 = 7.9 7.9 371 3
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1016/j.bmcl.2011.08.038
162648487 180069 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 423 2 0 5 4.3 Brc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4746716 180069 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 423 2 0 5 4.3 Brc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
23598619 94592 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 498 4 1 4 5.6 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL251771 94592 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 498 4 1 4 5.6 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
11337030 66056 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 349 4 0 6 3.4 COc1ccc(-n2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837012 66056 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 349 4 0 6 3.4 COc1ccc(-n2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
21064040 66074 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 377 3 0 7 3.1 COc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
CHEMBL1837030 66074 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 377 3 0 7 3.1 COc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
162661774 181511 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 439 3 0 3 4.1 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C(C)C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4763639 181511 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 439 3 0 3 4.1 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C(C)C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
44336418 108243 None 0 Human Functional pIC50 = 6.9 6.9 2 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 569 6 2 5 5.0 COC(=O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3C)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL319636 108243 None 0 Human Functional pIC50 = 6.9 6.9 2 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 569 6 2 5 5.0 COC(=O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3C)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
145961670 161458 None 0 Human Functional pIC50 = 7.9 7.9 123 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1139 19 14 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
CHEMBL4126100 161458 None 0 Human Functional pIC50 = 7.9 7.9 123 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1139 19 14 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
162646538 179712 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 412 1 0 3 3.8 CC(=O)N1CCN(C(=O)N2CCN(c3ccccc3C)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
CHEMBL4742335 179712 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 412 1 0 3 3.8 CC(=O)N1CCN(C(=O)N2CCN(c3ccccc3C)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
162656367 180996 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCNc3ccc(Cl)cc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4757593 180996 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCNc3ccc(Cl)cc32)CC1 10.1016/j.bmcl.2020.127416
162660975 181963 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 365 2 0 5 3.8 Clc1ccc2c(c1)CCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4778700 181963 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 365 2 0 5 3.8 Clc1ccc2c(c1)CCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
56672569 66065 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 4 0 5 3.7 Cc1ccc(Cn2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837021 66065 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 4 0 5 3.7 Cc1ccc(Cn2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
44352783 116845 None 0 Human Functional pIC50 = 6.8 6.8 -4 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 508 6 2 4 6.5 O=C(Nc1ccc(C(=O)N2CCC(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
CHEMBL337725 116845 None 0 Human Functional pIC50 = 6.8 6.8 -4 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 508 6 2 4 6.5 O=C(Nc1ccc(C(=O)N2CCC(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
44336403 5384 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 580 7 2 4 5.6 O=C(NCCN1CCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL107058 5384 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 580 7 2 4 5.6 O=C(NCCN1CCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
3537 4004 None 22 Human Functional pIC50 = 5.8 5.8 -57 4
Antagonist activity at V1A receptor (unknown origin) by cAMP accumulation assayAntagonist activity at V1A receptor (unknown origin) by cAMP accumulation assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/acs.jmedchem.8b00697
5311500 4004 None 22 Human Functional pIC50 = 5.8 5.8 -57 4
Antagonist activity at V1A receptor (unknown origin) by cAMP accumulation assayAntagonist activity at V1A receptor (unknown origin) by cAMP accumulation assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/acs.jmedchem.8b00697
CHEMBL363910 4004 None 22 Human Functional pIC50 = 5.8 5.8 -57 4
Antagonist activity at V1A receptor (unknown origin) by cAMP accumulation assayAntagonist activity at V1A receptor (unknown origin) by cAMP accumulation assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/acs.jmedchem.8b00697
11740204 66066 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 375 7 0 5 4.4 CCCCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837022 66066 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 375 7 0 5 4.4 CCCCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
21925639 66075 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
CHEMBL1837031 66075 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
162647212 179807 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 391 1 1 4 3.6 O=C(N1CCN(c2ncccc2Cl)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
CHEMBL4743785 179807 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 391 1 1 4 3.6 O=C(N1CCN(c2ncccc2Cl)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
135192932 171631 None 0 Human Functional pIC50 = 5.8 5.8 -190 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 443 7 0 7 3.8 CCOCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
CHEMBL4464246 171631 None 0 Human Functional pIC50 = 5.8 5.8 -190 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 443 7 0 7 3.8 CCOCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
9828129 116685 None 0 Human Functional pIC50 = 5.8 5.8 -91 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL336825 116685 None 0 Human Functional pIC50 = 5.8 5.8 -91 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
10318802 66071 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 400 6 0 8 2.7 c1ccc(Cn2c(Cn3nccn3)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837027 66071 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 400 6 0 8 2.7 c1ccc(Cn2c(Cn3nccn3)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
162646888 179665 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 437 3 0 3 3.8 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4741743 179665 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 437 3 0 3 3.8 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
142391805 174081 None 0 Human Functional pIC50 = 5.7 5.7 -35 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 435 5 0 6 4.2 COc1ccc(-n2c(C(F)F)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4541860 174081 None 0 Human Functional pIC50 = 5.7 5.7 -35 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 435 5 0 6 4.2 COc1ccc(-n2c(C(F)F)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
145976595 163810 None 0 Human Functional pIC50 = 7.7 7.7 -2 3
Antagonist activity at human V1A receptor expressed in human HeLa cells assessed as inhibition of AVP-induced cAMP accumulation incubated for 10 mins by radioimmunoassayAntagonist activity at human V1A receptor expressed in human HeLa cells assessed as inhibition of AVP-induced cAMP accumulation incubated for 10 mins by radioimmunoassay
ChEMBL 408 2 1 4 4.9 Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 10.1021/acs.jmedchem.8b00697
CHEMBL4205046 163810 None 0 Human Functional pIC50 = 7.7 7.7 -2 3
Antagonist activity at human V1A receptor expressed in human HeLa cells assessed as inhibition of AVP-induced cAMP accumulation incubated for 10 mins by radioimmunoassayAntagonist activity at human V1A receptor expressed in human HeLa cells assessed as inhibition of AVP-induced cAMP accumulation incubated for 10 mins by radioimmunoassay
ChEMBL 408 2 1 4 4.9 Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 10.1021/acs.jmedchem.8b00697
44444761 94218 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 532 4 1 4 6.2 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL249536 94218 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 532 4 1 4 6.2 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
135192895 174090 None 0 Human Functional pIC50 = 5.7 5.7 -8 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 485 7 0 8 3.5 COc1ccc(-n2c(CO[C@@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4542267 174090 None 0 Human Functional pIC50 = 5.7 5.7 -8 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 485 7 0 8 3.5 COc1ccc(-n2c(CO[C@@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
11473073 66057 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 3 0 5 3.7 Cc1ccccc1-n1c(C)nnc1C1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2011.08.038
CHEMBL1837013 66057 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 3 0 5 3.7 Cc1ccccc1-n1c(C)nnc1C1CCN(c2ccccn2)CC1 10.1016/j.bmcl.2011.08.038
59657596 118730 None 34 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
CHEMBL3416885 118730 None 34 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
59657596 118730 None 34 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/acs.jmedchem.1c00863
CHEMBL3416885 118730 None 34 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/acs.jmedchem.1c00863
162655215 180915 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 382 2 0 5 5.1 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4756737 180915 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 382 2 0 5 5.1 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
162655954 180873 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4756212 180873 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162643927 181913 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 466 2 0 3 4.2 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)N3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127417
CHEMBL4778087 181913 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 466 2 0 3 4.2 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)N3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127417
162658238 181112 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 2 0 5 3.5 C#Cc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4759005 181112 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 2 0 5 3.5 C#Cc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
10411308 203691 None 0 Human Functional pIC50 = 8.6 8.6 -2 3
Antagonist activity at V1A receptor (unknown origin)Antagonist activity at V1A receptor (unknown origin)
ChEMBL 446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1021/acs.jmedchem.8b00697
CHEMBL603708 203691 None 0 Human Functional pIC50 = 8.6 8.6 -2 3
Antagonist activity at V1A receptor (unknown origin)Antagonist activity at V1A receptor (unknown origin)
ChEMBL 446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1021/acs.jmedchem.8b00697
17989455 65639 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 361 2 0 6 3.4 Cc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
CHEMBL1834004 65639 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 361 2 0 6 3.4 Cc1ccc2c(c1)COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
22017591 66067 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 377 7 0 6 3.6 CCOCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837023 66067 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 377 7 0 6 3.6 CCOCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
162664826 182204 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 448 2 0 4 3.1 Cc1ccccc1N1CCN(C(=O)N2CN(S(C)(=O)=O)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4781783 182204 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 448 2 0 4 3.1 Cc1ccccc1N1CCN(C(=O)N2CN(S(C)(=O)=O)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
23598595 154893 None 0 Human Functional pIC50 = 7.7 7.7 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 542 5 2 3 7.0 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL400266 154893 None 0 Human Functional pIC50 = 7.7 7.7 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 542 5 2 3 7.0 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
162645320 179612 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 360 3 0 5 4.3 c1ccc(O[C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)nc1 10.1016/j.bmcl.2020.127417
CHEMBL4741178 179612 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 360 3 0 5 4.3 c1ccc(O[C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)nc1 10.1016/j.bmcl.2020.127417
4391207 57240 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 311 3 0 3 4.9 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1649949 57240 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 311 3 0 3 4.9 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1 10.1016/j.bmcl.2011.08.038
162658540 181209 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 1 0 2 4.3 Cc1ccccc1N1CCN(C(=O)N2CCCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4760164 181209 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 1 0 2 4.3 Cc1ccccc1N1CCN(C(=O)N2CCCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
44352804 18966 None 0 Human Functional pIC50 = 5.7 5.7 -24 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL128688 18966 None 0 Human Functional pIC50 = 5.7 5.7 -24 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
162648022 180080 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4746818 180080 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
44352757 118518 None 0 Human Functional pIC50 = 5.7 5.7 -58 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL341173 118518 None 0 Human Functional pIC50 = 5.7 5.7 -58 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
162655687 180888 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 452 5 0 7 4.6 COC(=O)CC1Cc2cc(Cl)ccc2-n2c1nnc2[C@H]1CC[C@H](Oc2ccccn2)CC1 10.1016/j.bmcl.2020.127417
CHEMBL4756354 180888 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 452 5 0 7 4.6 COC(=O)CC1Cc2cc(Cl)ccc2-n2c1nnc2[C@H]1CC[C@H](Oc2ccccn2)CC1 10.1016/j.bmcl.2020.127417
10444 2326 None 17 Human Functional pIC50 = 5.7 5.7 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
139030525 2326 None 17 Human Functional pIC50 = 5.7 5.7 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
145711714 2326 None 17 Human Functional pIC50 = 5.7 5.7 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4204210 2326 None 17 Human Functional pIC50 = 5.7 5.7 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced response incubated for 30 mins by beta-arrestin recruitment assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
44336799 107287 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 596 7 2 5 4.8 O=C(NCCN1CCOCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL316736 107287 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 596 7 2 5 4.8 O=C(NCCN1CCOCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
56672567 66059 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 344 3 0 6 3.2 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(C#N)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837015 66059 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 344 3 0 6 3.2 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(C#N)cc1 10.1016/j.bmcl.2011.08.038
22017582 66070 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 407 8 1 7 2.7 O=C(O)COCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837026 66070 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 407 8 1 7 2.7 O=C(O)COCc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1ccccc1 10.1016/j.bmcl.2011.08.038
22017577 66068 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 418 6 0 7 2.9 c1ccc(Cn2c(CN3CCOCC3)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837024 66068 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 418 6 0 7 2.9 c1ccc(Cn2c(CN3CCOCC3)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
162670181 182859 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4790089 182859 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162667087 182545 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 348 2 0 5 4.5 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4786172 182545 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 348 2 0 5 4.5 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
162676230 183431 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 373 3 0 5 4.1 CCc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4797387 183431 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 373 3 0 5 4.1 CCc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
162657843 181251 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 2 0 4 3.4 CN1CCN(C(=O)C2CCN(c3ccccn3)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
CHEMBL4760698 181251 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 2 0 4 3.4 CN1CCN(C(=O)C2CCN(c3ccccn3)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
162652318 180428 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 356 2 1 4 3.4 O=C(C1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127417
CHEMBL4751140 180428 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 356 2 1 4 3.4 O=C(C1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127417
25133000 94247 None 0 Human Functional pIC50 = 7.6 7.6 -2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 626 6 3 6 4.4 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)NS(N)(=O)=O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL249740 94247 None 0 Human Functional pIC50 = 7.6 7.6 -2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 626 6 3 6 4.4 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)NS(N)(=O)=O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
21925586 66080 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 360 2 0 6 3.0 CN1Cc2ccccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837036 66080 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 360 2 0 6 3.0 CN1Cc2ccccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
162648022 180080 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4746818 180080 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162665294 182479 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 383 0 1 3 4.2 O=C(N1CCC2(CC1)OCc1ccccc12)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
CHEMBL4785083 182479 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 383 0 1 3 4.2 O=C(N1CCC2(CC1)OCc1ccccc12)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
162661801 181561 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 336 1 1 3 3.2 Cc1ccccc1N1CCN(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4764410 181561 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 336 1 1 3 3.2 Cc1ccccc1N1CCN(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2020.127416
135192983 176222 None 16 Human Functional pIC50 = 5.5 5.5 -190 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
CHEMBL4591825 176222 None 16 Human Functional pIC50 = 5.5 5.5 -190 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
10474163 66064 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 367 4 0 5 4.1 Cc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1cccc(Cl)c1 10.1016/j.bmcl.2011.08.038
CHEMBL1837020 66064 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 367 4 0 5 4.1 Cc1nnc(C2CCN(c3ccccn3)CC2)n1Cc1cccc(Cl)c1 10.1016/j.bmcl.2011.08.038
23598600 5369 None 0 Human Functional pIC50 = 7.5 7.5 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 594 7 2 4 5.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL106938 5369 None 0 Human Functional pIC50 = 7.5 7.5 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 594 7 2 4 5.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
44336784 109264 None 0 Human Functional pIC50 = 7.5 7.5 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 626 9 2 4 7.0 CN(C)CCCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL321656 109264 None 0 Human Functional pIC50 = 7.5 7.5 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 626 9 2 4 7.0 CN(C)CCCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
56682562 66072 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 434 6 0 8 3.4 Clc1cccc(Cn2c(Cn3nccn3)nnc2C2CCN(c3ccccn3)CC2)c1 10.1016/j.bmcl.2011.08.038
CHEMBL1837028 66072 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 434 6 0 8 3.4 Clc1cccc(Cn2c(Cn3nccn3)nnc2C2CCN(c3ccccn3)CC2)c1 10.1016/j.bmcl.2011.08.038
10615 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
46200932 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
CHEMBL4297183 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
DB14823 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
151171 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
151171.0 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
216322 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
2203 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
732 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
CHEMBL1755 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
DB00872 1164 None 41 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
10615 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
46200932 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
CHEMBL4297183 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
DB14823 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
10615 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
46200932 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
CHEMBL4297183 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
DB14823 572 None 35 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
56672570 66082 None 0 Human Functional pIC50 = 8.5 8.5 9 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 438 2 0 7 3.8 COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837038 66082 None 0 Human Functional pIC50 = 8.5 8.5 9 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 438 2 0 7 3.8 COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
162660856 181975 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4778839 181975 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
121301508 176323 None 5 Human Functional pIC50 = 8.4 8.4 -2 4
Assay with bioluminescence detection (AVPR1). (The vasopressin receptor cells react to stimulation of the recombinantly expressed V1a receptors by intracellular release of calcium ions, which can be quantified by the resulting photoprotein luminescence).Assay with bioluminescence detection (AVPR1). (The vasopressin receptor cells react to stimulation of the recombinantly expressed V1a receptors by intracellular release of calcium ions, which can be quantified by the resulting photoprotein luminescence).
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
CHEMBL4594444 176323 None 5 Human Functional pIC50 = 8.4 8.4 -2 4
Assay with bioluminescence detection (AVPR1). (The vasopressin receptor cells react to stimulation of the recombinantly expressed V1a receptors by intracellular release of calcium ions, which can be quantified by the resulting photoprotein luminescence).Assay with bioluminescence detection (AVPR1). (The vasopressin receptor cells react to stimulation of the recombinantly expressed V1a receptors by intracellular release of calcium ions, which can be quantified by the resulting photoprotein luminescence).
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
162672471 183147 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 384 1 0 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCN(C)c3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4794001 183147 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 384 1 0 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCN(C)c3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
11237434 66081 None 13 Human Functional pIC50 = 7.5 7.5 102 2
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 394 2 0 6 3.6 CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
CHEMBL1837037 66081 None 13 Human Functional pIC50 = 7.5 7.5 102 2
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 394 2 0 6 3.6 CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
25132999 154993 None 0 Human Functional pIC50 = 6.5 6.5 3 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 572 5 2 5 6.0 COc1cc(C(=O)N2CC[C@]3(C=C(C4=NCCN4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL400860 154993 None 0 Human Functional pIC50 = 6.5 6.5 3 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 572 5 2 5 6.0 COc1cc(C(=O)N2CC[C@]3(C=C(C4=NCCN4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
11278622 66055 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 319 3 0 5 3.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccccc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837011 66055 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 319 3 0 5 3.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccccc1 10.1016/j.bmcl.2011.08.038
21925546 66073 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 2 0 6 3.1 c1ccc(N2CCC(c3nnc4n3-c3ccccc3COC4)CC2)nc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837029 66073 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 2 0 6 3.1 c1ccc(N2CCC(c3nnc4n3-c3ccccc3COC4)CC2)nc1 10.1016/j.bmcl.2011.08.038
162647523 179883 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 428 2 1 4 2.7 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)CO)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4744606 179883 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 428 2 1 4 2.7 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)CO)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162653495 180600 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 4.6 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4753130 180600 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 465 3 0 3 4.6 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162656299 181057 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 474 2 0 3 5.0 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)c3ccccc3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4758331 181057 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 474 2 0 3 5.0 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)c3ccccc3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
145963213 161575 None 0 Human Functional pIC50 = 7.5 7.5 8 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
CHEMBL4127791 161575 None 0 Human Functional pIC50 = 7.5 7.5 8 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
54586172 61931 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium releaseAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release
ChEMBL 485 7 3 3 4.2 O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.02.096
CHEMBL1774024 61931 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium releaseAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release
ChEMBL 485 7 3 3 4.2 O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.02.096
11157078 94248 None 8 Human Functional pIC50 = 7.4 7.4 2 4
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL249741 94248 None 8 Human Functional pIC50 = 7.4 7.4 2 4
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
162643184 181784 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 1 1 2 4.9 Cc1ccccc1C1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4776471 181784 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 369 1 1 2 4.9 Cc1ccccc1C1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
11432362 94190 None 0 Human Functional pIC50 = 6.4 6.4 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 518 4 2 3 6.1 O=C(O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL249340 94190 None 0 Human Functional pIC50 = 6.4 6.4 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 518 4 2 3 6.1 O=C(O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
135192928 175008 None 0 Human Functional pIC50 = 5.4 5.4 -125 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3cccc(F)c3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
CHEMBL4564411 175008 None 0 Human Functional pIC50 = 5.4 5.4 -125 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 429 6 0 7 3.4 COCc1nnc(N2C[C@@H]3C[C@]3(c3cccc(F)c3Cl)C2)n1-c1ccc(OC)nc1 10.1021/acsmedchemlett.9b00186
162651435 180311 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 383 1 0 2 4.7 Cc1ccccc1N1CCN(C(=O)N2CCCCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4749660 180311 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 383 1 0 2 4.7 Cc1ccccc1N1CCN(C(=O)N2CCCCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL5085869 217485 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL None None None Cc1ccc2c(c1)-n1c(nnc1[C@H]1CC[C@H](Oc3ccccn3)CC1)CC(O)C2 10.1021/acs.jmedchem.1c00863
10461417 107357 None 0 Human Functional pIC50 = 8.4 8.4 7 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL317243 107357 None 0 Human Functional pIC50 = 8.4 8.4 7 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336379 107473 None 0 Human Functional pIC50 = 8.4 8.4 6 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 582 8 2 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL318083 107473 None 0 Human Functional pIC50 = 8.4 8.4 6 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 582 8 2 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
10345610 66085 None 0 Human Functional pIC50 = 8.3 8.3 204 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 422 2 0 6 3.6 CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837040 66085 None 0 Human Functional pIC50 = 8.3 8.3 204 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 422 2 0 6 3.6 CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
162648022 180080 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4746818 180080 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 479 3 0 3 5.0 Cc1ccccc1N1CCN(C(=O)C2CN(C(=O)C3CCCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162658817 181097 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.5 Cc1ccccc1N1CCN(C(=O)N2CNCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4758799 181097 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.5 Cc1ccccc1N1CCN(C(=O)N2CNCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162671049 182926 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 703 11 1 6 5.6 C[C@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmcl.2020.127416
CHEMBL4790970 182926 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 703 11 1 6 5.6 C[C@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmcl.2020.127416
46890707 6729 None 0 Human Functional pIC50 = 7.4 7.4 20 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 419 3 0 3 6.6 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1csc2ccccc12 10.1016/j.bmcl.2010.04.068
CHEMBL1083703 6729 None 0 Human Functional pIC50 = 7.4 7.4 20 2
Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assayAntagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay
ChEMBL 419 3 0 3 6.6 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1csc2ccccc12 10.1016/j.bmcl.2010.04.068
145962220 161671 None 0 Human Functional pIC50 = 5.4 5.4 -128 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
CHEMBL4129142 161671 None 0 Human Functional pIC50 = 5.4 5.4 -128 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1095 17 11 14 -0.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
11961325 66078 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 346 2 1 6 2.7 c1ccc(N2CCC(c3nnc4n3-c3ccccc3CNC4)CC2)nc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837034 66078 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 346 2 1 6 2.7 c1ccc(N2CCC(c3nnc4n3-c3ccccc3CNC4)CC2)nc1 10.1016/j.bmcl.2011.08.038
14306032 151596 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human Vasopressin V1a receptorAntagonist activity at human Vasopressin V1a receptor
ChEMBL 568 9 0 7 4.3 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.ejmech.2010.09.035
CHEMBL396270 151596 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human Vasopressin V1a receptorAntagonist activity at human Vasopressin V1a receptor
ChEMBL 568 9 0 7 4.3 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.ejmech.2010.09.035
44444762 154819 None 0 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL399888 154819 None 0 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
54582950 63057 None 0 Human Functional pIC50 = 7.4 7.4 -1 4
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788220 63057 None 0 Human Functional pIC50 = 7.4 7.4 -1 4
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
162674253 183331 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 371 1 1 4 3.2 Cc1cccnc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4796133 183331 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 371 1 1 4 3.2 Cc1cccnc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
44352768 115320 None 0 Human Functional pIC50 = 5.3 5.3 -47 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL334777 115320 None 0 Human Functional pIC50 = 5.3 5.3 -47 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
137212776 138020 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 532 10 3 8 4.6 Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 10.1016/j.ejmech.2015.11.050
CHEMBL3763823 138020 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 532 10 3 8 4.6 Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 10.1016/j.ejmech.2015.11.050
137212776 138020 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 532 10 3 8 4.6 Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 10.1016/j.ejmech.2017.10.059
CHEMBL3763823 138020 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 532 10 3 8 4.6 Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 10.1016/j.ejmech.2017.10.059
135192948 175719 None 0 Human Functional pIC50 = 5.3 5.3 -5 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 499 7 0 8 3.9 COc1ccc(-n2c(COC3CCOCC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4580413 175719 None 0 Human Functional pIC50 = 5.3 5.3 -5 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 499 7 0 8 3.9 COc1ccc(-n2c(COC3CCOCC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
216237 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
216237.0 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
2226 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
4110 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
443894 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
443894.0 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
CHEMBL344159 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
DB06212 3843 None 51 Human Functional pIC50 = 6.3 6.3 -66 11
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerInhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1021/acs.jmedchem.1c00863
23598598 4969 None 0 Human Functional pIC50 = 7.3 7.3 -1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL104839 4969 None 0 Human Functional pIC50 = 7.3 7.3 -1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
44336636 164260 None 0 Human Functional pIC50 = 8.3 8.3 7 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 585 7 3 4 6.0 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL421039 164260 None 0 Human Functional pIC50 = 8.3 8.3 7 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 585 7 3 4 6.0 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
145970269 163677 None 0 Human Functional pIC50 = 7.3 7.3 15 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 475 5 3 6 2.5 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4203314 163677 None 0 Human Functional pIC50 = 7.3 7.3 15 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 475 5 3 6 2.5 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C 10.1021/acs.jmedchem.8b00697
162663957 182259 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 412 1 0 3 3.7 CC(=O)N1Cc2cc(Cl)ccc2N(C(=O)N2CCN(c3ccccc3C)CC2)C1 10.1016/j.bmcl.2020.127416
CHEMBL4782389 182259 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 412 1 0 3 3.7 CC(=O)N1Cc2cc(Cl)ccc2N(C(=O)N2CCN(c3ccccc3C)CC2)C1 10.1016/j.bmcl.2020.127416
11238362 169011 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 562 6 2 4 6.5 CCOc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL438523 169011 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 562 6 2 4 6.5 CCOc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
162670083 182855 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3C3CC43)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4790066 182855 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3C3CC43)CC2)no1 10.1016/j.bmcl.2020.127417
21064021 66076 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1ccc2c(c1)-n1c(nnc1C1CCN(c3ccccn3)CC1)COC2 10.1016/j.bmcl.2011.08.038
CHEMBL1837032 66076 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1ccc2c(c1)-n1c(nnc1C1CCN(c3ccccn3)CC1)COC2 10.1016/j.bmcl.2011.08.038
54584254 61930 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium releaseAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
CHEMBL1774023 61930 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium releaseAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
162676406 183526 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 405 1 0 4 3.6 CN1CCN(C(=O)N2CCN(c3ncccc3Cl)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
CHEMBL4798542 183526 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 405 1 0 4 3.6 CN1CCN(C(=O)N2CCN(c3ncccc3Cl)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
56672568 66060 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 387 3 0 5 4.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837016 66060 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 387 3 0 5 4.4 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2011.08.038
10444 2326 None 17 Human Functional pIC50 = 5.2 5.2 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
139030525 2326 None 17 Human Functional pIC50 = 5.2 5.2 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
145711714 2326 None 17 Human Functional pIC50 = 5.2 5.2 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4204210 2326 None 17 Human Functional pIC50 = 5.2 5.2 -61 4
Antagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assayAntagonist activity at human V1a receptor expressed in HEK293FT cells assessed as inhibition of AVP-induced calcium release by Aequorin based assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
11237434 66081 None 13 Human Functional pIC50 = 8.2 8.2 102 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 394 2 0 6 3.6 CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
CHEMBL1837037 66081 None 13 Human Functional pIC50 = 8.2 8.2 102 2
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 394 2 0 6 3.6 CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1 10.1016/j.bmcl.2011.08.038
56679250 66069 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 431 6 0 7 2.9 CN1CCN(Cc2nnc(C3CCN(c4ccccn4)CC3)n2Cc2ccccc2)CC1 10.1016/j.bmcl.2011.08.038
CHEMBL1837025 66069 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 431 6 0 7 2.9 CN1CCN(Cc2nnc(C3CCN(c4ccccn4)CC3)n2Cc2ccccc2)CC1 10.1016/j.bmcl.2011.08.038
135506374 137987 None 19 Human Functional pIC50 = 6.2 6.2 -1 4
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2015.11.050
CHEMBL3763342 137987 None 19 Human Functional pIC50 = 6.2 6.2 -1 4
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2015.11.050
135506374 137987 None 19 Human Functional pIC50 = 6.2 6.2 -1 4
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2017.10.059
CHEMBL3763342 137987 None 19 Human Functional pIC50 = 6.2 6.2 -1 4
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assayAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preincubated for 30 mins followed by vasopressin addition measured after 1 hr by HTRF assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2017.10.059
25132666 94582 None 0 Human Functional pIC50 = 7.2 7.2 -1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 572 5 2 6 5.7 COc1cc(C(=O)N2CC[C@]3(C=C(c4nnn[nH]4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL251715 94582 None 0 Human Functional pIC50 = 7.2 7.2 -1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 572 5 2 6 5.7 COc1cc(C(=O)N2CC[C@]3(C=C(c4nnn[nH]4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
23598642 154894 None 0 Human Functional pIC50 = 6.2 6.2 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 541 6 2 3 7.1 CNCC1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL400267 154894 None 0 Human Functional pIC50 = 6.2 6.2 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 541 6 2 3 7.1 CNCC1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
162645988 179798 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3[C@H]3C[C@@H]43)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4743652 179798 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3[C@H]3C[C@@H]43)CC2)no1 10.1016/j.bmcl.2020.127417
11157078 94248 None 8 Rat Functional pIC50 = 6.2 6.2 -46 4
Antagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL249741 94248 None 8 Rat Functional pIC50 = 6.2 6.2 -46 4
Antagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at rat vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
44336404 111022 None 0 Human Functional pIC50 = 7.2 7.2 2 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 568 7 2 4 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL326225 111022 None 0 Human Functional pIC50 = 7.2 7.2 2 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 568 7 2 4 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
162646537 179711 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 357 1 1 4 2.9 O=C(N1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
CHEMBL4742334 179711 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 357 1 1 4 2.9 O=C(N1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
135506374 137987 None 19 Human Functional pIC50 = 8.2 8.2 -1 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
CHEMBL3763342 137987 None 19 Human Functional pIC50 = 8.2 8.2 -1 4
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
162664620 182253 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 3 0 5 4.5 Clc1ccc2c(c1)CCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4782340 182253 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayInhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 380 3 0 5 4.5 Clc1ccc2c(c1)CCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
11461755 66058 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 3 0 5 3.7 Cc1ccc(-n2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837014 66058 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 333 3 0 5 3.7 Cc1ccc(-n2c(C)nnc2C2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmcl.2011.08.038
23598598 4969 None 0 Human Functional pIC50 = 7.2 7.2 -1 2
Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL104839 4969 None 0 Human Functional pIC50 = 7.2 7.2 -1 2
Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
9871426 117075 None 0 Human Functional pIC50 = 6.1 6.1 -44 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL338901 117075 None 0 Human Functional pIC50 = 6.1 6.1 -44 2
Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsInhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cells
ChEMBL 522 6 2 4 6.6 O=C(O)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
162645370 179700 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 385 1 1 4 3.6 Cc1cccnc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)[C@H](C)C1 10.1016/j.bmcl.2020.127416
CHEMBL4742173 179700 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 385 1 1 4 3.6 Cc1cccnc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)[C@H](C)C1 10.1016/j.bmcl.2020.127416
135192979 175942 None 0 Human Functional pIC50 = 5.1 5.1 -41 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 485 7 0 8 3.5 COc1ccc(-n2c(CO[C@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4585239 175942 None 0 Human Functional pIC50 = 5.1 5.1 -41 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 485 7 0 8 3.5 COc1ccc(-n2c(CO[C@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
137189941 138165 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 560 12 1 8 5.2 COc1cc(CN2CCN(CCCCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
CHEMBL3765689 138165 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 560 12 1 8 5.2 COc1cc(CN2CCN(CCCCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
135193003 175488 None 0 Human Functional pIC50 = 6.1 6.1 -3 3
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 424 5 0 7 3.3 COc1ccc(-n2c(CC#N)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4575160 175488 None 0 Human Functional pIC50 = 6.1 6.1 -3 3
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 424 5 0 7 3.3 COc1ccc(-n2c(CC#N)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
9937535 63058 None 1 Human Functional pIC50 = 7.1 7.1 25 4
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788221 63058 None 1 Human Functional pIC50 = 7.1 7.1 25 4
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336768 163447 None 0 Human Functional pIC50 = 7.1 7.1 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 599 7 3 4 6.1 O=C(O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL419183 163447 None 0 Human Functional pIC50 = 7.1 7.1 1 2
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 599 7 3 4 6.1 O=C(O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44444760 154709 None 0 Human Functional pIC50 = 6.1 6.1 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 518 4 2 3 6.1 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL399288 154709 None 0 Human Functional pIC50 = 6.1 6.1 1 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 518 4 2 3 6.1 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
145960494 161655 None 0 Human Functional pIC50 = 5.1 5.1 -72 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1081 17 11 14 -0.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
CHEMBL4128839 161655 None 0 Human Functional pIC50 = 5.1 5.1 -72 4
Antagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assayAntagonist activity at human liver vasopressin V1a receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by AVP addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
ChEMBL 1081 17 11 14 -0.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1016/j.bmc.2018.03.019
135413563 122996 None 20 Human Functional pIC50 = 8.1 8.1 3 3
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 10.1021/acs.jmedchem.8b00697
CHEMBL360648 122996 None 20 Human Functional pIC50 = 8.1 8.1 3 3
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 600 4 2 7 4.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 10.1021/acs.jmedchem.8b00697
162667594 182633 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4787242 182633 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 1 1 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CCNc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
31112441 180444 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 439 4 1 4 4.9 Cc1ccccc1N1CCN(C(=O)c2ccc(Cl)c(NC(=O)c3cccs3)c2)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4751260 180444 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 439 4 1 4 4.9 Cc1ccccc1N1CCN(C(=O)c2ccc(Cl)c(NC(=O)c3cccs3)c2)CC1 10.1016/j.bmcl.2020.127416
142391767 169745 None 0 Human Functional pIC50 = 6.1 6.1 -6 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 442 5 0 7 3.7 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc2c(c1)OCO2 10.1021/acsmedchemlett.9b00186
CHEMBL4437214 169745 None 0 Human Functional pIC50 = 6.1 6.1 -6 2
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 442 5 0 7 3.7 COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc2c(c1)OCO2 10.1021/acsmedchemlett.9b00186
135192997 173934 None 0 Human Functional pIC50 = 6.1 6.1 -18 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 461 8 0 7 3.7 COc1ccc(-n2c(COCCF)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
CHEMBL4538696 173934 None 0 Human Functional pIC50 = 6.1 6.1 -18 4
Antagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assayAntagonist activity at human vasopressin V1A receptor expressed in HEK293 cells assessed as decrease in vasopressin-stimulated calcium flux measured after 10 mins by Fluo-4 dye based microplate reader based assay
ChEMBL 461 8 0 7 3.7 COc1ccc(-n2c(COCCF)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 10.1021/acsmedchemlett.9b00186
137212770 138141 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 532 10 1 8 4.4 COc1cc(CN2CCN(CCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
CHEMBL3765356 138141 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
ChEMBL 532 10 1 8 4.4 COc1cc(CN2CCN(CCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2015.11.050
10383074 66063 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 4 0 5 3.7 Cc1cccc(Cn2c(C)nnc2C2CCN(c3ccccn3)CC2)c1 10.1016/j.bmcl.2011.08.038
CHEMBL1837019 66063 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 347 4 0 5 3.7 Cc1cccc(Cn2c(C)nnc2C2CCN(c3ccccn3)CC2)c1 10.1016/j.bmcl.2011.08.038
162675154 183530 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 2 1 3 3.5 O=C(N1CCN(Cc2ccccc2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
CHEMBL4798616 183530 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 370 2 1 3 3.5 O=C(N1CCN(Cc2ccccc2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127416
162658968 181388 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 384 1 0 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CN(C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4762200 181388 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 384 1 0 3 3.8 Cc1ccccc1N1CCN(C(=O)N2CN(C)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162676890 183596 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 355 1 0 2 4.0 Cc1ccccc1N1CCN(C(=O)N2CCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4799501 183596 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assayAntagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay
ChEMBL 355 1 0 2 4.0 Cc1ccccc1N1CCN(C(=O)N2CCc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
11261339 154710 None 0 Human Functional pIC50 = 7.1 7.1 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CCC3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL399289 154710 None 0 Human Functional pIC50 = 7.1 7.1 2 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CCC3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
11451056 66061 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 353 3 0 5 4.0 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2011.08.038
CHEMBL1837017 66061 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 353 3 0 5 4.0 Cc1nnc(C2CCN(c3ccccn3)CC2)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2011.08.038
145974527 164855 None 0 Human Functional pIC50 = 8.1 8.1 67 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 491 5 3 6 3.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4217872 164855 None 0 Human Functional pIC50 = 8.1 8.1 67 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 491 5 3 6 3.3 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C 10.1021/acs.jmedchem.8b00697
23598641 94330 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 528 5 2 3 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2007.09.059
CHEMBL250346 94330 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 528 5 2 3 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2007.09.059
21925559 66077 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1cccc2c1COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
CHEMBL1837033 66077 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assayAntagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay
ChEMBL 381 2 0 6 3.7 Clc1cccc2c1COCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2011.08.038
145972114 164722 None 0 Human Functional pIC50 = 7.0 7.0 3 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 515 4 2 6 3.4 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=O)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4216174 164722 None 0 Human Functional pIC50 = 7.0 7.0 3 2
Antagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVPAntagonist activity at human V1A receptor expressed in HEK cells assessed as inhibition of AVP-induced intracellular calcium flux incubated for 45 mins by Indo1-AM dye based fluorescence assay relative to AVP
ChEMBL 515 4 2 6 3.4 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=O)N(C)C 10.1021/acs.jmedchem.8b00697
25133001 94551 None 0 Human Functional pIC50 = 7.0 7.0 7 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 570 5 2 4 6.9 COc1cc(C(=O)N2CC[C@]3(C=C(c4ncc[nH]4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL251561 94551 None 0 Human Functional pIC50 = 7.0 7.0 7 2
Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium levelAntagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level
ChEMBL 570 5 2 4 6.9 COc1cc(C(=O)N2CC[C@]3(C=C(c4ncc[nH]4)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
44336402 168234 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 594 7 2 4 6.0 O=C(NCCN1CCCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL432973 168234 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 594 7 2 4 6.0 O=C(NCCN1CCCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336791 8126 None 0 Human Functional pIC50 = 7 7.0 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 527 6 3 4 4.5 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL109166 8126 None 0 Human Functional pIC50 = 7 7.0 - 1
Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorEvaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptor
ChEMBL 527 6 3 4 4.5 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
42645362 195878 None 0 Rat Functional pKd = 5.8 5.8 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1128 20 13 14 -2.2 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1016/j.ejmech.2008.12.010
CHEMBL541246 195878 None 0 Rat Functional pKd = 5.8 5.8 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1128 20 13 14 -2.2 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1016/j.ejmech.2008.12.010
45270786 198346 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1168 18 12 13 0.8 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1016/j.ejmech.2008.12.010
CHEMBL558950 198346 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1168 18 12 13 0.8 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1016/j.ejmech.2008.12.010
45267363 197973 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1107 17 12 14 -1.2 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1016/j.ejmech.2008.12.010
CHEMBL553710 197973 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1107 17 12 14 -1.2 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1016/j.ejmech.2008.12.010
42645836 194918 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1128 20 13 14 -2.2 N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1016/j.ejmech.2008.12.010
CHEMBL538934 194918 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challengeAntagonist activity at vasopressin V1a receptor in phenoxybenzamine-treated Wistar rat uterus assessed as inhibition of vasopressin-induced arterial vasopressor activity treated 1 min prior to vasopressin challenge
ChEMBL 1128 20 13 14 -2.2 N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1016/j.ejmech.2008.12.010
46225081 204686 None 0 Human Functional pKi = 6 6.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 431 7 0 8 3.1 COCc1nnc(N2CC[C@@H](Oc3cc(F)cc(F)c3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL609848 204686 None 0 Human Functional pKi = 6 6.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 431 7 0 8 3.1 COCc1nnc(N2CC[C@@H](Oc3cc(F)cc(F)c3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
53316694 56782 None 0 Human Functional pKi = 6 6.0 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 11 1 6 5.7 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)C)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643585 56782 None 0 Human Functional pKi = 6 6.0 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 11 1 6 5.7 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)C)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
44571530 180022 None 0 Human Functional pKi = 5 5.0 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 379 7 0 3 4.7 COc1ccc(C)cc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL474609 180022 None 0 Human Functional pKi = 5 5.0 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 379 7 0 3 4.7 COc1ccc(C)cc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
46884414 7840 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 334 4 0 5 3.1 COc1ccc(N(C)C(=O)c2cnc(-c3ccccc3C)cn2)cn1 10.1016/j.bmcl.2010.02.018
CHEMBL1089682 7840 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 334 4 0 5 3.1 COc1ccc(N(C)C(=O)c2cnc(-c3ccccc3C)cn2)cn1 10.1016/j.bmcl.2010.02.018
11538526 202029 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 397 5 0 7 3.5 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccc(F)cc3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL592494 202029 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 397 5 0 7 3.5 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccc(F)cc3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
11683187 202388 None 41 Human Functional pKi = 6.0 6.0 - 2
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL594828 202388 None 41 Human Functional pKi = 6.0 6.0 - 2
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
44571387 184170 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 401 7 0 3 5.2 COc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL482321 184170 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 401 7 0 3 5.2 COc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
46884479 8263 None 0 Human Functional pKi = 4.9 4.9 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 403 7 0 7 3.0 COCCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
CHEMBL1092457 8263 None 0 Human Functional pKi = 4.9 4.9 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 403 7 0 7 3.0 COCCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
44577939 189299 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 406 6 0 8 3.4 COCc1nnc(-c2cnc(-c3ccc(F)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL511265 189299 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 406 6 0 8 3.4 COCc1nnc(-c2cnc(-c3ccc(F)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
46225023 201999 None 1 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 365 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3)CC2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL592250 201999 None 1 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 365 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3)CC2)cn1 10.1016/j.bmcl.2009.11.097
46881861 8274 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 345 4 0 4 2.9 COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2010.01.143
CHEMBL1092499 8274 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 345 4 0 4 2.9 COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2010.01.143
11384094 178688 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 6 0 8 3.6 COCc1nnc(-c2cnc(-c3cccc(C)c3C)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL467186 178688 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 6 0 8 3.6 COCc1nnc(-c2cnc(-c3cccc(C)c3C)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
46225117 201749 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 401 7 0 8 2.7 COCc1nnc(N2CC(Oc3ccccc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL590349 201749 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 401 7 0 8 2.7 COCc1nnc(N2CC(Oc3ccccc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
44581242 175991 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 475 8 0 6 4.9 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
CHEMBL458635 175991 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 475 8 0 6 4.9 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
44571488 183928 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 6 0 3 5.0 N#Cc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL480584 183928 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 396 6 0 3 5.0 N#Cc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
44571490 184052 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 415 7 0 3 5.5 COc1ccc(C)cc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL481568 184052 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 415 7 0 3 5.5 COc1ccc(C)cc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
46225118 203509 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)ccc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL602641 203509 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)ccc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
11486351 193086 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 398 10 0 8 3.2 CCOc1ccc(-c2nnc(COCCOC)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
CHEMBL522255 193086 None 0 Human Functional pKi = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 398 10 0 8 3.2 CCOc1ccc(-c2nnc(COCCOC)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
46225048 204270 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 415 5 0 7 3.6 COc1ccc(-n2c(C)nnc2N2CCC(Oc3cc(F)cc(F)c3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL606976 204270 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 415 5 0 7 3.6 COc1ccc(-n2c(C)nnc2N2CCC(Oc3cc(F)cc(F)c3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
46225049 203601 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 351 5 0 7 2.6 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL603205 203601 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 351 5 0 7 2.6 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3)C2)cn1 10.1016/j.bmcl.2009.11.097
46225116 201709 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 371 5 0 7 2.9 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3Cl)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL590099 201709 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 371 5 0 7 2.9 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3Cl)C2)cn1 10.1016/j.bmcl.2009.11.097
44572048 189623 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 349 6 0 2 4.7 Cc1cc(-c2ccccc2)ccc1C(=O)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL514031 189623 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 349 6 0 2 4.7 Cc1cc(-c2ccccc2)ccc1C(=O)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
53317994 56783 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 11 0 6 5.8 CCN(CC)Cc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643586 56783 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 11 0 6 5.8 CCN(CC)Cc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
53323297 56785 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 499 11 1 6 5.5 CCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643588 56785 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 499 11 1 6 5.5 CCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
44571386 184172 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 403 6 0 2 5.6 Cc1cc(F)ccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL482323 184172 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 403 6 0 2 5.6 Cc1cc(F)ccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
46884440 8406 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 352 4 0 5 3.3 COc1ccc(N(C)C(=O)c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2010.02.018
CHEMBL1093366 8406 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 352 4 0 5 3.3 COc1ccc(N(C)C(=O)c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2010.02.018
44577982 178743 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 378 4 0 7 3.8 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccccc3Cl)cn2)cn1 10.1016/j.bmcl.2008.06.098
CHEMBL467545 178743 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 378 4 0 7 3.8 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccccc3Cl)cn2)cn1 10.1016/j.bmcl.2008.06.098
11625088 202028 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 379 5 0 7 3.3 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL592493 202028 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 379 5 0 7 3.3 COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3C)CC2)cn1 10.1016/j.bmcl.2009.11.097
44579442 186934 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 391 7 0 9 2.7 CCOc1ccc(-c2nnc(Cn3nccn3)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
CHEMBL489387 186934 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 391 7 0 9 2.7 CCOc1ccc(-c2nnc(Cn3nccn3)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
46884437 7741 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 348 5 0 5 3.5 CCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
CHEMBL1089025 7741 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 348 5 0 5 3.5 CCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
16062053 195098 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 360 5 0 8 3.2 COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 10.1016/j.bmcl.2009.03.160
CHEMBL539665 195098 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 360 5 0 8 3.2 COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 10.1016/j.bmcl.2009.03.160
11502419 202030 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 409 7 0 8 3.2 COCc1nnc(N2CCC(Oc3ccccc3C)CC2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL592495 202030 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 409 7 0 8 3.2 COCc1nnc(N2CCC(Oc3ccccc3C)CC2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
11574636 201566 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 389 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2010.01.143
CHEMBL589125 201566 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 389 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2010.01.143
44577984 189384 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 418 7 0 9 3.3 COCc1nnc(-c2cnc(-c3ccc(OC)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL511917 189384 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 418 7 0 9 3.3 COCc1nnc(-c2cnc(-c3ccc(OC)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
11574636 201566 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 389 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL589125 201566 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 389 5 0 7 3.0 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2009.11.097
44581241 175990 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 495 8 0 6 5.2 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
CHEMBL458634 175990 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 495 8 0 6 5.2 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
44571491 184053 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 367 6 0 2 4.8 Cc1cc(F)ccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL481569 184053 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 367 6 0 2 4.8 Cc1cc(F)ccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
50941635 56781 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 12 1 6 5.8 CCCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643584 56781 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 513 12 1 6 5.8 CCCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 10.1016/j.bmcl.2010.11.061
46225079 201708 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 395 7 0 8 2.8 COCc1nnc(N2CC[C@@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL590097 201708 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 395 7 0 8 2.8 COCc1nnc(N2CC[C@@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
44577937 178687 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 7 0 7 4.2 COCc1nnc(-c2ccc(-c3ccccc3OC)cc2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL467185 178687 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 7 0 7 4.2 COCc1nnc(-c2ccc(-c3ccccc3OC)cc2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
44215484 178685 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 440 7 0 6 4.6 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 10.1016/j.bmcl.2008.06.098
CHEMBL467154 178685 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 440 7 0 6 4.6 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 10.1016/j.bmcl.2008.06.098
44579441 186933 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 374 7 0 7 3.5 CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1Cl 10.1016/j.bmcl.2008.08.066
CHEMBL489386 186933 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 374 7 0 7 3.5 CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1Cl 10.1016/j.bmcl.2008.08.066
44572107 180036 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 6 0 2 5.5 Cc1cc(C(=O)N(Cc2ccccc2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
CHEMBL474621 180036 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 6 0 2 5.5 Cc1cc(C(=O)N(Cc2ccccc2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
44571429 183921 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 6 0 3 5.6 O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL480546 183921 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 6 0 3 5.6 O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
53323298 56786 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 553 11 1 6 6.6 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC4CCCCC4)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643589 56786 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 553 11 1 6 6.6 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC4CCCCC4)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
44577981 189400 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 369 5 0 8 2.8 COCc1nnc(-c2cnc(-c3cccc(C#N)c3)cn2)n1-c1cccnc1 10.1016/j.bmcl.2008.06.098
CHEMBL512105 189400 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 369 5 0 8 2.8 COCc1nnc(-c2cnc(-c3cccc(C#N)c3)cn2)n1-c1cccnc1 10.1016/j.bmcl.2008.06.098
46884439 8405 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 378 7 0 6 3.1 COCCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
CHEMBL1093365 8405 None 0 Human Functional pKi = 5.5 5.5 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 378 7 0 6 3.1 COCCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
44579401 187203 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 354 7 0 7 3.2 CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
CHEMBL491422 187203 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 354 7 0 7 3.2 CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C 10.1016/j.bmcl.2008.08.066
11257380 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2009.03.160
CHEMBL467378 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2009.03.160
11257380 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL467378 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2009.11.097
11257380 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2008.06.098
CHEMBL467378 178719 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 376 4 0 7 3.6 COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 10.1016/j.bmcl.2008.06.098
44572105 172550 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 336 6 0 3 3.8 O=C(c1ccc(-c2ccccc2)nc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL447916 172550 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 336 6 0 3 3.8 O=C(c1ccc(-c2ccccc2)nc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
44572047 180813 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 360 6 0 3 4.3 N#Cc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL475561 180813 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 360 6 0 3 4.3 N#Cc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
44571529 189809 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 404 6 0 3 4.8 O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL515447 189809 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 404 6 0 3 4.8 O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
53324622 56788 None 0 Human Functional pKi = 4.4 4.4 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 577 12 1 7 6.3 COc1ccc(CNCc2ccc(-c3nc(CN(C4CCCC4)S(=O)(=O)c4ccc(OC)cc4)cs3)cc2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643591 56788 None 0 Human Functional pKi = 4.4 4.4 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 577 12 1 7 6.3 COc1ccc(CNCc2ccc(-c3nc(CN(C4CCCC4)S(=O)(=O)c4ccc(OC)cc4)cs3)cc2)cc1 10.1016/j.bmcl.2010.11.061
11475469 178899 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 413 6 0 9 3.1 COCc1nnc(-c2cnc(-c3ccc(C#N)cc3C)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL469005 178899 None 0 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 413 6 0 9 3.1 COCc1nnc(-c2cnc(-c3ccc(C#N)cc3C)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
44578010 189288 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 6 0 8 3.6 COCc1nnc(-c2cnc(-c3ccc(C)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL511215 189288 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 402 6 0 8 3.6 COCc1nnc(-c2cnc(-c3ccc(C)c(C)c3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
44577938 189415 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 374 6 0 8 2.9 COCc1nnc(-c2cnc(-c3ccccc3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
CHEMBL512257 189415 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 374 6 0 8 2.9 COCc1nnc(-c2cnc(-c3ccccc3)cn2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.06.098
44581266 175499 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 479 8 0 6 4.7 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
CHEMBL457544 175499 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 479 8 0 6 4.7 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
44581240 189833 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 486 8 0 7 4.4 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
CHEMBL515660 189833 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human recombinant vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 486 8 0 7 4.4 COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 10.1016/j.bmcl.2008.11.018
44571388 192698 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 6 0 2 5.5 Cc1cc(-c2ccccc2)ccc1C(=O)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL521444 192698 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 385 6 0 2 5.5 Cc1cc(-c2ccccc2)ccc1C(=O)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
44571489 192393 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 372 6 0 3 4.6 O=C(c1ccc(-c2ccccc2)nc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL520595 192393 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 372 6 0 3 4.6 O=C(c1ccc(-c2ccccc2)nc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
46225082 202071 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 395 7 0 8 2.8 COCc1nnc(N2CC[C@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL592733 202071 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 395 7 0 8 2.8 COCc1nnc(N2CC[C@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
16062053 195098 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 360 5 0 8 3.2 COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 10.1016/j.bmcl.2009.03.160
CHEMBL539665 195098 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assay
ChEMBL 360 5 0 8 3.2 COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 10.1016/j.bmcl.2009.03.160
44577936 178686 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 371 5 0 5 4.9 COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cc1 10.1016/j.bmcl.2008.06.098
CHEMBL467184 178686 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 371 5 0 5 4.9 COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cc1 10.1016/j.bmcl.2008.06.098
45483204 200343 None 0 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2010.11.061
CHEMBL1204126 200343 None 0 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2010.11.061
CHEMBL1204403 200343 None 0 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2010.11.061
CHEMBL572709 200343 None 0 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2010.11.061
2202 2761 None 30 Human Functional pKi = 7.2 7.2 - 1
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 629 8 1 9 2.9 COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl 10.1016/j.bmcl.2010.11.061
9895468 2761 None 30 Human Functional pKi = 7.2 7.2 - 1
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 629 8 1 9 2.9 COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl 10.1016/j.bmcl.2010.11.061
CHEMBL582857 2761 None 30 Human Functional pKi = 7.2 7.2 - 1
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 629 8 1 9 2.9 COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl 10.1016/j.bmcl.2010.11.061
DB12643 2761 None 30 Human Functional pKi = 7.2 7.2 - 1
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 629 8 1 9 2.9 COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl 10.1016/j.bmcl.2010.11.061
46225080 202070 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 413 7 0 8 2.9 COCc1nnc(N2CC[C@@H](Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL592732 202070 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 413 7 0 8 2.9 COCc1nnc(N2CC[C@@H](Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
46884480 8264 None 0 Human Functional pKi = 5.2 5.2 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 366 5 0 5 3.7 CCN(C(=O)c1cnc(-c2cccc(F)c2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
CHEMBL1092458 8264 None 0 Human Functional pKi = 5.2 5.2 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 366 5 0 5 3.7 CCN(C(=O)c1cnc(-c2cccc(F)c2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
44579399 187268 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 368 8 0 7 3.6 CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.08.066
CHEMBL492029 187268 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assay
ChEMBL 368 8 0 7 3.6 CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2008.08.066
11667812 202343 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL594591 202343 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
11667812 202343 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2010.01.143
CHEMBL594591 202343 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 369 5 0 7 2.7 COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2010.01.143
53325929 56787 None 0 Human Functional pKi = 5.2 5.2 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 537 11 1 7 5.8 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCc4ccoc4)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643590 56787 None 0 Human Functional pKi = 5.2 5.2 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 537 11 1 7 5.8 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCc4ccoc4)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
46225153 201567 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 399 7 0 8 2.5 COCc1nnc(N2CC(Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL589128 201567 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 399 7 0 8 2.5 COCc1nnc(N2CC(Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
46884478 8492 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 373 5 0 6 3.4 CCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
CHEMBL1094002 8492 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assayAntagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase reporter gene assay
ChEMBL 373 5 0 6 3.4 CCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 10.1016/j.bmcl.2010.02.018
11848692 178635 None 1 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 396 4 0 7 3.9 COc1ccc(-n2c(C)nnc2-c2cnc(-c3cccc(F)c3Cl)cn2)cn1 10.1016/j.bmcl.2008.06.098
CHEMBL466762 178635 None 1 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at vasopressin V1a receptorAntagonist activity at vasopressin V1a receptor
ChEMBL 396 4 0 7 3.9 COc1ccc(-n2c(C)nnc2-c2cnc(-c3cccc(F)c3Cl)cn2)cn1 10.1016/j.bmcl.2008.06.098
46225050 202069 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 365 5 0 7 2.9 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL592731 202069 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 365 5 0 7 2.9 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
46881862 7940 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 365 4 0 4 3.2 COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2010.01.143
CHEMBL1090417 7940 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1A receptorAntagonist activity at human vasopressin V1A receptor
ChEMBL 365 4 0 4 3.2 COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3Cl)C2)cn1 10.1016/j.bmcl.2010.01.143
42611262 180665 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 349 6 0 2 4.7 Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
CHEMBL475395 180665 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 349 6 0 2 4.7 Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
44571389 184171 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 6 0 3 5.6 O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL482322 184171 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 440 6 0 3 5.6 O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(Cc1ccccc1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
44572045 189760 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 365 7 0 3 4.4 COc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
CHEMBL515111 189760 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 365 7 0 3 4.4 COc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 10.1016/j.bmcl.2008.11.064
44571492 184074 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 404 6 0 3 4.8 O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
CHEMBL481730 184074 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assayAntagonist activity at human vasopressin V1a receptor expressed in CHO cells by FLIPR assay
ChEMBL 404 6 0 3 4.8 O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(CC1CC1)CC1CCCO1 10.1016/j.bmcl.2008.11.064
53316695 56784 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 527 10 1 6 6.1 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)(C)C)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
CHEMBL1643587 56784 None 0 Human Functional pKi = 5.1 5.1 - 0
Antagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM stainingAntagonist activity at recombinant V1a receptor expressed in CHO cells assessed as inhibition of vasopressin-induced calcium release after 10 mins by Fluo4-AM staining
ChEMBL 527 10 1 6 6.1 COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)(C)C)cc3)n2)C2CCCC2)cc1 10.1016/j.bmcl.2010.11.061
46225051 201892 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 383 5 0 7 3.1 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
CHEMBL591310 201892 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assayAntagonist activity at human cloned vasopressin V1a receptor by cell based beta lactamase assay
ChEMBL 383 5 0 7 3.1 COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccc(F)cc3C)C2)cn1 10.1016/j.bmcl.2009.11.097
2042 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
2174 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
2176 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
439302 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
439302.0 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
CHEMBL395429 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
DB00107 2983 None 40 Human Functional pEC50 = 8.2 8.2 -3 5
NoneNone
Drug Central None None None None None
11169 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
131676677 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
165708555 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
165708555.0 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
16681432 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
16681432.0 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
495 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
CHEMBL3301668 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
DB01282 797 None 33 Human Functional pEC50 = 8.1 8.1 -1 5
NoneNone
Drug Central None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C None
11454 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21411496
53330936 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21411496
CHEMBL1817709 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21411496
DB12495 3577 None 12 Human Functional pEC50 = 8.6 8.6 -4 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21411496




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16362 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
16362.0 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3125 None 49 Human Binding pAC50 = 5.0 5.0 - 29
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
3149 12618 None 11 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12618 None 11 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
448537 160344 None 54 Human Binding pAC50 = 5.0 5.0 -45 25
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL411 160344 None 54 Human Binding pAC50 = 5.0 5.0 -45 25
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
11980903 14498 None 13 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14498 None 13 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14498 None 13 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14498 None 13 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
1222 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396.0 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 1664 None 37 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
72093 35070 None 5 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35070 None 5 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35070 None 5 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
6436173 55132 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 55132 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
2713 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 207729 None 57 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
103 4153 None 44 Human Binding pAC50 = 4.8 4.8 - 53
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2875 4153 None 44 Human Binding pAC50 = 4.8 4.8 - 53
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
5736 4153 None 44 Human Binding pAC50 = 4.8 4.8 - 53
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL285802 4153 None 44 Human Binding pAC50 = 4.8 4.8 - 53
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB09225 4153 None 44 Human Binding pAC50 = 4.8 4.8 - 53
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2335 11852 None 18 Human Binding pAC50 = 4.8 4.8 - 12
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11852 None 18 Human Binding pAC50 = 4.8 4.8 - 12
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11852 None 18 Human Binding pAC50 = 4.8 4.8 - 12
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11852 None 18 Human Binding pAC50 = 4.8 4.8 - 12
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
41684 31229 None 62 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31229 None 62 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
2213 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
3008 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
5311010 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
5311010.0 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
68613 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
68613.0 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL378642 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL382301 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB09059 518 None 30 Human Binding pAC50 = 7.7 7.7 28 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
72081 211735 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1038/s41467-023-40064-9
72081.0 211735 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1038/s41467-023-40064-9
CHEMBL2135460 211735 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1038/s41467-023-40064-9
DB02638 211735 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1038/s41467-023-40064-9
135409453 3773 None 26 Human Binding pAC50 = 4.7 4.7 - 19
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3773 None 26 Human Binding pAC50 = 4.7 4.7 - 19
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3773 None 26 Human Binding pAC50 = 4.7 4.7 - 19
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
1385580 29284 None 49 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 29284 None 49 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615.0 29284 None 49 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 29284 None 49 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
DB12877 29284 None 49 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
24826799 10802 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 10802 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
242 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795.0 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 70 Human Binding pAC50 = 5.6 5.6 - 51
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
26248 161633 None 72 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
CHEMBL41286 161633 None 72 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
135398735 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
1549120 198942 None 55 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 198942 None 55 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
104850 3330 None 58 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3330 None 58 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3330 None 58 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3330 None 58 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3330 None 58 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
54585 14508 None 49 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1201346 14508 None 49 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
30323 62505 None 35 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 62505 None 35 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 62505 None 35 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
5328940 100270 None 65 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL288441 100270 None 65 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
392622 56328 None 57 Human Binding pAC50 = 5.2 5.2 -2 4
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56328 None 57 Human Binding pAC50 = 5.2 5.2 -2 4
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
135564886 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
2194 63103 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 63103 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
2168 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
2810 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
644077 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
644077.0 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
CHEMBL373742 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
DB00067 3976 None 29 Human Binding pEC50 = 9.6 9.6 -5 9
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
2042 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
2174 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
2176 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
439302 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
439302.0 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
CHEMBL395429 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
DB00107 2983 None 40 Human Binding pEC50 = 8 8.0 -29 8
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None None 10.1021/jm500365s
118719829 115817 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1035 23 11 14 -1.1 CCCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL3353940 115817 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1035 23 11 14 -1.1 CCCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
10411308 203691 None 0 Human Binding pEC50 = 7.9 7.9 -2 3
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1021/jm901084f
CHEMBL603708 203691 None 0 Human Binding pEC50 = 7.9 7.9 -2 3
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 446 4 1 2 6.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1021/jm901084f
118719827 115815 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1021 22 11 14 -1.5 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL3353938 115815 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1021 22 11 14 -1.5 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
449224 169078 None 10 Human Binding pEC50 = 7.7 7.7 - 1
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL439044 169078 None 10 Human Binding pEC50 = 7.7 7.7 - 1
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 17 11 14 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
2168 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
2810 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
644077 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
644077.0 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
CHEMBL373742 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
DB00067 3976 None 29 Human Binding pEC50 = 7.5 7.5 -5 9
Activation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assayActivation of human 3X-HA N-tagged AVP1a expressed in CHO-K1 cells incubated for 10 mins by cell Western assay
ChEMBL None None None None 10.1021/acsmedchemlett.2c00455
2252 2230 None 35 Human Binding pEC50 = 5.5 5.5 -851 5
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 507 5 0 6 3.8 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C 10.1021/jm901084f
6918320 2230 None 35 Human Binding pEC50 = 5.5 5.5 -851 5
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 507 5 0 6 3.8 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C 10.1021/jm901084f
CHEMBL24781 2230 None 35 Human Binding pEC50 = 5.5 5.5 -851 5
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 507 5 0 6 3.8 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C 10.1021/jm901084f
11169 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
131676677 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
165708555 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
165708555.0 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
16681432 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
16681432.0 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
495 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
CHEMBL3301668 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
DB01282 797 None 33 Human Binding pEC50 = 7.4 7.4 - 2
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL None None None CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C 10.1021/jm500365s
3537 4004 None 22 Human Binding pEC50 = 6.3 6.3 -9 3
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/jm901084f
5311500 4004 None 22 Human Binding pEC50 = 6.3 6.3 -9 3
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/jm901084f
CHEMBL363910 4004 None 22 Human Binding pEC50 = 6.3 6.3 -9 3
Activity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assayActivity at human vasopressin V1a receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1021/jm901084f
118720282 115918 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 20 11 13 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354592 115918 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 20 11 13 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118719821 115809 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1005 19 11 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353932 115809 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1005 19 11 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720275 115911 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1004 22 11 13 -1.8 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL3354585 115911 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAgonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1004 22 11 13 -1.8 CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL2370569 212330 None 21 Human Binding pIC50 = 9.2 9.2 - 1
Binding affinity to human vasopressin V1a receptor by radioligand displacement assayBinding affinity to human vasopressin V1a receptor by radioligand displacement assay
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1016/j.ejmech.2013.01.044
CHEMBL2370569 212330 None 21 Human Binding pIC50 = 9 9.0 - 1
Displacement of [3H]AVP from human recombinant V1a receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AVP from human recombinant V1a receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1016/j.bmc.2016.11.014
CHEMBL2370569 212330 None 21 Human Binding pIC50 = 9 9.0 - 1
Displacement of [3H]AVP from human recombinant arginine vasopressin receptor 1a expressed in CHO cellsDisplacement of [3H]AVP from human recombinant arginine vasopressin receptor 1a expressed in CHO cells
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1016/j.bmc.2016.03.006
56849411 153267 None 0 Human Binding pIC50 = 9 9.0 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 609 10 3 8 3.3 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
CHEMBL3976964 153267 None 0 Human Binding pIC50 = 9 9.0 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 609 10 3 8 3.3 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
72548703 161661 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161661 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL2370569 212330 None 21 Human Binding pIC50 = 8.7 8.7 - 1
Binding affinity to human vasopressin V1a receptor by radioligand displacement assayBinding affinity to human vasopressin V1a receptor by radioligand displacement assay
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1016/j.bmc.2013.03.016
44428419 152676 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 568 9 1 6 5.0 CC(C)(C)C(O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL397187 152676 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 568 9 1 6 5.0 CC(C)(C)C(O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
23598598 4969 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL104839 4969 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
56848626 143805 None 0 Human Binding pIC50 = 8 8.0 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 557 9 2 7 4.2 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)c1ccccc1Cl nan
CHEMBL3900528 143805 None 0 Human Binding pIC50 = 8 8.0 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 557 9 2 7 4.2 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)c1ccccc1Cl nan
10527151 102228 None 0 Rat Binding pIC50 = 8 8.0 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 441 3 1 3 5.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm980179c
CHEMBL302709 102228 None 0 Rat Binding pIC50 = 8 8.0 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 441 3 1 3 5.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm980179c
44332181 4237 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 451 3 2 3 5.8 Nc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL100402 4237 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 451 3 2 3 5.8 Nc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
23598556 4367 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 454 3 1 2 6.4 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1F 10.1016/j.bmcl.2004.02.103
CHEMBL101157 4367 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 454 3 1 2 6.4 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1F 10.1016/j.bmcl.2004.02.103
44332273 169220 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL440147 169220 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
10527151 102228 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 441 3 1 3 5.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL302709 102228 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 441 3 1 3 5.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(03)00388-3
14969547 100969 None 0 Rat Binding pIC50 = 7 7.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 9 1 4 4.2 NCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL293905 100969 None 0 Rat Binding pIC50 = 7 7.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 9 1 4 4.2 NCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44428417 93343 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 586 10 0 6 5.5 O=C(OCc1ccccc1)C(C(=O)c1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL245086 93343 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 586 10 0 6 5.5 O=C(OCc1ccccc1)C(C(=O)c1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44293778 101675 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 476 3 1 4 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(Cl)ccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL298911 101675 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 476 3 1 4 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(Cl)ccc1Cl 10.1016/s0960-894x(99)00279-6
23598638 94071 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.09.059
CHEMBL248733 94071 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.09.059
44444759 154842 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 484 4 2 3 5.5 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL400048 154842 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 484 4 2 3 5.5 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
44428428 142635 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1ccccc1Cl)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL389091 142635 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1ccccc1Cl)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
10599369 114876 None 0 Rat Binding pIC50 = 6 6.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 443 5 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL334082 114876 None 0 Rat Binding pIC50 = 6 6.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 443 5 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
44433367 89881 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 489 3 1 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.08.053
CHEMBL237772 89881 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 489 3 1 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.08.053
44433372 89960 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 426 5 3 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1 10.1016/j.bmcl.2007.08.053
CHEMBL237987 89960 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 426 5 3 3 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1 10.1016/j.bmcl.2007.08.053
44433375 90221 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 505 7 3 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1 10.1016/j.bmcl.2007.08.053
CHEMBL238206 90221 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 505 7 3 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1 10.1016/j.bmcl.2007.08.053
44433363 146740 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 489 3 1 3 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.08.053
CHEMBL392363 146740 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 489 3 1 3 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2007.08.053
10690528 113575 None 0 Rat Binding pIC50 = 5 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
CHEMBL332090 113575 None 0 Rat Binding pIC50 = 5 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
44213444 101969 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 442 3 1 4 5.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL300963 101969 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 442 3 1 4 5.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1Cl 10.1016/s0960-894x(99)00279-6
44374802 120067 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 442 3 1 3 6.1 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCCCc3sccc32)c(Cl)c1 10.1016/s0960-894x(00)00084-6
CHEMBL350089 120067 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 442 3 1 3 6.1 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCCCc3sccc32)c(Cl)c1 10.1016/s0960-894x(00)00084-6
44273355 74973 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 587 8 0 6 3.9 CN(C)CCSC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL20319 74973 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 587 8 0 6 3.9 CN(C)CCSC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL2112655 211703 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
14969508 101042 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 324 2 0 3 2.9 O=C(c1ccco1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL294293 101042 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 324 2 0 3 2.9 O=C(c1ccco1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969530 202245 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 377 3 1 3 2.4 NC(=O)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59397 202245 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 377 3 1 3 2.4 NC(=O)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
10713341 12960 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 357 3 1 3 3.9 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccnc1 10.1021/jm960133o
CHEMBL118933 12960 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 357 3 1 3 3.9 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccnc1 10.1021/jm960133o
9828129 116685 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL336825 116685 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
44352777 21389 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 572 7 2 5 6.4 O=C(Nc1ccc(C(=O)N2CCC(CCS(=O)(=O)O)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
CHEMBL131439 21389 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 572 7 2 5 6.4 O=C(Nc1ccc(C(=O)N2CCC(CCS(=O)(=O)O)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
86690917 150499 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 555 8 2 9 2.7 NC(=O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl nan
CHEMBL3953766 150499 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 555 8 2 9 2.7 NC(=O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl nan
56848490 146840 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 575 10 3 8 2.9 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
CHEMBL3924331 146840 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 575 10 3 8 2.9 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
44332209 4322 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 470 3 1 2 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1Cl 10.1016/j.bmcl.2004.02.103
CHEMBL100893 4322 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 470 3 1 2 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1Cl 10.1016/j.bmcl.2004.02.103
22405322 71806 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 406 4 0 2 6.3 CCCc1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
CHEMBL196737 71806 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 406 4 0 2 6.3 CCCc1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
14969554 102302 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 491 10 1 4 4.3 CC(=O)NCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL303134 102302 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 491 10 1 4 4.3 CC(=O)NCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
86690931 149117 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 543 6 1 7 5.1 O=c1n(Cc2cc(-c3cccc(Cl)c3Cl)ncn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3942564 149117 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 543 6 1 7 5.1 O=c1n(Cc2cc(-c3cccc(Cl)c3Cl)ncn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
67412781 154361 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 499 6 1 8 4.0 O=c1n(Cc2nnc(-c3ccccc3Cl)o2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3986461 154361 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 499 6 1 8 4.0 O=c1n(Cc2nnc(-c3ccccc3Cl)o2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
10503858 208015 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 453 3 1 3 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(C)c1 10.1021/jm980179c
CHEMBL81133 208015 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 453 3 1 3 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(C)c1 10.1021/jm980179c
21837107 206358 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1cc(Cl)ccc1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL68948 206358 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1cc(Cl)ccc1Cl 10.1016/s0960-894x(03)00388-3
14969514 205770 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1ccc(Cl)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL64811 205770 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1ccc(Cl)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
44352302 18965 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 521 6 1 4 6.7 CN(C)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL128687 18965 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 521 6 1 4 6.7 CN(C)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
118719845 115833 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1047 20 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353956 115833 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1047 20 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
76073634 115920 None 5 Human Binding pIC50 = 5.9 5.9 - 1
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1041 20 11 13 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354594 115920 None 5 Human Binding pIC50 = 5.9 5.9 - 1
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1041 20 11 13 -1.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720290 115928 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1013 20 10 13 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354602 115928 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1013 20 10 13 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10766187 12859 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 455 6 1 3 6.1 CCCN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118863 12859 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 455 6 1 3 6.1 CCCN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
10620180 113568 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 3 1 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCOc3ccccc32)cc1 10.1021/jm960133o
CHEMBL332060 113568 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 3 1 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCOc3ccccc32)cc1 10.1021/jm960133o
14969509 204398 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 3 0 2 3.2 O=C(Cc1ccccc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL60773 204398 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 3 0 2 3.2 O=C(Cc1ccccc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL2112651 211701 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
172997 2332 None 49 Human Binding pIC50 = 6.9 6.9 -64 2
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.08.053
2238 2332 None 49 Human Binding pIC50 = 6.9 6.9 -64 2
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.08.053
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.9 6.9 -64 2
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.08.053
DB06666 2332 None 49 Human Binding pIC50 = 6.9 6.9 -64 2
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.08.053
9805201 56273 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 480 3 2 4 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)c(Cl)c1 10.1016/s0960-894x(00)00084-6
CHEMBL162748 56273 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 480 3 2 4 5.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)c(Cl)c1 10.1016/s0960-894x(00)00084-6
392622 56328 None 57 Human Binding pIC50 = 4.9 4.9 -2 4
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 56328 None 57 Human Binding pIC50 = 4.9 4.9 -2 4
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
44428427 161829 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 537 10 1 4 5.2 CC(C)C[C@@H](C(=O)NCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL413711 161829 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 537 10 1 4 5.2 CC(C)C[C@@H](C(=O)NCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
56848553 145705 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 651 9 3 8 5.0 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(Cl)c1Cl nan
CHEMBL3915616 145705 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 651 9 3 8 5.0 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(Cl)c1Cl nan
11432362 94190 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.1 O=C(O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL249340 94190 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.1 O=C(O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
15298022 72064 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 370 2 0 3 5.4 O=C(c1ccc(-c2cccs2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
CHEMBL197616 72064 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 370 2 0 3 5.4 O=C(c1ccc(-c2cccs2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
22861321 134408 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 421 4 0 3 5.4 CN(C)Cc1ccc2n1Cc1ccccc1N(C(=O)c1ccc(-c3ccccc3)cc1)C2 10.1016/j.bmcl.2005.08.007
CHEMBL371721 134408 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 421 4 0 3 5.4 CN(C)Cc1ccc2n1Cc1ccccc1N(C(=O)c1ccc(-c3ccccc3)cc1)C2 10.1016/j.bmcl.2005.08.007
56848687 150569 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 581 11 2 9 2.5 COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NCC(NS(C)(=O)=O)c2ccccc2C(F)(F)F)c1=O nan
CHEMBL3954357 150569 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 581 11 2 9 2.5 COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NCC(NS(C)(=O)=O)c2ccccc2C(F)(F)F)c1=O nan
14969526 203230 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1ccc(O)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL60054 203230 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1ccc(O)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969516 203508 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1cccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)c1 10.1021/jm00066a010
CHEMBL60262 203508 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1cccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)c1 10.1021/jm00066a010
118719822 115810 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1017 19 10 14 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](OC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353933 115810 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1017 19 10 14 -2.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](OC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118719840 115828 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccnc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353951 115828 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccnc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720262 115899 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1048 21 12 15 -2.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCC2CCCN2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354573 115899 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1048 21 12 15 -2.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCC2CCCN2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720285 115922 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1025 20 10 12 -1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354596 115922 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1025 20 10 12 -1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
2241 2218 None 2 Rat Binding pIC50 = 5.9 5.9 -117 4
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None None 10.1021/jm00099a019
9810632 2218 None 2 Rat Binding pIC50 = 5.9 5.9 -117 4
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None None 10.1021/jm00099a019
CHEMBL127686 2218 None 2 Rat Binding pIC50 = 5.9 5.9 -117 4
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None None 10.1021/jm00099a019
CHEMBL338018 214061 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
CHEMBL405289 215014 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10838493 13919 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 481 4 1 3 6.3 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL119638 13919 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 481 4 1 3 6.3 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)c2ccccc21 10.1021/jm960133o
14981576 78901 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 610 12 1 7 2.9 CCN(CC)[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1021/jm00031a004
CHEMBL2112894 78901 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 610 12 1 7 2.9 CCN(CC)[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1021/jm00031a004
44273473 72809 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 542 5 0 6 3.2 CC(=O)OC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL20002 72809 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 542 5 0 6 3.2 CC(=O)OC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
44273259 73545 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 1 6 2.5 CN(CCO)C1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL20171 73545 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 1 6 2.5 CN(CCO)C1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
56848684 148500 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 545 9 2 7 3.9 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(CCC(F)(F)F)c1=O)c1ccccc1Cl nan
CHEMBL3937650 148500 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 545 9 2 7 3.9 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(CCC(F)(F)F)c1=O)c1ccccc1Cl nan
44352804 18966 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL128688 18966 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
10715974 11926 None 0 Rat Binding pIC50 = 6.9 6.9 - 2
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL118271 11926 None 0 Rat Binding pIC50 = 6.9 6.9 - 2
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3ccccc32)cc1 10.1021/jm960133o
44332238 107451 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 464 3 1 2 6.9 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1C 10.1016/j.bmcl.2004.02.103
CHEMBL317919 107451 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 464 3 1 2 6.9 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1C 10.1016/j.bmcl.2004.02.103
14969533 203924 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 352 2 0 2 3.4 O=C(c1ccc(F)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL60502 203924 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 352 2 0 2 3.4 O=C(c1ccc(F)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969521 205656 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1ccccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL64332 205656 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1ccccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
118719826 115814 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 947 19 11 13 -3.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353937 115814 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 947 19 11 13 -3.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118719836 115824 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(C)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353947 115824 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(C)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720268 115905 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354579 115905 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720278 115914 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1023 20 11 13 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354588 115914 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1023 20 11 13 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
119369 2606 None 50 Rat Binding pIC50 = 5.9 5.9 -31 8
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C 10.1021/jm960133o
2197 2606 None 50 Rat Binding pIC50 = 5.9 5.9 -31 8
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C 10.1021/jm960133o
4004 2606 None 50 Rat Binding pIC50 = 5.9 5.9 -31 8
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C 10.1021/jm960133o
CHEMBL420762 2606 None 50 Rat Binding pIC50 = 5.9 5.9 -31 8
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C 10.1021/jm960133o
10666852 113127 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL331164 113127 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL1790938 211366 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10573075 114509 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 400 5 1 3 4.9 CCOc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
CHEMBL333340 114509 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 400 5 1 3 4.9 CCOc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
10766720 105506 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 4 1 4 5.4 COc1cc(NC(=O)c2cc(F)ccc2C)ccc1C(=O)N1Cc2cccn2Cc2ccccc21 10.1021/jm980179c
CHEMBL312036 105506 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 4 1 4 5.4 COc1cc(NC(=O)c2cc(F)ccc2C)ccc1C(=O)N1Cc2cccn2Cc2ccccc21 10.1021/jm980179c
9826254 163404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL418890 163404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
23598619 94592 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 498 4 1 4 5.6 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL251771 94592 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 498 4 1 4 5.6 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
9826254 163404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
CHEMBL418890 163404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
44332226 4371 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 482 4 1 3 7.0 CSc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL101187 4371 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 482 4 1 3 7.0 CSc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
172997 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Binding affinity towards human V1a receptorsBinding affinity towards human V1a receptors
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)01059-4
2238 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Binding affinity towards human V1a receptorsBinding affinity towards human V1a receptors
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)01059-4
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Binding affinity towards human V1a receptorsBinding affinity towards human V1a receptors
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)01059-4
DB06666 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Binding affinity towards human V1a receptorsBinding affinity towards human V1a receptors
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)01059-4
172997 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.09.059
2238 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.09.059
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.09.059
DB06666 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2007.09.059
15307968 103110 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL307271 103110 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
172997 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)00649-2
2238 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)00649-2
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)00649-2
DB06666 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(02)00649-2
14969524 102902 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1ccccc1O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL305588 102902 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1ccccc1O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969539 168064 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 434 8 0 3 5.2 CCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL431723 168064 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 434 8 0 3 5.2 CCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118720261 115898 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1035 20 11 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CCCO2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354572 115898 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1035 20 11 15 -2.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CCCO2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
44309805 206740 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 434 3 1 3 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Oc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL71283 206740 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 434 3 1 3 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Oc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
44273369 99598 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL283524 99598 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 10.1016/0960-894X(94)00469-V
23598598 4969 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor (Compound 7o)Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor (Compound 7o)
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL104839 4969 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor (Compound 7o)Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor (Compound 7o)
ChEMBL 608 7 2 4 6.3 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
10459252 52667 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 517 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
CHEMBL159359 52667 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 517 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
44332207 107318 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 504 3 1 2 7.6 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2004.02.103
CHEMBL316958 107318 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 504 3 1 2 7.6 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2004.02.103
14969553 102100 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 477 9 1 4 4.0 CC(=O)NCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL301850 102100 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 477 9 1 4 4.0 CC(=O)NCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44352767 115185 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 528 6 1 3 7.8 O=C(Nc1ccc(C(=O)N2CCC(CC(F)F)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
CHEMBL334363 115185 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 528 6 1 3 7.8 O=C(Nc1ccc(C(=O)N2CCC(CC(F)F)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
44273346 163042 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 570 8 1 6 2.8 CN(C)CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL417458 163042 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 570 8 1 6 2.8 CN(C)CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
118720280 115916 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1007 20 10 12 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354590 115916 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1007 20 10 12 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL126765 211127 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O 10.1021/jm00099a019
CHEMBL419793 215701 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
2981363 12527 None 4 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
CHEMBL118660 12527 None 4 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
10598596 12946 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 5 2 3 5.3 CCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118922 12946 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 5 2 3 5.3 CCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
10642000 114456 None 7 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 356 3 1 2 4.5 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1 10.1021/jm960133o
CHEMBL333139 114456 None 7 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 356 3 1 2 4.5 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1 10.1021/jm960133o
10790546 110710 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 470 5 2 4 4.9 CC(=O)Nc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL325819 110710 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 470 5 2 4 4.9 CC(=O)Nc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
10501216 113196 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 401 4 1 4 4.4 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccc([N+](=O)[O-])c1 10.1021/jm960133o
CHEMBL331424 113196 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 401 4 1 4 4.4 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccc([N+](=O)[O-])c1 10.1021/jm960133o
118719824 115812 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1017 19 11 14 -3.1 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 10.1021/jm500365s
CHEMBL3353935 115812 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1017 19 11 14 -3.1 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 10.1021/jm500365s
86690920 145630 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 548 6 1 7 5.5 O=c1n(Cc2cnc(-c3ccccc3C(F)(F)F)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3915055 145630 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 548 6 1 7 5.5 O=c1n(Cc2cnc(-c3ccccc3C(F)(F)F)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
56848555 151838 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 560 9 4 7 2.5 NC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
CHEMBL3964694 151838 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 560 9 4 7 2.5 NC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
15340668 206227 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 407 3 1 3 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL68033 206227 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 407 3 1 3 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
44273368 98848 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 584 9 1 6 3.2 CN(C)CCCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL278377 98848 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 584 9 1 6 3.2 CN(C)CCCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
53379068 142458 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 551 7 2 6 5.4 O=C(O)c1ccc(-c2ccccc2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O nan
CHEMBL3889504 142458 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 551 7 2 6 5.4 O=C(O)c1ccc(-c2ccccc2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O nan
10832492 114863 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 362 3 1 3 4.6 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccsc1 10.1021/jm960133o
CHEMBL334009 114863 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 362 3 1 3 4.6 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccsc1 10.1021/jm960133o
19699097 120068 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 446 3 2 4 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
CHEMBL350090 120068 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 446 3 2 4 5.0 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
44374839 120233 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 442 3 1 5 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cn(C)nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
CHEMBL351587 120233 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 442 3 1 5 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cn(C)nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
441243 9838 None 41 Human Binding pIC50 = 4.8 4.8 -33 8
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 9838 None 41 Human Binding pIC50 = 4.8 4.8 -33 8
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
9931699 75077 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 415 2 1 5 5.0 Cn1ccc(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(Cl)c2)n1 10.1016/j.bmcl.2005.10.107
CHEMBL203513 75077 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 415 2 1 5 5.0 Cn1ccc(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(Cl)c2)n1 10.1016/j.bmcl.2005.10.107
56848686 144626 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 653 9 2 8 6.0 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)s2)n(Cc2ccccc2F)c1=O)c1ccccc1C(F)(F)F nan
CHEMBL3907257 144626 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 653 9 2 8 6.0 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)s2)n(Cc2ccccc2F)c1=O)c1ccccc1C(F)(F)F nan
23598642 154894 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 541 6 2 3 7.1 CNCC1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL400267 154894 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 541 6 2 3 7.1 CNCC1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
44352796 21483 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 510 6 1 3 7.5 O=C(Nc1ccc(C(=O)N2CCC(CCF)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
CHEMBL131566 21483 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 510 6 1 3 7.5 O=C(Nc1ccc(C(=O)N2CCC(CCF)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
172997 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2005.08.007
2238 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2005.08.007
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2005.08.007
DB06666 2332 None 49 Human Binding pIC50 = 6.8 6.8 -64 2
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/j.bmcl.2005.08.007
118719831 115819 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1009 21 11 15 -3.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353942 115819 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1009 21 11 15 -3.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
118720269 115906 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354580 115906 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 12 14 -3.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10834761 114602 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCN(C)Cc3ccccc32)cc1 10.1021/jm960133o
CHEMBL333652 114602 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCN(C)Cc3ccccc32)cc1 10.1021/jm960133o
44273080 98672 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 571 7 1 7 2.4 COC(=O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL277022 98672 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 571 7 1 7 2.4 COC(=O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
23598600 5369 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 594 7 2 4 5.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL106938 5369 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 594 7 2 4 5.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN4CCCC4)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
69940391 148637 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 512 7 2 7 3.7 O=c1n(Cc2nnc(Cc3ccccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3938717 148637 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 512 7 2 7 3.7 O=c1n(Cc2nnc(Cc3ccccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
56848556 147125 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 579 10 3 7 2.9 O=CNC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
CHEMBL3926829 147125 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 579 10 3 7 2.9 O=CNC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
11261339 154710 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CCC3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL399289 154710 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CCC3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
44309820 206686 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 433 3 2 3 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Nc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL70949 206686 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 433 3 2 3 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Nc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
14969510 203093 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 334 2 0 2 3.3 O=C(c1ccccc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL59947 203093 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 334 2 0 2 3.3 O=C(c1ccccc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
118719834 115822 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353945 115822 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 20 11 14 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10550481 12880 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 428 4 2 4 4.6 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3N)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118878 12880 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 428 4 2 4 4.6 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3N)cc2)c2ccccc21 10.1021/jm960133o
10527137 12791 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 4 0 3 5.3 Cc1ccccc1C(=O)N(C)c1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL118805 12791 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 4 0 3 5.3 Cc1ccccc1C(=O)N(C)c1ccc(C(=O)N2CCCC(N(C)C)c3ccccc32)cc1 10.1021/jm960133o
10834036 13640 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL119442 13640 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
44428412 143228 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 556 9 0 7 4.8 CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccco1 10.1016/j.bmc.2006.12.031
CHEMBL389581 143228 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 556 9 0 7 4.8 CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccco1 10.1016/j.bmc.2006.12.031
54582950 63057 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788220 63057 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44444762 154819 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL399888 154819 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
18917534 206752 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 485 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Br 10.1016/s0960-894x(03)00388-3
CHEMBL71355 206752 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 485 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1Br 10.1016/s0960-894x(03)00388-3
44404614 165845 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 378 2 0 2 5.7 Cc1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
CHEMBL424663 165845 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 378 2 0 2 5.7 Cc1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
10003306 206231 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 439 3 1 3 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
CHEMBL68085 206231 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 439 3 1 3 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
44332168 4487 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 436 3 1 2 6.3 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1 10.1016/j.bmcl.2004.02.103
CHEMBL101935 4487 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 436 3 1 2 6.3 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1 10.1016/j.bmcl.2004.02.103
10003306 206231 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 439 3 1 3 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL68085 206231 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 439 3 1 3 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
14969520 205164 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1ccc([N+](=O)[O-])cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL61688 205164 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1ccc([N+](=O)[O-])cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969543 205205 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 393 5 1 4 2.6 NCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL61947 205205 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 393 5 1 4 2.6 NCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118719830 115818 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1033 19 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353941 115818 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1033 19 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL338294 214065 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
19699060 56163 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 466 3 2 4 5.4 O=C(Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1)c1ccc(F)cc1Cl 10.1016/s0960-894x(00)00084-6
CHEMBL162588 56163 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 466 3 2 4 5.4 O=C(Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1)c1ccc(F)cc1Cl 10.1016/s0960-894x(00)00084-6
44374839 120233 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 442 3 1 5 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cn(C)nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
CHEMBL351587 120233 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 442 3 1 5 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cn(C)nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
6734379 163805 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 409 3 1 6 2.5 O=C(OCc1ccc2c(c1)OCO2)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
CHEMBL420500 163805 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 409 3 1 6 2.5 O=C(OCc1ccc2c(c1)OCO2)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
44293763 101563 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of (Phe-3,4,5 [3H]-) AVP binding towards isolated rat hepatic Vasopressin V1a receptorIn vitro inhibition of (Phe-3,4,5 [3H]-) AVP binding towards isolated rat hepatic Vasopressin V1a receptor
ChEMBL 422 3 1 4 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
CHEMBL297990 101563 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of (Phe-3,4,5 [3H]-) AVP binding towards isolated rat hepatic Vasopressin V1a receptorIn vitro inhibition of (Phe-3,4,5 [3H]-) AVP binding towards isolated rat hepatic Vasopressin V1a receptor
ChEMBL 422 3 1 4 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
22405324 70620 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 442 3 0 4 4.8 Cc1ccc(S(=O)(=O)c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
CHEMBL194970 70620 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 442 3 0 4 4.8 Cc1ccc(S(=O)(=O)c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
14969552 203283 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 8 1 4 3.6 CC(=O)NCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60096 203283 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 8 1 4 3.6 CC(=O)NCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969536 204345 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 378 4 0 3 3.7 CCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60736 204345 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 378 4 0 3 3.7 CCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118720288 115926 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354600 115926 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
19699133 119995 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 496 3 1 5 5.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)c3ccc(Cl)cc3Cl)cc1)CC2 10.1016/s0960-894x(00)00084-6
CHEMBL349506 119995 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 496 3 1 5 5.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)c3ccc(Cl)cc3Cl)cc1)CC2 10.1016/s0960-894x(00)00084-6
19699093 120102 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 428 3 2 4 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
CHEMBL350383 120102 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 428 3 2 4 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
14981580 78902 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 637 11 3 8 1.9 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCNCC2)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112895 78902 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 637 11 3 8 1.9 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCNCC2)C3(C)C)CC1 10.1021/jm00031a004
118719839 115827 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353950 115827 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10524202 13767 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
CHEMBL119534 13767 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)cc1 10.1021/jm960133o
11059058 10093 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 10093 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
53378730 153032 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 548 7 1 7 5.4 O=c1n(Cc2nnc(Cc3ccccc3C(F)(F)F)[nH]2)nc(-c2ccc(Cl)s2)n1Cc1ccccc1F nan
CHEMBL3975038 153032 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 548 7 1 7 5.4 O=c1n(Cc2nnc(Cc3ccccc3C(F)(F)F)[nH]2)nc(-c2ccc(Cl)s2)n1Cc1ccccc1F nan
9826254 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL418890 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
9826254 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
CHEMBL418890 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
9826254 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL418890 163404 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(03)00388-3
53378840 149803 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 532 6 1 7 5.3 O=c1n(Cc2cnc(-c3cccc(Cl)c3Cl)o2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3947893 149803 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 532 6 1 7 5.3 O=c1n(Cc2cnc(-c3cccc(Cl)c3Cl)o2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
172997 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
2238 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
DB06666 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
21467152 53173 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 478 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2CCCCc3sc(Cl)cc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
CHEMBL159831 53173 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 478 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2CCCCc3sc(Cl)cc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(00)00084-6
172997 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
2238 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
DB06666 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
172997 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00278-4
2238 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00278-4
CHEMBL49429 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00278-4
DB06666 2332 None 49 Human Binding pIC50 = 6.6 6.6 -64 2
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00278-4
10789935 11820 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).
ChEMBL 455 4 1 5 5.0 CC(=O)O/N=C1\CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118204 11820 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).
ChEMBL 455 4 1 5 5.0 CC(=O)O/N=C1\CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
10620049 114170 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 5 1 2 4.9 O=C(CCc1ccccc1)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL332757 114170 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 5 1 2 4.9 O=C(CCc1ccccc1)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
71458039 78906 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 530 8 3 5 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2 10.1021/jm00031a004
CHEMBL2112899 78906 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 530 8 3 5 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2 10.1021/jm00031a004
44273077 99238 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](NCc3ccccc3)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL281361 99238 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](NCc3ccccc3)C1=O)C2 10.1016/0960-894X(94)00469-V
44273173 99079 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 555 7 0 5 4.0 CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL280202 99079 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 555 7 0 5 4.0 CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
44336768 163447 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 599 7 3 4 6.1 O=C(O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL419183 163447 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 599 7 3 4 6.1 O=C(O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
56848489 144970 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 637 11 3 8 4.0 CCNC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
CHEMBL3909988 144970 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 637 11 3 8 4.0 CCNC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
44335329 167941 None 0 Human Binding pIC50 = 7.6 7.6 -1 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 561 4 1 3 7.6 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(C5)N4Cc4cc(Cl)ccc43)cc2)cc1 10.1016/s0960-894x(02)00649-2
CHEMBL430841 167941 None 0 Human Binding pIC50 = 7.6 7.6 -1 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 561 4 1 3 7.6 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(C5)N4Cc4cc(Cl)ccc43)cc2)cc1 10.1016/s0960-894x(02)00649-2
9915472 169626 None 0 Human Binding pIC50 = 7.6 7.6 -14 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 547 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(02)00649-2
CHEMBL443498 169626 None 0 Human Binding pIC50 = 7.6 7.6 -14 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 547 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(02)00649-2
14969549 204225 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 8 1 4 2.8 O=CNCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60672 204225 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 8 1 4 2.8 O=CNCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
19699093 120102 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 428 3 2 4 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
CHEMBL350383 120102 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 428 3 2 4 4.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3c[nH]nc3-c3sccc32)cc1 10.1016/s0960-894x(00)00084-6
10503021 102791 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 435 3 1 3 5.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)c1C 10.1016/s0960-894x(03)00388-3
CHEMBL304956 102791 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 435 3 1 3 5.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)c1C 10.1016/s0960-894x(03)00388-3
5099582 110569 None 6 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 322 3 1 2 3.9 CC(C)C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL324935 110569 None 6 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 322 3 1 2 3.9 CC(C)C(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
10574499 113051 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)c1 10.1021/jm960133o
CHEMBL331098 113051 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)c1 10.1021/jm960133o
56848557 146761 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 607 9 3 7 3.5 CC(=O)NC(C)(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
CHEMBL3923775 146761 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 607 9 3 7 3.5 CC(=O)NC(C)(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
10719289 208090 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1Cl 10.1021/jm980179c
CHEMBL81755 208090 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1Cl 10.1021/jm980179c
14969550 202704 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 9 1 4 3.2 O=CNCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59699 202704 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 9 1 4 3.2 O=CNCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44335356 5227 None 0 Human Binding pIC50 = 6.6 6.6 -5 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 385 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCNc3ccccc32)cc1 10.1016/s0960-894x(02)00649-2
CHEMBL106229 5227 None 0 Human Binding pIC50 = 6.6 6.6 -5 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 385 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCNc3ccccc32)cc1 10.1016/s0960-894x(02)00649-2
14969505 102706 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 340 2 0 3 3.3 O=C(c1cccs1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL304430 102706 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 340 2 0 3 3.3 O=C(c1cccs1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
118720267 115904 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 975 21 10 13 -3.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354578 115904 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 975 21 10 13 -3.0 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10763869 11879 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 406 4 1 3 4.5 O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCCCc2ccccc21 10.1021/jm960133o
CHEMBL118244 11879 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 406 4 1 3 4.5 O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCCCc2ccccc21 10.1021/jm960133o
15307967 102346 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL303376 102346 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
448537 160344 None 54 Human Binding pIC50 = 4.6 4.6 -45 25
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 160344 None 54 Human Binding pIC50 = 4.6 4.6 -45 25
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
10551037 206692 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 439 3 1 3 5.4 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
CHEMBL70981 206692 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 439 3 1 3 5.4 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
11798757 206746 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 475 3 1 3 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1C(F)(F)F 10.1021/jm980179c
CHEMBL71305 206746 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 475 3 1 3 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1C(F)(F)F 10.1021/jm980179c
23598560 4452 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 512 4 1 2 7.9 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.02.103
CHEMBL101678 4452 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 512 4 1 2 7.9 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.02.103
10551037 206692 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 439 3 1 3 5.4 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL70981 206692 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 439 3 1 3 5.4 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
11798757 206746 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(03)00388-3
CHEMBL71305 206746 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(03)00388-3
53378841 145985 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 508 6 1 6 5.1 O=c1n(Cc2cncc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
CHEMBL3917760 145985 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 508 6 1 6 5.1 O=c1n(Cc2cncc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
86690918 151909 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 547 6 1 6 6.4 O=c1n(Cc2ccc(-c3cccc(Cl)c3Cl)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3965329 151909 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 547 6 1 6 6.4 O=c1n(Cc2ccc(-c3cccc(Cl)c3Cl)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
44294195 101370 None 1 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 519 4 1 5 6.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(-c2ccccn2)ccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL296619 101370 None 1 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 519 4 1 5 6.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(-c2ccccn2)ccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL2112249 211695 None 2 Rat Binding pIC50 = 5.6 5.6 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10838492 13469 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 481 4 1 3 6.3 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3cc(Cl)cc(Cl)c3)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL119318 13469 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 481 4 1 3 6.3 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3cc(Cl)cc(Cl)c3)cc2)c2ccccc21 10.1021/jm960133o
11798122 114596 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 458 5 1 5 4.9 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3[N+](=O)[O-])cc2)c2ccccc21 10.1021/jm960133o
CHEMBL333597 114596 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 458 5 1 5 4.9 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3[N+](=O)[O-])cc2)c2ccccc21 10.1021/jm960133o
14969506 205652 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 336 2 0 4 2.1 O=C(c1cnccn1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL64319 205652 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 336 2 0 4 2.1 O=C(c1cnccn1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
10693776 10163 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)cc1 10.1021/jm960133o
CHEMBL115853 10163 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 427 4 1 3 5.3 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)cc1 10.1021/jm960133o
44428431 167352 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1ccc(Cl)cc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL429281 167352 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1ccc(Cl)cc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
69939726 145117 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 498 6 1 8 3.6 O=c1n(Cc2cn(-c3ccccc3Cl)nn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3911148 145117 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 498 6 1 8 3.6 O=c1n(Cc2cn(-c3ccccc3Cl)nn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
44309960 206739 None 1 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1cccc(Cl)c1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL71282 206739 None 1 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1cccc(Cl)c1Cl 10.1016/s0960-894x(03)00388-3
118719842 115830 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 21 11 14 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353953 115830 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1055 21 11 14 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
21837085 102311 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 421 3 1 3 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cccn3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL303176 102311 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 421 3 1 3 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3cccn3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
10621059 114326 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 401 4 1 4 4.4 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1[N+](=O)[O-] 10.1021/jm960133o
CHEMBL333055 114326 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 401 4 1 4 4.4 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccccc1[N+](=O)[O-] 10.1021/jm960133o
44273321 167600 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 542 7 2 6 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCN)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL429971 167600 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 542 7 2 6 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCN)C1=O)C2 10.1016/0960-894X(94)00469-V
14969546 163375 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 8 1 4 3.8 NCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL418692 163375 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 8 1 4 3.8 NCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118720260 115897 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1061 21 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2cccs2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354571 115897 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1061 21 11 15 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2cccs2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
22405326 72360 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 394 3 0 3 5.8 Cc1ccc(Oc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
CHEMBL198446 72360 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 394 3 0 3 5.8 Cc1ccc(Oc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2005.08.007
14969531 102156 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 391 3 1 3 3.2 CC(=O)Nc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL302233 102156 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 391 3 1 3 3.2 CC(=O)Nc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
10548204 12388 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1cccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c1 10.1021/jm960133o
CHEMBL118562 12388 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 4 1 3 4.5 COc1cccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c1 10.1021/jm960133o
10601045 13966 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 487 4 1 3 6.6 O=C(Nc1ccc(C(=O)N2CCCC(N3CCCCC3)c3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
CHEMBL119671 13966 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 487 4 1 3 6.6 O=C(Nc1ccc(C(=O)N2CCCC(N3CCCCC3)c3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
10599903 14576 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 456 4 3 3 4.7 CNC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL120449 14576 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 456 4 3 3 4.7 CNC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
69940395 149166 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 514 6 1 7 5.1 O=c1n(Cc2ncc(-c3ccccc3Cl)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3943019 149166 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 514 6 1 7 5.1 O=c1n(Cc2ncc(-c3ccccc3Cl)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
10742994 110435 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 470 6 2 4 4.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)CC(N)=O)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL324251 110435 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 470 6 2 4 4.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)CC(N)=O)c3ccccc32)cc1 10.1021/jm960133o
44273316 98925 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL279022 98925 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 589 7 1 5 4.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 10.1016/0960-894X(94)00469-V
44273417 99561 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 555 7 0 5 4.0 CCN(CC)[C@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL283317 99561 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 555 7 0 5 4.0 CCN(CC)[C@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
9799174 140660 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 364 2 0 2 5.4 O=C(c1ccc(-c2ccccc2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
CHEMBL381248 140660 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 364 2 0 2 5.4 O=C(c1ccc(-c2ccccc2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
9935001 53166 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 483 4 1 3 6.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
CHEMBL159823 53166 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 483 4 1 3 6.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
25109291 191495 None 6 Human Binding pIC50 = 8.4 8.4 -56 12
Displacement of radiolabeled [d(CH2)51,Tyr(Me)2]-AVP from human vasopressin V1a receptorDisplacement of radiolabeled [d(CH2)51,Tyr(Me)2]-AVP from human vasopressin V1a receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 191495 None 6 Human Binding pIC50 = 8.4 8.4 -56 12
Displacement of radiolabeled [d(CH2)51,Tyr(Me)2]-AVP from human vasopressin V1a receptorDisplacement of radiolabeled [d(CH2)51,Tyr(Me)2]-AVP from human vasopressin V1a receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
18917553 101517 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 484 4 1 4 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(99)00279-6
CHEMBL297705 101517 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 484 4 1 4 6.0 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(99)00279-6
44332239 4535 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 466 4 1 3 6.3 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL102311 4535 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 466 4 1 3 6.3 COc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
14969555 202789 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 519 12 1 4 5.1 CC(=O)NCCCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59754 202789 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 519 12 1 4 5.1 CC(=O)NCCCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118720273 115909 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL3354583 115909 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL338020 214062 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10837161 11924 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 447 4 1 3 5.6 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118270 11924 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 447 4 1 3 5.6 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c2ccccc21 10.1021/jm960133o
10716675 114979 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 413 4 1 3 5.0 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL334225 114979 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 413 4 1 3 5.0 CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3)cc2)c2ccccc21 10.1021/jm960133o
67409800 146986 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 497 6 1 7 4.2 O=c1n(Cc2cnn(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3925572 146986 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 497 6 1 7 4.2 O=c1n(Cc2cnn(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
10503021 102791 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 435 3 1 3 5.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)c1C 10.1021/jm980179c
CHEMBL304956 102791 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 435 3 1 3 5.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)c1C 10.1021/jm980179c
10789117 207070 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 437 4 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
CHEMBL73286 207070 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 437 4 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
10789117 207070 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 437 4 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL73286 207070 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 437 4 1 4 5.0 COc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
44293784 188003 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 444 3 1 4 4.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(F)ccc1F 10.1016/s0960-894x(99)00279-6
CHEMBL49657 188003 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 444 3 1 4 4.6 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(F)ccc1F 10.1016/s0960-894x(99)00279-6
14969532 100974 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 359 2 0 3 3.1 N#Cc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL293922 100974 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 359 2 0 3 3.1 N#Cc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969519 204325 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1cccc([N+](=O)[O-])c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL60726 204325 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1cccc([N+](=O)[O-])c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
9826033 57479 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards VIa receptorBinding affinity towards VIa receptor
ChEMBL 471 4 2 2 6.7 O=C(Nc1ccc(C(=O)N2CCCc3c[nH]c4cccc2c34)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(02)01059-4
CHEMBL165670 57479 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards VIa receptorBinding affinity towards VIa receptor
ChEMBL 471 4 2 2 6.7 O=C(Nc1ccc(C(=O)N2CCCc3c[nH]c4cccc2c34)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(02)01059-4
10619160 11849 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c1 10.1021/jm960133o
CHEMBL118220 11849 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.8 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c1 10.1021/jm960133o
44352768 115320 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL334777 115320 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 536 7 2 4 7.0 O=C(O)CC[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
52912189 73564 None 50 Human Binding pIC50 = 4.5 4.5 - 0
Selectivity interaction (BET inhibitor selectivity panel (Human antagonist intracellular Ca2+ fluorescence assay)) EUB0000102c AVPR1ASelectivity interaction (BET inhibitor selectivity panel (Human antagonist intracellular Ca2+ fluorescence assay)) EUB0000102c AVPR1A
ChEMBL 415 4 1 7 4.2 COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 10.6019/CHEMBL5465560
CHEMBL2017291 73564 None 50 Human Binding pIC50 = 4.5 4.5 - 0
Selectivity interaction (BET inhibitor selectivity panel (Human antagonist intracellular Ca2+ fluorescence assay)) EUB0000102c AVPR1ASelectivity interaction (BET inhibitor selectivity panel (Human antagonist intracellular Ca2+ fluorescence assay)) EUB0000102c AVPR1A
ChEMBL 415 4 1 7 4.2 COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 10.6019/CHEMBL5465560
10696913 208027 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 505 4 1 4 6.3 COc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1NC(=O)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL81269 208027 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 505 4 1 4 6.3 COc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1NC(=O)c1ccc(Cl)cc1Cl 10.1021/jm980179c
44444760 154709 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.1 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL399288 154709 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 518 4 2 3 6.1 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
14969537 202763 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 5 0 3 4.1 CCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59740 202763 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 5 0 3 4.1 CCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14981574 78905 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 568 10 2 7 1.8 CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1021/jm00031a004
CHEMBL2112898 78905 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 568 10 2 7 1.8 CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1021/jm00031a004
10483105 90714 None 1 Rat Binding pIC50 = 6.5 6.5 - 4
Inhibition of rat liver V1a receptorInhibition of rat liver V1a receptor
ChEMBL 568 10 2 7 1.8 CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1016/j.bmcl.2012.10.116
CHEMBL2391300 90714 None 1 Rat Binding pIC50 = 6.5 6.5 - 4
Inhibition of rat liver V1a receptorInhibition of rat liver V1a receptor
ChEMBL 568 10 2 7 1.8 CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C 10.1016/j.bmcl.2012.10.116
118719841 115829 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccncc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353952 115829 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1042 20 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccncc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL339118 214076 None 0 Rat Binding pIC50 = 5.5 5.5 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10527129 13854 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 4 2 3 4.9 CC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL119591 13854 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 4 2 3 4.9 CC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
10499401 14037 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 4 1 2 4.5 O=C(Cc1ccccc1)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL119730 14037 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 4 1 2 4.5 O=C(Cc1ccccc1)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
10647295 110330 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 452 5 1 4 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)CC#N)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL323802 110330 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 452 5 1 4 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N(C)CC#N)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL435021 216122 None 2 Rat Binding pIC50 = 4.5 4.5 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
9954905 101967 None 4 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 440 3 1 4 4.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
CHEMBL300946 101967 None 4 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 440 3 1 4 4.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
10528416 104785 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 471 4 1 4 5.6 COc1cc(Cl)ccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
CHEMBL310581 104785 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 471 4 1 4 5.6 COc1cc(Cl)ccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
10743659 208160 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 489 3 1 3 6.6 Cc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1NC(=O)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL82376 208160 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 489 3 1 3 6.6 Cc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1NC(=O)c1ccc(Cl)cc1Cl 10.1021/jm980179c
54582950 63057 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Evaluated for binding affinity towards vasopressin V1a receptor in ratEvaluated for binding affinity towards vasopressin V1a receptor in rat
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788220 63057 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Evaluated for binding affinity towards vasopressin V1a receptor in ratEvaluated for binding affinity towards vasopressin V1a receptor in rat
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=C[C@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
14969541 100962 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 376 4 0 2 4.2 CCCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL293863 100962 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 376 4 0 2 4.2 CCCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969545 102716 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 421 7 1 4 3.4 NCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL304485 102716 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 421 7 1 4 3.4 NCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118720287 115925 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1022 21 10 12 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354599 115925 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1022 21 10 12 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL52813 218195 None 0 Rat Binding pIC50 = 5.5 5.5 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O 10.1021/jm00099a019
10667727 11037 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 3 1 2 5.1 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c(C)c1 10.1021/jm960133o
CHEMBL117566 11037 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 3 1 2 5.1 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCCc4ccccc43)cc2)c(C)c1 10.1021/jm960133o
89701036 151892 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 496 7 2 7 3.2 O=c1n(Cc2nnc(Cc3ccccc3F)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3965167 151892 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 496 7 2 7 3.2 O=c1n(Cc2nnc(Cc3ccccc3F)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
172997 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
2238 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
CHEMBL49429 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
DB06666 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1021/jm980179c
10814200 163599 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 3 1 3 6.2 Cc1ccc(C)c(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)c1 10.1021/jm980179c
CHEMBL420216 163599 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 3 1 3 6.2 Cc1ccc(C)c(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)c1 10.1021/jm980179c
172997 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
2238 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
CHEMBL49429 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
DB06666 2332 None 49 Rat Binding pIC50 = 6.5 6.5 - 2
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(00)00084-6
118719832 115820 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1009 21 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353943 115820 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1009 21 12 15 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
44335343 107526 None 0 Human Binding pIC50 = 7.5 7.5 -1 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 519 3 1 3 6.6 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(CC4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(02)00649-2
CHEMBL318392 107526 None 0 Human Binding pIC50 = 7.5 7.5 -1 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 519 3 1 3 6.6 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(CC4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(02)00649-2
20825285 109253 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 595 4 1 3 8.2 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(C5)N4Cc4cc(Cl)ccc43)c(Cl)c2)cc1 10.1016/s0960-894x(02)00649-2
CHEMBL321561 109253 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 595 4 1 3 8.2 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(C5)N4Cc4cc(Cl)ccc43)c(Cl)c2)cc1 10.1016/s0960-894x(02)00649-2
14969542 203008 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 390 5 0 2 4.6 CCCCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59900 203008 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 390 5 0 2 4.6 CCCCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
118719844 115832 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccncc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353955 115832 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccncc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
14969528 205272 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.1 COC(=O)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL62344 205272 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.1 COC(=O)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL2370623 212350 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O 10.1021/jm00099a019
15307998 101151 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 438 3 1 3 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccsc3Cc3ccccc32)cc1 10.1016/s0960-894x(99)00278-4
CHEMBL295014 101151 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 438 3 1 3 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccsc3Cc3ccccc32)cc1 10.1016/s0960-894x(99)00278-4
14969557 204981 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 465 7 1 5 3.4 COC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL61154 204981 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 465 7 1 5 3.4 COC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14981575 78903 None 0 Rat Binding pIC50 = 6.4 6.4 - 1
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 582 10 1 7 2.1 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112896 78903 None 0 Rat Binding pIC50 = 6.4 6.4 - 1
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 582 10 1 7 2.1 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 10.1021/jm00031a004
11005810 10469 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL116463 10469 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10743786 163574 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 493 3 1 3 6.4 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(F)cc1Cl 10.1021/jm980179c
CHEMBL420031 163574 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 493 3 1 3 6.4 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(F)cc1Cl 10.1021/jm980179c
23598595 154893 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 542 5 2 3 7.0 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL400266 154893 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 542 5 2 3 7.0 O=C(O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
10437668 78911 None 1 Rat Binding pIC50 = 6.4 6.4 - 2
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 554 9 2 7 1.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112903 78911 None 1 Rat Binding pIC50 = 6.4 6.4 - 2
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 554 9 2 7 1.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 10.1021/jm00031a004
10459252 52667 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 517 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
CHEMBL159359 52667 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 517 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
2249 2227 None 17 Rat Binding pIC50 = 6.4 6.4 -30 7
Inhibition of rat liver V1a receptorInhibition of rat liver V1a receptor
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1016/j.bmcl.2012.10.116
9872389 2227 None 17 Rat Binding pIC50 = 6.4 6.4 -30 7
Inhibition of rat liver V1a receptorInhibition of rat liver V1a receptor
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1016/j.bmcl.2012.10.116
CHEMBL1253853 2227 None 17 Rat Binding pIC50 = 6.4 6.4 -30 7
Inhibition of rat liver V1a receptorInhibition of rat liver V1a receptor
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1016/j.bmcl.2012.10.116
14969527 205696 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 349 2 1 3 2.9 Nc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL64520 205696 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 349 2 1 3 2.9 Nc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969522 205774 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1cccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)c1 10.1021/jm00066a010
CHEMBL64836 205774 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1cccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)c1 10.1021/jm00066a010
CHEMBL2112247 211693 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
14969507 162450 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 335 2 0 3 2.7 O=C(c1ccncc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL416505 162450 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 335 2 0 3 2.7 O=C(c1ccncc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
10764664 206837 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 421 3 1 3 5.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
CHEMBL71797 206837 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 421 3 1 3 5.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1021/jm980179c
10764664 206837 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 421 3 1 3 5.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL71797 206837 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 421 3 1 3 5.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
118720289 115927 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354601 115927 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1029 20 11 14 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10524974 114124 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 1 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL332685 114124 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 1 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3ccccc32)cc1 10.1021/jm960133o
44428420 92226 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 538 10 0 5 5.6 CC(C)C[C@@H](C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL242517 92226 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 538 10 0 5 5.6 CC(C)C[C@@H](C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
86690936 149215 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 596 7 1 10 3.2 O=c1n(S(=O)(=O)c2ncnn2Cc2ccccc2C(F)(F)F)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
CHEMBL3943296 149215 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 596 7 1 10 3.2 O=c1n(S(=O)(=O)c2ncnn2Cc2ccccc2C(F)(F)F)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
118720259 115896 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1031 20 11 15 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccco2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354570 115896 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1031 20 11 15 -1.9 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccco2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10692311 164133 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL420880 164133 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 399 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N)c3ccccc32)cc1 10.1021/jm960133o
44336791 8126 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 527 6 3 4 4.5 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL109166 8126 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 527 6 3 4 4.5 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
9937535 63058 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788221 63058 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336799 107287 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 596 7 2 5 4.8 O=C(NCCN1CCOCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL316736 107287 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 596 7 2 5 4.8 O=C(NCCN1CCOCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
67409933 150153 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 554 8 1 7 5.5 COc1ccc(Cn2c(-c3ccc(Cl)cc3)nn(Cc3nnc(Cc4c(Cl)cccc4Cl)[nH]3)c2=O)cc1 nan
CHEMBL3950716 150153 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 554 8 1 7 5.5 COc1ccc(Cn2c(-c3ccc(Cl)cc3)nn(Cc3nnc(Cc4c(Cl)cccc4Cl)[nH]3)c2=O)cc1 nan
56848491 152508 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 651 9 3 8 4.7 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
CHEMBL3970631 152508 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 651 9 3 8 4.7 CC(C)(C)OC(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
56848624 160861 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 566 9 3 7 3.0 O=C(Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)N[C@@H](CO)Cc1cccc(C(F)(F)F)c1 nan
CHEMBL4114132 160861 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 566 9 3 7 3.0 O=C(Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)N[C@@H](CO)Cc1cccc(C(F)(F)F)c1 nan
10392505 108648 None 0 Human Binding pIC50 = 8.4 8.4 -4 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 539 3 1 3 6.6 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00649-2
CHEMBL320416 108648 None 0 Human Binding pIC50 = 8.4 8.4 -4 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 539 3 1 3 6.6 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00649-2
88064173 151715 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 530 7 1 6 5.4 O=c1n(Cc2nnc(Cc3c(Cl)cccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1CCC(F)(F)F nan
CHEMBL3963751 151715 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 530 7 1 6 5.4 O=c1n(Cc2nnc(Cc3c(Cl)cccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1CCC(F)(F)F nan
44428429 92228 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1cccc(Cl)c1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL242534 92228 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 571 10 1 4 5.9 CC(C)C[C@@H](C(=O)NCc1cccc(Cl)c1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44293777 188215 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 460 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1c(F)cccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL49824 188215 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 460 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1c(F)cccc1Cl 10.1016/s0960-894x(99)00279-6
44444761 94218 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 532 4 1 4 6.2 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
CHEMBL249536 94218 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 532 4 1 4 6.2 COC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3Cl)cc1)c1ccccc1C2 10.1016/j.bmcl.2007.09.059
44428418 92225 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 482 8 0 5 4.2 O=C(CN1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)OCc1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL242516 92225 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 482 8 0 5 4.2 O=C(CN1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)OCc1ccccc1 10.1016/j.bmc.2006.12.031
15307988 206820 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 450 3 1 3 6.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Sc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL71712 206820 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 450 3 1 3 6.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3Sc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL2112248 211694 None 0 Rat Binding pIC50 = 5.4 5.4 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O 10.1021/jm00099a019
2984025 12896 None 4 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 346 3 1 3 4.1 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccco1 10.1021/jm960133o
CHEMBL118892 12896 None 4 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 346 3 1 3 4.1 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccco1 10.1021/jm960133o
44428423 92349 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 578 10 0 7 4.5 CC1(C(C(=O)OCC[Si](C)(C)C)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
CHEMBL242733 92349 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 578 10 0 7 4.5 CC1(C(C(=O)OCC[Si](C)(C)C)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
44428430 93309 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 605 10 1 4 6.2 CC(C)C[C@@H](C(=O)NCc1cccc(C(F)(F)F)c1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL244865 93309 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 605 10 1 4 6.2 CC(C)C[C@@H](C(=O)NCc1cccc(C(F)(F)F)c1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44332269 167922 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 496 5 1 4 6.3 COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL430676 167922 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 496 5 1 4 6.3 COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
10692266 14135 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 398 3 1 2 5.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL119806 14135 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 398 3 1 2 5.6 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCCc3ccccc32)cc1 10.1021/jm960133o
172997 2332 None 49 Rat Binding pIC50 = 6.4 6.4 - 2
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(03)00388-3
2238 2332 None 49 Rat Binding pIC50 = 6.4 6.4 - 2
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(03)00388-3
CHEMBL49429 2332 None 49 Rat Binding pIC50 = 6.4 6.4 - 2
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(03)00388-3
DB06666 2332 None 49 Rat Binding pIC50 = 6.4 6.4 - 2
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(03)00388-3
19699133 119995 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 496 3 1 5 5.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)c3ccc(Cl)cc3Cl)cc1)CC2 10.1016/s0960-894x(00)00084-6
CHEMBL349506 119995 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 496 3 1 5 5.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)c3ccc(Cl)cc3Cl)cc1)CC2 10.1016/s0960-894x(00)00084-6
44273034 99102 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.3 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCC(=O)O)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL280356 99102 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.3 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCC(=O)O)C1=O)C2 10.1016/0960-894X(94)00469-V
44273459 73953 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 482 4 0 4 3.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C=CC1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL20205 73953 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 482 4 0 4 3.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C=CC1=O)C2 10.1016/0960-894X(94)00469-V
14969551 204639 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 6 1 4 2.8 CC(=O)NCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60954 204639 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 435 6 1 4 2.8 CC(=O)NCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969538 205741 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 406 6 0 3 4.5 CCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL64695 205741 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 406 6 0 3 4.5 CCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44428424 152677 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 567 9 1 6 3.9 CC1(C(C(=O)NCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
CHEMBL397188 152677 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 567 9 1 6 3.9 CC1(C(C(=O)NCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
15307999 101461 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 492 3 1 3 7.1 O=C(Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(99)00278-4
CHEMBL297293 101461 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 492 3 1 3 7.1 O=C(Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cc1)c1ccc(Cl)cc1Cl 10.1016/s0960-894x(99)00278-4
10648029 105476 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 3 1 3 6.2 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)c1C 10.1021/jm980179c
CHEMBL311931 105476 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 469 3 1 3 6.2 Cc1cccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)c1C 10.1021/jm980179c
977621 10091 None 7 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 322 4 1 2 4.0 CCCC(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL115434 10091 None 7 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 322 4 1 2 4.0 CCCC(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
9937535 63058 None 1 Rat Binding pIC50 = 6.4 6.4 - 0
Evaluated for binding affinity towards vasopressin receptor V1a in ratEvaluated for binding affinity towards vasopressin receptor V1a in rat
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL1788221 63058 None 1 Rat Binding pIC50 = 6.4 6.4 - 0
Evaluated for binding affinity towards vasopressin receptor V1a in ratEvaluated for binding affinity towards vasopressin receptor V1a in rat
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=C[C@@]2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
114904 2954 None 43 Rat Binding pIC50 = 6.4 6.4 7 7
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 7 1 4 3.2 CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 10.1021/jm00066a010
2196 2954 None 43 Rat Binding pIC50 = 6.4 6.4 7 7
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 7 1 4 3.2 CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 10.1021/jm00066a010
CHEMBL296908 2954 None 43 Rat Binding pIC50 = 6.4 6.4 7 7
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 449 7 1 4 3.2 CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 10.1021/jm00066a010
44352757 118518 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL341173 118518 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)C[C@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
14981581 78900 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 686 11 2 9 1.7 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCS(=O)(=O)CC2)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112893 78900 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 686 11 2 9 1.7 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCS(=O)(=O)CC2)C3(C)C)CC1 10.1021/jm00031a004
14969513 205678 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1cccc(Cl)c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL64434 205678 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1cccc(Cl)c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
10673699 106740 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 527 3 1 3 6.8 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1cccc(C(F)(F)F)c1F 10.1021/jm980179c
CHEMBL314344 106740 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 527 3 1 3 6.8 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1cccc(C(F)(F)F)c1F 10.1021/jm980179c
14306032 151596 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 568 9 0 7 4.3 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
CHEMBL396270 151596 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 568 9 0 7 4.3 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
10673295 104952 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 509 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL311230 104952 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 509 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
10835094 12090 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 404 3 1 2 5.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
CHEMBL118387 12090 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 404 3 1 2 5.6 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1Cl 10.1021/jm960133o
21837089 103865 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 451 5 1 4 5.3 CCOc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL309096 103865 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 451 5 1 4 5.3 CCOc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
86690916 151014 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 549 6 1 8 4.9 O=c1n(Cc2nnc(-c3ccccc3C(F)(F)F)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3957738 151014 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 549 6 1 8 4.9 O=c1n(Cc2nnc(-c3ccccc3C(F)(F)F)s2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
44332208 4246 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 504 3 1 2 7.6 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2004.02.103
CHEMBL100447 4246 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 504 3 1 2 7.6 O=C(Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2004.02.103
9951649 205196 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 377 3 0 3 3.3 CN(C)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL61906 205196 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 377 3 0 3 3.3 CN(C)c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
19699114 53392 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 434 3 1 5 4.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)C3CCCCC3)cc1)CC2 10.1016/s0960-894x(00)00084-6
CHEMBL160029 53392 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro binding affinity for rat V1a receptorIn vitro binding affinity for rat V1a receptor
ChEMBL 434 3 1 5 4.9 Cn1cc2c(n1)-c1sccc1N(C(=O)c1ccc(NC(=O)C3CCCCC3)cc1)CC2 10.1016/s0960-894x(00)00084-6
118720283 115919 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1022 20 10 12 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354593 115919 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1022 20 10 12 -1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
14969523 205577 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL64046 205577 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 392 3 0 4 3.2 CC(=O)Oc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44232512 115923 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354597 115923 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
67408780 152218 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 550 7 2 6 4.8 NC(=O)c1ccc(-c2ccccc2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O nan
CHEMBL3967902 152218 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 550 7 2 6 4.8 NC(=O)c1ccc(-c2ccccc2Cl)cc1Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O nan
44273013 99524 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 543 7 2 6 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCO)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL283126 99524 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 543 7 2 6 2.2 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCO)C1=O)C2 10.1016/0960-894X(94)00469-V
44428416 142979 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 566 9 0 6 5.2 CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL389363 142979 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 566 9 0 6 5.2 CC(C)(C)C(=O)C(C(=O)OCc1ccccc1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
10461417 107357 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL317243 107357 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 612 8 2 4 6.6 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336379 107473 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 582 8 2 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL318083 107473 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 582 8 2 4 5.8 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
44336784 109264 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 626 9 2 4 7.0 CN(C)CCCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL321656 109264 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 626 9 2 4 7.0 CN(C)CCCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336404 111022 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 568 7 2 4 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
CHEMBL326225 111022 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 568 7 2 4 5.4 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=C(C(=O)NCCN(C)C)CC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.04.016
56848623 151770 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 561 9 3 8 2.9 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
CHEMBL3964135 151770 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 561 9 3 8 2.9 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
11157078 94248 None 8 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL249741 94248 None 8 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 548 5 2 4 6.1 COc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
44335345 5173 None 0 Human Binding pIC50 = 8.3 8.3 -4 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 505 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(02)00649-2
CHEMBL105961 5173 None 0 Human Binding pIC50 = 8.3 8.3 -4 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 505 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1Cl 10.1016/s0960-894x(02)00649-2
53378731 153817 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 556 8 2 9 3.3 O=C(O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl nan
CHEMBL3981686 153817 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 556 8 2 9 3.3 O=C(O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl nan
44332272 107295 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)c1 10.1016/j.bmcl.2004.02.103
CHEMBL316849 107295 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1cccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)c1 10.1016/j.bmcl.2004.02.103
14969540 100862 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 362 3 0 2 3.8 CCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL293184 100862 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 362 3 0 2 3.8 CCc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
14969534 167987 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 412 2 0 2 4.0 O=C(c1ccc(Br)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL431159 167987 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 412 2 0 2 4.0 O=C(c1ccc(Br)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969517 202998 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL59896 202998 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
15307972 206807 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Compound was tested for the inhibition of [3H]AVP binding to Dawley rat kidney medullary Vasopressin V1a receptorCompound was tested for the inhibition of [3H]AVP binding to Dawley rat kidney medullary Vasopressin V1a receptor
ChEMBL 446 3 1 2 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL71626 206807 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Compound was tested for the inhibition of [3H]AVP binding to Dawley rat kidney medullary Vasopressin V1a receptorCompound was tested for the inhibition of [3H]AVP binding to Dawley rat kidney medullary Vasopressin V1a receptor
ChEMBL 446 3 1 2 6.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
56848685 151884 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 603 10 2 9 4.5 COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NCC(NC(=O)OC(C)(C)C)c2ccccc2C(F)(F)F)c1=O nan
CHEMBL3965109 151884 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 603 10 2 9 4.5 COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NCC(NC(=O)OC(C)(C)C)c2ccccc2C(F)(F)F)c1=O nan
CHEMBL340204 214091 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
44357890 168496 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards rat Vasopressin V1a receptor after peroral administration of the compoundBinding affinity towards rat Vasopressin V1a receptor after peroral administration of the compound
ChEMBL 462 5 1 3 6.0 Cc1ccccc1OCC(=O)Nc1ccc(C(=O)N2CCCCc3cc(Cl)ccc32)c(C)c1 10.1021/jm000108p
CHEMBL434654 168496 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards rat Vasopressin V1a receptor after peroral administration of the compoundBinding affinity towards rat Vasopressin V1a receptor after peroral administration of the compound
ChEMBL 462 5 1 3 6.0 Cc1ccccc1OCC(=O)Nc1ccc(C(=O)N2CCCCc3cc(Cl)ccc32)c(C)c1 10.1021/jm000108p
10762667 12820 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 385 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCN(C)c3ccccc32)cc1 10.1021/jm960133o
CHEMBL118829 12820 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 385 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCN(C)c3ccccc32)cc1 10.1021/jm960133o
10668163 13796 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccc(Cl)cc1 10.1021/jm960133o
CHEMBL119551 13796 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1ccc(Cl)cc1 10.1021/jm960133o
10927276 110684 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 391 2 1 4 3.2 O=C(OC1CCc2ccccc21)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
CHEMBL325674 110684 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 391 2 1 4 3.2 O=C(OC1CCc2ccccc21)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
44273425 98957 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.6 C[C@@H](O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL279281 98957 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.6 C[C@@H](O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
44428426 152681 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 598 9 0 5 5.4 CC(C)C[C@@H](C(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL397189 152681 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 598 9 0 5 5.4 CC(C)C[C@@H](C(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
10742418 104542 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 455 3 1 3 5.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
CHEMBL310416 104542 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.
ChEMBL 455 3 1 3 5.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
44303524 102220 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 7 0 4 3.5 CC(=O)N(C)CCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL302624 102220 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 7 0 4 3.5 CC(=O)N(C)CCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
10672170 207854 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
CHEMBL80029 207854 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 473 3 1 3 6.1 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
118719825 115813 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1032 20 10 14 -2.5 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](OC)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 10.1021/jm500365s
CHEMBL3353936 115813 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1032 20 10 14 -2.5 CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](OC)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 10.1021/jm500365s
11740743 14113 None 0 Rat Binding pIC50 = 7.3 7.3 - 3
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 3 1 2 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL119793 14113 None 0 Rat Binding pIC50 = 7.3 7.3 - 3
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 384 3 1 2 5.2 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/jm960133o
21837086 169553 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 425 3 1 3 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1F 10.1016/s0960-894x(03)00388-3
CHEMBL442743 169553 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 425 3 1 3 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1F 10.1016/s0960-894x(03)00388-3
15307971 207015 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 418 3 1 2 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL72945 207015 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 418 3 1 2 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3ccccc3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
10436379 74205 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 510 6 2 4 3.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 10.1016/0960-894X(94)00469-V
CHEMBL20230 74205 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 510 6 2 4 3.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 10.1016/0960-894X(94)00469-V
53378951 144868 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 507 6 1 5 5.7 O=c1n(Cc2cccc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
CHEMBL3909196 144868 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 507 6 1 5 5.7 O=c1n(Cc2cccc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F nan
CHEMBL129733 211141 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10742418 104542 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 455 3 1 3 5.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
CHEMBL310416 104542 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 455 3 1 3 5.9 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 10.1021/jm980179c
22099567 101394 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [3H]- AVP binding to rat V1a receptorIn vitro inhibition of [3H]- AVP binding to rat V1a receptor
ChEMBL 457 3 1 4 5.6 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00278-4
CHEMBL296814 101394 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [3H]- AVP binding to rat V1a receptorIn vitro inhibition of [3H]- AVP binding to rat V1a receptor
ChEMBL 457 3 1 4 5.6 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00278-4
44335241 168101 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 575 4 1 3 8.0 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(CC5)N4Cc4cc(Cl)ccc43)cc2)cc1 10.1016/s0960-894x(02)00649-2
CHEMBL432009 168101 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 575 4 1 3 8.0 Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3C[C@@H]4C5CCC(CC5)N4Cc4cc(Cl)ccc43)cc2)cc1 10.1016/s0960-894x(02)00649-2
9824954 73886 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 449 2 1 5 5.5 Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.10.107
CHEMBL201889 73886 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 449 2 1 5 5.5 Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.10.107
44336636 164260 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 585 7 3 4 6.0 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL421039 164260 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 585 7 3 4 6.0 O=C(NCCO)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44213442 102085 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 460 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccc(F)cc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL301788 102085 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 460 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccc(F)cc1Cl 10.1016/s0960-894x(99)00279-6
10837633 103079 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 459 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(F)cc1Cl 10.1021/jm980179c
CHEMBL306970 103079 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 459 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(F)cc1Cl 10.1021/jm980179c
69940338 150717 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 497 6 1 7 4.2 O=c1n(Cc2cn(-c3ccccc3Cl)cn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3955416 150717 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 497 6 1 7 4.2 O=c1n(Cc2cn(-c3ccccc3Cl)cn2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
121301508 176323 None 5 Human Binding pIC50 = 8.2 8.2 -1 3
Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
CHEMBL4594444 176323 None 5 Human Binding pIC50 = 8.2 8.2 -1 3
Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
71146879 146223 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 498 6 2 7 3.8 O=c1n(Cc2nnc(-c3ccccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3919631 146223 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 498 6 2 7 3.8 O=c1n(Cc2nnc(-c3ccccc3Cl)[nH]2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
87388676 151955 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 533 6 1 8 4.4 O=c1n(Cc2nc(-c3ccccc3C(F)(F)F)no2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3965602 151955 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 533 6 1 8 4.4 O=c1n(Cc2nc(-c3ccccc3C(F)(F)F)no2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
14981577 78908 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 636 11 2 7 3.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCCCC2)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112900 78908 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 636 11 2 7 3.5 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCCCC2)C3(C)C)CC1 10.1021/jm00031a004
9805972 98668 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](N)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL276990 98668 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](N)C1=O)C2 10.1016/0960-894X(94)00469-V
14306046 151597 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 552 8 0 7 3.5 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)c4ccccc4C3=O)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
CHEMBL396271 151597 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 552 8 0 7 3.5 CC1(C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](N3C(=O)c4ccccc4C3=O)[C@H]2/C=C/c2ccccc2)OCCO1 10.1016/j.bmc.2006.12.031
14969535 203606 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 364 3 0 3 3.3 COc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60323 203606 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 364 3 0 3 3.3 COc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
56848488 149643 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 609 10 3 8 3.3 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
CHEMBL3946734 149643 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 609 10 3 8 3.3 NC(=O)OCC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(C(F)(F)F)c1 nan
22405325 133629 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 427 4 0 4 5.5 CN(C)Cc1ccc2n1Cc1ccccc1N(C(=O)c1ccc(-c3cccs3)cc1)C2 10.1016/j.bmcl.2005.08.007
CHEMBL371055 133629 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 427 4 0 4 5.5 CN(C)Cc1ccc2n1Cc1ccccc1N(C(=O)c1ccc(-c3cccs3)cc1)C2 10.1016/j.bmcl.2005.08.007
10762739 114447 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 3 1 3 4.4 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCOCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL333135 114447 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 386 3 1 3 4.4 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCOCc3ccccc32)cc1 10.1021/jm960133o
14969525 203584 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1cccc(O)c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL60312 203584 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 350 2 1 3 3.0 O=C(c1cccc(O)c1)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
22405327 140363 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 409 3 0 4 5.3 O=C(c1ccc(-c2ccccc2[N+](=O)[O-])cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
CHEMBL380579 140363 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 409 3 0 4 5.3 O=C(c1ccc(-c2ccccc2[N+](=O)[O-])cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
118720286 115924 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354598 115924 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1038 21 11 13 -1.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
10673295 104952 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 509 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
CHEMBL311230 104952 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.
ChEMBL 509 3 1 3 6.9 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1)c1ccc(Cl)cc1Cl 10.1021/jm980179c
10548464 15388 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccc(Cl)c1 10.1021/jm960133o
CHEMBL121455 15388 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 390 3 1 2 5.2 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cccc(Cl)c1 10.1021/jm960133o
71450903 78909 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 614 12 3 9 0.8 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(CO)CO)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112901 78909 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 614 12 3 9 0.8 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(CO)CO)C3(C)C)CC1 10.1021/jm00031a004
10939174 10031 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 443 3 1 6 3.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
CHEMBL115076 10031 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of human V1A vasopressin receptorInhibition of human V1A vasopressin receptor
ChEMBL 443 3 1 6 3.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm010878g
118719823 115811 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1033 19 10 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](SC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353934 115811 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1033 19 10 14 -2.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](SC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
14969548 204588 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 477 11 1 4 4.9 NCCCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL60905 204588 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 477 11 1 4 4.9 NCCCCCCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
44335386 108066 None 0 Human Binding pIC50 = 7.2 7.2 -14 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 489 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1F 10.1016/s0960-894x(02)00649-2
CHEMBL319433 108066 None 0 Human Binding pIC50 = 7.2 7.2 -14 2
Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptorInhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor
ChEMBL 489 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2C[C@@H]3C4CCC(C4)N3Cc3cc(Cl)ccc32)cc1)c1ccccc1F 10.1016/s0960-894x(02)00649-2
14981578 78904 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 638 11 2 8 2.3 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCOCC2)C3(C)C)CC1 10.1021/jm00031a004
CHEMBL2112897 78904 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 638 11 2 8 2.3 Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCOCC2)C3(C)C)CC1 10.1021/jm00031a004
44336418 108243 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 569 6 2 5 5.0 COC(=O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3C)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL319636 108243 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 569 6 2 5 5.0 COC(=O)CNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3cc(F)ccc3C)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336402 168234 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 594 7 2 4 6.0 O=C(NCCN1CCCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL432973 168234 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 594 7 2 4 6.0 O=C(NCCN1CCCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
56848625 145281 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 9 3 8 3.5 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(Cl)c1Cl nan
CHEMBL3912406 145281 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 9 3 8 3.5 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1cccc(Cl)c1Cl nan
18917497 101775 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 486 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1Br 10.1016/s0960-894x(99)00279-6
CHEMBL299532 101775 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 486 3 1 4 5.1 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1Br 10.1016/s0960-894x(99)00279-6
10837633 103079 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 459 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(F)cc1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL306970 103079 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 459 3 1 3 5.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccc(F)cc1Cl 10.1016/s0960-894x(03)00388-3
11282041 88599 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Activity at vasopressin V1A receptorActivity at vasopressin V1A receptor
ChEMBL 437 4 2 4 2.8 Cc1ccc(C(=O)N2CC3CNCC(C2)O3)cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm700949w
CHEMBL235393 88599 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Activity at vasopressin V1A receptorActivity at vasopressin V1A receptor
ChEMBL 437 4 2 4 2.8 Cc1ccc(C(=O)N2CC3CNCC(C2)O3)cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm700949w
44434716 148481 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Activity at vasopressin V1A receptorActivity at vasopressin V1A receptor
ChEMBL 457 4 2 4 3.1 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)N2CC3CNCC(C2)O3)ccc1Cl 10.1021/jm700949w
CHEMBL393754 148481 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Activity at vasopressin V1A receptorActivity at vasopressin V1A receptor
ChEMBL 457 4 2 4 3.1 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)N2CC3CNCC(C2)O3)ccc1Cl 10.1021/jm700949w
10716676 110474 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 413 4 2 3 4.9 CNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL324488 110474 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 413 4 2 3 4.9 CNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
9871426 117075 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
CHEMBL338901 117075 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 522 6 2 4 6.6 O=C(O)CC1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1 10.1016/j.bmcl.2003.08.051
118719843 115831 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccn2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353954 115831 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1056 21 11 15 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccn2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL2112654 211702 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
44332237 108655 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL320462 108655 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 450 3 1 2 6.6 Cc1ccc(C(=O)Nc2ccc(C(=O)N3CCC4(C=CCCC4)Cc4ccccc43)cc2)cc1 10.1016/j.bmcl.2004.02.103
118720274 115910 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
CHEMBL3354584 115910 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 974 21 10 12 -1.9 CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm500365s
579 3144 None 18 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity to V1a receptorBinding affinity to V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
6918468 3144 None 18 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity to V1a receptorBinding affinity to V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
CHEMBL41547 3144 None 18 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity to V1a receptorBinding affinity to V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
CHEMBL2371928 212613 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity to V1a receptorBinding affinity to V1a receptor
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2006.07.036
CHEMBL1790937 211365 None 0 Rat Binding pIC50 = 5.1 5.1 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
669479 113548 None 9 Rat Binding pIC50 = 4.1 4.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 294 2 1 2 3.2 CC(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL331956 113548 None 9 Rat Binding pIC50 = 4.1 4.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 294 2 1 2 3.2 CC(=O)Nc1ccc(C(=O)N2CCCc3ccccc32)cc1 10.1021/jm960133o
14969544 102717 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 407 6 1 4 3.0 NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL304486 102717 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 407 6 1 4 3.0 NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL2112250 211696 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O 10.1021/jm00099a019
10810133 113867 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 385 3 2 2 5.3 O=C(Nc1ccccc1)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/jm960133o
CHEMBL332450 113867 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 385 3 2 2 5.3 O=C(Nc1ccccc1)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/jm960133o
10595449 10519 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 372 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCOc3ccccc32)cc1 10.1021/jm960133o
CHEMBL116820 10519 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 372 3 1 3 4.3 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCOc3ccccc32)cc1 10.1021/jm960133o
3537 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2005.10.107
5311500 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2005.10.107
CHEMBL363910 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2005.10.107
3537 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2007.08.053
5311500 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2007.08.053
CHEMBL363910 4004 None 22 Human Binding pIC50 = 6.1 6.1 -9 3
Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 402 2 0 4 4.8 Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 10.1016/j.bmcl.2007.08.053
44428425 142194 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 626 11 0 5 6.0 CC(C)C[C@@H](C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL388253 142194 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 626 11 0 5 6.0 CC(C)C[C@@H](C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
14969556 205679 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 8 1 4 3.6 CCC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
CHEMBL64436 205679 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 463 8 1 4 3.6 CCC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1 10.1021/jm00066a010
10548205 12712 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).
ChEMBL 386 3 1 3 5.3 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)Oc1ccccc1 10.1021/jm960133o
CHEMBL118760 12712 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).Compound was tested for its ability to displace [3H]AVP from its specific binding sites in Rat liver (AVP-V1a receptor).
ChEMBL 386 3 1 3 5.3 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)Oc1ccccc1 10.1021/jm960133o
9829108 5238 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL106293 5238 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 554 7 2 4 5.1 CN(C)CCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
44336403 5384 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 580 7 2 4 5.6 O=C(NCCN1CCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
CHEMBL107058 5384 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorBinding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor
ChEMBL 580 7 2 4 5.6 O=C(NCCN1CCCC1)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 10.1016/j.bmcl.2004.04.016
56848622 148028 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 9 3 8 3.3 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
CHEMBL3933782 148028 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 9 3 8 3.3 NC(=O)OC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1C(F)(F)F nan
56848554 151934 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 10 3 8 2.3 CS(=O)(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
CHEMBL3965460 151934 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular in Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtitre plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtitre plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 595 10 3 8 2.3 CS(=O)(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C[C@H](O)C(F)(F)F)c1=O)c1ccccc1Cl nan
11238362 169011 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 562 6 2 4 6.5 CCOc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
CHEMBL438523 169011 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 562 6 2 4 6.5 CCOc1cc(C(=O)N2CC[C@]3(C=C(C(=O)O)CC3)Cc3ccccc32)ccc1NC(=O)c1cc(F)ccc1Cl 10.1016/j.bmcl.2007.09.059
10322392 4693 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 468 3 1 2 6.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
CHEMBL103406 4693 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptorIn vitro inhibitory concentration against [3H]AVP binding to cloned human vasopressin V1a receptor
ChEMBL 468 3 1 2 6.7 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CCC3(C=CCCC3)Cc3ccccc32)cc1 10.1016/j.bmcl.2004.02.103
15308000 187450 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 438 3 1 3 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cc1 10.1016/s0960-894x(99)00278-4
CHEMBL49322 187450 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneIn vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane
ChEMBL 438 3 1 3 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3sccc3Cc3ccccc32)cc1 10.1016/s0960-894x(99)00278-4
69940428 149959 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 568 8 2 7 5.2 O=C(O)c1cccc(Cn2c(-c3ccc(Cl)cc3)nn(Cc3nnc(Cc4c(Cl)cccc4Cl)[nH]3)c2=O)c1 nan
CHEMBL3949118 149959 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 568 8 2 7 5.2 O=C(O)c1cccc(Cn2c(-c3ccc(Cl)cc3)nn(Cc3nnc(Cc4c(Cl)cccc4Cl)[nH]3)c2=O)c1 nan
CHEMBL338308 214067 None 0 Rat Binding pIC50 = 6.1 6.1 - 2
Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O 10.1021/jm00099a019
172997 2332 None 49 Rat Binding pIC50 = 7.1 7.1 - 2
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00279-6
2238 2332 None 49 Rat Binding pIC50 = 7.1 7.1 - 2
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00279-6
CHEMBL49429 2332 None 49 Rat Binding pIC50 = 7.1 7.1 - 2
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00279-6
DB06666 2332 None 49 Rat Binding pIC50 = 7.1 7.1 - 2
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 473 3 1 3 6.1 Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C 10.1016/s0960-894x(99)00279-6
44294175 101894 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 520 3 1 4 5.8 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(Br)ccc1Cl 10.1016/s0960-894x(99)00279-6
CHEMBL300433 101894 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 520 3 1 4 5.8 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1cc(Br)ccc1Cl 10.1016/s0960-894x(99)00279-6
44374781 53197 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 486 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2CCCCc3sc(Cl)cc32)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
CHEMBL159856 53197 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 486 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2CCCCc3sc(Cl)cc32)cc1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
53378729 142542 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 473 7 0 6 5.2 C=CCn1c(-c2ccc(Cl)cc2)nn(Cc2cncn2Cc2c(Cl)cccc2Cl)c1=O nan
CHEMBL3890193 142542 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 473 7 0 6 5.2 C=CCn1c(-c2ccc(Cl)cc2)nn(Cc2cncn2Cc2c(Cl)cccc2Cl)c1=O nan
14969518 205142 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1ccccc1[N+](=O)[O-])N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL61578 205142 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 379 3 0 4 3.2 O=C(c1ccccc1[N+](=O)[O-])N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
14969515 205664 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1ccccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL64375 205664 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 348 2 0 2 3.6 Cc1ccccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
44428432 92073 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 654 10 0 6 5.6 CC(C)(C)C(=O)[C@@H](C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@H]2c2ccccc2)C1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL241859 92073 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 654 10 0 6 5.6 CC(C)(C)C(=O)[C@@H](C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@H]2c2ccccc2)C1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44310140 206925 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 423 3 2 4 4.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1O 10.1016/s0960-894x(03)00388-3
CHEMBL72342 206925 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 423 3 2 4 4.7 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1ccccc1O 10.1016/s0960-894x(03)00388-3
22405331 135409 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 400 2 0 2 5.6 O=C(c1ccc(-c2cc(F)cc(F)c2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
CHEMBL372766 135409 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 400 2 0 2 5.6 O=C(c1ccc(-c2cc(F)cc(F)c2)cc1)N1Cc2cccn2Cc2ccccc21 10.1016/j.bmcl.2005.08.007
21467141 119731 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 486 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2CCCCc3sccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
CHEMBL347020 119731 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to human V1a receptorIn vitro binding affinity to human V1a receptor
ChEMBL 486 4 1 3 7.3 O=C(Nc1ccc(C(=O)N2CCCCc3sccc32)c(Cl)c1)c1ccccc1-c1ccccc1 10.1016/s0960-894x(00)00084-6
44272960 73290 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 527 6 1 5 3.2 CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL20126 73290 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 527 6 1 5 3.2 CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
69940091 148005 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 508 6 1 6 5.1 O=c1n(Cc2ccnc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3933604 148005 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 508 6 1 6 5.1 O=c1n(Cc2ccnc(-c3ccccc3Cl)c2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
10156521 72500 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 378 2 0 2 5.7 Cc1ccccc1-c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/j.bmcl.2005.08.007
CHEMBL198931 72500 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor
ChEMBL 378 2 0 2 5.7 Cc1ccccc1-c1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/j.bmcl.2005.08.007
118719837 115825 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1059 20 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353948 115825 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1059 20 11 14 -1.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
8105663 13434 None 2 Rat Binding pIC50 = 4.1 4.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 356 3 1 2 4.5 O=C(Nc1ccccc1C(=O)N1CCCc2ccccc21)c1ccccc1 10.1021/jm960133o
CHEMBL119291 13434 None 2 Rat Binding pIC50 = 4.1 4.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 356 3 1 2 4.5 O=C(Nc1ccccc1C(=O)N1CCCc2ccccc21)c1ccccc1 10.1021/jm960133o
69940642 151868 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 509 6 1 7 4.4 O=c1n(Cc2ccnc(-c3ccccc3Cl)n2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
CHEMBL3964983 151868 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 509 6 1 7 4.4 O=c1n(Cc2ccnc(-c3ccccc3Cl)n2)nc(-c2ccc(Cl)cc2)n1C[C@H](O)C(F)(F)F nan
10765617 12457 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 6 2 3 5.7 CCCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL118609 12457 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 441 6 2 3 5.7 CCCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
71449109 78910 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 565 8 2 6 2.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2 10.1021/jm00031a004
CHEMBL2112902 78910 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liverDisplacement of [3H]AVP from binding to arginine vasopressin 1a (V1a) column of rat liver
ChEMBL 565 8 2 6 2.4 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2 10.1021/jm00031a004
44213443 177123 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 440 3 1 4 4.8 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
CHEMBL46295 177123 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 440 3 1 4 4.8 Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
23598641 94330 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 528 5 2 3 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2007.09.059
CHEMBL250346 94330 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsDisplacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells
ChEMBL 528 5 2 3 6.9 O=C(Nc1ccc(C(=O)N2CCC3(C=C(CO)CC3)Cc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2007.09.059
21837162 102588 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 453 4 1 4 5.7 CSc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL304060 102588 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 453 4 1 4 5.7 CSc1ccccc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
18917508 188189 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 453 4 1 6 4.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(99)00279-6
CHEMBL49796 188189 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 453 4 1 6 4.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cn1)c1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(99)00279-6
69940703 146287 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 490 6 0 6 5.8 O=c1n(Cc2ncc(Cc3cccc(C(F)(F)F)c3)s2)nc(-c2ccc(Cl)cc2)n1C1CC1 nan
CHEMBL3920097 146287 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 490 6 0 6 5.8 O=c1n(Cc2ncc(Cc3cccc(C(F)(F)F)c3)s2)nc(-c2ccc(Cl)cc2)n1C1CC1 nan
67412584 150865 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 473 6 1 5 5.1 O=c1n(Cc2ncc(Cc3cccc(C(F)(F)F)c3)[nH]2)nc(-c2ccc(Cl)cc2)n1C1CC1 nan
CHEMBL3956553 150865 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.Cellular In Vitro Assay: On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates and kept in a cell incubator (96% humidity, 5% v/v CO2, 37° C.). On the day of the assay, the culture medium is replaced by a Tyrode solution (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 20 mM glucose, 20 mM HEPES), which additionally contains the cofactor coelenterazine (50 μM), and the microtiter plate is then incubated for a further 3-4 hours. The test substances in various concentrations are placed for 10 to 20 minutes in the wells of the microtiter plate before the agonist [Arg8]-vasopressin is added, and the resulting light signal is measured immediately in the luminometer.
ChEMBL 473 6 1 5 5.1 O=c1n(Cc2ncc(Cc3cccc(C(F)(F)F)c3)[nH]2)nc(-c2ccc(Cl)cc2)n1C1CC1 nan
44310163 102278 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1c(Cl)cccc1Cl 10.1016/s0960-894x(03)00388-3
CHEMBL302955 102278 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 475 3 1 3 6.3 O=C(Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1)c1c(Cl)cccc1Cl 10.1016/s0960-894x(03)00388-3
10741034 13941 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 424 3 1 2 5.8 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cc(Cl)cc(Cl)c1 10.1021/jm960133o
CHEMBL119651 13941 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 424 3 1 2 5.8 O=C(Nc1ccc(C(=O)N2CCCc3ccccc32)cc1)c1cc(Cl)cc(Cl)c1 10.1021/jm960133o
44272990 99660 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](O)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL283994 99660 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 500 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](O)C1=O)C2 10.1016/0960-894X(94)00469-V
10595343 114489 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.9 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1 10.1021/jm960133o
CHEMBL333201 114489 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 370 3 1 2 4.9 O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1 10.1021/jm960133o
44352783 116845 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 508 6 2 4 6.5 O=C(Nc1ccc(C(=O)N2CCC(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
CHEMBL337725 116845 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to displace [3H]arginine vasopressin in cloned human V1a receptorAbility to displace [3H]arginine vasopressin in cloned human V1a receptor
ChEMBL 508 6 2 4 6.5 O=C(Nc1ccc(C(=O)N2CCC(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2003.08.051
118719838 115826 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1071 21 11 15 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(OC)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3353949 115826 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 1071 21 11 15 -1.5 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(OC)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
44272997 71745 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 10.1016/0960-894X(94)00469-V
CHEMBL19658 71745 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 499 4 1 5 2.6 CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 10.1016/0960-894X(94)00469-V
44212554 103730 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3ccccc3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
CHEMBL308741 103730 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.
ChEMBL 432 3 1 2 6.1 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCc3ccccc3-c3ccccc32)cc1 10.1016/s0960-894x(03)00388-3
10743970 113128 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 499 7 1 5 5.2 CCOC(=O)CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
CHEMBL331173 113128 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [3H]AVP from AVP-V1a receptor binding site in rat liverDisplacement of [3H]AVP from AVP-V1a receptor binding site in rat liver
ChEMBL 499 7 1 5 5.2 CCOC(=O)CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc21 10.1021/jm960133o
18917554 189930 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 497 5 1 5 4.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3ccc(CN(C)C)n3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
CHEMBL51645 189930 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorDisplacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor
ChEMBL 497 5 1 5 4.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3ccc(CN(C)C)n3Cc3ccccc32)cn1 10.1016/s0960-894x(99)00279-6
118720265 115902 None 0 Human Binding pIC50 = 6 6.0 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 11 14 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
CHEMBL3354576 115902 None 0 Human Binding pIC50 = 6 6.0 - 0
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assayAntagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL 991 21 11 14 -3.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm500365s
44273426 77135 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.6 C[C@H](CO)NC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
CHEMBL20757 77135 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptorInhibition of binding of [3H]vasopressin to rat liver vasopressin V1a receptor
ChEMBL 557 7 2 6 2.6 C[C@H](CO)NC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O 10.1016/0960-894X(94)00469-V
14969512 100860 None 0 Rat Binding pIC50 = 5 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1ccccc1Cl)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
CHEMBL293177 100860 None 0 Rat Binding pIC50 = 5 5.0 - 0
Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)Ability to displace [3H]- Arginine Vasopressin (AVP) from its specific binding sites in rat liver (V1 receptor)
ChEMBL 368 2 0 2 3.9 O=C(c1ccccc1Cl)N1CCC(N2C(=O)CCc3ccccc32)CC1 10.1021/jm00066a010
44297517 155816 None 0 Rat Binding pKd = 10.4 10.4 28 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL405440 155816 None 0 Rat Binding pKd = 10.4 10.4 28 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297525 96862 None 0 Rat Binding pKd = 10.3 10.3 10 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL265048 96862 None 0 Rat Binding pKd = 10.3 10.3 10 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297516 161385 None 0 Rat Binding pKd = 9.8 9.8 22 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL412192 161385 None 0 Rat Binding pKd = 9.8 9.8 22 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
71461726 79723 None 0 Rat Binding pKd = 9.7 9.7 257 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2115369 79723 None 0 Rat Binding pKd = 9.7 9.7 257 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
71461726 79723 None 0 Rat Binding pKd = 9.7 9.7 257 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2115369 79723 None 0 Rat Binding pKd = 9.7 9.7 257 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
71449189 79721 None 0 Rat Binding pKd = 9.7 9.7 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2115365 79721 None 0 Rat Binding pKd = 9.7 9.7 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
44297505 165952 None 0 Rat Binding pKd = 9.7 9.7 7 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL424905 165952 None 0 Rat Binding pKd = 9.7 9.7 7 3
Tested for dissociation constant at V1a receptor of rat liver membraneTested for dissociation constant at V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
71449189 79721 None 0 Rat Binding pKd = 9.7 9.7 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2115365 79721 None 0 Rat Binding pKd = 9.7 9.7 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
71461726 79723 None 0 Rat Binding pKd = 9.6 9.6 257 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2115369 79723 None 0 Rat Binding pKd = 9.6 9.6 257 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
71461726 79723 None 0 Rat Binding pKd = 9.6 9.6 257 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2115369 79723 None 0 Rat Binding pKd = 9.6 9.6 257 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
145981637 166588 None 0 Human Binding pKd = 9.5 9.5 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4278500 166588 None 0 Human Binding pKd = 9.5 9.5 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
70689895 74545 None 0 Rat Binding pKd = 9.5 9.5 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
CHEMBL2028983 74545 None 0 Rat Binding pKd = 9.5 9.5 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
70689895 74545 None 0 Rat Binding pKd = 9.5 9.5 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
CHEMBL2028983 74545 None 0 Rat Binding pKd = 9.5 9.5 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
145986380 167189 None 0 Human Binding pKd = 9.4 9.4 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4289837 167189 None 0 Human Binding pKd = 9.4 9.4 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
71458135 79720 None 0 Rat Binding pKd = 9.3 9.3 123 2
Negative log of Kd.Negative log of Kd.
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115364 79720 None 0 Rat Binding pKd = 9.3 9.3 123 2
Negative log of Kd.Negative log of Kd.
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71458135 79720 None 0 Rat Binding pKd = 9.3 9.3 123 2
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115364 79720 None 0 Rat Binding pKd = 9.3 9.3 123 2
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
145993846 167476 None 0 Human Binding pKd = 9.2 9.2 - 1
Binding affinity to human V1A receptor expressed in CHO cell membranesBinding affinity to human V1A receptor expressed in CHO cell membranes
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4294901 167476 None 0 Human Binding pKd = 9.2 9.2 - 1
Binding affinity to human V1A receptor expressed in CHO cell membranesBinding affinity to human V1A receptor expressed in CHO cell membranes
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
71458135 79720 None 0 Rat Binding pKd = 9.2 9.2 123 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115364 79720 None 0 Rat Binding pKd = 9.2 9.2 123 2
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71458135 79720 None 0 Rat Binding pKd = 9.2 9.2 123 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115364 79720 None 0 Rat Binding pKd = 9.2 9.2 123 2
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
2168 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
2810 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
644077 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
644077.0 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
CHEMBL373742 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
DB00067 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Binding potency against V1 receptor in rat liver cellsBinding potency against V1 receptor in rat liver cells
ChEMBL None None None None 10.1021/jm00079a020
2168 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
2810 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
644077 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
644077.0 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
CHEMBL373742 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
DB00067 3976 None 29 Rat Binding pKd = 9.2 9.2 -8 9
Negative log of Kd.Negative log of Kd.
ChEMBL None None None None 10.1021/jm00079a020
70689895 74545 None 0 Rat Binding pKd = 9.0 9.0 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
CHEMBL2028983 74545 None 0 Rat Binding pKd = 9.0 9.0 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
70689895 74545 None 0 Rat Binding pKd = 9.0 9.0 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
CHEMBL2028983 74545 None 0 Rat Binding pKd = 9.0 9.0 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1326 27 14 17 -0.4 C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCC/N=C(/N)c1ccc(N=[N+]=[N-])cc1)C(N)=O)N(C)C(=O)[C@H]1CSSCC2(CCCC2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm00079a020
145993846 167476 None 0 Human Binding pKd = 9 9.0 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4294901 167476 None 0 Human Binding pKd = 9 9.0 - 1
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
71454576 79722 None 0 Rat Binding pKd = 8.8 8.8 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115368 79722 None 0 Rat Binding pKd = 8.8 8.8 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71454576 79722 None 0 Rat Binding pKd = 8.8 8.8 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115368 79722 None 0 Rat Binding pKd = 8.8 8.8 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71454576 79722 None 0 Rat Binding pKd = 8.7 8.7 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115368 79722 None 0 Rat Binding pKd = 8.7 8.7 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71454576 79722 None 0 Rat Binding pKd = 8.7 8.7 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115368 79722 None 0 Rat Binding pKd = 8.7 8.7 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1174 20 11 16 0.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
71312201 115451 None 11 Rat Binding pKd = 8.0 8.0 -1 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1074 19 11 15 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL3350118 115451 None 11 Rat Binding pKd = 8.0 8.0 -1 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1074 19 11 15 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
118718751 115454 None 0 Rat Binding pKd = 7.9 7.9 1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1151 19 12 15 -2.3 CN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
CHEMBL3350123 115454 None 0 Rat Binding pKd = 7.9 7.9 1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1151 19 12 15 -2.3 CN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
118718384 115410 None 0 Rat Binding pKd = 6.8 6.8 -7 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1154 18 12 16 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349465 115410 None 0 Rat Binding pKd = 6.8 6.8 -7 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1154 18 12 16 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL2372422 212703 None 0 Rat Binding pKd = 7.8 7.8 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None [N-]=[N+]=Nc1ccc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2372422 212703 None 0 Rat Binding pKd = 7.8 7.8 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None [N-]=[N+]=Nc1ccc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)cc1 10.1021/jm00079a020
136961688 118657 None 0 Human Binding pKd = 7.7 7.7 -14 3
Binding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 1206 23 5 13 7.4 CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCNC(=O)CCc2ccc(S(=O)(=O)N(CC(=O)N/N=C3\C(=O)Nc4ccccc43)c3ccc(Cl)cc3)cc2)c2cc(S(=O)(=O)O)ccc21 10.1021/jm501395b
CHEMBL3416750 118657 None 0 Human Binding pKd = 7.7 7.7 -14 3
Binding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 1206 23 5 13 7.4 CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCNC(=O)CCc2ccc(S(=O)(=O)N(CC(=O)N/N=C3\C(=O)Nc4ccccc43)c3ccc(Cl)cc3)cc2)c2cc(S(=O)(=O)O)ccc21 10.1021/jm501395b
118718750 115453 None 0 Rat Binding pKd = 8.6 8.6 8 2
Compound was evaluated for the anti-vasopressor activity at V1a receptor.. Compound was evaluated for the anti-vasopressor activity at V1a receptor..
ChEMBL 1151 19 12 15 -2.3 CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
CHEMBL3350120 115453 None 0 Rat Binding pKd = 8.6 8.6 8 2
Compound was evaluated for the anti-vasopressor activity at V1a receptor.. Compound was evaluated for the anti-vasopressor activity at V1a receptor..
ChEMBL 1151 19 12 15 -2.3 CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
CHEMBL2372416 212697 None 0 Rat Binding pKd = 8.6 8.6 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2372416 212697 None 0 Rat Binding pKd = 8.6 8.6 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC1=O 10.1021/jm00079a020
71449189 79721 None 0 Rat Binding pKd = 8.6 8.6 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2115365 79721 None 0 Rat Binding pKd = 8.6 8.6 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
71449189 79721 None 0 Rat Binding pKd = 8.6 8.6 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2115365 79721 None 0 Rat Binding pKd = 8.6 8.6 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1203 22 11 16 1.1 CCC1(CC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC1=O 10.1021/jm00079a020
CHEMBL2372420 212701 None 0 Rat Binding pKd = 7.6 7.6 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372420 212701 None 0 Rat Binding pKd = 7.6 7.6 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
118718748 115450 None 0 Rat Binding pKd = 7.6 7.6 -1 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1126 19 13 14 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL3350116 115450 None 0 Rat Binding pKd = 7.6 7.6 -1 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1126 19 13 14 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
10011419 115456 None 0 Rat Binding pKd = 7.6 7.6 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1092 17 11 13 -1.0 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL3350125 115456 None 0 Rat Binding pKd = 7.6 7.6 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1092 17 11 13 -1.0 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00010a020
118718386 115412 None 0 Rat Binding pKd = 6.6 6.6 -12 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 991 14 10 14 -0.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349467 115412 None 0 Rat Binding pKd = 6.6 6.6 -12 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 991 14 10 14 -0.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
118718747 115449 None 0 Rat Binding pKd = 7.5 7.5 -2 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1126 19 13 14 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL3350115 115449 None 0 Rat Binding pKd = 7.5 7.5 -2 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1126 19 13 14 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL2372415 212696 None 0 Rat Binding pKd = 8.5 8.5 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C2(CCCC2)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372415 212696 None 0 Rat Binding pKd = 8.5 8.5 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)C2(CCCC2)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
118718383 115409 None 0 Rat Binding pKd = 6.5 6.5 -16 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1000 14 11 13 0.2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349464 115409 None 0 Rat Binding pKd = 6.5 6.5 -16 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1000 14 11 13 0.2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL2372421 212702 None 0 Rat Binding pKd = 7.5 7.5 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None [N-]=[N+]=Nc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2372421 212702 None 0 Rat Binding pKd = 7.5 7.5 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None [N-]=[N+]=Nc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)cc1 10.1021/jm00079a020
10463677 115413 None 1 Rat Binding pKd = 6.5 6.5 -38 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 991 15 10 14 -0.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349468 115413 None 1 Rat Binding pKd = 6.5 6.5 -38 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 991 15 10 14 -0.2 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL2372414 212695 None 0 Rat Binding pKd = 7.5 7.5 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C2(CCCC2)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372414 212695 None 0 Rat Binding pKd = 7.5 7.5 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C2(CCCC2)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
118718385 115411 None 0 Rat Binding pKd = 5.4 5.4 -251 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1000 14 11 13 0.2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349466 115411 None 0 Rat Binding pKd = 5.4 5.4 -251 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1000 14 11 13 0.2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL2372419 212700 None 0 Rat Binding pKd = 8.3 8.3 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372417 212698 None 0 Rat Binding pKd = 7.4 7.4 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372417 212698 None 0 Rat Binding pKd = 7.4 7.4 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372419 212700 None 0 Rat Binding pKd = 8.3 8.3 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372418 212699 None 0 Rat Binding pKd = 7.3 7.3 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL None None None NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2372418 212699 None 0 Rat Binding pKd = 7.3 7.3 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL None None None NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
118718753 115457 None 0 Rat Binding pKd = 7.3 7.3 -1 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1074 18 11 15 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL3350126 115457 None 0 Rat Binding pKd = 7.3 7.3 -1 3
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1074 18 11 15 -1.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL2370617 212346 None 0 Rat Binding pKd = 8.2 8.2 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL None None None CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00010a020
CHEMBL2370976 212431 None 10 Rat Binding pKd = 8.2 8.2 2 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL None None None CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00010a020
136961687 118656 None 0 Human Binding pKd = 7.2 7.2 -35 3
Binding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 1053 21 7 12 6.4 O=C(CCCCCNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)NCCNC(=O)CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm501395b
CHEMBL3416749 118656 None 0 Human Binding pKd = 7.2 7.2 -35 3
Binding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assayBinding affinity to V1aR (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 1053 21 7 12 6.4 O=C(CCCCCNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)NCCNC(=O)CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm501395b
118718752 115455 None 0 Rat Binding pKd = 7.2 7.2 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1136 18 11 14 -0.5 CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
CHEMBL3350124 115455 None 0 Rat Binding pKd = 7.2 7.2 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1136 18 11 14 -0.5 CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
70681483 74546 None 0 Rat Binding pKd = 7.1 7.1 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1183 35 13 14 -2.0 CCOc1ccc(C[C@@H](NC(=O)Cc2ccncc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)cc1 10.1021/jm00079a020
CHEMBL2028984 74546 None 0 Rat Binding pKd = 7.1 7.1 - 1
Binding potency against Vasopressin V1 receptor in rat liver cells.Binding potency against Vasopressin V1 receptor in rat liver cells.
ChEMBL 1183 35 13 14 -2.0 CCOc1ccc(C[C@@H](NC(=O)Cc2ccncc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)cc1 10.1021/jm00079a020
70681483 74546 None 0 Rat Binding pKd = 7.1 7.1 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1183 35 13 14 -2.0 CCOc1ccc(C[C@@H](NC(=O)Cc2ccncc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)cc1 10.1021/jm00079a020
CHEMBL2028984 74546 None 0 Rat Binding pKd = 7.1 7.1 - 1
Negative log of Kd for Vasopressin V1 receptorNegative log of Kd for Vasopressin V1 receptor
ChEMBL 1183 35 13 14 -2.0 CCOc1ccc(C[C@@H](NC(=O)Cc2ccncc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)cc1 10.1021/jm00079a020
44294474 97065 None 0 Rat Binding pKd = 8.1 8.1 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1092 17 11 13 -1.0 CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O 10.1021/jm00010a020
CHEMBL266643 97065 None 0 Rat Binding pKd = 8.1 8.1 -1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1092 17 11 13 -1.0 CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O 10.1021/jm00010a020
118718749 115452 None 0 Rat Binding pKd = 8.1 8.1 1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1136 18 11 14 -0.5 CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
CHEMBL3350119 115452 None 0 Rat Binding pKd = 8.1 8.1 1 3
Anti-vasopressor activity at V1a receptor Anti-vasopressor activity at V1a receptor
ChEMBL 1136 18 11 14 -0.5 CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 10.1021/jm00010a020
10396464 115414 None 0 Rat Binding pKd = 7.0 7.0 -8 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1154 19 12 16 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
CHEMBL3349469 115414 None 0 Rat Binding pKd = 7.0 7.0 -8 2
Anti-vasopressor activity at V1a receptorAnti-vasopressor activity at V1a receptor
ChEMBL 1154 19 12 16 -0.4 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm00010a020
44428111 149541 None 0 Human Binding pKi = 10.5 10.5 - 1
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
CHEMBL394602 149541 None 0 Human Binding pKi = 10.5 10.5 - 1
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
44428111 149541 None 0 Human Binding pKi = 10.4 10.4 - 1
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
CHEMBL394602 149541 None 0 Human Binding pKi = 10.4 10.4 - 1
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
56680285 64077 None 0 Human Binding pKi = 10.4 10.4 37 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 513 8 2 3 5.0 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCCC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807272 64077 None 0 Human Binding pKi = 10.4 10.4 37 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 513 8 2 3 5.0 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCCC2)CC1 10.1016/j.bmcl.2011.05.092
56676958 64072 None 0 Human Binding pKi = 10.4 10.4 42 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 501 8 2 3 4.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807267 64072 None 0 Human Binding pKi = 10.4 10.4 42 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 501 8 2 3 4.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
44297517 155816 None 0 Rat Binding pKi = 10.4 10.4 28 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL405440 155816 None 0 Rat Binding pKi = 10.4 10.4 28 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
46890438 6588 None 0 Human Binding pKi = 10.3 10.3 4073 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 347 2 0 1 5.7 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)cc1 10.1016/j.bmcl.2010.04.068
CHEMBL1083094 6588 None 0 Human Binding pKi = 10.3 10.3 4073 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 347 2 0 1 5.7 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)cc1 10.1016/j.bmcl.2010.04.068
46890485 7032 None 0 Human Binding pKi = 10.2 10.2 7943 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 361 2 0 1 6.0 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)cc1C 10.1016/j.bmcl.2010.04.068
CHEMBL1084823 7032 None 0 Human Binding pKi = 10.2 10.2 7943 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 361 2 0 1 6.0 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)cc1C 10.1016/j.bmcl.2010.04.068
44275525 195356 None 0 Human Binding pKi = 10.2 10.2 16 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 10.1021/jm9804782
91931055 195356 None 0 Human Binding pKi = 10.2 10.2 16 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 10.1021/jm9804782
CHEMBL540192 195356 None 0 Human Binding pKi = 10.2 10.2 16 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 10.1021/jm9804782
44275104 97340 None 0 Human Binding pKi = 10.1 10.1 33 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1127 32 14 14 -3.9 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O 10.1021/jm9804782
CHEMBL269012 97340 None 0 Human Binding pKi = 10.1 10.1 33 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1127 32 14 14 -3.9 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O 10.1021/jm9804782
44428107 10319 None 0 Human Binding pKi = 10.1 10.1 11 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 2058 46 18 25 6.0 CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O 10.1021/jm061404q
91935616 10319 None 0 Human Binding pKi = 10.1 10.1 11 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 2058 46 18 25 6.0 CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O 10.1021/jm061404q
CHEMBL1161978 10319 None 0 Human Binding pKi = 10.1 10.1 11 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 2058 46 18 25 6.0 CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O 10.1021/jm061404q
56680284 64075 None 0 Human Binding pKi = 10.0 10.0 21 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 515 8 2 3 5.1 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CCC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807270 64075 None 0 Human Binding pKi = 10.0 10.0 21 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 515 8 2 3 5.1 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CCC2)CC1 10.1016/j.bmcl.2011.05.092
46890709 6839 None 0 Human Binding pKi = 10 10.0 6025 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 402 3 1 2 5.9 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1c[nH]c2ccccc12 10.1016/j.bmcl.2010.04.068
CHEMBL1084008 6839 None 0 Human Binding pKi = 10 10.0 6025 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 402 3 1 2 5.9 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1c[nH]c2ccccc12 10.1016/j.bmcl.2010.04.068
44314134 104848 None 0 Rat Binding pKi = 10.0 10.0 331 2
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 576 5 1 5 5.5 Cc1occc1C(=O)Nc1ccc(C(=O)N2CCC(F)(F)/C(=C/C(=O)N3CCC(N(C)C)CC3)c3ccccc32)cc1 10.1016/s0960-894x(01)00723-5
CHEMBL310921 104848 None 0 Rat Binding pKi = 10.0 10.0 331 2
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 576 5 1 5 5.5 Cc1occc1C(=O)Nc1ccc(C(=O)N2CCC(F)(F)/C(=C/C(=O)N3CCC(N(C)C)CC3)c3ccccc32)cc1 10.1016/s0960-894x(01)00723-5
44297505 165952 None 0 Rat Binding pKi = 10.0 10.0 7 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL424905 165952 None 0 Rat Binding pKi = 10.0 10.0 7 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297516 161385 None 0 Rat Binding pKi = 9.9 9.9 22 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL412192 161385 None 0 Rat Binding pKi = 9.9 9.9 22 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297525 96862 None 0 Rat Binding pKi = 9.9 9.9 10 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL265048 96862 None 0 Rat Binding pKi = 9.9 9.9 10 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
2213 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
3008 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
5311010 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
5311010.0 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
68613 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
68613.0 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
CHEMBL378642 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
CHEMBL382301 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
DB09059 518 None 30 Human Binding pKi = 9.8 9.8 28 5
Binding affinity to human vasopressin V1a receptorBinding affinity to human vasopressin V1a receptor
ChEMBL None None None None 10.1016/j.bmcl.2007.11.008
2205 4123 None 6 Rat Binding pKi = 9.8 9.8 1 5
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
9810140 4123 None 6 Rat Binding pKi = 9.8 9.8 1 5
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
CHEMBL307483 4123 None 6 Rat Binding pKi = 9.8 9.8 1 5
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
44297525 96862 None 0 Rat Binding pKi = 9.8 9.8 10 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL265048 96862 None 0 Rat Binding pKi = 9.8 9.8 10 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44275524 161387 None 0 Human Binding pKi = 9.8 9.8 9 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
91931053 161387 None 0 Human Binding pKi = 9.8 9.8 9 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
CHEMBL412210 161387 None 0 Human Binding pKi = 9.8 9.8 9 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
44275467 167830 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2ccc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)cc21 10.1021/jm9804782
91931056 167830 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2ccc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)cc21 10.1021/jm9804782
CHEMBL430272 167830 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2ccc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)cc21 10.1021/jm9804782
44400427 159903 None 0 Rat Binding pKi = 9.7 9.7 - 1
Binding affinity against rat vasopressin V1a receptorBinding affinity against rat vasopressin V1a receptor
ChEMBL 1469 40 15 16 -0.9 COc1ccc(C[C@@H](NC(=O)CCCc2ccc(N=[N+]=[N-])cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1 10.1021/jm040871+
CHEMBL410567 159903 None 0 Rat Binding pKi = 9.7 9.7 - 1
Binding affinity against rat vasopressin V1a receptorBinding affinity against rat vasopressin V1a receptor
ChEMBL 1469 40 15 16 -0.9 COc1ccc(C[C@@H](NC(=O)CCCc2ccc(N=[N+]=[N-])cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1 10.1021/jm040871+
44297517 155816 None 0 Rat Binding pKi = 9.7 9.7 28 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL405440 155816 None 0 Rat Binding pKi = 9.7 9.7 28 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
56680283 64071 None 0 Human Binding pKi = 9.7 9.7 44 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 475 8 2 3 4.3 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807266 64071 None 0 Human Binding pKi = 9.7 9.7 44 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 475 8 2 3 4.3 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
2200 3311 None 35 Human Binding pKi = 9.7 9.7 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
3482 3311 None 35 Human Binding pKi = 9.7 9.7 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
60943 3311 None 35 Human Binding pKi = 9.7 9.7 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
CHEMBL419667 3311 None 35 Human Binding pKi = 9.7 9.7 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
DB13929 3311 None 35 Human Binding pKi = 9.7 9.7 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
44428537 152659 None 0 Human Binding pKi = 9.7 9.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cccc(C(F)(F)F)c1F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL397179 152659 None 0 Human Binding pKi = 9.7 9.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cccc(C(F)(F)F)c1F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
145981307 166772 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1141 34 16 14 -3.1 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4281963 166772 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1141 34 16 14 -3.1 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
44297505 165952 None 0 Rat Binding pKi = 9.7 9.7 7 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL424905 165952 None 0 Rat Binding pKi = 9.7 9.7 7 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297516 161385 None 0 Rat Binding pKi = 9.7 9.7 22 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL412192 161385 None 0 Rat Binding pKi = 9.7 9.7 22 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
56663273 64087 None 0 Human Binding pKi = 9.7 9.7 28 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCCC1O 10.1016/j.bmcl.2011.05.092
CHEMBL1807281 64087 None 0 Human Binding pKi = 9.7 9.7 28 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCCC1O 10.1016/j.bmcl.2011.05.092
44428111 149541 None 0 Human Binding pKi = 9.7 9.7 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
CHEMBL394602 149541 None 0 Human Binding pKi = 9.7 9.7 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
44428111 149541 None 0 Human Binding pKi = 9.7 9.7 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
CHEMBL394602 149541 None 0 Human Binding pKi = 9.7 9.7 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
44274848 167531 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
91931059 167531 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
CHEMBL429725 167531 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1471 34 14 20 1.1 CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O 10.1021/jm9804782
54584254 61930 None 0 Human Binding pKi = 9.6 9.6 93 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
54584254 61930 None 0 Human Binding pKi = 9.6 9.6 93 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.05.092
CHEMBL1774023 61930 None 0 Human Binding pKi = 9.6 9.6 93 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
CHEMBL1774023 61930 None 0 Human Binding pKi = 9.6 9.6 93 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.05.092
53364234 64078 None 0 Human Binding pKi = 9.6 9.6 9 3
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 485 8 2 3 4.2 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807273 64078 None 0 Human Binding pKi = 9.6 9.6 9 3
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 485 8 2 3 4.2 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
44297449 169363 None 0 Rat Binding pKi = 9.6 9.6 1 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL441195 169363 None 0 Rat Binding pKi = 9.6 9.6 1 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
56683606 64076 None 0 Human Binding pKi = 9.6 9.6 19 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 499 8 2 3 4.6 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807271 64076 None 0 Human Binding pKi = 9.6 9.6 19 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 499 8 2 3 4.6 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCC2)CC1 10.1016/j.bmcl.2011.05.092
2168 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 9.6 9.6 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
44428516 161263 None 0 Human Binding pKi = 9.6 9.6 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL411757 161263 None 0 Human Binding pKi = 9.6 9.6 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44297525 96862 None 0 Rat Binding pKi = 9.6 9.6 10 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL265048 96862 None 0 Rat Binding pKi = 9.6 9.6 10 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44428111 149541 None 0 Human Binding pKi = 9.6 9.6 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
CHEMBL394602 149541 None 0 Human Binding pKi = 9.6 9.6 - 1
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 1127 32 16 14 -3.6 CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C1 10.1021/jm061404q
44428550 151051 None 21 Human Binding pKi = 9.5 9.5 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 703 11 1 6 5.6 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL395817 151051 None 21 Human Binding pKi = 9.5 9.5 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 703 11 1 6 5.6 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmc.2006.12.031
2204 4117 None 6 Human Binding pKi = 9.5 9.5 229 4
Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranesDisplacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes
ChEMBL 616 5 1 5 6.4 O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C 10.1021/acs.jmedchem.8b00697
9917025 4117 None 6 Human Binding pKi = 9.5 9.5 229 4
Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranesDisplacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes
ChEMBL 616 5 1 5 6.4 O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C 10.1021/acs.jmedchem.8b00697
CHEMBL3307200 4117 None 6 Human Binding pKi = 9.5 9.5 229 4
Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranesDisplacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes
ChEMBL 616 5 1 5 6.4 O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C 10.1021/acs.jmedchem.8b00697
CHEMBL5070075 216714 None 0 Human Binding pKi = 9.5 9.5 660 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None O[C@@H]1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
CHEMBL5070261 216717 None 0 Human Binding pKi = 9.5 9.5 1548 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None OC1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
CHEMBL5074709 216815 None 0 Human Binding pKi = 9.5 9.5 2951 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None O[C@H]1Cc2cc(Cl)ccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
46890440 7353 None 0 Human Binding pKi = 9.5 9.5 173 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 381 2 0 1 6.4 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)c(Cl)c1 10.1016/j.bmcl.2010.04.068
CHEMBL1086272 7353 None 0 Human Binding pKi = 9.5 9.5 173 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 381 2 0 1 6.4 Cc1ccccc1-c1ccc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)c(Cl)c1 10.1016/j.bmcl.2010.04.068
44297449 169363 None 0 Rat Binding pKi = 9.5 9.5 1 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL441195 169363 None 0 Rat Binding pKi = 9.5 9.5 1 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
2168 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 9.5 9.5 -5 9
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
46890612 6906 None 0 Human Binding pKi = 9.4 9.4 81 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 420 4 1 3 5.4 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccc(NC(C)=O)c1 10.1016/j.bmcl.2010.04.068
CHEMBL1084325 6906 None 0 Human Binding pKi = 9.4 9.4 81 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 420 4 1 3 5.4 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccc(NC(C)=O)c1 10.1016/j.bmcl.2010.04.068
56670128 64083 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 422 9 3 3 3.2 CC(CCO)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1 10.1016/j.bmcl.2011.05.092
CHEMBL1807278 64083 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 422 9 3 3 3.2 CC(CCO)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1 10.1016/j.bmcl.2011.05.092
44428538 160562 None 0 Human Binding pKi = 9.4 9.4 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.7 O=C(NCc1cccc(Cl)c1Cl)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL411179 160562 None 0 Human Binding pKi = 9.4 9.4 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.7 O=C(NCc1cccc(Cl)c1Cl)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL2370569 212330 None 21 Human Binding pKi = 9.4 9.4 - 1
Binding affinity to human vasopressin V1a receptor by radioligand displacement assayBinding affinity to human vasopressin V1a receptor by radioligand displacement assay
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1016/j.ejmech.2013.01.044
CHEMBL5081323 217231 None 0 Human Binding pKi = 9.4 9.4 2691 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None Cc1ccc2c(c1)CC(O)Cc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
145986380 167189 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4289837 167189 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
44428540 152669 None 0 Human Binding pKi = 9.4 9.4 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cc(C(F)(F)F)ccc1F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL397185 152669 None 0 Human Binding pKi = 9.4 9.4 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cc(C(F)(F)F)ccc1F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
151171 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
151171.0 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
216322 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
2203 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
732 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
CHEMBL1755 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
DB00872 1164 None 41 Human Binding pKi = 9.4 9.4 -3 6
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1016/j.bmcl.2010.04.068
162658238 181112 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 369 2 0 5 3.5 C#Cc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4759005 181112 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 369 2 0 5 3.5 C#Cc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
44428518 152390 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 785 13 1 6 6.7 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(CC2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL396954 152390 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 785 13 1 6 6.7 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(CC2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44297517 155816 None 0 Rat Binding pKi = 9.3 9.3 28 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL405440 155816 None 0 Rat Binding pKi = 9.3 9.3 28 3
Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtypeTested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
ChEMBL 1343 39 15 16 -1.4 CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
44297505 165952 None 0 Rat Binding pKi = 9.3 9.3 7 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL424905 165952 None 0 Rat Binding pKi = 9.3 9.3 7 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1329 38 15 16 -1.8 CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
151171 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
151171.0 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
216322 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
2203 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
732 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
CHEMBL1755 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
DB00872 1164 None 41 Rat Binding pKi = 9.3 9.3 1 6
Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting methodDisplacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method
ChEMBL 498 4 2 3 6.5 Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 10.1021/acs.jmedchem.8b00697
59657523 118726 None 0 Human Binding pKi = 9.3 9.3 28 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 451 3 0 4 4.0 CN(C)C(=O)Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
CHEMBL3416881 118726 None 0 Human Binding pKi = 9.3 9.3 28 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 451 3 0 4 4.0 CN(C)C(=O)Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
121301508 176323 None 5 Human Binding pKi = 9.3 9.3 -1 3
Radiometric AVPR1A binding assay (Eurofins #287530)Radiometric AVPR1A binding assay (Eurofins #287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
CHEMBL4594444 176323 None 5 Human Binding pKi = 9.3 9.3 -1 3
Radiometric AVPR1A binding assay (Eurofins #287530)Radiometric AVPR1A binding assay (Eurofins #287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
44428541 149898 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL394866 149898 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 789 12 1 6 6.6 O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
2200 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
3482 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
60943 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
CHEMBL419667 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
DB13929 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
56666701 64073 None 0 Human Binding pKi = 9.3 9.3 26 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 497 9 2 4 4.1 COc1ccc(C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C(=O)N[C@H]2CC[C@H](N(C)C)CC2)cc1 10.1016/j.bmcl.2011.05.092
CHEMBL1807268 64073 None 0 Human Binding pKi = 9.3 9.3 26 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 497 9 2 4 4.1 COc1ccc(C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C(=O)N[C@H]2CC[C@H](N(C)C)CC2)cc1 10.1016/j.bmcl.2011.05.092
2200 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
3482 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
60943 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
CHEMBL419667 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
DB13929 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
2200 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
3482 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
60943 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
CHEMBL419667 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
DB13929 3311 None 35 Human Binding pKi = 9.3 9.3 1 6
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
46890528 7034 None 0 Human Binding pKi = 9.3 9.3 199 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 411 3 0 2 6.4 COc1cc(-c2ccccc2C)c(Cl)cc1C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2 10.1016/j.bmcl.2010.04.068
CHEMBL1084825 7034 None 0 Human Binding pKi = 9.3 9.3 199 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 411 3 0 2 6.4 COc1cc(-c2ccccc2C)c(Cl)cc1C(=O)N1C[C@]2(C)C[C@H]1CC(C)(C)C2 10.1016/j.bmcl.2010.04.068
56680282 64064 None 0 Human Binding pKi = 9.3 9.3 21 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 490 10 2 4 3.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807259 64064 None 0 Human Binding pKi = 9.3 9.3 21 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 490 10 2 4 3.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
2168 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 9.3 9.3 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
54586172 61931 None 0 Human Binding pKi = 9.3 9.3 7 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 485 7 3 3 4.2 O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.02.096
CHEMBL1774024 61931 None 0 Human Binding pKi = 9.3 9.3 7 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 485 7 3 3 4.2 O=C(N[C@@H]1C[C@@H]2CC[C@H](C1)N2)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.02.096
44297516 161385 None 0 Rat Binding pKi = 9.2 9.2 22 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL412192 161385 None 0 Rat Binding pKi = 9.2 9.2 22 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
46890530 6738 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 391 3 0 2 6.0 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1c(C)cccc1C 10.1016/j.bmcl.2010.04.068
CHEMBL1083731 6738 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 391 3 0 2 6.0 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1c(C)cccc1C 10.1016/j.bmcl.2010.04.068
162655262 180852 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 426 2 0 5 5.3 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Br)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4756031 180852 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 426 2 0 5 5.3 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Br)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
162655954 180873 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4756212 180873 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 465 3 0 3 5.3 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
162643927 181913 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 466 2 0 3 4.2 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)N3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127417
CHEMBL4778087 181913 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 466 2 0 3 4.2 Cc1ccccc1N1CCN(C(=O)N2C[C@@H](C(=O)N3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127417
162676448 183589 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 438 3 0 5 5.0 Brc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4799412 183589 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 438 3 0 5 5.0 Brc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
57391220 70222 None 0 Human Binding pKi = 9.2 9.2 1862 2
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 721 11 1 6 5.7 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1cccc(F)c1)c1ccccc1 10.1016/j.bmc.2011.12.013
CHEMBL1940587 70222 None 0 Human Binding pKi = 9.2 9.2 1862 2
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 721 11 1 6 5.7 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1cccc(F)c1)c1ccccc1 10.1016/j.bmc.2011.12.013
56663268 64061 None 0 Human Binding pKi = 9.2 9.2 95 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 447 7 3 3 3.5 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCNCC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807256 64061 None 0 Human Binding pKi = 9.2 9.2 95 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 447 7 3 3 3.5 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCNCC1 10.1016/j.bmcl.2011.05.092
2205 4123 None 6 Human Binding pKi = 9.2 9.2 -1 5
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
9810140 4123 None 6 Human Binding pKi = 9.2 9.2 -1 5
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
CHEMBL307483 4123 None 6 Human Binding pKi = 9.2 9.2 -1 5
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1021/jm010544r
2205 4123 None 6 Rat Binding pKi = 9.2 9.2 1 5
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1016/s0960-894x(01)00723-5
9810140 4123 None 6 Rat Binding pKi = 9.2 9.2 1 5
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1016/s0960-894x(01)00723-5
CHEMBL307483 4123 None 6 Rat Binding pKi = 9.2 9.2 1 5
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 648 6 1 4 7.2 CN(C1CCN(CC1)C(=O)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1)C 10.1016/s0960-894x(01)00723-5
2213 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
3008 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
5311010 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
5311010.0 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
68613 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
68613.0 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
CHEMBL378642 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
CHEMBL382301 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
DB09059 518 None 30 Human Binding pKi = 9.2 9.2 28 5
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL None None None None 10.1021/jm050645f
57394727 70223 None 0 Human Binding pKi = 9.2 9.2 2041 2
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 717 11 1 6 5.9 Cc1cccc(/C=C/[C@@H]2[C@H](N3C(=O)OC[C@@H]3c3ccccc3)C(=O)N2[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)N[C@H](C)c2ccccc2)c1 10.1016/j.bmc.2011.12.013
CHEMBL1940588 70223 None 0 Human Binding pKi = 9.2 9.2 2041 2
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 717 11 1 6 5.9 Cc1cccc(/C=C/[C@@H]2[C@H](N3C(=O)OC[C@@H]3c3ccccc3)C(=O)N2[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)N[C@H](C)c2ccccc2)c1 10.1016/j.bmc.2011.12.013
135413562 2205 None 13 Human Binding pKi = 9.2 9.2 -16 5
Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue
ChEMBL 624 14 3 7 1.1 CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C 10.1021/jm901812z
2194 2205 None 13 Human Binding pKi = 9.2 9.2 -16 5
Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue
ChEMBL 624 14 3 7 1.1 CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C 10.1021/jm901812z
CHEMBL445816 2205 None 13 Human Binding pKi = 9.2 9.2 -16 5
Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue
ChEMBL 624 14 3 7 1.1 CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C 10.1021/jm901812z
11686429 98964 None 7 Human Binding pKi = 9.2 9.2 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 11 0 6 6.4 CN(Cc1cccc(C(F)(F)F)c1)C(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL279328 98964 None 7 Human Binding pKi = 9.2 9.2 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 11 0 6 6.4 CN(Cc1cccc(C(F)(F)F)c1)C(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44428542 171838 None 0 Human Binding pKi = 9.2 9.2 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 737 12 1 6 6.1 O=C(NCc1cccc(Cl)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL446720 171838 None 0 Human Binding pKi = 9.2 9.2 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 737 12 1 6 6.1 O=C(NCc1cccc(Cl)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
56676960 64084 None 0 Human Binding pKi = 9.2 9.2 75 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCC(O)C1 10.1016/j.bmcl.2011.05.092
CHEMBL1807279 64084 None 0 Human Binding pKi = 9.2 9.2 75 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCC(O)C1 10.1016/j.bmcl.2011.05.092
145993846 167476 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4294901 167476 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
2168 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
2810 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
644077 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
644077.0 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
CHEMBL373742 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
DB00067 3976 None 29 Human Binding pKi = 9.2 9.2 -5 9
Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 minsDisplacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
ChEMBL None None None None 10.1021/jm3006146
10615 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
46200932 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
CHEMBL4297183 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
DB14823 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1021/acs.jmedchem.1c00863
10615 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
10615 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
46200932 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
46200932 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
CHEMBL4297183 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
CHEMBL4297183 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
DB14823 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127416
DB14823 572 None 35 Human Binding pKi = 9.2 9.2 -501 4
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 409 3 0 6 4.4 CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 10.1016/j.bmcl.2020.127417
162648487 180069 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 423 2 0 5 4.3 Brc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4746716 180069 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 423 2 0 5 4.3 Brc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
162655215 180915 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 382 2 0 5 5.1 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4756737 180915 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 382 2 0 5 5.1 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
2200 3311 None 35 Human Binding pKi = 9.2 9.2 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
3482 3311 None 35 Human Binding pKi = 9.2 9.2 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
60943 3311 None 35 Human Binding pKi = 9.2 9.2 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
CHEMBL419667 3311 None 35 Human Binding pKi = 9.2 9.2 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
DB13929 3311 None 35 Human Binding pKi = 9.2 9.2 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
46890101 7305 None 0 Human Binding pKi = 9.2 9.2 181 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 414 3 0 3 6.0 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccc2cccnc12 10.1016/j.bmcl.2010.04.068
CHEMBL1086070 7305 None 0 Human Binding pKi = 9.2 9.2 181 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 414 3 0 3 6.0 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccc2cccnc12 10.1016/j.bmcl.2010.04.068
2253 2231 None 22 Rat Binding pKi = 9.1 9.1 5 6
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 586 7 0 7 4.4 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] 10.1021/jm901812z
5311202 2231 None 22 Rat Binding pKi = 9.1 9.1 5 6
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 586 7 0 7 4.4 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] 10.1021/jm901812z
CHEMBL306645 2231 None 22 Rat Binding pKi = 9.1 9.1 5 6
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 586 7 0 7 4.4 COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] 10.1021/jm901812z
46890707 6729 None 0 Human Binding pKi = 9.1 9.1 19 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 419 3 0 3 6.6 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1csc2ccccc12 10.1016/j.bmcl.2010.04.068
CHEMBL1083703 6729 None 0 Human Binding pKi = 9.1 9.1 19 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 419 3 0 3 6.6 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1csc2ccccc12 10.1016/j.bmcl.2010.04.068
162676461 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Antagonist activity against human V1A receptor expressed in human 1321N1 cellsAntagonist activity against human V1A receptor expressed in human 1321N1 cells
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c01215
CHEMBL4799793 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Antagonist activity against human V1A receptor expressed in human 1321N1 cellsAntagonist activity against human V1A receptor expressed in human 1321N1 cells
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c01215
44400408 96756 None 0 Human Binding pKi = 9.1 9.1 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1474 38 15 15 -1.4 NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(N)=O 10.1021/jm040871+
91936749 96756 None 0 Human Binding pKi = 9.1 9.1 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1474 38 15 15 -1.4 NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(N)=O 10.1021/jm040871+
CHEMBL264101 96756 None 0 Human Binding pKi = 9.1 9.1 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1474 38 15 15 -1.4 NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)c(I)c1)C(N)=O 10.1021/jm040871+
46890654 7133 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 377 3 0 2 5.7 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1ccc(C)cc1 10.1016/j.bmcl.2010.04.068
CHEMBL1085299 7133 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 377 3 0 2 5.7 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1ccc(C)cc1 10.1016/j.bmcl.2010.04.068
44275447 96476 None 0 Human Binding pKi = 9.1 9.1 1 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1111 32 13 13 -3.6 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O 10.1021/jm9804782
CHEMBL262035 96476 None 0 Human Binding pKi = 9.1 9.1 1 4
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1111 32 13 13 -3.6 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O 10.1021/jm9804782
145981307 166772 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1141 34 16 14 -3.1 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4281963 166772 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1141 34 16 14 -3.1 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
162676461 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
CHEMBL4799793 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c00863
162676461 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4799793 183618 None 0 Human Binding pKi = 9.1 9.1 707 2
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 394 3 0 5 4.9 Clc1ccc2c(c1)CCCc1nnc([C@H]3CC[C@H](Oc4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
44428543 168989 None 0 Human Binding pKi = 9.1 9.1 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 739 12 1 6 5.7 O=C(NCc1cc(F)cc(F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL438319 168989 None 0 Human Binding pKi = 9.1 9.1 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 739 12 1 6 5.7 O=C(NCc1cc(F)cc(F)c1)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
2200 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
3482 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
60943 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
CHEMBL419667 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
DB13929 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
145981637 166588 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4278500 166588 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
145986380 167189 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4289837 167189 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1206 34 16 14 -3.8 COc1ccc(C[C@@H](NC(=O)CCc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2C[Se]C[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
162671049 182926 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 703 11 1 6 5.6 C[C@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmcl.2020.127416
CHEMBL4790970 182926 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 703 11 1 6 5.6 C[C@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1ccccc1 10.1016/j.bmcl.2020.127416
2200 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
3482 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
60943 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
CHEMBL419667 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
DB13929 3311 None 35 Human Binding pKi = 9.1 9.1 1 6
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/acs.jmedchem.8b01320
44428544 149899 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1ccccc1C(F)(F)F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL394867 149899 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1ccccc1C(F)(F)F)[C@H](CCC(=O)N1CCN(C2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
59657596 118730 None 34 Human Binding pKi = 9 9.0 16 2
Antagonist activity at human vasopressin 1a receptorAntagonist activity at human vasopressin 1a receptor
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/acs.jmedchem.6b01437
CHEMBL3416885 118730 None 34 Human Binding pKi = 9 9.0 16 2
Antagonist activity at human vasopressin 1a receptorAntagonist activity at human vasopressin 1a receptor
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/acs.jmedchem.6b01437
59657616 118713 None 0 Human Binding pKi = 9 9.0 40 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 506 3 0 5 3.7 CN1CCN(C(=O)Cn2cc(C(=O)N3CCC4(CC3)OCc3ccccc34)c3ccc(Cl)cc32)CC1 10.1021/jm501745f
CHEMBL3416868 118713 None 0 Human Binding pKi = 9 9.0 40 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 506 3 0 5 3.7 CN1CCN(C(=O)Cn2cc(C(=O)N3CCC4(CC3)OCc3ccccc34)c3ccc(Cl)cc32)CC1 10.1021/jm501745f
11993729 118728 None 0 Human Binding pKi = 9 9.0 12 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 3 0 4 5.1 CN1CCC[C@H]1Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
CHEMBL3416883 118728 None 0 Human Binding pKi = 9 9.0 12 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 3 0 4 5.1 CN1CCC[C@H]1Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
59657596 118730 None 34 Human Binding pKi = 9 9.0 16 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
CHEMBL3416885 118730 None 34 Human Binding pKi = 9 9.0 16 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 437 4 0 4 4.5 CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
162658180 181167 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 466 2 0 3 4.9 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
CHEMBL4759676 181167 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 466 2 0 3 4.9 Cc1ccccc1N1CCN(C(=O)N2CN(C(=O)C3CCCC3)Cc3cc(Cl)ccc32)CC1 10.1016/j.bmcl.2020.127416
10304617 208685 None 0 Human Binding pKi = 9 9.0 32 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 625 8 0 6 7.9 Cc1cccc(OCc2ccc(C(=O)N3CCC(N4CCCCC4)CC3)cc2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
CHEMBL86667 208685 None 0 Human Binding pKi = 9 9.0 32 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 625 8 0 6 7.9 Cc1cccc(OCc2ccc(C(=O)N3CCC(N4CCCCC4)CC3)cc2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
46890572 7360 None 0 Human Binding pKi = 9.0 9.0 1148 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 420 4 1 3 4.8 CNC(=O)c1cccc(-c2ccc(C(=O)N3C[C@]4(C)C[C@H]3CC(C)(C)C4)cc2OC)c1 10.1016/j.bmcl.2010.04.068
CHEMBL1086294 7360 None 0 Human Binding pKi = 9.0 9.0 1148 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 420 4 1 3 4.8 CNC(=O)c1cccc(-c2ccc(C(=O)N3C[C@]4(C)C[C@H]3CC(C)(C)C4)cc2OC)c1 10.1016/j.bmcl.2010.04.068
15416418 157231 None 0 Human Binding pKi = 9.0 9.0 8 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC[C@@H](O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
CHEMBL4075127 157231 None 0 Human Binding pKi = 9.0 9.0 8 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC[C@@H](O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
10164478 209143 None 0 Human Binding pKi = 9.0 9.0 16 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 509 11 0 6 6.1 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCCCCCN1CCN(C)CC1 10.1021/jm010544r
CHEMBL89552 209143 None 0 Human Binding pKi = 9.0 9.0 16 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 509 11 0 6 6.1 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCCCCCN1CCN(C)CC1 10.1021/jm010544r
10303620 208734 None 0 Human Binding pKi = 9.0 9.0 9 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 577 12 0 6 7.8 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCCCCCN1CCC(N2CCCCC2)CC1 10.1021/jm010544r
CHEMBL86949 208734 None 0 Human Binding pKi = 9.0 9.0 9 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 577 12 0 6 7.8 Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCCCCCN1CCC(N2CCCCC2)CC1 10.1021/jm010544r
46890055 6453 None 0 Human Binding pKi = 9.0 9.0 2290 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 398 3 0 3 5.5 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccnc1Cl 10.1016/j.bmcl.2010.04.068
CHEMBL1082493 6453 None 0 Human Binding pKi = 9.0 9.0 2290 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 398 3 0 3 5.5 COc1cc(C(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)ccc1-c1cccnc1Cl 10.1016/j.bmcl.2010.04.068
2168 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
2810 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
644077 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
644077.0 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
CHEMBL373742 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
DB00067 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Displacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 minsDisplacement of [3H]AVP from human vasopressin V1a receptor expressed CHO cells after 60 mins
ChEMBL None None None None 10.1021/jm1016208
57399933 70221 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 829 11 1 6 6.2 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1cccc(I)c1)c1ccccc1 10.1016/j.bmc.2011.12.013
CHEMBL1940586 70221 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counterDisplacement of [3H]arginine-vasopressin from human Vasopressin V1a receptor after 30 mins by liquid scintillation counter
ChEMBL 829 11 1 6 6.2 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1cccc(I)c1)c1ccccc1 10.1016/j.bmc.2011.12.013
44297449 169363 None 0 Rat Binding pKi = 9.0 9.0 1 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
CHEMBL441195 169363 None 0 Rat Binding pKi = 9.0 9.0 1 3
Inhibition constant for V1a receptor of rat liver membraneInhibition constant for V1a receptor of rat liver membrane
ChEMBL 1315 37 15 16 -2.2 CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm00038a013
56683607 64079 None 0 Human Binding pKi = 9.0 9.0 61 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 8 2 3 3.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807274 64079 None 0 Human Binding pKi = 9.0 9.0 61 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 459 8 2 3 3.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2011.05.092
44428492 149854 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 780 12 2 6 6.2 NC1CC[N+](Cc2ccccc2)(C(=O)C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
CHEMBL394829 149854 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 780 12 2 6 6.2 NC1CC[N+](Cc2ccccc2)(C(=O)C[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
44428569 152465 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 775 11 1 6 6.2 O=C(NCc1cccc(C(F)(F)F)c1F)[C@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL397025 152465 None 0 Human Binding pKi = 9.0 9.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 775 11 1 6 6.2 O=C(NCc1cccc(C(F)(F)F)c1F)[C@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
2168 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 9.0 9.0 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
24896178 92053 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.3 O=C(NCc1cccc(C(F)(F)F)c1)C(C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL241826 92053 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.3 O=C(NCc1cccc(C(F)(F)F)c1)C(C(=O)N1CCC(CCN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44428520 166562 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 793 14 1 6 6.3 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(CCc2ccccc2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL427810 166562 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 793 14 1 6 6.3 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCN(CCc2ccccc2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
44428529 152391 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 731 13 1 6 5.5 CCCN1CCN(C(=O)CC[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
CHEMBL396955 152391 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 731 13 1 6 5.5 CCCN1CCN(C(=O)CC[C@@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
44428551 93119 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 11 1 6 6.6 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1cccc(C(F)(F)F)c1 10.1016/j.bmc.2006.12.031
44428551.0 93119 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 11 1 6 6.6 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1cccc(C(F)(F)F)c1 10.1016/j.bmc.2006.12.031
CHEMBL244243 93119 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 11 1 6 6.6 C[C@@H](NC(=O)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1)c1cccc(C(F)(F)F)c1 10.1016/j.bmc.2006.12.031
44275137 157333 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)ccc21 10.1021/jm9804782
91931058 157333 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)ccc21 10.1021/jm9804782
CHEMBL407644 157333 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cellsDisplacement of [125I]- HO-LVA from human Vasopressin V1a receptor in membranes of CHO cells
ChEMBL 1525 36 12 20 1.8 CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)ccc21 10.1021/jm9804782
2168 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by fluorescent binding assay using 384-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
121301508 176323 None 5 Human Binding pKi = 8.9 8.9 -1 3
Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
CHEMBL4594444 176323 None 5 Human Binding pKi = 8.9 8.9 -1 3
Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)Inhibition of Vasopressin V1A at 10 µM in the Eurofins-Panlabs radioligand binding assay (Eurofins_assay_287530)
ChEMBL 542 7 2 9 3.6 C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 10.6019/CHEMBL5463729
2168 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 8.9 8.9 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cellsInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells
ChEMBL None None None None 10.1021/jm061404q
56680285 64077 None 0 Rat Binding pKi = 8.9 8.9 -37 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 513 8 2 3 5.0 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCCC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807272 64077 None 0 Rat Binding pKi = 8.9 8.9 -37 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 513 8 2 3 5.0 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CCCC2)CC1 10.1016/j.bmcl.2011.05.092
162660856 181975 None 0 Human Binding pKi = 8.9 8.9 - 1
Antagonist activity against human V1A receptor expressed in human 1321N1 cellsAntagonist activity against human V1A receptor expressed in human 1321N1 cells
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c01215
CHEMBL4778839 181975 None 0 Human Binding pKi = 8.9 8.9 - 1
Antagonist activity against human V1A receptor expressed in human 1321N1 cellsAntagonist activity against human V1A receptor expressed in human 1321N1 cells
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1021/acs.jmedchem.1c01215
57978135 118727 None 0 Human Binding pKi = 8.9 8.9 89 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 449 3 1 4 4.7 O=C(c1cn(C[C@@H]2CCCN2)c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
CHEMBL3416882 118727 None 0 Human Binding pKi = 8.9 8.9 89 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 449 3 1 4 4.7 O=C(c1cn(C[C@@H]2CCCN2)c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
162652318 180428 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 356 2 1 4 3.4 O=C(C1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127417
CHEMBL4751140 180428 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 356 2 1 4 3.4 O=C(C1CCN(c2ccccn2)CC1)N1CCNc2cc(Cl)ccc21 10.1016/j.bmcl.2020.127417
162660856 181975 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
CHEMBL4778839 181975 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 379 2 0 5 4.2 Clc1ccc2c(c1)CCCc1nnc(C3CCN(c4ccccn4)CC3)n1-2 10.1016/j.bmcl.2020.127417
71461726 79723 None 0 Rat Binding pKi = 8.9 8.9 257 2
Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay (Vasopressin V1 receptor)Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay (Vasopressin V1 receptor)
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
CHEMBL2115369 79723 None 0 Rat Binding pKi = 8.9 8.9 257 2
Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay (Vasopressin V1 receptor)Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay (Vasopressin V1 receptor)
ChEMBL 1186 20 11 15 0.9 COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 10.1021/jm00079a020
2200 3311 None 35 Rat Binding pKi = 8.9 8.9 -1 6
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
3482 3311 None 35 Rat Binding pKi = 8.9 8.9 -1 6
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
60943 3311 None 35 Rat Binding pKi = 8.9 8.9 -1 6
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
CHEMBL419667 3311 None 35 Rat Binding pKi = 8.9 8.9 -1 6
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
DB13929 3311 None 35 Rat Binding pKi = 8.9 8.9 -1 6
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm010544r
44428522 161107 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL411629 161107 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 771 12 1 6 6.4 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
10208389 78662 None 0 Human Binding pKi = 8.8 8.8 70 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 523 11 0 6 6.4 Cc1cccc(OCCCCCCN2CCN(C)CC2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
CHEMBL2112339 78662 None 0 Human Binding pKi = 8.8 8.8 70 4
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 523 11 0 6 6.4 Cc1cccc(OCCCCCCN2CCN(C)CC2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
2200 3311 None 35 Human Binding pKi = 8.8 8.8 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
3482 3311 None 35 Human Binding pKi = 8.8 8.8 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
60943 3311 None 35 Human Binding pKi = 8.8 8.8 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
CHEMBL419667 3311 None 35 Human Binding pKi = 8.8 8.8 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
DB13929 3311 None 35 Human Binding pKi = 8.8 8.8 1 6
Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranesInhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.1021/jm061404q
11513323 142975 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 757 11 1 6 6.0 O=C(NCc1cccc(C(F)(F)F)c1)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL389359 142975 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 757 11 1 6 6.0 O=C(NCc1cccc(C(F)(F)F)c1)[C@@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL2369839 212163 None 0 Human Binding pKi = 8.8 8.8 1 4
Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptorsBinding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
ChEMBL None None None NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm030611c
2168 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2810 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
644077.0 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
CHEMBL373742 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
DB00067 3976 None 29 Human Binding pKi = 8.8 8.8 -5 9
Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranesInhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes
ChEMBL None None None None 10.1021/jm061404q
2168 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
2810 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
644077 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
644077.0 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
CHEMBL373742 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
DB00067 3976 None 29 Rat Binding pKi = 8.8 8.8 -8 9
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
10715974 11926 None 0 Human Binding pKi = 8.8 8.8 4 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
CHEMBL118271 11926 None 0 Human Binding pKi = 8.8 8.8 4 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
162667087 182545 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 348 2 0 5 4.5 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4786172 182545 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 348 2 0 5 4.5 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccccc3CCC4)CC2)no1 10.1016/j.bmcl.2020.127417
54587189 61929 None 0 Human Binding pKi = 8.8 8.8 33 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 499 7 2 3 4.5 CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2011.02.096
CHEMBL1774022 61929 None 0 Human Binding pKi = 8.8 8.8 33 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 499 7 2 3 4.5 CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c3ccc(Cl)cc3)CC1)C2 10.1016/j.bmcl.2011.02.096
56676958 64072 None 0 Rat Binding pKi = 8.8 8.8 -42 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 501 8 2 3 4.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807267 64072 None 0 Rat Binding pKi = 8.8 8.8 -42 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 501 8 2 3 4.7 CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2011.05.092
145993846 167476 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4294901 167476 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1179 19 15 14 -6.4 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
56666703 64086 None 0 Human Binding pKi = 8.8 8.8 72 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H]1CC[C@@H](O)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807280 64086 None 0 Human Binding pKi = 8.8 8.8 72 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H]1CC[C@@H](O)CC1 10.1016/j.bmcl.2011.05.092
15416417 159837 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC[C@H](O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
CHEMBL4104877 159837 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting methodDisplacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
ChEMBL 400 3 2 3 4.7 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCC[C@H](O)c3ccccc32)cc1 10.1021/acs.jmedchem.7b00422
15976308 149856 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 757 11 1 6 6.0 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL394830 149856 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 757 11 1 6 6.0 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CC(=O)N1CCC(N2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
71458135 79720 None 0 Rat Binding pKi = 8.7 8.7 123 2
Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assayInhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
CHEMBL2115364 79720 None 0 Rat Binding pKi = 8.7 8.7 123 2
Inhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assayInhibition of the 3 nM VP stimulation of phospholipase-C in cultured WRK cells was used as a V1-mediated assay
ChEMBL 1171 20 11 15 1.3 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(N=[N+]=[N-])cc2)NC(=O)C(C)(C)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm00079a020
44428531 169139 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 785 13 1 6 6.7 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCC(CN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
CHEMBL439462 169139 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 785 13 1 6 6.7 O=C(NCc1cccc(C(F)(F)F)c1)[C@H](CCC(=O)N1CCC(CN2CCCCC2)CC1)N1C(=O)[C@@H](N2C(=O)OC[C@@H]2c2ccccc2)[C@H]1/C=C/c1ccccc1 10.1016/j.bmc.2006.12.031
54581530 62401 None 0 Human Binding pKi = 8 8.0 -331 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation counting
ChEMBL 666 9 0 8 4.5 COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 10.1016/j.bmcl.2011.03.012
CHEMBL1779409 62401 None 0 Human Binding pKi = 8 8.0 -331 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation counting
ChEMBL 666 9 0 8 4.5 COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 10.1016/j.bmcl.2011.03.012
24894462 152672 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 745 14 1 6 5.9 CCCCN1CCN(C(=O)CC[C@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
CHEMBL397186 152672 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 745 14 1 6 5.9 CCCCN1CCN(C(=O)CC[C@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
2181 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
2182 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
27991 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
27991.0 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
CHEMBL1429 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
CHEMBL264448 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
DB00035 1331 None 29 Rat Binding pKi = 8.0 8.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
56673645 64063 None 0 Human Binding pKi = 8.0 8.0 17 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 447 7 2 3 3.5 CN1CCC(NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807258 64063 None 0 Human Binding pKi = 8.0 8.0 17 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 447 7 2 3 3.5 CN1CCC(NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
162670083 182855 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3C3CC43)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4790066 182855 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 380 2 0 5 5.2 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3C3CC43)CC2)no1 10.1016/j.bmcl.2020.127417
2181 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
2182 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
27991 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
27991.0 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
CHEMBL1429 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
CHEMBL264448 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
DB00035 1331 None 29 Rat Binding pKi = 7 7.0 -177 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL None None None None 10.1021/jm060928n
44325345 111625 None 0 Human Binding pKi = 7 7.0 -75 2
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorInhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor
ChEMBL 493 3 1 4 4.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2004.03.083
CHEMBL328079 111625 None 0 Human Binding pKi = 7 7.0 -75 2
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorInhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor
ChEMBL 493 3 1 4 4.9 Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc32)c(Cl)c1 10.1016/j.bmcl.2004.03.083
16109440 161710 None 0 Rat Binding pKi = 6 6.0 -3981 4
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 997 16 11 14 -2.3 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm060928n
CHEMBL412973 161710 None 0 Rat Binding pKi = 6 6.0 -3981 4
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 997 16 11 14 -2.3 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm060928n
54584478 62398 None 0 Human Binding pKi = 7 7.0 -1258 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation counting
ChEMBL 666 9 0 8 4.5 COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 10.1016/j.bmcl.2011.03.012
CHEMBL1779406 62398 None 0 Human Binding pKi = 7 7.0 -1258 3
Displacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation countingDisplacement of [3H]AVP from human vasopressin V1a receptor expressed in CHO cells by scintillation counting
ChEMBL 666 9 0 8 4.5 COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 10.1016/j.bmcl.2011.03.012
15951937 118707 None 0 Mouse Binding pKi = 6 6.0 -251 3
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 366 1 1 2 4.5 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
CHEMBL3416861 118707 None 0 Mouse Binding pKi = 6 6.0 -251 3
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 366 1 1 2 4.5 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
24997177 118715 None 0 Mouse Binding pKi = 6.0 6.0 -204 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 367 1 1 3 3.9 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1cccnc12 10.1021/jm501745f
CHEMBL3416870 118715 None 0 Mouse Binding pKi = 6.0 6.0 -204 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 367 1 1 3 3.9 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1cccnc12 10.1021/jm501745f
10208389 78662 None 0 Rat Binding pKi = 7.0 7.0 -70 4
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 523 11 0 6 6.4 Cc1cccc(OCCCCCCN2CCN(C)CC2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
CHEMBL2112339 78662 None 0 Rat Binding pKi = 7.0 7.0 -70 4
Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liverBinding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
ChEMBL 523 11 0 6 6.4 Cc1cccc(OCCCCCCN2CCN(C)CC2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
448537 160344 None 54 Human Binding pKi = 5.0 5.0 -45 25
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 160344 None 54 Human Binding pKi = 5.0 5.0 -45 25
DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
46890054 6921 None 0 Human Binding pKi = 7.0 7.0 19 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 443 4 0 3 6.6 COc1ccc2cc(-c3ccc(C(=O)N4C[C@]5(C)C[C@H]4CC(C)(C)C5)cc3OC)ccc2c1 10.1016/j.bmcl.2010.04.068
CHEMBL1084386 6921 None 0 Human Binding pKi = 7.0 7.0 19 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 443 4 0 3 6.6 COc1ccc2cc(-c3ccc(C(=O)N4C[C@]5(C)C[C@H]4CC(C)(C)C5)cc3OC)ccc2c1 10.1016/j.bmcl.2010.04.068
145959348 162079 None 0 Human Binding pKi = 6.0 6.0 - 1
Displacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assayDisplacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assay
ChEMBL 566 8 1 8 5.0 COc1cc(CN2CCN(c3ccccc3CCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2017.10.059
CHEMBL4159182 162079 None 0 Human Binding pKi = 6.0 6.0 - 1
Displacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assayDisplacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assay
ChEMBL 566 8 1 8 5.0 COc1cc(CN2CCN(c3ccccc3CCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 10.1016/j.ejmech.2017.10.059
56664849 63244 None 0 Human Binding pKi = 7.0 7.0 -426 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1308 18 14 20 0.2 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm010526+
CHEMBL1790721 63244 None 0 Human Binding pKi = 7.0 7.0 -426 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1308 18 14 20 0.2 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm010526+
145977918 163991 None 1 Human Binding pKi = 6.0 6.0 - 1
Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes by radioligand binding assayDisplacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes by radioligand binding assay
ChEMBL 308 2 1 2 3.6 CC(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/acs.jmedchem.8b00697
CHEMBL4207120 163991 None 1 Human Binding pKi = 6.0 6.0 - 1
Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes by radioligand binding assayDisplacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes by radioligand binding assay
ChEMBL 308 2 1 2 3.6 CC(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 10.1021/acs.jmedchem.8b00697
54581266 61909 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 481 10 2 5 2.8 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NCCN(C)C)c(C)c1C 10.1016/j.bmcl.2011.02.096
CHEMBL1774002 61909 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 481 10 2 5 2.8 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NCCN(C)C)c(C)c1C 10.1016/j.bmcl.2011.02.096
46890484 7031 None 0 Human Binding pKi = 8.0 8.0 93 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 381 2 0 1 6.4 Cc1ccccc1-c1ccc(C(=O)N2C[C@@]3(C)C[C@@H]2CC(C)(C)C3)c(Cl)c1 10.1016/j.bmcl.2010.04.068
CHEMBL1084822 7031 None 0 Human Binding pKi = 8.0 8.0 93 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 381 2 0 1 6.4 Cc1ccccc1-c1ccc(C(=O)N2C[C@@]3(C)C[C@@H]2CC(C)(C)C3)c(Cl)c1 10.1016/j.bmcl.2010.04.068
CHEMBL5071635 216753 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None Cc1cccc2c1-n1c(nnc1[C@H]1CC[C@H](Oc3ccccn3)CC1)C[C@H](O)C2 10.1021/acs.jmedchem.1c00863
118734429 118729 None 0 Mouse Binding pKi = 8.0 8.0 -2 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 2 0 4 5.2 CN1CCC(n2cc(C(=O)N3CCC4(CC3)OCc3ccccc34)c3ccc(Cl)cc32)CC1 10.1021/jm501745f
CHEMBL3416884 118729 None 0 Mouse Binding pKi = 8.0 8.0 -2 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 2 0 4 5.2 CN1CCC(n2cc(C(=O)N3CCC4(CC3)OCc3ccccc34)c3ccc(Cl)cc32)CC1 10.1021/jm501745f
44419025 84330 None 0 Human Binding pKi = 7.9 7.9 -45 8
Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptorsBinding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
ChEMBL 1039 17 13 14 -2.7 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm030611c
CHEMBL221436 84330 None 0 Human Binding pKi = 7.9 7.9 -45 8
Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptorsBinding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
ChEMBL 1039 17 13 14 -2.7 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm030611c
56657868 63241 None 0 Human Binding pKi = 7.9 7.9 -69 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1297 16 15 21 -0.8 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O 10.1021/jm010526+
CHEMBL1790719 63241 None 0 Human Binding pKi = 7.9 7.9 -69 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1297 16 15 21 -0.8 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O 10.1021/jm010526+
2249 2227 None 17 Rat Binding pKi = 7.0 7.0 -30 7
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1021/jm901812z
9872389 2227 None 17 Rat Binding pKi = 7.0 7.0 -30 7
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1021/jm901812z
CHEMBL1253853 2227 None 17 Rat Binding pKi = 7.0 7.0 -30 7
Displacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissueDisplacement of [3H]vasopressin from vasopressin V1a receptor in rat liver tissue
ChEMBL 554 9 2 7 1.5 O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C 10.1021/jm901812z
44325579 111990 None 0 Human Binding pKi = 7.0 7.0 -33 2
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorInhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor
ChEMBL 535 4 2 5 5.9 O=C(Nc1ccc(C(=O)N2CC3CSCCN3Cc3ccccc32)c(O)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.03.083
CHEMBL328791 111990 None 0 Human Binding pKi = 7.0 7.0 -33 2
Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorInhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor
ChEMBL 535 4 2 5 5.9 O=C(Nc1ccc(C(=O)N2CC3CSCCN3Cc3ccccc32)c(O)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.03.083
44325558 112632 None 0 Human Binding pKi = 5.0 5.0 -1096 2
Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptorInhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor
ChEMBL 553 4 2 5 5.8 O=C(Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1cccc(O)c1 10.1016/j.bmcl.2004.03.083
CHEMBL330094 112632 None 0 Human Binding pKi = 5.0 5.0 -1096 2
Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptorInhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor
ChEMBL 553 4 2 5 5.8 O=C(Nc1ccc(C(=O)N2C[C@H]3COCCN3Cc3ccccc32)c(Cl)c1)c1ccccc1-c1cccc(O)c1 10.1016/j.bmcl.2004.03.083
135461396 79096 None 0 Human Binding pKi = 6.0 6.0 -3 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 626 13 2 8 2.2 CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)N(CC(N)=O)c3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm050645f
CHEMBL2113196 79096 None 0 Human Binding pKi = 6.0 6.0 -3 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 626 13 2 8 2.2 CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)N(CC(N)=O)c3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm050645f
46890185 7205 None 0 Human Binding pKi = 7.0 7.0 -5 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 549 3 0 2 10.1 CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)c2ccc(-c3ccc(-c4csc5ccccc45)c4ccccc34)cc2Cl)C1 10.1016/j.bmcl.2010.04.068
CHEMBL1085624 7205 None 0 Human Binding pKi = 7.0 7.0 -5 2
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 549 3 0 2 10.1 CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)c2ccc(-c3ccc(-c4csc5ccccc45)c4ccccc34)cc2Cl)C1 10.1016/j.bmcl.2010.04.068
54581267 61911 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 507 8 2 5 3.4 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC2CCN(C)CC2)c(C)c1C 10.1016/j.bmcl.2011.02.096
CHEMBL1774004 61911 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 507 8 2 5 3.4 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC2CCN(C)CC2)c(C)c1C 10.1016/j.bmcl.2011.02.096
11683187 202388 None 41 Human Binding pKi = 6.0 6.0 -117 5
Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells at 10 uMDisplacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells at 10 uM
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/jm901812z
CHEMBL594828 202388 None 41 Human Binding pKi = 6.0 6.0 -117 5
Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells at 10 uMDisplacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells at 10 uM
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1021/jm901812z
45483204 200343 None 0 Human Binding pKi = 6.0 6.0 -11 5
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
CHEMBL1204126 200343 None 0 Human Binding pKi = 6.0 6.0 -11 5
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
CHEMBL1204403 200343 None 0 Human Binding pKi = 6.0 6.0 -11 5
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
CHEMBL572709 200343 None 0 Human Binding pKi = 6.0 6.0 -11 5
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 619 11 1 7 4.6 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
135506374 137987 None 19 Human Binding pKi = 7.0 7.0 1 3
Binding affinity to vasopressin 1a receptor (unknown origin)Binding affinity to vasopressin 1a receptor (unknown origin)
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2015.11.050
CHEMBL3763342 137987 None 19 Human Binding pKi = 7.0 7.0 1 3
Binding affinity to vasopressin 1a receptor (unknown origin)Binding affinity to vasopressin 1a receptor (unknown origin)
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1016/j.ejmech.2015.11.050
135506374 137987 None 19 Human Binding pKi = 7.0 7.0 1 3
Displacement of [3H]-vasopressin from V1A receptor (unknown origin) expressed in HEK293 cell membranes incubated for 60 minsDisplacement of [3H]-vasopressin from V1A receptor (unknown origin) expressed in HEK293 cell membranes incubated for 60 mins
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
CHEMBL3763342 137987 None 19 Human Binding pKi = 7.0 7.0 1 3
Displacement of [3H]-vasopressin from V1A receptor (unknown origin) expressed in HEK293 cell membranes incubated for 60 minsDisplacement of [3H]-vasopressin from V1A receptor (unknown origin) expressed in HEK293 cell membranes incubated for 60 mins
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
56666702 64082 None 0 Rat Binding pKi = 6.9 6.9 -57 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 422 9 3 3 3.2 CC(O)CCNC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1 10.1016/j.bmcl.2011.05.092
CHEMBL1807277 64082 None 0 Rat Binding pKi = 6.9 6.9 -57 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 422 9 3 3 3.2 CC(O)CCNC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(Cl)cc1 10.1016/j.bmcl.2011.05.092
44314536 207458 None 0 Rat Binding pKi = 5.9 5.9 1 2
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 620 8 1 6 7.0 Cc1occc1C(=O)Nc1ccc(C(=O)N(C)c2ccccc2Oc2ccccc2C(=O)N2CCC(N3CCCCC3)CC2)cc1 10.1016/s0960-894x(01)00723-5
CHEMBL76763 207458 None 0 Rat Binding pKi = 5.9 5.9 1 2
Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligandEvaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
ChEMBL 620 8 1 6 7.0 Cc1occc1C(=O)Nc1ccc(C(=O)N(C)c2ccccc2Oc2ccccc2C(=O)N2CCC(N3CCCCC3)CC2)cc1 10.1016/s0960-894x(01)00723-5
44400360 169135 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1519 40 15 17 -1.1 COc1ccc(C[C@@H](NC(=O)CNC(=O)c2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1 10.1021/jm040871+
91936754 169135 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1519 40 15 17 -1.1 COc1ccc(C[C@@H](NC(=O)CNC(=O)c2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1 10.1021/jm040871+
CHEMBL439430 169135 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity against human vasopressin V1a receptor expressed in CHO cellsBinding affinity against human vasopressin V1a receptor expressed in CHO cells
ChEMBL 1519 40 15 17 -1.1 COc1ccc(C[C@@H](NC(=O)CNC(=O)c2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(N)=O)cc1 10.1021/jm040871+
1135733 136081 None 7 Human Binding pKi = 6.9 6.9 1 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 436 6 0 4 3.5 COc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 10.1021/jm050645f
CHEMBL373167 136081 None 7 Human Binding pKi = 6.9 6.9 1 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 436 6 0 4 3.5 COc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 10.1021/jm050645f
46890258 6937 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 424 3 1 2 6.0 CC(=O)Nc1cccc(-c2ccc(C(=O)N3C[C@]4(C)C[C@H]3CC(C)(C)C4)c(Cl)c2)c1 10.1016/j.bmcl.2010.04.068
CHEMBL1084455 6937 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement [3H]Arg human recombinant Vasopressin V1a receptorDisplacement [3H]Arg human recombinant Vasopressin V1a receptor
ChEMBL 424 3 1 2 6.0 CC(=O)Nc1cccc(-c2ccc(C(=O)N3C[C@]4(C)C[C@H]3CC(C)(C)C4)c(Cl)c2)c1 10.1016/j.bmcl.2010.04.068
16063234 118725 None 2 Human Binding pKi = 6.9 6.9 16 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 373 2 1 2 4.4 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCN(c2ccccc2Cl)CC1 10.1021/jm501745f
CHEMBL3416880 118725 None 2 Human Binding pKi = 6.9 6.9 16 2
Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 373 2 1 2 4.4 O=C(c1c[nH]c2cc(Cl)ccc12)N1CCN(c2ccccc2Cl)CC1 10.1021/jm501745f
135469685 79110 None 0 Human Binding pKi = 5.9 5.9 -165 3
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 542 10 2 7 3.0 COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm050645f
CHEMBL2113211 79110 None 0 Human Binding pKi = 5.9 5.9 -165 3
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 542 10 2 7 3.0 COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 10.1021/jm050645f
CHEMBL5074961 216831 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
ChEMBL None None None OC1Cc2c(Cl)cccc2-n2c(nnc2[C@H]2CC[C@H](Oc3ccccn3)CC2)C1 10.1021/acs.jmedchem.1c00863
56680282 64064 None 0 Rat Binding pKi = 7.9 7.9 -21 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 490 10 2 4 3.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807259 64064 None 0 Rat Binding pKi = 7.9 7.9 -21 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 490 10 2 4 3.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2011.05.092
56671720 63243 None 0 Human Binding pKi = 7.9 7.9 -67 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1324 18 15 21 -0.9 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm010526+
CHEMBL1790720 63243 None 0 Human Binding pKi = 7.9 7.9 -67 3
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL 1324 18 15 21 -0.9 CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm010526+
135506374 137987 None 19 Human Binding pKi = 7.9 7.9 1 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
CHEMBL3763342 137987 None 19 Human Binding pKi = 7.9 7.9 1 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 581 5 4 8 4.1 Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 10.1021/acs.jmedchem.8b00697
54580270 61908 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 536 10 2 6 2.5 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NCCN2CCN(C)CC2)c(C)c1C 10.1016/j.bmcl.2011.02.096
CHEMBL1774001 61908 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 536 10 2 6 2.5 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NCCN2CCN(C)CC2)c(C)c1C 10.1016/j.bmcl.2011.02.096
42611262 180665 None 0 Human Binding pKi = 7.9 7.9 -31 4
Displacement of [3H]oxytocin from human vasopressin V1a receptor expressed in CHO cells by filtration binding assayDisplacement of [3H]oxytocin from human vasopressin V1a receptor expressed in CHO cells by filtration binding assay
ChEMBL 349 6 0 2 4.7 Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
CHEMBL475395 180665 None 0 Human Binding pKi = 7.9 7.9 -31 4
Displacement of [3H]oxytocin from human vasopressin V1a receptor expressed in CHO cells by filtration binding assayDisplacement of [3H]oxytocin from human vasopressin V1a receptor expressed in CHO cells by filtration binding assay
ChEMBL 349 6 0 2 4.7 Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 10.1016/j.bmcl.2008.11.064
44419039 137483 None 0 Rat Binding pKi = 7.9 7.9 -100 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 1096 20 14 15 -4.6 NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm060928n
CHEMBL375324 137483 None 0 Rat Binding pKi = 7.9 7.9 -100 8
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 1096 20 14 15 -4.6 NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm060928n
145981637 166588 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [Ph-Se-acetyl]-LVA from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Ph-Se-acetyl]-LVA from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
CHEMBL4278500 166588 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [Ph-Se-acetyl]-LVA from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of [Ph-Se-acetyl]-LVA from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1206 34 16 14 -4.3 COc1ccc(C[C@@H](NC(=O)C[Se]c2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)cc1 10.1021/acs.jmedchem.8b01320
5034737 208801 None 8 Human Binding pKi = 6.9 6.9 20 2
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 341 4 0 4 4.9 COc1ccccc1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
CHEMBL87351 208801 None 8 Human Binding pKi = 6.9 6.9 20 2
Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligandBinding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand
ChEMBL 341 4 0 4 4.9 COc1ccccc1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1 10.1021/jm010544r
2042 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
2174 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
2176 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
439302 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
439302.0 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
CHEMBL395429 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
DB00107 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity for human Vasopressin V1a receptorBinding affinity for human Vasopressin V1a receptor
ChEMBL None None None None 10.1021/jm010526+
2042 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
2174 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
2176 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
439302 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
439302.0 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
CHEMBL395429 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
DB00107 2983 None 40 Human Binding pKi = 6.9 6.9 -29 8
Binding affinity to V1aR (unknown origin)Binding affinity to V1aR (unknown origin)
ChEMBL None None None None 10.1021/jm501395b
44361522 121760 None 0 Human Binding pKi = 4.9 4.9 -2137 5
Binding affinity was evaluated by measuring the displacement of [3H]AVP (arginine vasopressin) from specific binding sites in human plateletsBinding affinity was evaluated by measuring the displacement of [3H]AVP (arginine vasopressin) from specific binding sites in human platelets
ChEMBL 477 4 0 5 3.8 CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 10.1021/jm00023a002
CHEMBL358793 121760 None 0 Human Binding pKi = 4.9 4.9 -2137 5
Binding affinity was evaluated by measuring the displacement of [3H]AVP (arginine vasopressin) from specific binding sites in human plateletsBinding affinity was evaluated by measuring the displacement of [3H]AVP (arginine vasopressin) from specific binding sites in human platelets
ChEMBL 477 4 0 5 3.8 CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 10.1021/jm00023a002
57978135 118727 None 0 Mouse Binding pKi = 6.9 6.9 -89 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 449 3 1 4 4.7 O=C(c1cn(C[C@@H]2CCCN2)c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
CHEMBL3416882 118727 None 0 Mouse Binding pKi = 6.9 6.9 -89 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 449 3 1 4 4.7 O=C(c1cn(C[C@@H]2CCCN2)c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 10.1021/jm501745f
44419029 96963 None 0 Rat Binding pKi = 5.9 5.9 -31622 4
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 1053 18 13 14 -2.4 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm060928n
CHEMBL265859 96963 None 0 Rat Binding pKi = 5.9 5.9 -31622 4
Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membraneDisplacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane
ChEMBL 1053 18 13 14 -2.4 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/jm060928n
10444 2326 None 17 Human Binding pKi = 5.9 5.9 -5 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
139030525 2326 None 17 Human Binding pKi = 5.9 5.9 -5 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
145711714 2326 None 17 Human Binding pKi = 5.9 5.9 -5 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
CHEMBL4204210 2326 None 17 Human Binding pKi = 5.9 5.9 -5 3
Displacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assayDisplacement of DY647 from SNAP-tagged V1A receptor (unknown origin) expressed in HEK293 cells by TR-FRET assay
ChEMBL 531 4 2 6 4.2 Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C 10.1021/acs.jmedchem.8b00697
45483325 200727 None 0 Human Binding pKi = 5.9 5.9 -20 3
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 577 11 1 7 3.4 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
CHEMBL575797 200727 None 0 Human Binding pKi = 5.9 5.9 -20 3
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 577 11 1 7 3.4 COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CC3)CC2)c(OC)c1 10.1016/j.bmcl.2009.09.050
10416272 104795 None 5 Human Binding pKi = 5.9 5.9 -630 2
Compound was tested for its ability to displace vasopressin from human Vasopressin V1a receptorCompound was tested for its ability to displace vasopressin from human Vasopressin V1a receptor
ChEMBL 608 6 1 7 4.7 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 10.1016/s0960-894x(02)00160-9
CHEMBL31065 104795 None 5 Human Binding pKi = 5.9 5.9 -630 2
Compound was tested for its ability to displace vasopressin from human Vasopressin V1a receptorCompound was tested for its ability to displace vasopressin from human Vasopressin V1a receptor
ChEMBL 608 6 1 7 4.7 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 10.1016/s0960-894x(02)00160-9
10416272 104795 None 5 Human Binding pKi = 5.9 5.9 -630 2
Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 608 6 1 7 4.7 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 10.1021/jm901812z
CHEMBL31065 104795 None 5 Human Binding pKi = 5.9 5.9 -630 2
Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cellsDisplacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells
ChEMBL 608 6 1 7 4.7 O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 10.1021/jm901812z
45483256 200754 None 0 Human Binding pKi = 5.9 5.9 -8 3
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 565 11 1 7 3.4 CCCNC1CCN(S(=O)(=O)CCC2CCc3ccccc3N2S(=O)(=O)c2ccc(OC)cc2OC)CC1 10.1016/j.bmcl.2009.09.050
CHEMBL575987 200754 None 0 Human Binding pKi = 5.9 5.9 -8 3
Displacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counterDisplacement of [3H]Arg8-vasopressin from human vasopressin V1a receptor expressed in CHO-K1 cells by Packard Topcount scintillation counter
ChEMBL 565 11 1 7 3.4 CCCNC1CCN(S(=O)(=O)CCC2CCc3ccccc3N2S(=O)(=O)c2ccc(OC)cc2OC)CC1 10.1016/j.bmcl.2009.09.050
54581268 61913 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 533 8 2 5 3.9 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3C)c(C)c1C 10.1016/j.bmcl.2011.02.096
CHEMBL1774006 61913 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 533 8 2 5 3.9 COc1cc(C)c(S(=O)(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3C)c(C)c1C 10.1016/j.bmcl.2011.02.096
54582311 61923 None 0 Human Binding pKi = 6.9 6.9 1 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 493 7 3 3 4.3 O=C(Cc1ccc(Cl)c(Cl)c1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
CHEMBL1774016 61923 None 0 Human Binding pKi = 6.9 6.9 1 2
Displacement of [3H]AVP from human V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from human V1A receptor expressed in CHO cells
ChEMBL 493 7 3 3 4.3 O=C(Cc1ccc(Cl)c(Cl)c1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 10.1016/j.bmcl.2011.02.096
56683608 64081 None 0 Rat Binding pKi = 6.9 6.9 -18 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 446 9 3 3 3.5 O=C(NCCCO)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(F)cc2)CCCC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807276 64081 None 0 Rat Binding pKi = 6.9 6.9 -18 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 446 9 3 3 3.5 O=C(NCCCO)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1(c2ccc(F)cc2)CCCC1 10.1016/j.bmcl.2011.05.092
56676960 64084 None 0 Rat Binding pKi = 6.9 6.9 -75 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCC(O)C1 10.1016/j.bmcl.2011.05.092
CHEMBL1807279 64084 None 0 Rat Binding pKi = 6.9 6.9 -75 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)NC1CCCC(O)C1 10.1016/j.bmcl.2011.05.092
56666703 64086 None 0 Rat Binding pKi = 6.9 6.9 -72 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H]1CC[C@@H](O)CC1 10.1016/j.bmcl.2011.05.092
CHEMBL1807280 64086 None 0 Rat Binding pKi = 6.9 6.9 -72 2
Displacement of [3H]AVP from rat V1A receptor expressed in CHO cellsDisplacement of [3H]AVP from rat V1A receptor expressed in CHO cells
ChEMBL 448 7 3 3 3.7 O=C(Cc1ccc(Cl)cc1)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H]1CC[C@@H](O)CC1 10.1016/j.bmcl.2011.05.092
145990668 167035 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1099 19 15 14 -6.0 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4286989 167035 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysisDisplacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis
ChEMBL 1099 19 15 14 -6.0 N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O 10.1021/acs.jmedchem.8b01320
135489430 79095 None 0 Human Binding pKi = 5.9 5.9 -11 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 627 12 2 9 3.1 COC(=O)c1cccc2c1NC(=O)/C2=N\NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCCN(C)C)cc1 10.1021/jm050645f
CHEMBL2113195 79095 None 0 Human Binding pKi = 5.9 5.9 -11 2
Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cellsDisplacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells
ChEMBL 627 12 2 9 3.1 COC(=O)c1cccc2c1NC(=O)/C2=N\NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCCN(C)C)cc1 10.1021/jm050645f
CHEMBL2369838 212162 None 0 Human Binding pKi = 7.9 7.9 -6 4
Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptorsBinding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
ChEMBL None None None NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1 10.1021/jm030611c
44428547 93230 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 731 12 1 6 5.5 CC(C)N1CCN(C(=O)CC[C@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
CHEMBL244389 93230 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity for human cloned vasopressin V1a receptor expressed in CHO cellsBinding affinity for human cloned vasopressin V1a receptor expressed in CHO cells
ChEMBL 731 12 1 6 5.5 CC(C)N1CCN(C(=O)CC[C@H](C(=O)NCc2cccc(C(F)(F)F)c2)N2C(=O)[C@@H](N3C(=O)OC[C@@H]3c3ccccc3)[C@H]2/C=C/c2ccccc2)CC1 10.1016/j.bmc.2006.12.031
53349471 118667 None 0 Human Binding pKi = 7.9 7.9 22 2
Binding affinity to human V1a assessed as inhibition constantBinding affinity to human V1a assessed as inhibition constant
ChEMBL 413 3 1 3 5.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3cccc(C)c32)cc1 10.1016/j.bmcl.2017.11.050
CHEMBL3416774 118667 None 0 Human Binding pKi = 7.9 7.9 22 2
Binding affinity to human V1a assessed as inhibition constantBinding affinity to human V1a assessed as inhibition constant
ChEMBL 413 3 1 3 5.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3cccc(C)c32)cc1 10.1016/j.bmcl.2017.11.050
53349471 118667 None 0 Human Binding pKi = 7.9 7.9 22 2
Displacement of [3H]-(Arg8)-vasopressin from human vasopressin V1a receptor transfected in CHO cell membranesDisplacement of [3H]-(Arg8)-vasopressin from human vasopressin V1a receptor transfected in CHO cell membranes
ChEMBL 413 3 1 3 5.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3cccc(C)c32)cc1 10.1021/acs.jmedchem.5b00289
CHEMBL3416774 118667 None 0 Human Binding pKi = 7.9 7.9 22 2
Displacement of [3H]-(Arg8)-vasopressin from human vasopressin V1a receptor transfected in CHO cell membranesDisplacement of [3H]-(Arg8)-vasopressin from human vasopressin V1a receptor transfected in CHO cell membranes
ChEMBL 413 3 1 3 5.0 Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCN(C)c3cccc(C)c32)cc1 10.1021/acs.jmedchem.5b00289
11993729 118728 None 0 Mouse Binding pKi = 7.9 7.9 -12 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 3 0 4 5.1 CN1CCC[C@H]1Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
CHEMBL3416883 118728 None 0 Mouse Binding pKi = 7.9 7.9 -12 2
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assayDisplacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay
ChEMBL 463 3 0 4 5.1 CN1CCC[C@H]1Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccc(Cl)cc21 10.1021/jm501745f
162646538 179712 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 412 1 0 3 3.8 CC(=O)N1CCN(C(=O)N2CCN(c3ccccc3C)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
CHEMBL4742335 179712 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 412 1 0 3 3.8 CC(=O)N1CCN(C(=O)N2CCN(c3ccccc3C)CC2)c2ccc(Cl)cc21 10.1016/j.bmcl.2020.127416
162649115 179975 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 368 2 0 5 4.8 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CC4)CC2)no1 10.1016/j.bmcl.2020.127417
CHEMBL4745524 179975 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayDisplacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay
ChEMBL 368 2 0 5 4.8 Cc1cc([C@H]2CC[C@H](c3nnc4n3-c3ccc(Cl)cc3CC4)CC2)no1 10.1016/j.bmcl.2020.127417
54580516 62402 None 0 Human