Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 1185 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 3038517 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| DB06494 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 1185 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 3038517 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| DB06494 | 3701 | None | 34 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 53386917 | 63539 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800156 | 63539 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53388960 | 63589 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 682 | 11 | 2 | 9 | 6.0 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800663 | 63589 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 682 | 11 | 2 | 9 | 6.0 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 11512905 | 138505 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL377396 | 138505 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 9961721 | 168582 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 53388958 | 63587 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800661 | 63587 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 18324807 | 63594 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800668 | 63594 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 20691661 | 79644 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL211485 | 79644 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 10100930 | 63538 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800155 | 63538 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386915 | 63536 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800153 | 63536 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53389117 | 63592 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 688 | 11 | 2 | 9 | 4.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN2CCCC2=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800666 | 63592 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 688 | 11 | 2 | 9 | 4.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN2CCCC2=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53389115 | 63590 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 698 | 11 | 3 | 10 | 5.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccc(CO)n2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800664 | 63590 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 698 | 11 | 3 | 10 | 5.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccc(CO)n2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53387071 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800157 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10371708 | 63541 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800158 | 63541 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53389118 | 63593 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 712 | 12 | 2 | 10 | 4.2 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN(C)S(C)(=O)=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800667 | 63593 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 712 | 12 | 2 | 10 | 4.2 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN(C)S(C)(=O)=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53386756 | 63595 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 617 | 13 | 2 | 10 | 3.6 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCOC)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800669 | 63595 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 617 | 13 | 2 | 10 | 3.6 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCOC)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 16221494 | 162046 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL415659 | 162046 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 53386757 | 63596 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 631 | 14 | 2 | 10 | 4.0 | CCOCCn1c(=O)c2c(CN(C)CCOC)c(-c3ccc(NC(=O)NOC)cc3)sc2n(Cc2c(F)cccc2F)c1=O | 10.1021/jm200216q | |||
| CHEMBL1800670 | 63596 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 631 | 14 | 2 | 10 | 4.0 | CCOCCn1c(=O)c2c(CN(C)CCOC)c(-c3ccc(NC(=O)NOC)cc3)sc2n(Cc2c(F)cccc2F)c1=O | 10.1021/jm200216q | |||
| 10100930 | 63538 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800155 | 63538 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386917 | 63539 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800156 | 63539 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 11421412 | 178846 | None | 12 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 545 | 7 | 1 | 6 | 5.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](N)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| CHEMBL468551 | 178846 | None | 12 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 545 | 7 | 1 | 6 | 5.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](N)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| 11477988 | 91044 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 524 | 9 | 1 | 7 | 4.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@@H](C)NCc3ccccn3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL23969 | 91044 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 524 | 9 | 1 | 7 | 4.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@@H](C)NCc3ccccn3)c2=O)c1F | 10.1021/jm030472z | |||
| 16155709 | 168578 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1661 | 42 | 17 | 19 | 1.7 | CONC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL435141 | 168578 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1661 | 42 | 17 | 19 | 1.7 | CONC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16155709 | 168578 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1661 | 42 | 17 | 19 | 1.7 | CONC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL435141 | 168578 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1661 | 42 | 17 | 19 | 1.7 | CONC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL262747 | 213005 | None | 8 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||||
| 101755083 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 16136245 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 16136245.0 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 4379 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 5585 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| CHEMBL415606 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| DB06699 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 101755083 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 16136245 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 16136245.0 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 4379 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| 5585 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| CHEMBL415606 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| DB06699 | 1359 | None | 35 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm060240a | |||||
| CHEMBL407661 | 215135 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 11262242 | 188846 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 645 | 13 | 2 | 7 | 6.1 | Cc1c(-c2cccc(OCCCCCC(=O)O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| CHEMBL505033 | 188846 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 645 | 13 | 2 | 7 | 6.1 | Cc1c(-c2cccc(OCCCCCC(=O)O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| 16221267 | 142089 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1564 | 41 | 14 | 17 | 3.7 | CS[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O | 10.1021/jm0613931 | |||
| CHEMBL387499 | 142089 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1564 | 41 | 14 | 17 | 3.7 | CS[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O | 10.1021/jm0613931 | |||
| 1184 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| 9874838 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| 1184 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| 9874838 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| CHEMBL407661 | 215135 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 53387071 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL1800157 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL262747 | 213005 | None | 8 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL262747 | 213005 | None | 8 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL434380 | 216115 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@@H](C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)cc1 | 10.1021/jm060240a | |||||
| 44395623 | 124724 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 551 | 7 | 3 | 8 | 5.3 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL364167 | 124724 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 551 | 7 | 3 | 8 | 5.3 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL434380 | 216115 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@@H](C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)cc1 | 10.1021/jm060240a | |||||
| 16221104 | 85592 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](NC(C)=O)Sc2ccc3ccccc3c2)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL227861 | 85592 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](NC(C)=O)Sc2ccc3ccccc3c2)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 87285768 | 170598 | None | 4 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4449332 | 170598 | None | 4 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 16156699 | 166661 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1647 | 41 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL427976 | 166661 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1647 | 41 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16221266 | 166454 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1564 | 41 | 14 | 17 | 3.7 | CS[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O | 10.1021/jm0613931 | |||
| CHEMBL427438 | 166454 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1564 | 41 | 14 | 17 | 3.7 | CS[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O | 10.1021/jm0613931 | |||
| 44395435 | 123879 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 523 | 7 | 3 | 8 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL362371 | 123879 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 523 | 7 | 3 | 8 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 16221495 | 85557 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL227451 | 85557 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1550 | 40 | 14 | 17 | 3.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 16156699 | 166661 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1647 | 41 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL427976 | 166661 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1647 | 41 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 9895596 | 63535 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800152 | 63535 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 16221556 | 168452 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1580 | 41 | 14 | 17 | 2.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(N)=O)[S+](C)[O-])cc1 | 10.1021/jm0613931 | |||
| CHEMBL434371 | 168452 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1580 | 41 | 14 | 17 | 2.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(N)=O)[S+](C)[O-])cc1 | 10.1021/jm0613931 | |||
| CHEMBL429527 | 215997 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| 155531714 | 176295 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4593521 | 176295 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL429527 | 215997 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NO)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| 16221496 | 142834 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1580 | 41 | 14 | 17 | 2.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N)=O)[S+](C)[O-])cc1 | 10.1021/jm0613931 | |||
| CHEMBL389248 | 142834 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1580 | 41 | 14 | 17 | 2.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N)=O)[S+](C)[O-])cc1 | 10.1021/jm0613931 | |||
| 16156573 | 168979 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1747 | 48 | 17 | 20 | 2.2 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL438239 | 168979 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1747 | 48 | 17 | 20 | 2.2 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16156573 | 168979 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1747 | 48 | 17 | 20 | 2.2 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL438239 | 168979 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1747 | 48 | 17 | 20 | 2.2 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 10649568 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL219061 | 211863 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL219061 | 211863 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 53387071 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800157 | 63540 | None | 5 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10371708 | 63541 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800158 | 63541 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 137498593 | 195446 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 637 | 10 | 2 | 11 | 4.1 | CCOc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5403996 | 195446 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 637 | 10 | 2 | 11 | 4.1 | CCOc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 10649568 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm701249f | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm701249f | |||
| 53386916 | 63537 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 654 | 11 | 2 | 10 | 4.5 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(F)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800154 | 63537 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 654 | 11 | 2 | 10 | 4.5 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(F)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10649568 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| 44321052 | 208729 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 578 | 9 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(O)nc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86912 | 208729 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 578 | 9 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(O)nc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 16155593 | 158529 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 1767 | 53 | 17 | 21 | 2.2 | CONC(=O)NCCOCCOCCOCCC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL409044 | 158529 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 1767 | 53 | 17 | 21 | 2.2 | CONC(=O)NCCOCCOCCOCCC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16155593 | 158529 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 1767 | 53 | 17 | 21 | 2.2 | CONC(=O)NCCOCCOCCOCCC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL409044 | 158529 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 1767 | 53 | 17 | 21 | 2.2 | CONC(=O)NCCOCCOCCOCCC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL409043 | 215203 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 172441438 | 195051 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 653 | 8 | 2 | 10 | 4.8 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc4c(c2F)OCO4)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5395542 | 195051 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 653 | 8 | 2 | 10 | 4.8 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc4c(c2F)OCO4)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL409043 | 215203 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 16221433 | 142250 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1548 | 40 | 13 | 16 | 4.7 | CS[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||
| CHEMBL388369 | 142250 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1548 | 40 | 13 | 16 | 4.7 | CS[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||
| 16221211 | 169365 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1566 | 40 | 14 | 17 | 2.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL441211 | 169365 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1566 | 40 | 14 | 17 | 2.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| 53386915 | 63536 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800153 | 63536 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 44395650 | 169424 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 4.9 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL441676 | 169424 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 4.9 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL2105773 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||||
| CHEMBL409018 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||||
| 16155157 | 96501 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1622 | 44 | 16 | 18 | 3.6 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL262180 | 96501 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1622 | 44 | 16 | 18 | 3.6 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44398152 | 160309 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1675 | 42 | 17 | 20 | 0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL410967 | 160309 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1675 | 42 | 17 | 20 | 0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16155157 | 96501 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1622 | 44 | 16 | 18 | 3.6 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL262180 | 96501 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1622 | 44 | 16 | 18 | 3.6 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL2105773 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||||
| CHEMBL409018 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||||
| 18324807 | 63594 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800668 | 63594 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 44321964 | 96472 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL261979 | 96472 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 16156328 | 96705 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1592 | 43 | 16 | 17 | 3.4 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL263691 | 96705 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1592 | 43 | 16 | 17 | 3.4 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44398047 | 96966 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL265879 | 96966 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16156328 | 96705 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1592 | 43 | 16 | 17 | 3.4 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL263691 | 96705 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1592 | 43 | 16 | 17 | 3.4 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL376654 | 214713 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| CHEMBL376654 | 214713 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| 44398065 | 155803 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1671 | 41 | 17 | 18 | 2.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL405273 | 155803 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1671 | 41 | 17 | 18 | 2.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 11250647 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| 11250647.0 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| 5293 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| 8362 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| CHEMBL1208155 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| DB11979 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 977 | 7 | ChEMBL | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | 10.1021/jm8006454 | |||
| 44449120 | 95286 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 567 | 8 | 1 | 6 | 5.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL256109 | 95286 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 567 | 8 | 1 | 6 | 5.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| 44380487 | 167678 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]ncc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL430069 | 167678 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]ncc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 23656390 | 161777 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 659 | 10 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL413245 | 161777 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 659 | 10 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL219562 | 211876 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=O)CNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL219562 | 211876 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=O)CNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 44398064 | 167106 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1647 | 40 | 17 | 20 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL428825 | 167106 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1647 | 40 | 17 | 20 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 145957953 | 162224 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 633 | 9 | 1 | 9 | 4.3 | COc1ccccc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4161566 | 162224 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 633 | 9 | 1 | 9 | 4.3 | COc1ccccc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 44398063 | 161903 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1661 | 41 | 17 | 20 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL414347 | 161903 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1661 | 41 | 17 | 20 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 58239302 | 162084 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 577 | 12 | 2 | 7 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(C)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4159247 | 162084 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 577 | 12 | 2 | 7 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(C)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 44395462 | 168326 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 551 | 7 | 3 | 8 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL433594 | 168326 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 551 | 7 | 3 | 8 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 16155358 | 138223 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1778 | 49 | 18 | 21 | 1.9 | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL376728 | 138223 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1778 | 49 | 18 | 21 | 1.9 | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 172467595 | 196584 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 673 | 9 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5427278 | 196584 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 673 | 9 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44398043 | 161791 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1603 | 37 | 17 | 18 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(=O)NC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL413450 | 161791 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1603 | 37 | 17 | 18 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(=O)NC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16155358 | 138223 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1778 | 49 | 18 | 21 | 1.9 | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL376728 | 138223 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1778 | 49 | 18 | 21 | 1.9 | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 101755083 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| 16136245 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| 16136245.0 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| 4379 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| 5585 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| CHEMBL415606 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| DB06699 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm050134t | |||||
| 16156341 | 161825 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1929 | 63 | 17 | 25 | 2.5 | CONC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)NOC)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL413688 | 161825 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1929 | 63 | 17 | 25 | 2.5 | CONC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)NOC)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16156341 | 161825 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1929 | 63 | 17 | 25 | 2.5 | CONC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)NOC)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL413688 | 161825 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1929 | 63 | 17 | 25 | 2.5 | CONC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)NOC)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16155098 | 160759 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1656 | 43 | 19 | 19 | 0.1 | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL411337 | 160759 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1656 | 43 | 19 | 19 | 0.1 | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16155098 | 160759 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1656 | 43 | 19 | 19 | 0.1 | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL411337 | 160759 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1656 | 43 | 19 | 19 | 0.1 | CONC(=O)NCC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 170268938 | 196894 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 675 | 10 | 2 | 9 | 5.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5434324 | 196894 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 675 | 10 | 2 | 9 | 5.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44398150 | 96754 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1617 | 40 | 17 | 18 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL264090 | 96754 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1617 | 40 | 17 | 18 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44398066 | 97199 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1701 | 41 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCNC(C(=O)O)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL267873 | 97199 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1701 | 41 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCNC(C(=O)O)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44398045 | 162060 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1715 | 40 | 19 | 20 | -1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=O)[C@H]1CC(=O)NC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL415820 | 162060 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1715 | 40 | 19 | 20 | -1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=O)[C@H]1CC(=O)NC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 172458448 | 196240 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 639 | 9 | 2 | 9 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5419489 | 196240 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 639 | 9 | 2 | 9 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44398151 | 162044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 43 | 17 | 20 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL415595 | 162044 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 43 | 17 | 20 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44398046 | 161420 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N(C)[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL412500 | 161420 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N(C)[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 162514345 | 196508 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5425604 | 196508 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 1185 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 3038517 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| DB06494 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 44320921 | 107225 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 548 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL316362 | 107225 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 548 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44398135 | 96857 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1675 | 41 | 16 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN(C)CCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL265020 | 96857 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1675 | 41 | 16 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN(C)CCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44398001 | 169058 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1661 | 41 | 17 | 20 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CNCCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL438905 | 169058 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1661 | 41 | 17 | 20 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CNCCC(=O)OC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44460342 | 168025 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 606 | 9 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL431402 | 168025 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 606 | 9 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 16656823 | 128730 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 468 | 5 | 2 | 6 | 4.3 | CC(C)(C(=O)c1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1)c1ccccc1 | nan | |||
| CHEMBL3668011 | 128730 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 468 | 5 | 2 | 6 | 4.3 | CC(C)(C(=O)c1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1)c1ccccc1 | nan | |||
| 11191675 | 63402 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 487 | 8 | 1 | 6 | 4.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCC3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL179600 | 63402 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 487 | 8 | 1 | 6 | 4.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCC3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL3085404 | 63402 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 487 | 8 | 1 | 6 | 4.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCC3)c2=O)c1F | 10.1021/jm030472z | |||
| 1185 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 3038517 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| DB06494 | 3701 | None | 34 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 44380317 | 168592 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cncc3ccccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL435262 | 168592 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cncc3ccccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44359191 | 12210 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184298 | 12210 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL343396 | 12210 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44398121 | 96686 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1655 | 41 | 18 | 19 | 0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 77232195 | 96686 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1655 | 41 | 18 | 19 | 0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL263507 | 96686 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1655 | 41 | 18 | 19 | 0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16145131 | 159574 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cc(O)nc(O)n3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361540 | 159574 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cc(O)nc(O)n3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL410165 | 159574 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cc(O)nc(O)n3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361888 | 141863 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL386105 | 141863 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL2369138 | 212056 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CNC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 44380222 | 57612 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 614 | 10 | 2 | 5 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166778 | 57612 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 614 | 10 | 2 | 5 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 172458154 | 196392 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 676 | 10 | 2 | 10 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cncc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5422863 | 196392 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 676 | 10 | 2 | 10 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cncc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 1179 | 961 | None | 28 | Human | Functional | pIC50 | = | 6 | 6.0 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| 9957278 | 961 | None | 28 | Human | Functional | pIC50 | = | 6 | 6.0 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| CHEMBL494803 | 961 | None | 28 | Human | Functional | pIC50 | = | 6 | 6.0 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| 44434414 | 88560 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 709 | 14 | 3 | 9 | 4.6 | C#CCNC(=O)CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCC)cc2)nc2n(Cc3c(F)cccc3F)cc(C(=O)OCC)c(=O)n12 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL235179 | 88560 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 709 | 14 | 3 | 9 | 4.6 | C#CCNC(=O)CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCC)cc2)nc2n(Cc3c(F)cccc3F)cc(C(=O)OCC)c(=O)n12 | 10.1016/j.bmc.2007.04.065 | |||
| 145993478 | 167416 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 602 | 8 | 3 | 9 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1)C(=O)O | 10.1039/C7MD00320J | |||
| CHEMBL4294163 | 167416 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 602 | 8 | 3 | 9 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1)C(=O)O | 10.1039/C7MD00320J | |||
| 44577102 | 178631 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 303 | 5 | 1 | 4 | 4.1 | CCSc1nc2cc(NC(=O)C3CC3)ccc2n1C(C)C | 10.1021/jm701249f | |||
| CHEMBL466735 | 178631 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 303 | 5 | 1 | 4 | 4.1 | CCSc1nc2cc(NC(=O)C3CC3)ccc2n1C(C)C | 10.1021/jm701249f | |||
| 118098039 | 128724 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 461 | 4 | 1 | 6 | 3.5 | Cc1cccc(N(C)S(=O)(=O)c2ccc(Cl)c(-n3c(=O)[nH]c4sccc4c3=O)c2)c1 | nan | |||
| CHEMBL3668005 | 128724 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 461 | 4 | 1 | 6 | 3.5 | Cc1cccc(N(C)S(=O)(=O)c2ccc(Cl)c(-n3c(=O)[nH]c4sccc4c3=O)c2)c1 | nan | |||
| 44380681 | 58791 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 669 | 9 | 3 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(F)(F)F)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168726 | 58791 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 669 | 9 | 3 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(F)(F)F)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44341198 | 113121 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 620 | 10 | 3 | 4 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL331144 | 113121 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 620 | 10 | 3 | 4 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 145959547 | 162377 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 604 | 9 | 1 | 9 | 3.9 | Cc1ccccc1C(N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4164102 | 162377 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 604 | 9 | 1 | 9 | 3.9 | Cc1ccccc1C(N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 11467552 | 172814 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 603 | 11 | 2 | 6 | 5.7 | O=C(O)CCCN[C@@H](Cn1c(=O)c(-c2ccccc2Cl)cn(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1016/j.bmcl.2008.04.036 | |||
| CHEMBL450471 | 172814 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 603 | 11 | 2 | 6 | 5.7 | O=C(O)CCCN[C@@H](Cn1c(=O)c(-c2ccccc2Cl)cn(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1016/j.bmcl.2008.04.036 | |||
| 44561397 | 189933 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 458 | 4 | 3 | 5 | 3.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5c[nH]c(=O)[nH]c5=O)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL516479 | 189933 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 458 | 4 | 3 | 5 | 3.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5c[nH]c(=O)[nH]c5=O)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44341197 | 109091 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 587 | 9 | 2 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C#N)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL321258 | 109091 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 587 | 9 | 2 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C#N)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44321394 | 106995 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 592 | 10 | 2 | 4 | 7.5 | COc1ccc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)cn1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL314860 | 106995 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 592 | 10 | 2 | 4 | 7.5 | COc1ccc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)cn1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44395677 | 66759 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 565 | 7 | 2 | 8 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185738 | 66759 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 565 | 7 | 2 | 8 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44380538 | 59102 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 619 | 9 | 2 | 5 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169620 | 59102 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 619 | 9 | 2 | 5 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380318 | 120443 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL353308 | 120443 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44293151 | 101228 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 510 | 12 | 2 | 3 | 6.9 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C(C)C | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295595 | 101228 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 510 | 12 | 2 | 3 | 6.9 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C(C)C | 10.1016/s0960-894x(01)00275-x | |||
| 44451397 | 95956 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 856 | 16 | 4 | 10 | 5.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N[C@@H](C)C(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL259220 | 95956 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 856 | 16 | 4 | 10 | 5.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N[C@@H](C)C(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 44444665 | 94254 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL249772 | 94254 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44432638 | 86818 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 506 | 9 | 2 | 3 | 5.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL232151 | 86818 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 506 | 9 | 2 | 3 | 5.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 10208964 | 66703 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 536 | 7 | 2 | 7 | 7.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CCCC2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185438 | 66703 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 536 | 7 | 2 | 7 | 7.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CCCC2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44444676 | 155028 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 646 | 9 | 1 | 6 | 5.8 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(OCC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401080 | 155028 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 646 | 9 | 1 | 6 | 5.8 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(OCC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44444628 | 94372 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 722 | 8 | 2 | 5 | 8.8 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL250568 | 94372 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 722 | 8 | 2 | 5 | 8.8 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44340929 | 113566 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 604 | 10 | 2 | 4 | 7.7 | CC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL332049 | 113566 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 604 | 10 | 2 | 4 | 7.7 | CC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44293591 | 101651 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 496 | 12 | 2 | 3 | 6.5 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL298700 | 101651 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 496 | 12 | 2 | 3 | 6.5 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 11237922 | 65541 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1021/jm701249f | |||
| CHEMBL183066 | 65541 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1021/jm701249f | |||
| 44292919 | 101199 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 14 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295376 | 101199 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 14 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 25193798 | 170301 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 562 | 6 | 2 | 5 | 6.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL444509 | 170301 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 562 | 6 | 2 | 5 | 6.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44293164 | 167934 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 482 | 11 | 3 | 3 | 6.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)NC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL430763 | 167934 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 482 | 11 | 3 | 3 | 6.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)NC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44321496 | 106019 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 657 | 13 | 2 | 5 | 6.3 | CCS(=O)(=O)N1CCN(C(=O)C(C)(C)c2ccc3[nH]c(-c4cc(C)cc(C)c4)c([C@H](C)CNCCCCc4ccncc4)c3c2)CC1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL312995 | 106019 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 657 | 13 | 2 | 5 | 6.3 | CCS(=O)(=O)N1CCN(C(=O)C(C)(C)c2ccc3[nH]c(-c4cc(C)cc(C)c4)c([C@H](C)CNCCCCc4ccncc4)c3c2)CC1 | 10.1016/s0960-894x(01)00512-1 | |||
| 145980339 | 166682 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 380 | 4 | 1 | 3 | 4.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCF)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4280124 | 166682 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 380 | 4 | 1 | 3 | 4.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCF)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 44361524 | 168697 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1623 | 40 | 15 | 17 | 3.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL435925 | 168697 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1623 | 40 | 15 | 17 | 3.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 44444632 | 94373 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 622 | 7 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccccc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL250569 | 94373 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 622 | 7 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccccc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 9895596 | 63535 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800152 | 63535 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 16221557 | 166111 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1546 | 41 | 15 | 17 | 1.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL425486 | 166111 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1546 | 41 | 15 | 17 | 1.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| 44573276 | 187522 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 484 | 6 | 1 | 5 | 5.9 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)n1CC | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL493731 | 187522 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 484 | 6 | 1 | 5 | 5.9 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)n1CC | 10.1016/j.bmcl.2009.02.043 | |||
| 44321100 | 107149 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC(CC5)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL315909 | 107149 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC(CC5)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44380394 | 120012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL349638 | 120012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 172447106 | 195481 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 605 | 9 | 2 | 9 | 4.5 | CONC(=O)Nc1ccc(-c2oc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5404509 | 195481 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 605 | 9 | 2 | 9 | 4.5 | CONC(=O)Nc1ccc(-c2oc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44398117 | 162059 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1649 | 43 | 19 | 19 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNc1ncc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL415813 | 162059 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 1649 | 43 | 19 | 19 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNc1ncc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44358957 | 12148 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cccnc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184158 | 12148 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cccnc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL336039 | 12148 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cccnc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44380212 | 57635 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166843 | 57635 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44434437 | 151062 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 1663 | 42 | 6 | 27 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL395826 | 151062 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 1663 | 42 | 6 | 27 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44359254 | 11636 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 8 | 3 | 8 | 5.8 | COc1nccc(NC(=O)c2cc3c(OCCC4CCCCN4)c(-c4cc(C)cc(C)c4)c(O)nc3cc2Cl)n1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180716 | 11636 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 8 | 3 | 8 | 5.8 | COc1nccc(NC(=O)c2cc3c(OCCC4CCCCN4)c(-c4cc(C)cc(C)c4)c(O)nc3cc2Cl)n1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL139292 | 11636 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 8 | 3 | 8 | 5.8 | COc1nccc(NC(=O)c2cc3c(OCCC4CCCCN4)c(-c4cc(C)cc(C)c4)c(O)nc3cc2Cl)n1 | 10.1016/s0960-894x(00)00024-x | |||
| 44434412 | 161871 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 1565 | 39 | 4 | 26 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL414045 | 161871 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 1565 | 39 | 4 | 26 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44572236 | 172002 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 599 | 6 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)n(Cc7cccnc7)c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL446978 | 172002 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 599 | 6 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)n(Cc7cccnc7)c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 11496945 | 176580 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 496 | 4 | 3 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL459659 | 176580 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 496 | 4 | 3 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 24825725 | 192736 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL521674 | 192736 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| 44321510 | 107195 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 608 | 15 | 2 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL316159 | 107195 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 608 | 15 | 2 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 9983568 | 99036 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 503 | 10 | 1 | 6 | 4.6 | CCC(CC)N[C@@H](C)Cn1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1021/jm030472z | |||
| CHEMBL279885 | 99036 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 503 | 10 | 1 | 6 | 4.6 | CCC(CC)N[C@@H](C)Cn1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1021/jm030472z | |||
| 44215053 | 185726 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL48641 | 185726 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44359285 | 11631 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180695 | 11631 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138747 | 11631 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44572287 | 180909 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 475 | 4 | 1 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6cccnc6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL475660 | 180909 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 475 | 4 | 1 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6cccnc6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 145952400 | 162830 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(CC(N)c2ccccc2F)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4171296 | 162830 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(CC(N)c2ccccc2F)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 145950534 | 162900 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(CC(N)c2cccc(F)c2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4172405 | 162900 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(CC(N)c2cccc(F)c2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 24825725 | 192736 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL521674 | 192736 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2010.02.099 | |||
| 12283 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | nan | |||
| 16656889 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | nan | |||
| 16656889.0 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | nan | |||
| CHEMBL3668014 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | nan | |||
| DB17083 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | nan | |||
| 16656891 | 128733 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 522 | 9 | 2 | 8 | 3.5 | COCCOc1ccc(F)c(F)c1COc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| CHEMBL3668015 | 128733 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 522 | 9 | 2 | 8 | 3.5 | COCCOc1ccc(F)c(F)c1COc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| 10438167 | 101236 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 578 | 12 | 2 | 3 | 8.6 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295641 | 101236 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 578 | 12 | 2 | 3 | 8.6 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293803 | 188990 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C(C)CCC4C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL50721 | 188990 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C(C)CCC4C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 20691661 | 79644 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL211485 | 79644 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 145953549 | 162512 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 619 | 8 | 2 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4166067 | 162512 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 619 | 8 | 2 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 44434435 | 88596 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 1575 | 36 | 6 | 25 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL235361 | 88596 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 1575 | 36 | 6 | 25 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44572286 | 180907 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 5.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6c(c5)NCC(=O)N6)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL475650 | 180907 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 494 | 4 | 3 | 5 | 5.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6c(c5)NCC(=O)N6)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 44293222 | 176064 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138464 | 176064 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL45883 | 176064 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 9958318 | 90261 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 520 | 10 | 0 | 7 | 3.9 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CCN(C)CCc3ccccn3)c2=O)c1 | 10.1021/jm030472z | |||
| CHEMBL23830 | 90261 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 520 | 10 | 0 | 7 | 3.9 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CCN(C)CCc3ccccn3)c2=O)c1 | 10.1021/jm030472z | |||
| 44293348 | 100546 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 12 | 2 | 3 | 7.8 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL290991 | 100546 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 12 | 2 | 3 | 7.8 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432653 | 86738 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 650 | 9 | 3 | 4 | 6.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2cc4nn[nH]c4cc2F)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL231761 | 86738 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 650 | 9 | 3 | 4 | 6.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2cc4nn[nH]c4cc2F)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44380146 | 120341 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 627 | 10 | 2 | 4 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352565 | 120341 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 627 | 10 | 2 | 4 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 145973813 | 163118 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 604 | 9 | 1 | 9 | 3.9 | Cc1cccc(C(N)Cn2c(=O)c(N3CCN(Cc4cccc([N+](=O)[O-])c4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4175816 | 163118 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 604 | 9 | 1 | 9 | 3.9 | Cc1cccc(C(N)Cn2c(=O)c(N3CCN(Cc4cccc([N+](=O)[O-])c4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| 44432656 | 159251 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 645 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL409825 | 159251 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 645 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44444641 | 155059 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 601 | 7 | 1 | 5 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401212 | 155059 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 601 | 7 | 1 | 5 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 67143420 | 163003 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 590 | 9 | 1 | 9 | 3.6 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4173938 | 163003 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 590 | 9 | 1 | 9 | 3.6 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 145955260 | 162629 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccc(F)cc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4167957 | 162629 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 608 | 9 | 1 | 9 | 3.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccc(F)cc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 16656887 | 128731 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 504 | 6 | 2 | 7 | 4.8 | COc1ccc(F)cc1C(C)(C)Sc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| CHEMBL3668012 | 128731 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 504 | 6 | 2 | 7 | 4.8 | COc1ccc(F)cc1C(C)(C)Sc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| 44380551 | 58775 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168649 | 58775 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44293555 | 101264 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 574 | 11 | 2 | 3 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C4(C(=O)N5C6CCC5CC6)CCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295897 | 101264 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 574 | 11 | 2 | 3 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C4(C(=O)N5C6CCC5CC6)CCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44444649 | 155095 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 646 | 10 | 3 | 7 | 4.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(O)CN3CCNCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401418 | 155095 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 646 | 10 | 3 | 7 | 4.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(O)CN3CCNCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44398149 | 161388 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1621 | 40 | 18 | 19 | 0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL412212 | 161388 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 1621 | 40 | 18 | 19 | 0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 44577104 | 178851 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 5 | 2 | 4 | 5.4 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL468565 | 178851 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 456 | 5 | 2 | 4 | 5.4 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| 44293249 | 185549 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL48616 | 185549 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 10077523 | 122780 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 613 | 7 | 3 | 7 | 7.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C(F)(F)F)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL360429 | 122780 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 613 | 7 | 3 | 7 | 7.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C(F)(F)F)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44395463 | 126843 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 627 | 7 | 2 | 7 | 7.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C(F)(F)F)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL365366 | 126843 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 627 | 7 | 2 | 7 | 7.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C(F)(F)F)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44215055 | 101344 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 576 | 11 | 1 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(C)CCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL296442 | 101344 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 576 | 11 | 1 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(C)CCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293249 | 185549 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL48616 | 185549 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 21899433 | 154792 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 631 | 8 | 1 | 6 | 5.0 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL399772 | 154792 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 631 | 8 | 1 | 6 | 5.0 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44341081 | 168167 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 590 | 10 | 2 | 3 | 8.0 | CCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL432450 | 168167 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 590 | 10 | 2 | 3 | 8.0 | CCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 16656822 | 128729 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 455 | 4 | 2 | 6 | 3.4 | CN(C(=O)c1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1)c1ccccc1 | nan | |||
| CHEMBL3668010 | 128729 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 455 | 4 | 2 | 6 | 3.4 | CN(C(=O)c1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1)c1ccccc1 | nan | |||
| 44359333 | 11634 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180707 | 11634 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138999 | 11634 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 530 | 7 | 3 | 6 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44293592 | 162985 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 496 | 12 | 2 | 3 | 6.5 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL417363 | 162985 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 496 | 12 | 2 | 3 | 6.5 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44434434 | 148161 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1531 | 33 | 6 | 24 | 8.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL393486 | 148161 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1531 | 33 | 6 | 24 | 8.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44434392 | 169101 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1389 | 27 | 4 | 22 | 9.4 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL439200 | 169101 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1389 | 27 | 4 | 22 | 9.4 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44444652 | 94555 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 588 | 7 | 1 | 5 | 6.3 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL251578 | 94555 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 588 | 7 | 1 | 5 | 6.3 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44444642 | 94423 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 629 | 8 | 1 | 6 | 5.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2C(=O)CN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL250770 | 94423 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 629 | 8 | 1 | 6 | 5.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2C(=O)CN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 58022100 | 128722 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 473 | 3 | 1 | 6 | 3.5 | O=c1[nH]c2ccsc2c(=O)n1-c1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl | nan | |||
| CHEMBL3668003 | 128722 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 473 | 3 | 1 | 6 | 3.5 | O=c1[nH]c2ccsc2c(=O)n1-c1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl | nan | |||
| 138978203 | 166796 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 639 | 7 | 3 | 11 | 3.1 | Cc1cn([C@H]2C[C@@H](n3cc(CN4CCN(c5cccc6[nH]c(-c7ccc(C(C)(C)C)cc7)nc56)CC4)nn3)[C@@H](CO)O2)c(=O)[nH]c1=O | 10.1039/C7MD00320J | |||
| CHEMBL4282476 | 166796 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 639 | 7 | 3 | 11 | 3.1 | Cc1cn([C@H]2C[C@@H](n3cc(CN4CCN(c5cccc6[nH]c(-c7ccc(C(C)(C)C)cc7)nc56)CC4)nn3)[C@@H](CO)O2)c(=O)[nH]c1=O | 10.1039/C7MD00320J | |||
| 145984647 | 166511 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 5.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6ccc(F)cc6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4277116 | 166511 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 5.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6ccc(F)cc6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 138978207 | 167249 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 372 | 3 | 1 | 3 | 4.3 | C#CCN1CCN(c2cccc3[nH]c(-c4ccc(C(C)(C)C)cc4)nc23)CC1 | 10.1039/C7MD00320J | |||
| CHEMBL4290761 | 167249 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 372 | 3 | 1 | 3 | 4.3 | C#CCN1CCN(c2cccc3[nH]c(-c4ccc(C(C)(C)C)cc4)nc23)CC1 | 10.1039/C7MD00320J | |||
| 16657781 | 128725 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 517 | 4 | 2 | 7 | 3.2 | O=C(O)c1scc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12 | nan | |||
| CHEMBL3668006 | 128725 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 517 | 4 | 2 | 7 | 3.2 | O=C(O)c1scc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12 | nan | |||
| 44380798 | 59344 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 9 | 3 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170606 | 59344 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 9 | 3 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380537 | 96614 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL263004 | 96614 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL2371821 | 212588 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN[C@H](C(=O)O)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||||
| 170269052 | 195907 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 622 | 9 | 3 | 11 | 3.8 | CNc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5413078 | 195907 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 622 | 9 | 3 | 11 | 3.8 | CNc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 172464696 | 196806 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5432553 | 196806 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL438629 | 216244 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NCCOCCOCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL438629 | 216244 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NCCOCCOCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 162514316 | 195301 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 659 | 10 | 2 | 11 | 4.3 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5400302 | 195301 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 659 | 10 | 2 | 11 | 4.3 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL2371822 | 212589 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | C#C[C@H](NC(=O)[C@H](Cc1ccc(NC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||||
| 16156049 | 96836 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 44 | 17 | 19 | 2.5 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL264781 | 96836 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 44 | 17 | 19 | 2.5 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16156049 | 96836 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 44 | 17 | 19 | 2.5 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL264781 | 96836 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1689 | 44 | 17 | 19 | 2.5 | CCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 165412728 | 196267 | None | 4 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 721 | 12 | 2 | 12 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5420128 | 196267 | None | 4 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 721 | 12 | 2 | 12 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 102090748 | 161901 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1532 | 40 | 14 | 16 | 3.4 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 16138575 | 161901 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1532 | 40 | 14 | 16 | 3.4 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL414344 | 161901 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1532 | 40 | 14 | 16 | 3.4 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 44395491 | 123917 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL362544 | 123917 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 10053165 | 184105 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL48192 | 184105 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44398044 | 155321 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1617 | 38 | 17 | 18 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)NC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL402683 | 155321 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1617 | 38 | 17 | 18 | 0.3 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)NC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 172441547 | 195178 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 689 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5398152 | 195178 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 689 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 172460388 | 196230 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 673 | 11 | 2 | 11 | 4.4 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5419365 | 196230 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 673 | 11 | 2 | 11 | 4.4 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 9873212 | 57593 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 588 | 9 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166649 | 57593 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 588 | 9 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 10008768 | 58751 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168563 | 58751 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL268450 | 213214 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@H](Cc2ccc(NC(=O)NCCOCCOCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL268450 | 213214 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@H](Cc2ccc(NC(=O)NCCOCCOCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 11365653 | 174294 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 631 | 12 | 2 | 7 | 5.7 | Cc1c(-c2cccc(OCCCCC(=O)O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| CHEMBL454774 | 174294 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 631 | 12 | 2 | 7 | 5.7 | Cc1c(-c2cccc(OCCCCC(=O)O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| 44448991 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL403234 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL556355 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| 44320895 | 164357 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL421160 | 164357 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44380626 | 58744 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 587 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168539 | 58744 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 587 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 16155654 | 166173 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1642 | 42 | 20 | 19 | -0.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CCNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL425813 | 166173 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1642 | 42 | 20 | 19 | -0.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CCNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16155654 | 166173 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1642 | 42 | 20 | 19 | -0.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CCNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL425813 | 166173 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1642 | 42 | 20 | 19 | -0.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CCNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44398178 | 161923 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1660 | 43 | 18 | 19 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNCc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL414507 | 161923 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1660 | 43 | 18 | 19 | 1.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNCc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44361795 | 168601 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1574 | 40 | 15 | 18 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL435322 | 168601 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1574 | 40 | 15 | 18 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL269711 | 213260 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 21036877 | 173754 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 627 | 13 | 2 | 7 | 5.9 | Cc1c(-c2cccc(OCCCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| CHEMBL453441 | 173754 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 627 | 13 | 2 | 7 | 5.9 | Cc1c(-c2cccc(OCCCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| 11167850 | 2741 | None | 28 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm8006454 | |||
| 1178 | 2741 | None | 28 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm8006454 | |||
| 1187 | 2741 | None | 28 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm8006454 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm8006454 | |||
| 44321101 | 96901 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL265288 | 96901 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 9960399 | 50557 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 603 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3nnnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL157412 | 50557 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 603 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3nnnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44398040 | 168914 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1681 | 41 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL437672 | 168914 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1681 | 41 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 172461575 | 196835 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 621 | 9 | 2 | 10 | 4.3 | CCc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5433025 | 196835 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 621 | 9 | 2 | 10 | 4.3 | CCc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL264779 | 213089 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL268813 | 213224 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| CHEMBL264779 | 213089 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CONC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NOC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| CHEMBL268813 | 213224 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||||
| 15602804 | 8083 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 458 | 4 | 2 | 6 | 3.0 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5c[nH]c(=O)[nH]c5=O)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1091209 | 8083 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 458 | 4 | 2 | 6 | 3.0 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5c[nH]c(=O)[nH]c5=O)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| 44340928 | 9746 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 606 | 10 | 3 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL113432 | 9746 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 606 | 10 | 3 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 16656888 | 128732 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 488 | 5 | 2 | 7 | 3.3 | CC(C)(c1ccccc1)S(=O)(=O)c1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| CHEMBL3668013 | 128732 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 488 | 5 | 2 | 7 | 3.3 | CC(C)(c1ccccc1)S(=O)(=O)c1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| 44293484 | 96769 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 604 | 12 | 1 | 3 | 8.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(CCCCc2ccncc2)C(C)C)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL264193 | 96769 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 604 | 12 | 1 | 3 | 8.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(CCCCc2ccncc2)C(C)C)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 16221614 | 136635 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1562 | 41 | 15 | 18 | 0.8 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)S(=O)(=O)C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL373725 | 136635 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 1562 | 41 | 15 | 18 | 0.8 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)S(=O)(=O)C(C)C)cc1 | 10.1021/jm0613931 | |||
| 44432646 | 147322 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 581 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCC2CCOCC2)CN(C(=O)Cc2ccccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL392843 | 147322 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 581 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCC2CCOCC2)CN(C(=O)Cc2ccccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44444639 | 155057 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 589 | 8 | 1 | 5 | 5.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N(C)C)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401193 | 155057 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 589 | 8 | 1 | 5 | 5.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N(C)C)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44321498 | 208763 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL87099 | 208763 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 12784 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | ChEMBL | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 10.6019/CHEMBL4507266 | |||
| 85469632 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | ChEMBL | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 10.6019/CHEMBL4507266 | |||
| CHEMBL4537788 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | ChEMBL | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 10.6019/CHEMBL4507266 | |||
| 44359471 | 12202 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 550 | 7 | 3 | 7 | 6.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ns4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184266 | 12202 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 550 | 7 | 3 | 7 | 6.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ns4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL341717 | 12202 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 550 | 7 | 3 | 7 | 6.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ns4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44444672 | 169505 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | COC1CCN(C(=O)C2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL442283 | 169505 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | COC1CCN(C(=O)C2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44561108 | 186536 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 468 | 3 | 2 | 4 | 4.8 | FC(F)(F)c1nc2c(N3CCN(Cc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL487627 | 186536 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 468 | 3 | 2 | 4 | 4.8 | FC(F)(F)c1nc2c(N3CCN(Cc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 44444670 | 94532 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 7 | 2 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCCC(O)C3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL251388 | 94532 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 7 | 2 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCCC(O)C3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44444673 | 94336 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 644 | 8 | 1 | 5 | 6.8 | COC1CCN(C(=O)C2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL250389 | 94336 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 644 | 8 | 1 | 5 | 6.8 | COC1CCN(C(=O)C2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| 145954439 | 162751 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 622 | 9 | 1 | 9 | 4.0 | Cc1cc(F)cc([C@@H](N)Cn2c(=O)c(N3CCN(Cc4cccc([N+](=O)[O-])c4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4169864 | 162751 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 622 | 9 | 1 | 9 | 4.0 | Cc1cc(F)cc([C@@H](N)Cn2c(=O)c(N3CCN(Cc4cccc([N+](=O)[O-])c4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| 44341046 | 10078 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 5 | 7.5 | CC(=O)OCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL115365 | 10078 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 634 | 11 | 2 | 5 | 7.5 | CC(=O)OCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44359301 | 11640 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nncs4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180754 | 11640 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nncs4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL141221 | 11640 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nncs4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44293488 | 101609 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 594 | 15 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL298366 | 101609 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 594 | 15 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293335 | 172730 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 550 | 12 | 2 | 3 | 7.8 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL449351 | 172730 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 550 | 12 | 2 | 3 | 7.8 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432657 | 149555 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 635 | 10 | 3 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(C(=O)O)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL394613 | 149555 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 635 | 10 | 3 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(C(=O)O)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44398396 | 162017 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 1737 | 44 | 17 | 20 | 2.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCN(c1ccccn1)c1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL415328 | 162017 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 1737 | 44 | 17 | 20 | 2.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCN(c1ccccn1)c1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44444675 | 154812 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 7 | 1 | 5 | 6.3 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCOCC3)C(C)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL399857 | 154812 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 630 | 7 | 1 | 5 | 6.3 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCOCC3)C(C)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44321497 | 98146 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 665 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL273390 | 98146 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 665 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44587394 | 172576 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 599 | 11 | 2 | 7 | 5.1 | Cc1c(-c2cccc(OCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| CHEMBL448253 | 172576 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 599 | 11 | 2 | 7 | 5.1 | Cc1c(-c2cccc(OCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| 44573110 | 187300 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 4 | 1 | 5 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL492327 | 187300 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 442 | 4 | 1 | 5 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1C | 10.1016/j.bmcl.2009.02.043 | |||
| 25193700 | 173386 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 534 | 7 | 2 | 5 | 5.9 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL452547 | 173386 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 534 | 7 | 2 | 5 | 5.9 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44444668 | 154368 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 630 | 7 | 1 | 6 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2C(=O)CN2CCC(C(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL398648 | 154368 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 630 | 7 | 1 | 6 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2C(=O)CN2CCC(C(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44434389 | 169007 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 838 | 21 | 2 | 14 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL438504 | 169007 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 838 | 21 | 2 | 14 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44561369 | 190577 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=O)c(=O)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL517881 | 190577 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=O)c(=O)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44341082 | 9779 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 590 | 9 | 2 | 3 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)nc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL113574 | 9779 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 590 | 9 | 2 | 3 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)nc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL4564312 | 216484 | None | 6 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | None | None | None | O=C(NCc1ncc(C(F)(F)F)cc1Cl)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)[C@@H](C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.6019/CHEMBL4507266 | |||||
| 54584354 | 61275 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 515 | 7 | 2 | 6 | 6.1 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@H]2CCCCN2)c1 | 10.1021/jm101501b | |||
| CHEMBL1766108 | 61275 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 515 | 7 | 2 | 6 | 6.1 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@H]2CCCCN2)c1 | 10.1021/jm101501b | |||
| 16221434 | 97240 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 1548 | 40 | 13 | 16 | 4.7 | CS[C@@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||
| CHEMBL268297 | 97240 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 1548 | 40 | 13 | 16 | 4.7 | CS[C@@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(C)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0613931 | |||
| 44341199 | 113122 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 620 | 10 | 2 | 5 | 7.2 | COC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL331145 | 113122 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 620 | 10 | 2 | 5 | 7.2 | COC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44398119 | 97312 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 1646 | 41 | 18 | 19 | -0.4 | CNC(=O)C[C@H](NC(=O)[C@H](Cc1ccc(NC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL268829 | 97312 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 1646 | 41 | 18 | 19 | -0.4 | CNC(=O)C[C@H](NC(=O)[C@H](Cc1ccc(NC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44359252 | 11635 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180715 | 11635 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL139291 | 11635 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44448991 | 155431 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL403234 | 155431 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL556355 | 155431 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| 44434387 | 152864 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 750 | 15 | 2 | 12 | 5.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL397360 | 152864 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 750 | 15 | 2 | 12 | 5.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44587393 | 172737 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 613 | 12 | 2 | 7 | 5.5 | Cc1c(-c2cccc(OCCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| CHEMBL449468 | 172737 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 613 | 12 | 2 | 7 | 5.5 | Cc1c(-c2cccc(OCCCCC(=O)O)c2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.059 | |||
| 44341164 | 9566 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL112378 | 9566 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44432651 | 86737 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 632 | 9 | 3 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4[nH]nnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL231760 | 86737 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 632 | 9 | 3 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4[nH]nnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44293594 | 101622 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 512 | 13 | 3 | 4 | 5.5 | CCN(CCO)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL298497 | 101622 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 512 | 13 | 3 | 4 | 5.5 | CCN(CCO)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293131 | 188947 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 520 | 10 | 2 | 3 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL50663 | 188947 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 520 | 10 | 2 | 3 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432641 | 167601 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 540 | 9 | 2 | 3 | 6.4 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2Cl)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL429976 | 167601 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 540 | 9 | 2 | 3 | 6.4 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2Cl)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 25156400 | 188967 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 581 | 12 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| CHEMBL506877 | 188967 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 581 | 12 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| 11214860 | 84805 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 541 | 10 | 1 | 7 | 4.8 | CCc1ccc(CN[C@@H](C)Cn2c(=O)c(-c3cccc(OC)c3F)c(C)n(Cc3c(F)cccc3F)c2=O)o1 | 10.1021/jm030472z | |||
| CHEMBL22314 | 84805 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 541 | 10 | 1 | 7 | 4.8 | CCc1ccc(CN[C@@H](C)Cn2c(=O)c(-c3cccc(OC)c3F)c(C)n(Cc3c(F)cccc3F)c2=O)o1 | 10.1021/jm030472z | |||
| 44380483 | 59092 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 635 | 9 | 4 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2F)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169569 | 59092 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 635 | 9 | 4 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2F)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 1185 | 3701 | None | 34 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 3038517 | 3701 | None | 34 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| DB06494 | 3701 | None | 34 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 44432640 | 155063 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 9 | 2 | 3 | 5.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL401226 | 155063 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 524 | 9 | 2 | 3 | 5.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 16656819 | 128727 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 4 | 2 | 7 | 2.9 | CNC(=O)c1scc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12 | nan | |||
| CHEMBL3668008 | 128727 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 4 | 2 | 7 | 2.9 | CNC(=O)c1scc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12 | nan | |||
| 11496610 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| 5582 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| CHEMBL474991 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| 11496610 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| 5582 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL474991 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 4 | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| 44444647 | 155091 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 688 | 10 | 2 | 7 | 4.6 | CC(=O)N1CCN(CC(O)CN2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401352 | 155091 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 688 | 10 | 2 | 7 | 4.6 | CC(=O)N1CCN(CC(O)CN2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| 25194090 | 189036 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 484 | 6 | 3 | 5 | 5.3 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL507973 | 189036 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 484 | 6 | 3 | 5 | 5.3 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44444635 | 154794 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 637 | 7 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccncc3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL399779 | 154794 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 637 | 7 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccncc3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 16656821 | 128728 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 474 | 6 | 2 | 7 | 3.9 | COc1cccc(F)c1C(C)Oc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| CHEMBL3668009 | 128728 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 474 | 6 | 2 | 7 | 3.9 | COc1cccc(F)c1C(C)Oc1ccc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| 16656892 | 128735 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 491 | 6 | 2 | 7 | 3.5 | COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1CN(C)c1c(F)cccc1F | nan | |||
| CHEMBL3668017 | 128735 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 491 | 6 | 2 | 7 | 3.5 | COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1CN(C)c1c(F)cccc1F | nan | |||
| 16146022 | 170222 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1631 | 41 | 17 | 18 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL444381 | 170222 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1631 | 41 | 17 | 18 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 9918188 | 154811 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 708 | 8 | 2 | 5 | 8.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL399856 | 154811 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 708 | 8 | 2 | 5 | 8.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44444626 | 154973 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 680 | 7 | 2 | 5 | 7.6 | COC(=O)/N=C(/NC[C@@H](C)c1c(-c2cc(C)cc(C)c2)[nH]c2sc(C(C)(C)C(=O)N3C4CCC3CC4)cc12)N1CCC(c2ccncc2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL400739 | 154973 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 680 | 7 | 2 | 5 | 7.6 | COC(=O)/N=C(/NC[C@@H](C)c1c(-c2cc(C)cc(C)c2)[nH]c2sc(C(C)(C)C(=O)N3C4CCC3CC4)cc12)N1CCC(c2ccncc2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| 16221212 | 166426 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1566 | 40 | 14 | 17 | 2.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL427269 | 166426 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1566 | 40 | 14 | 17 | 2.5 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| 145954419 | 162724 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 651 | 9 | 1 | 9 | 4.4 | COc1ccc(F)cc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4169486 | 162724 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 651 | 9 | 1 | 9 | 4.4 | COc1ccc(F)cc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 16156517 | 160821 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1642 | 42 | 19 | 19 | -0.3 | CONC(=O)NC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL411381 | 160821 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1642 | 42 | 19 | 19 | -0.3 | CONC(=O)NC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL219532 | 211875 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 16156517 | 160821 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1642 | 42 | 19 | 19 | -0.3 | CONC(=O)NC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL411381 | 160821 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1642 | 42 | 19 | 19 | -0.3 | CONC(=O)NC[C@@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL219532 | 211875 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCOCCOCCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||||
| 54582417 | 61273 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 488 | 6 | 2 | 5 | 5.8 | Cc1cc(C)cc(-c2c(OCCC3CCCCN3)c3cc(-c4ccncn4)c(Cl)cc3[nH]c2=O)c1 | 10.1021/jm101501b | |||
| CHEMBL1766106 | 61273 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 488 | 6 | 2 | 5 | 5.8 | Cc1cc(C)cc(-c2c(OCCC3CCCCN3)c3cc(-c4ccncn4)c(Cl)cc3[nH]c2=O)c1 | 10.1021/jm101501b | |||
| 25156943 | 188544 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 597 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3Cl)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| CHEMBL502341 | 188544 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 597 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3Cl)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| CHEMBL2370890 | 212404 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 44449681 | 96098 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 551 | 8 | 1 | 6 | 5.3 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL259906 | 96098 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 551 | 8 | 1 | 6 | 5.3 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1016/j.bmcl.2008.04.029 | |||
| 9872676 | 78224 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| CHEMBL210514 | 78224 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| 9893269 | 66317 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 532 | 7 | 2 | 7 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL184819 | 66317 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 532 | 7 | 2 | 7 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 16155218 | 166918 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1628 | 41 | 20 | 19 | -0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL428484 | 166918 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1628 | 41 | 20 | 19 | -0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16155218 | 166918 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1628 | 41 | 20 | 19 | -0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL428484 | 166918 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1628 | 41 | 20 | 19 | -0.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](CNC(=O)NO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44398182 | 162040 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1635 | 42 | 19 | 19 | 0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNc1ncc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL415549 | 162040 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1635 | 42 | 19 | 19 | 0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNc1ncc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 1188 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16131215 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16131215.0 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 35 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL1252 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB00106 | 219 | None | 37 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16130957 | 211120 | None | 27 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 16130957.0 | 211120 | None | 27 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL1251 | 211120 | None | 27 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL5314377 | 211120 | None | 27 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| DB06785 | 211120 | None | 27 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 44398179 | 161902 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1674 | 44 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNCc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL414346 | 161902 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1674 | 44 | 18 | 19 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNCc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44321963 | 105997 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 622 | 11 | 2 | 5 | 6.8 | COCn1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccc1=O | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL312864 | 105997 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 622 | 11 | 2 | 5 | 6.8 | COCn1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccc1=O | 10.1016/s0960-894x(01)00512-1 | |||
| 44380536 | 120455 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 602 | 9 | 2 | 4 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL353395 | 120455 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 602 | 9 | 2 | 4 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44293378 | 101948 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 618 | 13 | 1 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(CCCCc2ccncc2)CC(C)C)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL300792 | 101948 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 618 | 13 | 1 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN(CCCCc2ccncc2)CC(C)C)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 10985312 | 78777 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL21126 | 78777 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 44434390 | 151732 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 882 | 24 | 2 | 15 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL396385 | 151732 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 882 | 24 | 2 | 15 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44434438 | 146283 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1707 | 45 | 6 | 28 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL392008 | 146283 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1707 | 45 | 6 | 28 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44321458 | 106021 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 658 | 11 | 2 | 3 | 9.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCCC5C5CCCCC54)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL313004 | 106021 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 658 | 11 | 2 | 3 | 9.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCCC5C5CCCCC54)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 172467255 | 196669 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 679 | 10 | 2 | 12 | 3.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN2CC[C@@H](OC)C2)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5429424 | 196669 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 679 | 10 | 2 | 12 | 3.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN2CC[C@@H](OC)C2)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44380192 | 57464 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL165534 | 57464 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44434402 | 146839 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 1433 | 30 | 4 | 23 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL392433 | 146839 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 1433 | 30 | 4 | 23 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 145958075 | 162406 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 638 | 10 | 1 | 10 | 3.7 | COc1ccc(F)cc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4164522 | 162406 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 638 | 10 | 1 | 10 | 3.7 | COc1ccc(F)cc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 44395502 | 165993 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 553 | 7 | 3 | 9 | 5.0 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2COCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL424991 | 165993 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 553 | 7 | 3 | 9 | 5.0 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2COCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44432647 | 86774 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 622 | 9 | 2 | 4 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(=O)n(C)c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL231954 | 86774 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 622 | 9 | 2 | 4 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(=O)n(C)c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44359264 | 11632 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180700 | 11632 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138866 | 11632 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44380796 | 59221 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 598 | 9 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170159 | 59221 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 598 | 9 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44561141 | 193910 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 432 | 3 | 3 | 4 | 4.4 | FC(F)(F)c1nc2c(N3CCN(Cc4cccc5[nH]c(=S)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL527422 | 193910 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 432 | 3 | 3 | 4 | 4.4 | FC(F)(F)c1nc2c(N3CCN(Cc4cccc5[nH]c(=S)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 44577069 | 178821 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 467 | 9 | 1 | 6 | 4.7 | CCSc1nc2cc(S(=O)(=O)NCc3ccccc3OC)ccc2n1Cc1ccccc1 | 10.1021/jm701249f | |||
| CHEMBL468348 | 178821 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 467 | 9 | 1 | 6 | 4.7 | CCSc1nc2cc(S(=O)(=O)NCc3ccccc3OC)ccc2n1Cc1ccccc1 | 10.1021/jm701249f | |||
| 44432628 | 87789 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 484 | 8 | 2 | 3 | 5.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C2CCCC2)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL233762 | 87789 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 484 | 8 | 2 | 3 | 5.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C2CCCC2)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 10649568 | 14572 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| 44293130 | 181998 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 482 | 11 | 3 | 3 | 5.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(N)=O)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL47791 | 181998 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 482 | 11 | 3 | 3 | 5.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(N)=O)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44434411 | 146841 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1521 | 36 | 4 | 25 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL392434 | 146841 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 1521 | 36 | 4 | 25 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44444678 | 155029 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 618 | 12 | 1 | 5 | 7.3 | CCN(CC)CCOC1CCN(CCc2c(-c3cc(C)cc(C)c3)[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc23)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401081 | 155029 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 618 | 12 | 1 | 5 | 7.3 | CCN(CC)CCOC1CCN(CCc2c(-c3cc(C)cc(C)c3)[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc23)CC1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44359456 | 12208 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184286 | 12208 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL342908 | 12208 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44434388 | 89838 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 794 | 18 | 2 | 13 | 5.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL237729 | 89838 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 794 | 18 | 2 | 13 | 5.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44341186 | 10046 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 606 | 10 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(=O)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL115192 | 10046 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 606 | 10 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(=O)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 11477970 | 89533 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 4.6 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NCc3ccccc3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL23729 | 89533 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 4.6 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NCc3ccccc3)c2=O)c1F | 10.1021/jm030472z | |||
| 44293377 | 101958 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 576 | 12 | 2 | 3 | 7.8 | CCC(C)(C(=O)N1C2CCC1CC2)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL300865 | 101958 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 576 | 12 | 2 | 3 | 7.8 | CCC(C)(C(=O)N1C2CCC1CC2)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293802 | 102087 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 550 | 11 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL301802 | 102087 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 550 | 11 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 145957253 | 162288 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 737 | 14 | 2 | 10 | 4.9 | COc1ccc(F)cc1[C@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O)NCCCC(=O)O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4162619 | 162288 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 737 | 14 | 2 | 10 | 4.9 | COc1ccc(F)cc1[C@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O)NCCCC(=O)O | 10.1016/j.ejmech.2017.12.095 | |||
| 44215908 | 94282 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 616 | 7 | 1 | 5 | 6.1 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL249982 | 94282 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 616 | 7 | 1 | 5 | 6.1 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(C(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 16221329 | 136634 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 1562 | 41 | 15 | 18 | 0.8 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)S(=O)(=O)C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL373724 | 136634 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 1562 | 41 | 15 | 18 | 0.8 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)S(=O)(=O)C(C)C)cc1 | 10.1021/jm0613931 | |||
| 44449120 | 95286 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 567 | 8 | 1 | 6 | 5.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL256109 | 95286 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 567 | 8 | 1 | 6 | 5.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| 16221613 | 167090 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 1530 | 41 | 15 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL428795 | 167090 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 1530 | 41 | 15 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 15602808 | 8111 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 476 | 4 | 0 | 6 | 5.6 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5cnc6ccccc6n5)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1091580 | 8111 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 476 | 4 | 0 | 6 | 5.6 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5cnc6ccccc6n5)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| 44321146 | 106461 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 592 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC(C)(C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL313946 | 106461 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 592 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC(C)(C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44593425 | 176870 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL460480 | 176870 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.024 | |||
| 44593425 | 176870 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL460480 | 176870 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2009.02.043 | |||
| 44321410 | 107064 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL315325 | 107064 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321393 | 208728 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 606 | 9 | 2 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)c(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86911 | 208728 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 606 | 9 | 2 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)c(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 11226531 | 99574 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 543 | 9 | 1 | 7 | 5.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NCc3sccc3C)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL283381 | 99574 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 543 | 9 | 1 | 7 | 5.0 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NCc3sccc3C)c2=O)c1F | 10.1021/jm030472z | |||
| 10985312 | 78777 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL21126 | 78777 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 16156639 | 138098 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1648 | 47 | 16 | 17 | 5.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL376466 | 138098 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1648 | 47 | 16 | 17 | 5.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16156639 | 138098 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1648 | 47 | 16 | 17 | 5.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL376466 | 138098 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1648 | 47 | 16 | 17 | 5.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 172448093 | 195968 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 663 | 10 | 2 | 11 | 4.7 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC5CCC5)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5414381 | 195968 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 663 | 10 | 2 | 11 | 4.7 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC5CCC5)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 1190 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 25074887 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 25074887.0 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 583 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL1200490 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB00050 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 44398180 | 156118 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1696 | 42 | 18 | 19 | 2.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNc1ccc2ccccc2n1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL406225 | 156118 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1696 | 42 | 18 | 19 | 2.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CNc1ccc2ccccc2n1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16147767 | 97412 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL269516 | 97412 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44380625 | 58743 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168538 | 58743 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9894997 | 120378 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352806 | 120378 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 16155412 | 161259 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1864 | 55 | 18 | 22 | 2.4 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL411749 | 161259 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1864 | 55 | 18 | 22 | 2.4 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16155412 | 161259 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1864 | 55 | 18 | 22 | 2.4 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| CHEMBL411749 | 161259 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1864 | 55 | 18 | 22 | 2.4 | CCOCCOCCNC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)NCCOCCOCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm060240a | |||
| 16221150 | 162029 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1564 | 40 | 13 | 16 | 3.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)[S+](C)[O-])C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL415432 | 162029 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1564 | 40 | 13 | 16 | 3.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)[S+](C)[O-])C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 9938925 | 57608 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 616 | 11 | 3 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166763 | 57608 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 616 | 11 | 3 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380478 | 58772 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168637 | 58772 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 172448837 | 195688 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 725 | 10 | 2 | 9 | 6.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5409192 | 195688 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 725 | 10 | 2 | 9 | 6.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 145955571 | 162754 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 721 | 13 | 2 | 9 | 5.2 | Cc1cc(F)cc([C@H](Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)NCCCC(=O)O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4169891 | 162754 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 721 | 13 | 2 | 9 | 5.2 | Cc1cc(F)cc([C@H](Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)NCCCC(=O)O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| 11331001 | 189130 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 617 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2cn(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.bmcl.2008.04.036 | |||
| CHEMBL509075 | 189130 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 617 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2cn(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.bmcl.2008.04.036 | |||
| 16156572 | 167209 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1678 | 48 | 16 | 18 | 5.2 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL429016 | 167209 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1678 | 48 | 16 | 18 | 5.2 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44293376 | 101730 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 590 | 13 | 2 | 3 | 8.2 | CCC(CC)(C(=O)N1C2CCC1CC2)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL299301 | 101730 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 590 | 13 | 2 | 3 | 8.2 | CCC(CC)(C(=O)N1C2CCC1CC2)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 11583756 | 189763 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL515123 | 189763 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 11532637 | 7716 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 456 | 5 | 0 | 6 | 5.1 | CCn1cnc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1088866 | 7716 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 456 | 5 | 0 | 6 | 5.1 | CCn1cnc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2010.02.099 | |||
| 44577103 | 178850 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 530 | 10 | 4 | 9 | 4.8 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(O)NC)c21 | 10.1021/jm701249f | |||
| CHEMBL468564 | 178850 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 530 | 10 | 4 | 9 | 4.8 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(O)NC)c21 | 10.1021/jm701249f | |||
| 44432645 | 87236 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 487 | 5 | 2 | 2 | 5.6 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CN)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL232752 | 87236 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 487 | 5 | 2 | 2 | 5.6 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CN)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 16048665 | 128734 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1COc1c(OC)ccc(F)c1F | nan | |||
| CHEMBL3668016 | 128734 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 7 | 2 | 8 | 3.5 | COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1COc1c(OC)ccc(F)c1F | nan | |||
| 44380192 | 57464 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL165534 | 57464 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 11634198 | 187472 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 6 | 1 | 5 | 5.8 | CCCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nc1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL493344 | 187472 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 6 | 1 | 5 | 5.8 | CCCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nc1C | 10.1016/j.bmcl.2009.02.043 | |||
| 44380624 | 59156 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 587 | 8 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169873 | 59156 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 587 | 8 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 11604354 | 187630 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 428 | 4 | 2 | 4 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c[nH]1 | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL494400 | 187630 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 428 | 4 | 2 | 4 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c[nH]1 | 10.1016/j.bmcl.2009.02.043 | |||
| 44359458 | 12151 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184171 | 12151 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL336884 | 12151 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44451342 | 96518 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 898 | 20 | 4 | 10 | 6.7 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCCCCCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL262334 | 96518 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 898 | 20 | 4 | 10 | 6.7 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCCCCCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 44444630 | 154913 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 596 | 7 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4CCCC4)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccccc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL400390 | 154913 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 596 | 7 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4CCCC4)cc3c2[C@H](C)CNC(=O)N2CCC(c3ccccc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 145951481 | 163050 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 620 | 10 | 1 | 10 | 3.6 | COc1ccccc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4174753 | 163050 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 620 | 10 | 1 | 10 | 3.6 | COc1ccccc1[C@@H](N)Cn1c(=O)c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 25193797 | 189774 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 548 | 7 | 2 | 5 | 6.4 | CC(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL515200 | 189774 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 548 | 7 | 2 | 5 | 6.4 | CC(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44593415 | 189488 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 462 | 5 | 3 | 5 | 4.3 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5[nH]c(=S)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL512893 | 189488 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 462 | 5 | 3 | 5 | 4.3 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5[nH]c(=S)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 44444617 | 94198 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 656 | 8 | 2 | 5 | 7.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N(C)C)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL249372 | 94198 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 656 | 8 | 2 | 5 | 7.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N(C)C)cc3c2[C@H](C)CN/C(=N/C(=O)OC(C)C)N2CCC(c3ccncc3)C2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44380319 | 58767 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168615 | 58767 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44451319 | 96228 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 882 | 15 | 3 | 10 | 6.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N2CCC[C@H]2C(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL260647 | 96228 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 882 | 15 | 3 | 10 | 6.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N2CCC[C@H]2C(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 44451396 | 156765 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 842 | 16 | 4 | 10 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL406958 | 156765 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 842 | 16 | 4 | 10 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 25113693 | 162008 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 896 | 15 | 3 | 10 | 6.2 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N2CCC(C(=O)NCC#Cc3ccccc3)CC2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL415279 | 162008 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 896 | 15 | 3 | 10 | 6.2 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N2CCC(C(=O)NCC#Cc3ccccc3)CC2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 44432639 | 86997 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 536 | 10 | 2 | 4 | 5.8 | COc1ccccc1CC(=O)N1CCc2[nH]c(-c3cc(C)cc(C)c3)c([C@H](C)CNCCc3ccncc3)c2C1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL232356 | 86997 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 536 | 10 | 2 | 4 | 5.8 | COc1ccccc1CC(=O)N1CCc2[nH]c(-c3cc(C)cc(C)c3)c([C@H](C)CNCCc3ccncc3)c2C1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44434431 | 88545 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 909 | 24 | 3 | 15 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL235132 | 88545 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 909 | 24 | 3 | 15 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 11331001 | 189130 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 617 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2cn(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| CHEMBL509075 | 189130 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 617 | 12 | 2 | 7 | 5.2 | COc1cccc(-c2cn(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1021/jm8006454 | |||
| 44432635 | 86817 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 512 | 8 | 2 | 3 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C2C(C)(C)C2(C)C)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL232150 | 86817 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 512 | 8 | 2 | 3 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C2C(C)(C)C2(C)C)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44341056 | 114598 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL333614 | 114598 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44398120 | 156383 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1660 | 41 | 17 | 19 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(=O)N(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL406535 | 156383 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1660 | 41 | 17 | 19 | -0.1 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(=O)N(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44358962 | 12147 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 559 | 7 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)nc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184155 | 12147 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 559 | 7 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)nc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL335764 | 12147 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 559 | 7 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)nc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44395583 | 124413 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 524 | 7 | 2 | 8 | 5.8 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL363663 | 124413 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 524 | 7 | 2 | 8 | 5.8 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL268875 | 213230 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | None | None | None | CCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 15602805 | 8109 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 486 | 5 | 1 | 7 | 3.5 | CCn1cc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1091579 | 8109 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 486 | 5 | 1 | 7 | 3.5 | CCn1cc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2010.02.099 | |||
| 44295755 | 193230 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2111956 | 193230 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL52278 | 193230 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44380513 | 120255 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 631 | 10 | 4 | 4 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(CO)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL351836 | 120255 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 631 | 10 | 4 | 4 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(CO)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380147 | 120342 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352566 | 120342 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 1184 | 3733 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| 9874838 | 3733 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| 16156572 | 167209 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1678 | 48 | 16 | 18 | 5.2 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL429016 | 167209 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1678 | 48 | 16 | 18 | 5.2 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 44398395 | 97033 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1751 | 45 | 17 | 20 | 2.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CN(Cc1ccccn1)Cc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL266444 | 97033 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1751 | 45 | 17 | 20 | 2.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CN(Cc1ccccn1)Cc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44448991 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL403234 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL556355 | 155431 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 583 | 9 | 2 | 7 | 4.7 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(C[C@H](CO)NC3CCCC3)c2=O)c1Cl | 10.1016/j.bmcl.2008.04.029 | |||
| 16146554 | 161553 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)CO | 10.1021/jm0003900 | |||
| CHEMBL412749 | 161553 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)CO | 10.1021/jm0003900 | |||
| 10051739 | 85467 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 4.4 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL22653 | 85467 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 4.4 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1021/jm030472z | |||
| 44398181 | 155772 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1710 | 43 | 18 | 19 | 2.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNc1ccc2ccccc2n1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL404973 | 155772 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1710 | 43 | 18 | 19 | 2.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCNc1ccc2ccccc2n1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 16147453 | 97170 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL267622 | 97170 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 9808288 | 111544 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL327704 | 111544 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 11421518 | 165391 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 553 | 10 | 1 | 7 | 4.8 | COc1ccccc1CNC[C@@H](C)n1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1021/jm030472z | |||
| CHEMBL423291 | 165391 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 553 | 10 | 1 | 7 | 4.8 | COc1ccccc1CNC[C@@H](C)n1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1021/jm030472z | |||
| 9808288 | 111544 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL327704 | 111544 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44361796 | 83424 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1583 | 42 | 17 | 18 | 0.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL219461 | 83424 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1583 | 42 | 17 | 18 | 0.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 44395533 | 66819 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 577 | 7 | 2 | 8 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CC3CCN2CC3)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185986 | 66819 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 577 | 7 | 2 | 8 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CC3CCN2CC3)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44380148 | 120375 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352782 | 120375 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9985901 | 110516 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL324654 | 110516 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 71449058 | 84440 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2111955 | 84440 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2219718 | 84440 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 145991962 | 166928 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 531 | 5 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6nc7ccccc7[nH]6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4285058 | 166928 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 531 | 5 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6nc7ccccc7[nH]6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 44398086 | 97088 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL266893 | 97088 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 1645 | 41 | 16 | 18 | 1.9 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44451379 | 169083 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 884 | 17 | 4 | 10 | 6.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N[C@H](C(=O)NCC#Cc2ccccc2)C(C)C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL439076 | 169083 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 884 | 17 | 4 | 10 | 6.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)N[C@H](C(=O)NCC#Cc2ccccc2)C(C)C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 44434428 | 146842 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 865 | 21 | 3 | 14 | 5.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL392435 | 146842 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 865 | 21 | 3 | 14 | 5.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44293486 | 187523 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 592 | 13 | 2 | 3 | 8.5 | CCN(C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL49374 | 187523 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 592 | 13 | 2 | 3 | 8.5 | CCN(C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432636 | 87419 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 550 | 8 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C24CC5CC(CC(C5)C2)C4)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL233341 | 87419 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 550 | 8 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)C24CC5CC(CC(C5)C2)C4)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44460343 | 207803 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 606 | 11 | 2 | 4 | 7.6 | COCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL79639 | 207803 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 606 | 11 | 2 | 4 | 7.6 | COCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44293274 | 101310 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 510 | 12 | 1 | 3 | 6.8 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCN(C)CCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL296199 | 101310 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 510 | 12 | 1 | 3 | 6.8 | CCN(CC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCN(C)CCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 22100905 | 184372 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 538 | 13 | 2 | 3 | 7.1 | CCN(CC)C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL48380 | 184372 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 538 | 13 | 2 | 3 | 7.1 | CCN(CC)C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293250 | 101788 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 552 | 11 | 2 | 4 | 6.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCOCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL299615 | 101788 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 552 | 11 | 2 | 4 | 6.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCOCC4)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44359193 | 11642 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180764 | 11642 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL141750 | 11642 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 16144515 | 156218 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL406337 | 156218 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 11249548 | 99144 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 530 | 9 | 1 | 8 | 4.1 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@@H](C)NCc3nccs3)c2=O)c1F | 10.1021/jm030472z | |||
| CHEMBL280664 | 99144 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 530 | 9 | 1 | 8 | 4.1 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@@H](C)NCc3nccs3)c2=O)c1F | 10.1021/jm030472z | |||
| 16221328 | 85634 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1530 | 41 | 15 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL228197 | 85634 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1530 | 41 | 15 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](SC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 145949496 | 162953 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 685 | 13 | 2 | 9 | 4.9 | Cc1cccc(F)c1Cn1c(C)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4173065 | 162953 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 685 | 13 | 2 | 9 | 4.9 | Cc1cccc(F)c1Cn1c(C)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 44361802 | 168952 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1547 | 41 | 15 | 16 | 2.6 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](Cc2ccc(CNC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL438018 | 168952 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1547 | 41 | 15 | 16 | 2.6 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](Cc2ccc(CNC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44340906 | 9573 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 578 | 9 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL112400 | 9573 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 578 | 9 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44321291 | 208735 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 632 | 11 | 2 | 3 | 9.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5(C)CC4CC(C)(C)C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86950 | 208735 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 632 | 11 | 2 | 3 | 9.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5(C)CC4CC(C)(C)C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 10032223 | 12207 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184284 | 12207 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL342822 | 12207 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 172457590 | 196464 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 771 | 12 | 2 | 12 | 5.5 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5424526 | 196464 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 771 | 12 | 2 | 12 | 5.5 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44380514 | 120276 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 645 | 10 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(=O)O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352051 | 120276 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 645 | 10 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(=O)O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL262747 | 213005 | None | 8 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 44321292 | 208744 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCCC4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL87000 | 208744 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCCC4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44380797 | 59310 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170499 | 59310 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL2105773 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL409018 | 215201 | None | 12 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 16221151 | 143683 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1564 | 40 | 13 | 16 | 3.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)[S+](C)[O-])C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| CHEMBL389945 | 143683 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1564 | 40 | 13 | 16 | 3.7 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)[S+](C)[O-])C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0613931 | |||
| 15602806 | 8298 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.2 | CCc1nc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1092638 | 8298 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 456 | 5 | 1 | 5 | 5.2 | CCc1nc(CN2CCN(c3cccn4cc(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| 44432648 | 150315 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 643 | 9 | 2 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4nccnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL395225 | 150315 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 643 | 9 | 2 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4nccnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44293305 | 101516 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 536 | 11 | 2 | 3 | 6.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCC4)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL297703 | 101516 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 536 | 11 | 2 | 3 | 6.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCC4)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293165 | 101748 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 556 | 16 | 2 | 5 | 5.7 | COCCN(CCOC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL299392 | 101748 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 556 | 16 | 2 | 5 | 5.7 | COCCN(CCOC)C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44341080 | 110641 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.4 | CCCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL325417 | 110641 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.4 | CCCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44293347 | 163206 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 550 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL417720 | 163206 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 550 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44293617 | 188782 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 522 | 10 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N4C(C)CCC4C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL50380 | 188782 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 522 | 10 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N4C(C)CCC4C)cc3c2CCNCCCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432643 | 146855 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 6.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL392446 | 146855 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 592 | 9 | 2 | 3 | 6.9 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44561368 | 176919 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 480 | 4 | 3 | 4 | 5.0 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=O)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL460892 | 176919 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 480 | 4 | 3 | 4 | 5.0 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6[nH]c(=O)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44432655 | 149574 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 675 | 11 | 3 | 6 | 6.5 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCOc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL394634 | 149574 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 675 | 11 | 3 | 6 | 6.5 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCOc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 172470823 | 197195 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 663 | 11 | 2 | 11 | 4.5 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC5CC5)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5441000 | 197195 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 663 | 11 | 2 | 11 | 4.5 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC5CC5)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 11583756 | 189763 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL515123 | 189763 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 11712618 | 180332 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 4 | 1 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6ncccc6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL474992 | 180332 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 4 | 1 | 4 | 6.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6ncccc6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 25194091 | 189118 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 498 | 7 | 3 | 5 | 5.5 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL508898 | 189118 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 498 | 7 | 3 | 5 | 5.5 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 145952498 | 162971 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 719 | 14 | 2 | 10 | 4.8 | COc1ccccc1[C@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O)NCCCC(=O)O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4173316 | 162971 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 719 | 14 | 2 | 10 | 4.8 | COc1ccccc1[C@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2F)c1=O)NCCCC(=O)O | 10.1016/j.ejmech.2017.12.095 | |||
| 44321148 | 96861 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 622 | 11 | 2 | 5 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CC4)OCCO5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL265042 | 96861 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 622 | 11 | 2 | 5 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CC4)OCCO5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321509 | 208647 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CCCC[C@H]5C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86431 | 208647 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CCCC[C@H]5C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 10187208 | 66769 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 540 | 7 | 2 | 9 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2OCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185785 | 66769 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 540 | 7 | 2 | 9 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2OCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 170269129 | 195607 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 624 | 9 | 2 | 12 | 3.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cncc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5407004 | 195607 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 624 | 9 | 2 | 12 | 3.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cncc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44434386 | 89842 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 638 | 11 | 2 | 8 | 5.1 | C#CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL237734 | 89842 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 638 | 11 | 2 | 8 | 5.1 | C#CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44434391 | 90122 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 926 | 27 | 2 | 16 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL238177 | 90122 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 926 | 27 | 2 | 16 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCOCCOCCN=[N+]=[N-])nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44451356 | 96416 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 870 | 18 | 4 | 10 | 5.9 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCCCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| CHEMBL261649 | 96416 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 870 | 18 | 4 | 10 | 5.9 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCCCC(=O)NCC#Cc2ccccc2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.01.054 | |||
| 16148338 | 162042 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL415573 | 162042 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 10649568 | 14572 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| 44321290 | 208864 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 548 | 9 | 2 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL87785 | 208864 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 548 | 9 | 2 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44432654 | 159889 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 10 | 3 | 6 | 6.1 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)nc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL410547 | 159889 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 10 | 3 | 6 | 6.1 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)nc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 9961721 | 168582 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 16144832 | 161873 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(N)=O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL414061 | 161873 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(N)=O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 10231401 | 2020 | None | 1 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| 5584 | 2020 | None | 1 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL314260 | 2020 | None | 1 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| 44572235 | 189616 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 522 | 4 | 2 | 6 | 4.4 | Cn1c(=O)c(=O)[nH]c2ccc(CN3CCN(c4cccc5[nH]c(-c6ccc(C(C)(C)C)cc6)nc45)CC3)cc21 | 10.1021/jm801572m | |||
| CHEMBL513998 | 189616 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 522 | 4 | 2 | 6 | 4.4 | Cn1c(=O)c(=O)[nH]c2ccc(CN3CCN(c4cccc5[nH]c(-c6ccc(C(C)(C)C)cc6)nc45)CC3)cc21 | 10.1021/jm801572m | |||
| 44340888 | 110588 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 592 | 10 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(CO)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL325091 | 110588 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 592 | 10 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(CO)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44380552 | 58776 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cncc3ccccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168655 | 58776 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cncc3ccccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380643 | 58735 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 659 | 10 | 3 | 5 | 7.7 | COC(=O)c1nc2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4ccc(C(C)(C)C(=O)N5CC6CCC5CC6)cc34)ccc2[nH]1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168498 | 58735 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 659 | 10 | 3 | 5 | 7.7 | COC(=O)c1nc2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4ccc(C(C)(C)C(=O)N5CC6CCC5CC6)cc34)ccc2[nH]1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44361468 | 161826 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL413698 | 161826 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 16147757 | 161898 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL414266 | 161898 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 16144824 | 96900 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CO | 10.1021/jm0003900 | |||
| CHEMBL265286 | 96900 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CO | 10.1021/jm0003900 | |||
| 44361351 | 161053 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@@H](Cc2ccc(CNC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL411565 | 161053 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@@H](Cc2ccc(CNC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361797 | 161897 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1659 | 42 | 17 | 18 | 1.5 | CNC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL414249 | 161897 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1659 | 42 | 17 | 18 | 1.5 | CNC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 9809394 | 120576 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 628 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL354524 | 120576 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 628 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9809382 | 100729 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 628 | 11 | 2 | 8 | 5.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL292291 | 100729 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 628 | 11 | 2 | 8 | 5.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44434373 | 90082 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 637 | 11 | 3 | 7 | 4.6 | C#CCNC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL238160 | 90082 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 637 | 11 | 3 | 7 | 4.6 | C#CCNC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44573791 | 187494 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 484 | 7 | 1 | 5 | 6.2 | CCCCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL493565 | 187494 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 484 | 7 | 1 | 5 | 6.2 | CCCCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| 44434415 | 88561 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 821 | 18 | 3 | 13 | 5.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL235180 | 88561 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 821 | 18 | 3 | 13 | 5.0 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44434432 | 88782 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 953 | 27 | 3 | 16 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL236221 | 88782 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 953 | 27 | 3 | 16 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44444663 | 94253 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 645 | 8 | 2 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CNC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL249771 | 94253 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 645 | 8 | 2 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CNC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44359287 | 11639 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 534 | 7 | 3 | 7 | 6.3 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)on4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180743 | 11639 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 534 | 7 | 3 | 7 | 6.3 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)on4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL139993 | 11639 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 534 | 7 | 3 | 7 | 6.3 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(C)on4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44359303 | 11641 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 520 | 7 | 4 | 7 | 5.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nc[nH]n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180760 | 11641 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 520 | 7 | 4 | 7 | 5.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nc[nH]n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL141539 | 11641 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 520 | 7 | 4 | 7 | 5.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4nc[nH]n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44576656 | 188353 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 571 | 10 | 2 | 7 | 4.2 | N[C@@H](Cn1c(=O)c(-c2ccc(COCC(=O)O)cc2)cn(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1016/j.bmcl.2008.04.036 | |||
| CHEMBL499588 | 188353 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 571 | 10 | 2 | 7 | 4.2 | N[C@@H](Cn1c(=O)c(-c2ccc(COCC(=O)O)cc2)cn(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1016/j.bmcl.2008.04.036 | |||
| 138978204 | 166850 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 461 | 6 | 1 | 6 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(CCF)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4283577 | 166850 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 461 | 6 | 1 | 6 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(CCF)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 145992260 | 167030 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 744 | 10 | 2 | 14 | 3.3 | CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1n1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1 | 10.1039/C7MD00320J | |||
| CHEMBL4286937 | 167030 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 744 | 10 | 2 | 14 | 3.3 | CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1n1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1 | 10.1039/C7MD00320J | |||
| 16147451 | 97067 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1644 | 41 | 15 | 18 | 2.3 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL266653 | 97067 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1644 | 41 | 15 | 18 | 2.3 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL2370894 | 212405 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)C[C@@H]3NC(=O)NC3=O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 16147765 | 161945 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cnc(O)nc3O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361477 | 161945 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cnc(O)nc3O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL414715 | 161945 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1628 | 41 | 16 | 20 | 2.9 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)c3cnc(O)nc3O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 10051739 | 85467 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 4.4 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1016/j.bmcl.2008.04.029 | |||
| CHEMBL22653 | 85467 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 4.4 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](C)NC3CCCC3)c2=O)c1F | 10.1016/j.bmcl.2008.04.029 | |||
| 44321345 | 208700 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 596 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCC2CCC(=O)N(C)C2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86758 | 208700 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 596 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCC2CCC(=O)N(C)C2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 10258659 | 12203 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184268 | 12203 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL341809 | 12203 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44293487 | 101689 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 594 | 15 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL299006 | 101689 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 594 | 15 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 145973618 | 163180 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 635 | 8 | 1 | 8 | 4.7 | Cc1cc(F)cc([C@@H](N)Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4176683 | 163180 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 635 | 8 | 1 | 8 | 4.7 | Cc1cc(F)cc([C@@H](N)Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| 44380236 | 58738 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 641 | 11 | 2 | 4 | 8.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168506 | 58738 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 641 | 11 | 2 | 4 | 8.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 16144222 | 97075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL266728 | 97075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44341113 | 9923 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL114438 | 9923 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44321411 | 107065 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@@H]5CC[C@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL315326 | 107065 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@@H]5CC[C@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 101755083 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16136245 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16136245.0 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 4379 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 5585 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL415606 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB06699 | 1359 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 44361587 | 161405 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.3 | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(CNC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O | 10.1021/jm0003900 | |||
| CHEMBL412336 | 161405 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.3 | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(CNC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O | 10.1021/jm0003900 | |||
| 44321412 | 208710 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86805 | 208710 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 590 | 11 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 16144865 | 83472 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1648 | 43 | 18 | 18 | 1.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)C(NC(N)=O)NC(N)=O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL219799 | 83472 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 1648 | 43 | 18 | 18 | 1.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)C(NC(N)=O)NC(N)=O)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 53239183 | 162938 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 603 | 8 | 1 | 8 | 4.3 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4172886 | 162938 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 603 | 8 | 1 | 8 | 4.3 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 58022331 | 128723 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 473 | 3 | 1 | 6 | 3.5 | O=c1[nH]c2sccc2c(=O)n1-c1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl | nan | |||
| CHEMBL3668004 | 128723 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 473 | 3 | 1 | 6 | 3.5 | O=c1[nH]c2sccc2c(=O)n1-c1cc(S(=O)(=O)N2CCCc3ccccc32)ccc1Cl | nan | |||
| 44292918 | 171518 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 552 | 14 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL44627 | 171518 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 552 | 14 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(C)C)CC(C)C)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432627 | 148216 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 430 | 7 | 2 | 3 | 4.5 | CC(=O)N1CCc2[nH]c(-c3cc(C)cc(C)c3)c([C@H](C)CNCCc3ccncc3)c2C1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL393540 | 148216 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 430 | 7 | 2 | 3 | 4.5 | CC(=O)N1CCc2[nH]c(-c3cc(C)cc(C)c3)c([C@H](C)CNCCc3ccncc3)c2C1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44321695 | 106037 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccn(C)c2=O)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL313086 | 106037 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccn(C)c2=O)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44434433 | 88783 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 997 | 30 | 3 | 17 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL236222 | 88783 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 997 | 30 | 3 | 17 | 5.1 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCOCCOCCN=[N+]=[N-])nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 44434436 | 151061 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 1619 | 39 | 6 | 26 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL395825 | 151061 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 1619 | 39 | 6 | 26 | 8.5 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(CC(=O)NCc2cn(CCOCCOCCn3cc(CNC(=O)CN(Cc4ccccc4)Cc4c(-c5ccc(NC(=O)NCC)cc5)nc5n(Cc6c(F)cccc6F)cc(C(=O)OCC)c(=O)n45)nn3)nn2)Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.04.065 | |||
| 16221379 | 162025 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1546 | 41 | 15 | 17 | 1.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| CHEMBL415380 | 162025 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1546 | 41 | 15 | 17 | 1.1 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)[S+]([O-])C(C)C)cc1 | 10.1021/jm0613931 | |||
| 58022131 | 128726 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 442 | 5 | 2 | 6 | 4.0 | Cc1ccccc1COc1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| CHEMBL3668007 | 128726 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 442 | 5 | 2 | 6 | 4.0 | Cc1ccccc1COc1ccc(Cl)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)c1 | nan | |||
| 44432642 | 153683 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 574 | 9 | 2 | 3 | 6.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL398060 | 153683 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 574 | 9 | 2 | 3 | 6.8 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccncc2)CN(C(=O)Cc2ccccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 44432649 | 86733 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 645 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4[nH]c(C)nc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL231739 | 86733 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 645 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc4[nH]c(C)nc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 172452282 | 196069 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 655 | 11 | 2 | 9 | 5.1 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)oc3n(Cc3c(F)cccc3F)c2=O)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5416399 | 196069 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 655 | 11 | 2 | 9 | 5.1 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)oc3n(Cc3c(F)cccc3F)c2=O)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 44185958 | 155088 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 615 | 8 | 1 | 5 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401349 | 155088 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 615 | 8 | 1 | 5 | 5.7 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCN(CC(=O)N3CCCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| 145956692 | 162167 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 606 | 9 | 2 | 10 | 3.3 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4160698 | 162167 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 606 | 9 | 2 | 10 | 3.3 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 44380488 | 59033 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ocnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169238 | 59033 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ocnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44432652 | 97194 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 633 | 9 | 3 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2cnc4[nH]nnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL267838 | 97194 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 633 | 9 | 3 | 5 | 6.2 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2cnc4[nH]nnc4c2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1016/j.bmcl.2007.05.009 | |||
| 16146884 | 97223 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CNC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL268146 | 97223 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CNC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44398118 | 167393 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1632 | 41 | 18 | 19 | -0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| CHEMBL429378 | 167393 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1632 | 41 | 18 | 19 | -0.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm050134t | |||
| 44593424 | 176237 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL459215 | 176237 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 44593424 | 176237 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL459215 | 176237 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 508 | 4 | 3 | 5 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 16156706 | 137188 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1745 | 48 | 17 | 19 | 4.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL374747 | 137188 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1745 | 48 | 17 | 19 | 4.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 16144863 | 96928 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL265556 | 96928 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16156706 | 137188 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1745 | 48 | 17 | 19 | 4.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| CHEMBL374747 | 137188 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1745 | 48 | 17 | 19 | 4.0 | CCCCCCCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)NOC)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm060240a | |||
| 11620431 | 179475 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 509 | 4 | 3 | 6 | 3.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cnc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL473807 | 179475 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 509 | 4 | 3 | 6 | 3.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cnc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 15602807 | 8222 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 476 | 4 | 0 | 6 | 5.6 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5ccc6nccnc6c5)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL1092245 | 8222 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 476 | 4 | 0 | 6 | 5.6 | CC(C)(C)c1ccc(-c2cn3cccc(N4CCN(Cc5ccc6nccnc6c5)CC4)c3n2)cc1 | 10.1016/j.bmcl.2010.02.099 | |||
| 44293485 | 101570 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 590 | 12 | 1 | 3 | 8.2 | CCN(CCCCc1ccncc1)CCc1c(-c2cc(C)cc(C)c2)[nH]c2ccc(C(C)(C)C(=O)N3C4CCC3CC4)cc12 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL298051 | 101570 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 590 | 12 | 1 | 3 | 8.2 | CCN(CCCCc1ccncc1)CCc1c(-c2cc(C)cc(C)c2)[nH]c2ccc(C(C)(C)C(=O)N3C4CCC3CC4)cc12 | 10.1016/s0960-894x(01)00275-x | |||
| 44293134 | 187507 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 604 | 12 | 2 | 3 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(F)(F)F)CC(F)(F)F)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL49366 | 187507 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 604 | 12 | 2 | 3 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N(CC(F)(F)F)CC(F)(F)F)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44432650 | 86805 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 703 | 10 | 3 | 5 | 6.5 | CCn1c(=O)[nH]c2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4c3CN(C(=O)Cc3c(F)cccc3C(F)(F)F)CC4)ccc2c1=O | 10.1016/j.bmcl.2007.05.009 | |||
| CHEMBL232097 | 86805 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 703 | 10 | 3 | 5 | 6.5 | CCn1c(=O)[nH]c2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4c3CN(C(=O)Cc3c(F)cccc3C(F)(F)F)CC4)ccc2c1=O | 10.1016/j.bmcl.2007.05.009 | |||
| 44560995 | 179259 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL472117 | 179259 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 44321147 | 163575 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 618 | 11 | 2 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CCCC5)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL420051 | 163575 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 618 | 11 | 2 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CCCC5)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44293511 | 101340 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 538 | 13 | 2 | 3 | 7.1 | CCN(CC)C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL296426 | 101340 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 538 | 13 | 2 | 3 | 7.1 | CCN(CC)C(=O)C(C)(C)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1 | 10.1016/s0960-894x(01)00275-x | |||
| 44444645 | 155090 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 672 | 9 | 2 | 6 | 4.8 | CC(=O)NC1CCN(C(=O)CN2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL401351 | 155090 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 672 | 9 | 2 | 6 | 4.8 | CC(=O)NC1CCN(C(=O)CN2CCN(CCc3c(-c4cc(C)cc(C)c4)[nH]c4sc(C(C)(C)C(=O)N5C6CCC5CC6)cc34)CC2)C1 | 10.1016/j.bmcl.2007.09.099 | |||
| 44434404 | 166663 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 1477 | 33 | 4 | 24 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| CHEMBL427981 | 166663 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 1477 | 33 | 4 | 24 | 9.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NCc4cn(CCOCCOCCn5cc(CNC(=O)Nc6ccc(-c7nc8n(Cc9c(F)cccc9F)cc(C(=O)OCC)c(=O)n8c7CN(C)Cc7ccccc7)cc6)nn5)nn4)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/j.bmc.2007.04.065 | |||
| 44359289 | 12155 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 547 | 8 | 3 | 7 | 6.3 | CCn1nccc1NC(=O)c1cc2c(OCCC3CCCCN3)c(-c3cc(C)cc(C)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184180 | 12155 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 547 | 8 | 3 | 7 | 6.3 | CCn1nccc1NC(=O)c1cc2c(OCCC3CCCCN3)c(-c3cc(C)cc(C)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL337323 | 12155 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 547 | 8 | 3 | 7 | 6.3 | CCn1nccc1NC(=O)c1cc2c(OCCC3CCCCN3)c(-c3cc(C)cc(C)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00024-x | |||
| 44361351 | 161053 | None | 0 | Human | Functional | pKd | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@@H](Cc2ccc(CNC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL411565 | 161053 | None | 0 | Human | Functional | pKd | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@@H](Cc2ccc(CNC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16144515 | 156218 | None | 0 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL406337 | 156218 | None | 0 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | 1533 | 40 | 15 | 16 | 2.9 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16130957 | 211120 | None | 27 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 16130957.0 | 211120 | None | 27 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL1251 | 211120 | None | 27 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL5314377 | 211120 | None | 27 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| DB06785 | 211120 | None | 27 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC/N=C(\NCC)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN/C(=N/CC)NCC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL2370890 | 212404 | None | 0 | Human | Functional | pKd | = | 9.3 | 9.3 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 101755083 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16136245 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16136245.0 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 4379 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 5585 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL415606 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB06699 | 1359 | None | 35 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16146884 | 97223 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CNC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL268146 | 97223 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.1 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CNC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361587 | 161405 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.3 | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(CNC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O | 10.1021/jm0003900 | |||
| CHEMBL412336 | 161405 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1602 | 41 | 16 | 17 | 2.3 | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(CNC(N)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O | 10.1021/jm0003900 | |||
| 16146554 | 161553 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)CO | 10.1021/jm0003900 | |||
| CHEMBL412749 | 161553 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)CO | 10.1021/jm0003900 | |||
| 44361802 | 168952 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1547 | 41 | 15 | 16 | 2.6 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](Cc2ccc(CNC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL438018 | 168952 | None | 0 | Human | Functional | pKd | = | 9.2 | 9.2 | - | 1 | ChEMBL | 1547 | 41 | 15 | 16 | 2.6 | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](Cc2ccc(CNC(N)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 1188 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16131215 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16131215.0 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 35 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL1252 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB00106 | 219 | None | 37 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 44361796 | 83424 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1583 | 42 | 17 | 18 | 0.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL219461 | 83424 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1583 | 42 | 17 | 18 | 0.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 16147451 | 97067 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1644 | 41 | 15 | 18 | 2.3 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL266653 | 97067 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1644 | 41 | 15 | 18 | 2.3 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361797 | 161897 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1659 | 42 | 17 | 18 | 1.5 | CNC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL414249 | 161897 | None | 0 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1659 | 42 | 17 | 18 | 1.5 | CNC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16144824 | 96900 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CO | 10.1021/jm0003900 | |||
| CHEMBL265286 | 96900 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1632 | 42 | 17 | 18 | 1.7 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CO | 10.1021/jm0003900 | |||
| 16144863 | 96928 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL265556 | 96928 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16144222 | 97075 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL266728 | 97075 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 44361888 | 141863 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL386105 | 141863 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 44361468 | 161826 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL413698 | 161826 | None | 0 | Human | Functional | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 1728 | 42 | 18 | 20 | 0.6 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 1190 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 25074887 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 25074887.0 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 583 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| CHEMBL1200490 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| DB00050 | 882 | None | 32 | Human | Functional | pKd | = | 8.9 | 8.9 | 6025 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0003900 | |||||
| 16147453 | 97170 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL267622 | 97170 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1645 | 42 | 17 | 18 | 1.2 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(CNC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| 16147767 | 97412 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL269516 | 97412 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 1 | ChEMBL | 1630 | 41 | 16 | 18 | 2.0 | CC(=O)Nc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL268875 | 213230 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CCNC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(=O)NCC)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 16148338 | 162042 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| CHEMBL415573 | 162042 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1644 | 42 | 16 | 18 | 1.7 | CC(=O)NCc1ccc(C[C@@H](NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||
| 16146022 | 170222 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1631 | 41 | 17 | 18 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL444381 | 170222 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 1631 | 41 | 17 | 18 | 1.5 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL269711 | 213260 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL2105773 | 215201 | None | 12 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| CHEMBL409018 | 215201 | None | 12 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||||
| 44361795 | 168601 | None | 0 | Human | Functional | pKd | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1574 | 40 | 15 | 18 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL435322 | 168601 | None | 0 | Human | Functional | pKd | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1574 | 40 | 15 | 18 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@H]2CC(=O)NC(=O)N2)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1021/jm0003900 | |||
| CHEMBL262747 | 213005 | None | 8 | Human | Functional | pKd | = | 8.6 | 8.6 | - | 1 | ChEMBL | None | None | None | CC(=O)Nc1ccc(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(C)=O)C(=O)N[C@H](Cc2ccc(NC(C)=O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(N)=O)cc1 | 10.1021/jm0003900 | |||||
| 1184 | 3733 | None | 26 | Human | Functional | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| 9874838 | 3733 | None | 26 | Human | Functional | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Functional | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1039/C7MD00320J | |||
| 145991962 | 166928 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 531 | 5 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6nc7ccccc7[nH]6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4285058 | 166928 | None | 0 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 531 | 5 | 2 | 7 | 5.3 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6nc7ccccc7[nH]6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 11583756 | 189763 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL515123 | 189763 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cccc6nccnc56)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 138978204 | 166850 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 461 | 6 | 1 | 6 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(CCF)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4283577 | 166850 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 461 | 6 | 1 | 6 | 4.4 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(CCF)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 145992260 | 167030 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 744 | 10 | 2 | 14 | 3.3 | CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1n1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1 | 10.1039/C7MD00320J | |||
| CHEMBL4286937 | 167030 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 744 | 10 | 2 | 14 | 3.3 | CC(=O)N[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O[C@H]1n1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1 | 10.1039/C7MD00320J | |||
| 145993478 | 167416 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 602 | 8 | 3 | 9 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1)C(=O)O | 10.1039/C7MD00320J | |||
| CHEMBL4294163 | 167416 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 602 | 8 | 3 | 9 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nn1)C(=O)O | 10.1039/C7MD00320J | |||
| 1179 | 961 | None | 28 | Human | Functional | pKi | = | 7.7 | 7.7 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| 9957278 | 961 | None | 28 | Human | Functional | pKi | = | 7.7 | 7.7 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| CHEMBL494803 | 961 | None | 28 | Human | Functional | pKi | = | 7.7 | 7.7 | 30 | 4 | ChEMBL | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 10.1039/C7MD00320J | |||
| 145980339 | 166682 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 380 | 4 | 1 | 3 | 4.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCF)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4280124 | 166682 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 380 | 4 | 1 | 3 | 4.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(CCF)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 138978203 | 166796 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 639 | 7 | 3 | 11 | 3.1 | Cc1cn([C@H]2C[C@@H](n3cc(CN4CCN(c5cccc6[nH]c(-c7ccc(C(C)(C)C)cc7)nc56)CC4)nn3)[C@@H](CO)O2)c(=O)[nH]c1=O | 10.1039/C7MD00320J | |||
| CHEMBL4282476 | 166796 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 639 | 7 | 3 | 11 | 3.1 | Cc1cn([C@H]2C[C@@H](n3cc(CN4CCN(c5cccc6[nH]c(-c7ccc(C(C)(C)C)cc7)nc56)CC4)nn3)[C@@H](CO)O2)c(=O)[nH]c1=O | 10.1039/C7MD00320J | |||
| 138978207 | 167249 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 372 | 3 | 1 | 3 | 4.3 | C#CCN1CCN(c2cccc3[nH]c(-c4ccc(C(C)(C)C)cc4)nc23)CC1 | 10.1039/C7MD00320J | |||
| CHEMBL4290761 | 167249 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 372 | 3 | 1 | 3 | 4.3 | C#CCN1CCN(c2cccc3[nH]c(-c4ccc(C(C)(C)C)cc4)nc23)CC1 | 10.1039/C7MD00320J | |||
| 145984647 | 166511 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 5.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6ccc(F)cc6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| CHEMBL4277116 | 166511 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 5.6 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cn(-c6ccc(F)cc6)nn5)CC4)cccc3[nH]2)cc1 | 10.1039/C7MD00320J | |||
| 3860 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| 436 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| 50225 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| 50225.0 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| CHEMBL2110824 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| DB06719 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 8 | 8.0 | -2 | 2 | Drug Central | None | None | None | None | None | |||||
| 3860 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 436 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 50225 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 50225.0 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| CHEMBL2110824 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| DB06719 | 744 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 1177 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| 25074470 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| 25074470.0 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| 2968 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| CHEMBL1201334 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| DB06825 | 3867 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | None | None | None | None | None | |||||
| 1162 | 1831 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | 16 | 3 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 16132914 | 1831 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | 16 | 3 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 3860 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 436 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 50225 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 50225.0 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| CHEMBL2110824 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| DB06719 | 744 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 1162 | 1831 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 16132914 | 1831 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 3860 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 436 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 50225 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 50225.0 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| CHEMBL2110824 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| DB06719 | 744 | None | 0 | Mouse | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 26774084 | |||||
| 11980076 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| 36523 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| 36523.0 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| 638793 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| 638793.0 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| CHEMBL1007 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| CHEMBL1981292 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| DB00644 | 210912 | None | 21 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | None | |||||
| 11250647 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| 11250647.0 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| 5293 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| 8362 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| CHEMBL1208155 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| DB11979 | 1545 | None | 35 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 977 | 7 | Drug Central | 631 | 12 | 2 | 7 | 5.5 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F | None | |||
| 10348973 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 10348973.0 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 5432 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 5586 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| CHEMBL1800159 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| DB11853 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 1175 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| 1559 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| 657181 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| 657181.0 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| CHEMBL1201199 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| DB00007 | 2298 | None | 30 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 3 | 2 | Drug Central | None | None | None | None | None | |||||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 8 | 8.0 | 1 | 2 | Drug Central | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | None | |||
| 12784 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | Guide to Pharmacology | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 32960053 | |||
| 85469632 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | Guide to Pharmacology | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 32960053 | |||
| CHEMBL4537788 | 577 | None | 15 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | Guide to Pharmacology | 671 | 6 | 1 | 6 | 5.3 | ClC1=C(CNC(C2=CC=C3N(S(=O)(C4=CC=C(F)C=C4)=O)[C@@H](C5CC5)C6(CCS(CC6)(=O)=O)C3=C2)=O)N=CC(C(F)(F)F)=C1 | 32960053 | |||
| 12283 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | 35690889 | |||
| 16656889 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | 35690889 | |||
| 16656889.0 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | 35690889 | |||
| CHEMBL3668014 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | 35690889 | |||
| DB17083 | 2323 | None | 21 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 508 | 7 | 2 | 8 | 3.5 | COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC | 35690889 | |||
| 11496610 | 4075 | None | 10 | Rat | Functional | pIC50 | = | 7.2 | 7.2 | -4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| 5582 | 4075 | None | 10 | Rat | Functional | pIC50 | = | 7.2 | 7.2 | -4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| CHEMBL474991 | 4075 | None | 10 | Rat | Functional | pIC50 | = | 7.2 | 7.2 | -4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| 1164 | 1832 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1164 | 1832 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 17942747 | |||||
| 1164 | 1832 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 19638591 | |||||
| 5581 | 1446 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 19638591 | |||||
| 11496610 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| 5582 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| CHEMBL474991 | 4075 | None | 10 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 4 | 2 | Guide to Pharmacology | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 19271735 | |||
| 1162 | 1831 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 16 | 3 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 16132914 | 1831 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 16 | 3 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1190 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 25074887 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 25074887.0 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 583 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| CHEMBL1200490 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| DB00050 | 882 | None | 32 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 6025 | 3 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 10231401 | 2020 | None | 1 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| 5584 | 2020 | None | 1 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| CHEMBL314260 | 2020 | None | 1 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| 101827019 | 2106 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 16130938 | 2106 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 3854 | 2106 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 73952264 | 2106 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| CHEMBL3989438 | 2106 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 11861490 | |||||
| 1175 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 1559 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 657181 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 657181.0 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| CHEMBL1201199 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| DB00007 | 2298 | None | 30 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 5583 | 248 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 19638591 | |||||
| 10231401 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| 10231401 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 12107234 | |||
| 5584 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| 5584 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 12107234 | |||
| CHEMBL314260 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 11551758 | |||
| CHEMBL314260 | 2020 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | Guide to Pharmacology | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 12107234 | |||
| 10348973 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 10348973 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 10348973.0 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 10348973.0 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 5432 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 5432 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 5586 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 5586 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| CHEMBL1800159 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| DB11853 | 3313 | None | 51 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| DB11853 | 3313 | None | 51 | Rat | Functional | pIC50 | = | 9.5 | 9.5 | -1 | 2 | Guide to Pharmacology | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 21657270 | |||
| 12394 | 2490 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | 752 | 12 | 2 | 9 | 6.0 | C1CN(CCC21c1c(CO2)n(c(=O)n(c1=O)C[C@@H](c1ccccc1)NCCCC(=O)O)Cc1c(cccc1F)C(F)(F)F)Cc1ccc(o1)C(F)(F)F | 26321528 | |||
| 71727383 | 2490 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | 752 | 12 | 2 | 9 | 6.0 | C1CN(CCC21c1c(CO2)n(c(=O)n(c1=O)C[C@@H](c1ccccc1)NCCCC(=O)O)Cc1c(cccc1F)C(F)(F)F)Cc1ccc(o1)C(F)(F)F | 26321528 | |||
| 1192 | 147 | None | 37 | Human | Functional | pIC50 | None | 4.3 | 4.3 | -9 | 4 | Guide to Pharmacology | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | 18344315 | |||
| 1794 | 147 | None | 37 | Human | Functional | pIC50 | None | 4.3 | 4.3 | -9 | 4 | Guide to Pharmacology | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | 18344315 | |||
| CHEMBL501701 | 147 | None | 37 | Human | Functional | pIC50 | None | 4.3 | 4.3 | -9 | 4 | Guide to Pharmacology | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | 18344315 | |||
| 10279142 | 1626 | None | 0 | Human | Functional | pIC50 | None | 5.3 | 5.3 | - | 1 | Guide to Pharmacology | 509 | 7 | 1 | 8 | 6.0 | COc1nc(OC)c(c(n1)OC)NC(=O)c1ccc(o1)Oc1cc2c(cc1C)C(C)(C)C(CC2(C)C)C | 18344315 | |||
| 1182 | 1626 | None | 0 | Human | Functional | pIC50 | None | 5.3 | 5.3 | - | 1 | Guide to Pharmacology | 509 | 7 | 1 | 8 | 6.0 | COc1nc(OC)c(c(n1)OC)NC(=O)c1ccc(o1)Oc1cc2c(cc1C)C(C)(C)C(CC2(C)C)C | 18344315 | |||
| 1171 | 3589 | None | 0 | Human | Functional | pIC50 | None | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 118856782 | 3589 | None | 0 | Human | Functional | pIC50 | None | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1173 | 3898 | None | 0 | Human | Functional | pIC50 | None | 6.7 | 6.7 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1172 | 3874 | None | 0 | Human | Functional | pIC50 | None | 7 | 7.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 16130930 | 3874 | None | 0 | Human | Functional | pIC50 | None | 7 | 7.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1169 | 1808 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 123777 | 1808 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 17452338 | |||||
| 1162 | 1831 | None | 0 | Rat | Functional | pIC50 | None | 7.7 | 7.7 | -39 | 3 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 16132914 | 1831 | None | 0 | Rat | Functional | pIC50 | None | 7.7 | 7.7 | -39 | 3 | Guide to Pharmacology | None | None | None | None | 8013367 | |||||
| 1179 | 961 | None | 28 | Human | Functional | pIC50 | None | 7.8 | 7.8 | 30 | 4 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 17176055 | |||
| 9957278 | 961 | None | 28 | Human | Functional | pIC50 | None | 7.8 | 7.8 | 30 | 4 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 17176055 | |||
| CHEMBL494803 | 961 | None | 28 | Human | Functional | pIC50 | None | 7.8 | 7.8 | 30 | 4 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 6.8 | COc1cc(OC)c(c(c1)OC)NC(=O)c1ccc(o1)Cc1cc2c(cc1C)C(C)(C)CCC2(C)C | 17176055 | |||
| 1162 | 1831 | None | 0 | Mouse | Functional | pIC50 | None | 8.3 | 8.3 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 1328228 | |||||
| 16132914 | 1831 | None | 0 | Mouse | Functional | pIC50 | None | 8.3 | 8.3 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 1328228 | |||||
| 1184 | 3733 | None | 26 | Human | Functional | pIC50 | None | 9.7 | 9.7 | - | 1 | Guide to Pharmacology | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 9784092 | |||
| 9874838 | 3733 | None | 26 | Human | Functional | pIC50 | None | 9.7 | 9.7 | - | 1 | Guide to Pharmacology | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 9784092 | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Functional | pIC50 | None | 9.7 | 9.7 | - | 1 | Guide to Pharmacology | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 9784092 | |||
| 1174 | 1386 | None | 0 | Mouse | Functional | pIC50 | None | 9.9 | 9.9 | - | 1 | Guide to Pharmacology | None | None | None | None | 1328228 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 11563584 | 139635 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 630 | 10 | 2 | 7 | 6.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)NC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL379629 | 139635 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 630 | 10 | 2 | 7 | 6.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)NC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 10100930 | 63538 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800155 | 63538 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53388960 | 63589 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 682 | 11 | 2 | 9 | 6.0 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800663 | 63589 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 682 | 11 | 2 | 9 | 6.0 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 11692959 | 78143 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 612 | 10 | 2 | 7 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2F)c2sc(-c3ccc(NC(=O)NC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL210294 | 78143 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 612 | 10 | 2 | 7 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2F)c2sc(-c3ccc(NC(=O)NC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 10348973 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 10348973.0 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5432 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5586 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| DB11853 | 3313 | None | 51 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 53387071 | 63540 | None | 5 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800157 | 63540 | None | 5 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53388958 | 63587 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800661 | 63587 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53389117 | 63592 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 688 | 11 | 2 | 9 | 4.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN2CCCC2=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800666 | 63592 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 688 | 11 | 2 | 9 | 4.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN2CCCC2=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 10258719 | 153330 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 650 | 12 | 2 | 10 | 4.8 | CCOCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | nan | |||
| CHEMBL3977463 | 153330 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 650 | 12 | 2 | 10 | 4.8 | CCOCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | nan | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 9939837 | 77879 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 651 | 9 | 2 | 7 | 6.6 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL2092994 | 77879 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 651 | 9 | 2 | 7 | 6.6 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm701249f | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm701249f | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm701249f | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm701249f | |||
| 44395650 | 169424 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 537 | 7 | 3 | 8 | 4.9 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL441676 | 169424 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 537 | 7 | 3 | 8 | 4.9 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 53386915 | 63536 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800153 | 63536 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53389115 | 63590 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 698 | 11 | 3 | 10 | 5.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccc(CO)n2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800664 | 63590 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 698 | 11 | 3 | 10 | 5.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccc(CO)n2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 18324807 | 63594 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800668 | 63594 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 11700433 | 77639 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 675 | 11 | 1 | 6 | 8.5 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)c2ccccc2)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL208812 | 77639 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 675 | 11 | 1 | 6 | 8.5 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)c2ccccc2)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 11707186 | 78301 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 629 | 11 | 1 | 7 | 7.2 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL210709 | 78301 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 629 | 11 | 1 | 7 | 7.2 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 20691661 | 79644 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL211485 | 79644 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 11512905 | 138505 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL377396 | 138505 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 155524081 | 170984 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 1542 | 39 | 20 | 23 | -4.2 | CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(=O)O[C@@H]1[C@@H](CO)O[C@@H](n2ccc(N)nc2=O)C1(F)F)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.ejmech.2019.01.041 | |||
| CHEMBL4454362 | 170984 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 1542 | 39 | 20 | 23 | -4.2 | CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(=O)O[C@@H]1[C@@H](CO)O[C@@H](n2ccc(N)nc2=O)C1(F)F)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.ejmech.2019.01.041 | |||
| 10371708 | 63541 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800158 | 63541 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 67143119 | 175958 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 742 | 14 | 2 | 11 | 4.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2OCCCC(=O)O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4585638 | 175958 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 742 | 14 | 2 | 11 | 4.7 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2OCCCC(=O)O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143780 | 172355 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 637 | 9 | 1 | 8 | 4.7 | CC(=O)c1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4474379 | 172355 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 637 | 9 | 1 | 8 | 4.7 | CC(=O)c1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| 67143102 | 173035 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 610 | 8 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C#N)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4516712 | 173035 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 610 | 8 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C#N)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143023 | 175101 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 656 | 9 | 2 | 10 | 4.2 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4566719 | 175101 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 656 | 9 | 2 | 10 | 4.2 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 9895596 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | nan | |||
| CHEMBL1800152 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | nan | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(02)00370-0 | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(02)00370-0 | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(02)00370-0 | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm020180i | |||
| 9875078 | 75956 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 680 | 11 | 1 | 8 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2cccc(OC)c2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL20511 | 75956 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 680 | 11 | 1 | 8 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2cccc(OC)c2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 9853275 | 79872 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 681 | 11 | 2 | 8 | 6.9 | CCONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL21217 | 79872 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 681 | 11 | 2 | 8 | 6.9 | CCONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 9831689 | 99071 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 679 | 10 | 2 | 7 | 7.4 | CC(C)NC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL280126 | 99071 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 679 | 10 | 2 | 7 | 7.4 | CC(C)NC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm701249f | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm701249f | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm701249f | |||
| 44321964 | 96472 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL261979 | 96472 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 592 | 9 | 2 | 4 | 6.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 9895596 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800152 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386916 | 63537 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 654 | 11 | 2 | 10 | 4.5 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(F)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800154 | 63537 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 654 | 11 | 2 | 10 | 4.5 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(F)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386917 | 63539 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800156 | 63539 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53388959 | 63588 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccnc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800662 | 63588 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 668 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2cccnc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53389118 | 63593 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 712 | 12 | 2 | 10 | 4.2 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN(C)S(C)(=O)=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800667 | 63593 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 712 | 12 | 2 | 10 | 4.2 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCN(C)S(C)(=O)=O)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 53386756 | 63595 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 617 | 13 | 2 | 10 | 3.6 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCOC)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800669 | 63595 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 617 | 13 | 2 | 10 | 3.6 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCOC)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386757 | 63596 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 631 | 14 | 2 | 10 | 4.0 | CCOCCn1c(=O)c2c(CN(C)CCOC)c(-c3ccc(NC(=O)NOC)cc3)sc2n(Cc2c(F)cccc2F)c1=O | 10.1021/jm200216q | |||
| CHEMBL1800670 | 63596 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 631 | 14 | 2 | 10 | 4.0 | CCOCCn1c(=O)c2c(CN(C)CCOC)c(-c3ccc(NC(=O)NOC)cc3)sc2n(Cc2c(F)cccc2F)c1=O | 10.1021/jm200216q | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm0512894 | |||
| 10794239 | 13069 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 643 | 11 | 1 | 7 | 7.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL1190107 | 13069 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 643 | 11 | 1 | 7 | 7.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL540109 | 13069 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 643 | 11 | 1 | 7 | 7.5 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 9809590 | 79668 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 641 | 11 | 1 | 6 | 8.1 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL211503 | 79668 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 641 | 11 | 1 | 6 | 8.1 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 11643195 | 79860 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 657 | 11 | 2 | 7 | 7.2 | CC(C)C(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)(C)O)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL212121 | 79860 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 657 | 11 | 2 | 7 | 7.2 | CC(C)C(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)(C)O)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 11628915 | 138312 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 629 | 11 | 2 | 7 | 6.5 | CC(C)C(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)CO)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL377015 | 138312 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 629 | 11 | 2 | 7 | 6.5 | CC(C)C(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)CO)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 11512905 | 138505 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL377396 | 138505 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 628 | 10 | 2 | 6 | 7.3 | CNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(01)00779-x | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(01)00779-x | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1016/s0960-894x(01)00779-x | |||
| 1184 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm9803673 | |||
| 9874838 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm9803673 | |||
| CHEMBL71917 | 3733 | None | 26 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 657 | 11 | 1 | 7 | 7.8 | CC(OC(=O)c1cn(Cc2c(F)cccc2F)c2c(c1=O)c(CN(Cc1ccccc1)C)c(s2)c1ccc(cc1)NC(=O)C(C)C)C | 10.1021/jm9803673 | |||
| 172460388 | 196230 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 673 | 11 | 2 | 11 | 4.4 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5419365 | 196230 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 673 | 11 | 2 | 11 | 4.4 | COc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOCC(F)F)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 172441547 | 195178 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 689 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5398152 | 195178 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 689 | 10 | 2 | 9 | 5.9 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)cc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 118074127 | 175821 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 714 | 12 | 2 | 11 | 3.9 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2OCC(=O)O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4582367 | 175821 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 714 | 12 | 2 | 11 | 3.9 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2OCC(=O)O)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 53387071 | 63540 | None | 5 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800157 | 63540 | None | 5 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 667 | 12 | 2 | 12 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10348973 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 10348973.0 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 5432 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 5586 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| DB11853 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1016/j.ejmech.2022.114679 | |||
| 162514316 | 195301 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 659 | 10 | 2 | 11 | 4.3 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5400302 | 195301 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 659 | 10 | 2 | 11 | 4.3 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 170268938 | 196894 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 675 | 10 | 2 | 9 | 5.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5434324 | 196894 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 675 | 10 | 2 | 9 | 5.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC(F)F)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 172461575 | 196835 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 621 | 9 | 2 | 10 | 4.3 | CCc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5433025 | 196835 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 621 | 9 | 2 | 10 | 4.3 | CCc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 1175 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| 1559 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| 657181 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| 657181.0 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| CHEMBL1201199 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| DB00007 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1039/C5MD00259A | |||||
| 145958346 | 162075 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 543 | 8 | 1 | 7 | 4.3 | COc1ccc(F)cc1C(N)Cn1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4159155 | 162075 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 543 | 8 | 1 | 7 | 4.3 | COc1ccc(F)cc1C(N)Cn1c(=O)c(-c2cccc(OC)c2F)c(C)n(Cc2c(F)cccc2F)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 10100930 | 63538 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800155 | 63538 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 665 | 12 | 2 | 10 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)cc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10985312 | 78777 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL21126 | 78777 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 650 | 10 | 1 | 7 | 7.2 | CCC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 9896373 | 99103 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 694 | 11 | 1 | 8 | 7.4 | COc1cccc(-n2c(=O)c3c(CN(C)Cc4ccccc4)c(-c4ccc(NC(=O)C(C)C)cc4)sc3n(Cc3c(F)cccc3F)c2=O)c1 | 10.1021/jm020180i | |||
| CHEMBL280365 | 99103 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 694 | 11 | 1 | 8 | 7.4 | COc1cccc(-n2c(=O)c3c(CN(C)Cc4ccccc4)c(-c4ccc(NC(=O)C(C)C)cc4)sc3n(Cc3c(F)cccc3F)c2=O)c1 | 10.1021/jm020180i | |||
| 44395623 | 124724 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 551 | 7 | 3 | 8 | 5.3 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL364167 | 124724 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 551 | 7 | 3 | 8 | 5.3 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 10053165 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL48192 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44321052 | 208729 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 9 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(O)nc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86912 | 208729 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 9 | 3 | 4 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc(O)nc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44340906 | 9573 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 9 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL112400 | 9573 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 578 | 9 | 2 | 3 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 9985901 | 110516 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL324654 | 110516 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 53386758 | 63533 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 603 | 12 | 3 | 10 | 3.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCO)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800150 | 63533 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 603 | 12 | 3 | 10 | 3.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCO)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386914 | 63534 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 631 | 12 | 3 | 10 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CC(C)(C)O)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800151 | 63534 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 631 | 12 | 3 | 10 | 3.8 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CC(C)(C)O)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53389116 | 63591 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 672 | 11 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCn2ccnn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800665 | 63591 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 672 | 11 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCn2ccnn2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 9895596 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800152 | 63535 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 636 | 11 | 2 | 10 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 53386915 | 63536 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800153 | 63536 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 650 | 11 | 2 | 10 | 4.7 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(C)cn1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 10009345 | 100973 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 642 | 11 | 2 | 8 | 5.8 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OC(C)C)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| CHEMBL293921 | 100973 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 642 | 11 | 2 | 8 | 5.8 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OC(C)C)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| 44380643 | 58735 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 659 | 10 | 3 | 5 | 7.7 | COC(=O)c1nc2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4ccc(C(C)(C)C(=O)N5CC6CCC5CC6)cc34)ccc2[nH]1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168498 | 58735 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 659 | 10 | 3 | 5 | 7.7 | COC(=O)c1nc2cc(CCNC[C@@H](C)c3c(-c4cc(C)cc(C)c4)[nH]c4ccc(C(C)(C)C(=O)N5CC6CCC5CC6)cc34)ccc2[nH]1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380625 | 58743 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168538 | 58743 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 10008768 | 58751 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168563 | 58751 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380488 | 59033 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ocnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169238 | 59033 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ocnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9894997 | 120378 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352806 | 120378 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 9 | 3 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 1175 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 1559 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 657181 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 657181.0 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| CHEMBL1201199 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| DB00007 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 10053165 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL48192 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/s0960-894x(00)00318-8 | |||
| 10053165 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL48192 | 184105 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2003.12.101 | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 1175 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| 1559 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| 657181 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| 657181.0 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| CHEMBL1201199 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| DB00007 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm9803673 | |||||
| 67144164 | 173990 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 643 | 9 | 1 | 10 | 3.9 | COC(=O)c1ccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)o1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4539811 | 173990 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 643 | 9 | 1 | 10 | 3.9 | COC(=O)c1ccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)o1 | 10.1021/acs.jmedchem.6b01071 | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| 44395435 | 123879 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 523 | 7 | 3 | 8 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL362371 | 123879 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 523 | 7 | 3 | 8 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 172458448 | 196240 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 639 | 9 | 2 | 9 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5419489 | 196240 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 639 | 9 | 2 | 9 | 5.1 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2cccc(OC)c2F)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 67143710 | 170439 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3ccccc3C#N)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4447139 | 170439 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3ccccc3C#N)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 87285473 | 174194 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 663 | 8 | 1 | 7 | 5.6 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4544693 | 174194 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 663 | 8 | 1 | 7 | 5.6 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 145955571 | 162754 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 721 | 13 | 2 | 9 | 5.2 | Cc1cc(F)cc([C@H](Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)NCCCC(=O)O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4169891 | 162754 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 721 | 13 | 2 | 9 | 5.2 | Cc1cc(F)cc([C@H](Cn2c(=O)c(N3CCN(Cc4ccc(C(F)(F)F)o4)CC3)c(C)n(Cc3c(F)cccc3F)c2=O)NCCCC(=O)O)c1 | 10.1016/j.ejmech.2017.12.095 | |||
| 10348973 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 10348973.0 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5432 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 5586 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| CHEMBL1800159 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| DB11853 | 3313 | None | 51 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 623 | 9 | 2 | 11 | 3.8 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(C)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccc(nn1)OC | 10.1021/jm200216q | |||
| 162514345 | 196508 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5425604 | 196508 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 691 | 10 | 2 | 11 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OCC(F)(F)F)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 172467595 | 196584 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 673 | 9 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5427278 | 196584 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 673 | 9 | 2 | 11 | 4.6 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2C(F)(F)F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 67144353 | 172326 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 673 | 9 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3cccc(S(C)(=O)=O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4474058 | 172326 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 673 | 9 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3cccc(S(C)(=O)=O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 145954246 | 162503 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 529 | 7 | 1 | 6 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3ccccc3Cl)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4165983 | 162503 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 529 | 7 | 1 | 6 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3ccccc3Cl)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 67143773 | 170608 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 619 | 8 | 1 | 8 | 4.8 | Cc1c(N2CCN(Cc3ccc(Cl)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4449450 | 170608 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 619 | 8 | 1 | 8 | 4.8 | Cc1c(N2CCN(Cc3ccc(Cl)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143621 | 171406 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 653 | 9 | 1 | 9 | 4.3 | COC(=O)c1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4460880 | 171406 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 653 | 9 | 1 | 9 | 4.3 | COC(=O)c1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| 87285554 | 173434 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 631 | 8 | 1 | 7 | 4.8 | Cc1c(N2CCN(Cc3cccc(F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4526641 | 173434 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 631 | 8 | 1 | 7 | 4.8 | Cc1c(N2CCN(Cc3cccc(F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 9917618 | 98695 | None | 1 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 653 | 9 | 3 | 8 | 6.4 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NO)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm020180i | |||
| CHEMBL277214 | 98695 | None | 1 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 653 | 9 | 3 | 8 | 6.4 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NO)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm020180i | |||
| 10919567 | 99084 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 664 | 10 | 1 | 7 | 7.4 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL280213 | 99084 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 664 | 10 | 1 | 7 | 7.4 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 44321963 | 105997 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 622 | 11 | 2 | 5 | 6.8 | COCn1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccc1=O | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL312864 | 105997 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 622 | 11 | 2 | 5 | 6.8 | COCn1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccc1=O | 10.1016/s0960-894x(01)00512-1 | |||
| 44321411 | 107065 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@@H]5CC[C@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL315326 | 107065 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@@H]5CC[C@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321345 | 208700 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 596 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCC2CCC(=O)N(C)C2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86758 | 208700 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 596 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCC2CCC(=O)N(C)C2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44341082 | 9779 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 590 | 9 | 2 | 3 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)nc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL113574 | 9779 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 590 | 9 | 2 | 3 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)nc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44341046 | 10078 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 634 | 11 | 2 | 5 | 7.5 | CC(=O)OCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL115365 | 10078 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 634 | 11 | 2 | 5 | 7.5 | CC(=O)OCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44340888 | 110588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 592 | 10 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(CO)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL325091 | 110588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 592 | 10 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(CO)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 9895731 | 205896 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 644 | 11 | 2 | 9 | 5.4 | CONC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OC(C)C)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| CHEMBL65769 | 205896 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 644 | 11 | 2 | 9 | 5.4 | CONC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OC(C)C)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| 9873212 | 57593 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 9 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166649 | 57593 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 9 | 3 | 4 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9938925 | 57608 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 11 | 3 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166763 | 57608 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 11 | 3 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2c[nH]c3ncnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380626 | 58744 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 587 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168539 | 58744 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 587 | 9 | 3 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]cnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380537 | 96614 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL263004 | 96614 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 588 | 9 | 2 | 4 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380394 | 120012 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL349638 | 120012 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380514 | 120276 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 645 | 10 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(=O)O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352051 | 120276 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 645 | 10 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(=O)O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9809394 | 120576 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 628 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL354524 | 120576 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 628 | 11 | 2 | 5 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 11614283 | 78154 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 627 | 11 | 1 | 6 | 7.9 | CCC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL210321 | 78154 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 627 | 11 | 1 | 6 | 7.9 | CCC(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 11592777 | 139340 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 643 | 11 | 2 | 6 | 8.0 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL378979 | 139340 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 643 | 11 | 2 | 6 | 8.0 | CC(C)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 44413067 | 139387 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 593 | 11 | 1 | 7 | 6.9 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL379198 | 139387 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 593 | 11 | 1 | 7 | 6.9 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 44352512 | 117363 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 7 | 3 | 7 | 4.7 | Cc1cc(-c2c(O)nc3ccc(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/s0960-894x(01)00779-x | |||
| CHEMBL339636 | 117363 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 7 | 3 | 7 | 4.7 | Cc1cc(-c2c(O)nc3ccc(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/s0960-894x(01)00779-x | |||
| 67143509 | 170168 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3cccc(C#N)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4443108 | 170168 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3cccc(C#N)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44309572 | 206797 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 517 | 7 | 3 | 7 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ncccn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/s0960-894x(02)00370-0 | |||
| CHEMBL71561 | 206797 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 517 | 7 | 3 | 7 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ncccn4)cc3c2OCC[C@@H]2CCN2)cc(C)c1C | 10.1016/s0960-894x(02)00370-0 | |||
| 10649568 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 87285768 | 170598 | None | 4 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4449332 | 170598 | None | 4 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 10649568 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| 10649568 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm049218c | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm049218c | |||
| 67142732 | 169726 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 640 | 9 | 1 | 9 | 4.5 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4436854 | 169726 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 640 | 9 | 1 | 9 | 4.5 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 145949496 | 162953 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 4.9 | Cc1cccc(F)c1Cn1c(C)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4173065 | 162953 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 4.9 | Cc1cccc(F)c1Cn1c(C)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c1=O | 10.1016/j.ejmech.2017.12.095 | |||
| 44460342 | 168025 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 606 | 9 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL431402 | 168025 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 606 | 9 | 2 | 3 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)[n+]([O-])c(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 18324807 | 63594 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800668 | 63594 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 635 | 11 | 2 | 9 | 5.0 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 10649568 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| CHEMBL120432 | 14572 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 517 | 7 | 3 | 6 | 4.9 | Cc1cc(-c2c(OCC[C@@H]3CCN3)c3cc(C(=O)Nc4ccncn4)c(Cl)cc3[nH]c2=O)cc(C)c1C | 10.1021/jm000275p | |||
| 9809382 | 100729 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 628 | 11 | 2 | 8 | 5.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| CHEMBL292291 | 100729 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 628 | 11 | 2 | 8 | 5.4 | CCNC(=O)Nc1ccc(-c2nc3n(Cc4c(F)cccc4F)cc(C(=O)OCC)c(=O)n3c2CN(C)Cc2ccccc2)cc1 | 10.1016/s0960-894x(02)00372-4 | |||
| 44380538 | 59102 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 619 | 9 | 2 | 5 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169620 | 59102 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 619 | 9 | 2 | 5 | 8.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3nsnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44293205 | 184067 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 643 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)ccc1I | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL48165 | 184067 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 643 | 7 | 3 | 7 | 6.1 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)ccc1I | 10.1016/s0960-894x(00)00318-8 | |||
| 44295699 | 101275 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C)N2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL295948 | 101275 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C)N2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| 9828888 | 101880 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@@H](C)N2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL300295 | 101880 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@@H](C)N2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| 44395462 | 168326 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 551 | 7 | 3 | 8 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL433594 | 168326 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 551 | 7 | 3 | 8 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 170269052 | 195907 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 622 | 9 | 3 | 11 | 3.8 | CNc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5413078 | 195907 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 622 | 9 | 3 | 11 | 3.8 | CNc1ccc(-n2c(=O)c3c(CN(C)C)c(-c4ccc(NC(=O)NOC)cc4)sc3n(Cc3c(F)cccc3F)c2=O)nn1 | 10.1016/j.ejmech.2022.114679 | |||
| 10371708 | 63541 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| CHEMBL1800158 | 63541 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 622 | 9 | 2 | 10 | 4.4 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm200216q | |||
| 165412728 | 196267 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 721 | 12 | 2 | 12 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| CHEMBL5420128 | 196267 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 721 | 12 | 2 | 12 | 4.7 | CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)CCOC(F)(F)F)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1016/j.ejmech.2022.114679 | |||
| 155531714 | 176295 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4593521 | 176295 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| 58239302 | 162084 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 577 | 12 | 2 | 7 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(C)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4159247 | 162084 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 577 | 12 | 2 | 7 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(C)cccc3F)c(=O)n(C[C@H](NCCCC(=O)O)c3ccccc3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1016/j.ejmech.2017.12.095 | |||
| 9896737 | 83399 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 695 | 11 | 2 | 8 | 7.3 | CC(C)ONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| CHEMBL21936 | 83399 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 695 | 11 | 2 | 8 | 7.3 | CC(C)ONC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm020180i | |||
| 9893269 | 66317 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 532 | 7 | 2 | 7 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL184819 | 66317 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 532 | 7 | 2 | 7 | 6.2 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCCC2CCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 10187208 | 66769 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 7 | 2 | 9 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2OCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185785 | 66769 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 7 | 2 | 9 | 5.4 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2OCCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44395533 | 66819 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 577 | 7 | 2 | 8 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CC3CCN2CC3)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185986 | 66819 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 577 | 7 | 2 | 8 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2CC3CCN2CC3)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 10231401 | 2020 | None | 1 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| 5584 | 2020 | None | 1 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL314260 | 2020 | None | 1 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(c1)c1[nH]c2c(c1[C@@H](CNCCc1ccncc1)C)cc(cc2)C(C(=O)N1CC2CCC1CC2)(C)C | 10.1016/s0960-894x(01)00512-1 | |||
| 44321148 | 96861 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 11 | 2 | 5 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CC4)OCCO5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL265042 | 96861 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 11 | 2 | 5 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC5(CC4)OCCO5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44320895 | 164357 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL421160 | 164357 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 9 | 2 | 3 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cccnc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321393 | 208728 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 9 | 2 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)c(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86911 | 208728 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 9 | 2 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc(C)c(=O)n(C)c2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44340928 | 9746 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 10 | 3 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL113432 | 9746 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 10 | 3 | 4 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44340929 | 113566 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 10 | 2 | 4 | 7.7 | CC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL332049 | 113566 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 10 | 2 | 4 | 7.7 | CC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 67143618 | 170398 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 8 | 1 | 10 | 4.1 | Cc1c(N2CCN(Cc3cccc4nonc34)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4446435 | 170398 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 8 | 1 | 10 | 4.1 | Cc1c(N2CCN(Cc3cccc4nonc34)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 9960399 | 50557 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 603 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3nnnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL157412 | 50557 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 603 | 9 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2c[nH]c3nnnc-3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380512 | 57450 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 9 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL165456 | 57450 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 9 | 4 | 4 | 7.6 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380236 | 58738 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 641 | 11 | 2 | 4 | 8.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168506 | 58738 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 641 | 11 | 2 | 4 | 8.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380796 | 59221 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 598 | 9 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170159 | 59221 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 598 | 9 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380798 | 59344 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 588 | 9 | 3 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170606 | 59344 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 588 | 9 | 3 | 4 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]nnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380536 | 120455 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 9 | 2 | 4 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL353395 | 120455 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 9 | 2 | 4 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3ncoc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44412890 | 78341 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 607 | 11 | 1 | 7 | 7.2 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL210888 | 78341 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 607 | 11 | 1 | 7 | 7.2 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)C(C)C)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 44295753 | 186852 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 7 | 3 | 7 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C)N2)cc(C)c1C | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL48879 | 186852 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 7 | 3 | 7 | 6.5 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCC[C@H](C)N2)cc(C)c1C | 10.1016/j.bmcl.2003.12.101 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm020180i | |||
| 87285708 | 174009 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 749 | 13 | 2 | 8 | 6.1 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4540232 | 174009 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 749 | 13 | 2 | 8 | 6.1 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 155517188 | 170266 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1542 | 39 | 20 | 23 | -4.2 | CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.ejmech.2019.01.041 | |||
| CHEMBL4444427 | 170266 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1542 | 39 | 20 | 23 | -4.2 | CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.ejmech.2019.01.041 | |||
| 44395502 | 165993 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 553 | 7 | 3 | 9 | 5.0 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2COCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL424991 | 165993 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 553 | 7 | 3 | 9 | 5.0 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCCC2COCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 9808288 | 111544 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL327704 | 111544 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321498 | 208763 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL87099 | 208763 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 564 | 11 | 2 | 3 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC(C)(C)C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44341197 | 109091 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 587 | 9 | 2 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C#N)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL321258 | 109091 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 587 | 9 | 2 | 4 | 7.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C#N)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44341198 | 113121 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 620 | 10 | 3 | 4 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL331144 | 113121 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 620 | 10 | 3 | 4 | 7.7 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C(C)(C)O)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44460343 | 207803 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 11 | 2 | 4 | 7.6 | COCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL79639 | 207803 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 606 | 11 | 2 | 4 | 7.6 | COCc1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 44305285 | 100672 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 630 | 11 | 2 | 9 | 5.0 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NOC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/s0960-894x(02)00372-4 | |||
| CHEMBL291896 | 100672 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 630 | 11 | 2 | 9 | 5.0 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)NOC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/s0960-894x(02)00372-4 | |||
| 44380478 | 58772 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168637 | 58772 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccc3cnccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380483 | 59092 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 9 | 4 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2F)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL169569 | 59092 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 9 | 4 | 4 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(O)nc3c2F)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 9808288 | 111544 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL327704 | 111544 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 8.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380513 | 120255 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 631 | 10 | 4 | 4 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(CO)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL351836 | 120255 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 631 | 10 | 4 | 4 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(CO)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44293045 | 185930 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 543 | 7 | 3 | 7 | 5.7 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3ccc4c(c3)CCC4)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL48674 | 185930 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 543 | 7 | 3 | 7 | 5.7 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3ccc4c(c3)CCC4)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| 44293206 | 187295 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1ccc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc1C | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL49230 | 187295 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1ccc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)cc1C | 10.1016/s0960-894x(00)00318-8 | |||
| 145955844 | 162787 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 527 | 7 | 1 | 6 | 4.6 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3cc(C)cc(F)c3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4170478 | 162787 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 527 | 7 | 1 | 6 | 4.6 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3cc(C)cc(F)c3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 44395491 | 123917 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL362544 | 123917 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCN2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44321412 | 208710 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 590 | 11 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86805 | 208710 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 590 | 11 | 2 | 3 | 8.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321290 | 208864 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 548 | 9 | 2 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL87785 | 208864 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 548 | 9 | 2 | 3 | 7.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44341164 | 9566 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL112378 | 9566 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 592 | 9 | 2 | 3 | 7.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2cc[n+]([O-])cc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44341056 | 114598 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL333614 | 114598 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccncc2C)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 53386917 | 63539 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| CHEMBL1800156 | 63539 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 666 | 12 | 2 | 11 | 4.4 | COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(-c1ccc(OC)nc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm200216q | |||
| 71449058 | 84440 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2111955 | 84440 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2219718 | 84440 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 537 | 7 | 3 | 8 | 5.9 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44380222 | 57612 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 614 | 10 | 2 | 5 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL166778 | 57612 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 614 | 10 | 2 | 5 | 7.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cnc3nccnc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 1175 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 1559 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 657181 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 657181.0 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| CHEMBL1201199 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| DB00007 | 2298 | None | 30 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0512894 | |||||
| 44395583 | 124413 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 7 | 2 | 8 | 5.8 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL363663 | 124413 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 7 | 2 | 8 | 5.8 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCO2)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44341113 | 9923 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL114438 | 9923 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 576 | 9 | 2 | 3 | 7.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccnc(C)c2)c1 | 10.1016/s0960-894x(02)00751-5 | |||
| 44341199 | 113122 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 10 | 2 | 5 | 7.2 | COC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| CHEMBL331145 | 113122 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 10 | 2 | 5 | 7.2 | COC(=O)c1cc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)ccn1 | 10.1016/s0960-894x(02)00751-5 | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 44295755 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL2111956 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL52278 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44380681 | 58791 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 669 | 9 | 3 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(F)(F)F)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168726 | 58791 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 669 | 9 | 3 | 3 | 9.0 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]c(C(F)(F)F)nc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380147 | 120342 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352566 | 120342 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 612 | 10 | 2 | 3 | 8.8 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 20691661 | 79644 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| CHEMBL211485 | 79644 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 657 | 12 | 2 | 7 | 7.2 | CCC(O)C(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)c(C(=O)C(C)C)cn3Cc2c(F)cccc2F)cc1 | 10.1021/jm0512894 | |||
| 44293222 | 176064 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL138464 | 176064 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL45883 | 176064 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| 44295755 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL2111956 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| CHEMBL52278 | 193230 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/j.bmcl.2003.12.101 | |||
| 67143518 | 174978 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4563562 | 174978 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 87285476 | 171570 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 653 | 8 | 1 | 8 | 5.2 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4463476 | 171570 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 653 | 8 | 1 | 8 | 5.2 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 11017929 | 99075 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 624 | 9 | 1 | 8 | 6.4 | COc1cccc(-n2c(=O)c3c(CN(C)Cc4ccccc4)c(-c4ccc(N)cc4)sc3n(Cc3c(F)cccc3F)c2=O)c1 | 10.1021/jm020180i | |||
| CHEMBL280170 | 99075 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 624 | 9 | 1 | 8 | 6.4 | COc1cccc(-n2c(=O)c3c(CN(C)Cc4ccccc4)c(-c4ccc(N)cc4)sc3n(Cc3c(F)cccc3F)c2=O)c1 | 10.1021/jm020180i | |||
| 10930638 | 99083 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm020180i | |||
| CHEMBL280212 | 99083 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm020180i | |||
| 44321101 | 96901 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL265288 | 96901 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 590 | 11 | 2 | 3 | 8.2 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321394 | 106995 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 592 | 10 | 2 | 4 | 7.5 | COc1ccc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)cn1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL314860 | 106995 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 592 | 10 | 2 | 4 | 7.5 | COc1ccc(CCNC[C@@H](C)c2c(-c3cc(C)cc(C)c3)[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc23)cn1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321410 | 107064 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL315325 | 107064 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 576 | 11 | 2 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 87285565 | 170372 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 679 | 9 | 1 | 8 | 5.4 | Cc1c(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4446131 | 170372 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 679 | 9 | 1 | 8 | 5.4 | Cc1c(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143755 | 175530 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3ccccc3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4576169 | 175530 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3ccccc3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| 44412945 | 96759 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 641 | 11 | 1 | 7 | 7.8 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)c4ccccc4)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL264121 | 96759 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 641 | 11 | 1 | 7 | 7.8 | CCOC(=O)c1cn(Cc2ccccc2)c2sc(-c3ccc(NC(=O)c4ccccc4)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 44293386 | 175636 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 7 | 6.5 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3ccc(Cl)c(Cl)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL45784 | 175636 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 7 | 6.5 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3ccc(Cl)c(Cl)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| 67143613 | 171129 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 614 | 8 | 1 | 8 | 4.1 | Cc1c(N2CCN(Cc3cccnc3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4456703 | 171129 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 614 | 8 | 1 | 8 | 4.1 | Cc1c(N2CCN(Cc3cccnc3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 87285570 | 170845 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 631 | 8 | 1 | 7 | 4.8 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4452347 | 170845 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 631 | 8 | 1 | 7 | 4.8 | Cc1c(N2CCN(Cc3cccc(C(F)(F)F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143804 | 173299 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 724 | 13 | 3 | 9 | 4.1 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4522657 | 173299 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 724 | 13 | 3 | 9 | 4.1 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 87285767 | 174981 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 775 | 13 | 2 | 10 | 5.1 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCS(=O)(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4563686 | 174981 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 775 | 13 | 2 | 10 | 5.1 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCS(=O)(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 9961721 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| CHEMBL435167 | 168582 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 665 | 10 | 2 | 7 | 7.0 | CCNC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| 44380146 | 120341 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 627 | 10 | 2 | 4 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL352565 | 120341 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 627 | 10 | 2 | 4 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCc2ccnc3nc(C)ccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380318 | 120443 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL353308 | 120443 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2ccc3ncccc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44380487 | 167678 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]ncc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL430069 | 167678 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 601 | 9 | 3 | 3 | 7.9 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CC5CCC4CC5)cc3c2[C@H](C)CNCCc2ccc3[nH]ncc3c2)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44292950 | 162540 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 546 | 7 | 4 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)Nc4cnccn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL416651 | 162540 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 546 | 7 | 4 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)Nc4cnccn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| 44292868 | 177012 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 7 | 6.5 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3cc(Cl)cc(Cl)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL46177 | 177012 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 7 | 6.5 | O=C(Nc1ccncn1)c1cc2c(OCC[C@@H]3CCCCN3)c(-c3cc(Cl)cc(Cl)c3)c(O)nc2cc1Cl | 10.1016/s0960-894x(00)00318-8 | |||
| 67143547 | 171619 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3ccc(C#N)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4464132 | 171619 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 620 | 8 | 1 | 8 | 4.4 | Cc1c(N2CCN(Cc3ccc(C#N)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44320921 | 107225 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 548 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL316362 | 107225 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 548 | 9 | 2 | 3 | 7.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CC[C@@H]4C5)cc3c2[C@H](C)CNCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 67143761 | 171464 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 710 | 12 | 3 | 9 | 3.8 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4461692 | 171464 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 710 | 12 | 3 | 9 | 3.8 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 87285550 | 174432 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 775 | 13 | 3 | 9 | 5.4 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCP(=O)(O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4550720 | 174432 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 775 | 13 | 3 | 9 | 5.4 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCP(=O)(O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 145953172 | 162567 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 563 | 7 | 1 | 6 | 5.5 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3cc(Cl)cc(Cl)c3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4167067 | 162567 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 563 | 7 | 1 | 6 | 5.5 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)c3cc(Cl)cc(Cl)c3)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL415547 | 215649 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||||
| 67143505 | 172333 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 601 | 8 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccs3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4474116 | 172333 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 601 | 8 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccs3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44321146 | 106461 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 592 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC(C)(C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL313946 | 106461 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 592 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCC(C)(C)CC4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL415547 | 215649 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | None | None | None | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@H](Cc1ccc(Nc2n[nH]c(N)n2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||||
| 44395677 | 66759 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 565 | 7 | 2 | 8 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| CHEMBL185738 | 66759 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 565 | 7 | 2 | 8 | 5.7 | Cc1cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cnsn4)cc3c2OCC[C@H]2CCC(=O)N2C)cc(C)c1C | 10.1016/j.bmcl.2004.08.056 | |||
| 44293249 | 185549 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL48616 | 185549 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 562 | 11 | 2 | 3 | 7.4 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 44321509 | 208647 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CCCC[C@H]5C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| CHEMBL86431 | 208647 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 604 | 11 | 2 | 3 | 8.5 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C[C@H]5CCCC[C@H]5C4)cc3c2[C@H](C)CNCCCCc2ccncc2)c1 | 10.1016/s0960-894x(01)00512-1 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 44359285 | 11631 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180695 | 11631 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138747 | 11631 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 565 | 7 | 3 | 7 | 6.5 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4cc(Cl)ncn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 67143570 | 171860 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 726 | 14 | 2 | 10 | 5.0 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4467407 | 171860 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 726 | 14 | 2 | 10 | 5.0 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 23656390 | 161777 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 659 | 10 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1021/jm701249f | |||
| CHEMBL413245 | 161777 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 659 | 10 | 3 | 5 | 6.7 | Cc1cc(C)cc(-c2[nH]c3c(c2[C@H](C)CNCCc2ccc(-c4nnn[nH]4)cc2)CN(C(=O)Cc2c(F)cccc2C(F)(F)F)CC3)c1 | 10.1021/jm701249f | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 67142962 | 174680 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 629 | 9 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4556717 | 174680 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 629 | 9 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 44380797 | 59310 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL170499 | 59310 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3cnccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44593425 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1021/jm701249f | |||
| CHEMBL460480 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1021/jm701249f | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm200216q | |||
| 70689073 | 77655 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1835 | 43 | 23 | 28 | -2.7 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(/C(C)=N/OCC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1016/j.ejmech.2012.08.014 | |||
| 91900370 | 77655 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1835 | 43 | 23 | 28 | -2.7 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(/C(C)=N/OCC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1016/j.ejmech.2012.08.014 | |||
| CHEMBL2088253 | 77655 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1835 | 43 | 23 | 28 | -2.7 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(/C(C)=N/OCC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1016/j.ejmech.2012.08.014 | |||
| 155531714 | 176295 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4593521 | 176295 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 715 | 13 | 2 | 9 | 5.2 | COc1cccc(N2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](NCCCC(=O)O)c4ccccc4)c3=O)CC2)c1F | 10.1021/acs.jmedchem.6b01071 | |||
| 44593425 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL460480 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmcl.2009.02.043 | |||
| 44593425 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL460480 | 176870 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 486 | 5 | 2 | 6 | 3.7 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.024 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 67144370 | 174719 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3cccc(F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4557575 | 174719 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 613 | 8 | 1 | 7 | 4.7 | Cc1c(N2CCN(Cc3cccc(F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44402640 | 161924 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1617 | 41 | 17 | 17 | 2.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)C2CCNC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1016/j.bmcl.2005.03.085 | |||
| CHEMBL414514 | 161924 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1617 | 41 | 17 | 17 | 2.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)C2CCNC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1016/j.bmcl.2005.03.085 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 87285770 | 176148 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 803 | 15 | 2 | 10 | 6.4 | CCOP(=O)(O)CCCN[C@@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4590493 | 176148 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 803 | 15 | 2 | 10 | 6.4 | CCOP(=O)(O)CCCN[C@@H](Cn1c(=O)c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)c1ccccc1 | 10.1021/acs.jmedchem.6b01071 | |||
| 11620431 | 179475 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 509 | 4 | 3 | 6 | 3.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cnc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL473807 | 179475 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 509 | 4 | 3 | 6 | 3.8 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5cnc6[nH]c(=O)c(=O)[nH]c6c5)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 44359264 | 11632 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180700 | 11632 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL138866 | 11632 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 545 | 7 | 3 | 7 | 6.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44293081 | 182810 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 7 | 4 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL47895 | 182810 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 7 | 4 | 7 | 6.2 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)Nc4ccncn4)cc3c2OCC[C@@H]2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| 44402639 | 155319 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1603 | 41 | 16 | 17 | 2.8 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CCC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| CHEMBL402671 | 155319 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1603 | 41 | 16 | 17 | 2.8 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CCC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| 164628446 | 186418 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1627 | 43 | 20 | 26 | -5.2 | CC(C)CC(NC(=O)C(CCCCNC(=O)/C=N/OCC(=O)OCC1OC(n2ccc(N)nc2=O)C(F)(F)C1O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1cc2ccccc2[nH]1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NCC(N)=O | 10.1016/j.ejmech.2020.113018 | |||
| CHEMBL4874610 | 186418 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1627 | 43 | 20 | 26 | -5.2 | CC(C)CC(NC(=O)C(CCCCNC(=O)/C=N/OCC(=O)OCC1OC(n2ccc(N)nc2=O)C(F)(F)C1O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1cc2ccccc2[nH]1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NCC(N)=O | 10.1016/j.ejmech.2020.113018 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 10438167 | 101236 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 578 | 12 | 2 | 3 | 8.6 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295641 | 101236 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 578 | 12 | 2 | 3 | 8.6 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1)C1CCCCCCC1 | 10.1016/s0960-894x(01)00275-x | |||
| 44380319 | 58767 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL168615 | 58767 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 626 | 11 | 2 | 3 | 9.1 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCCCCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 67143612 | 171153 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 638 | 9 | 2 | 8 | 3.6 | Cc1c(N2CCN(Cc3cccc(C(N)=O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4456937 | 171153 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 638 | 9 | 2 | 8 | 3.6 | Cc1c(N2CCN(Cc3cccc(C(N)=O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44402639 | 155319 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1603 | 41 | 16 | 17 | 2.8 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CCC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| CHEMBL402671 | 155319 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1603 | 41 | 16 | 17 | 2.8 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)[C@@H]2CCC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| 44402518 | 158618 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1649 | 43 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NC(=O)[C@H](N)CC(N)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| CHEMBL409138 | 158618 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1649 | 43 | 18 | 19 | 1.4 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)NC(=O)[C@H](N)CC(N)=O)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1016/j.bmcl.2005.03.085 | |||
| 44402640 | 161924 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1617 | 41 | 17 | 17 | 2.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)C2CCNC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1016/j.bmcl.2005.03.085 | |||
| CHEMBL414514 | 161924 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1617 | 41 | 17 | 17 | 2.0 | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(NC(=O)C2CCNC(=O)N2)cc1)C(=O)N[C@H](Cc1ccc(NC(N)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O | 10.1016/j.bmcl.2005.03.085 | |||
| 91810333 | 179684 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 595 | 7 | 1 | 4 | 5.4 | C=CCC1N(S(=O)(=O)c2ccc(F)cc2)c2ccc(C(=O)NCc3ccccc3Cl)cc2C12CCN(C(C)=O)CC2 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4741994 | 179684 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 595 | 7 | 1 | 4 | 5.4 | C=CCC1N(S(=O)(=O)c2ccc(F)cc2)c2ccc(C(=O)NCc3ccccc3Cl)cc2C12CCN(C(C)=O)CC2 | 10.1021/acs.jmedchem.0c01076 | |||
| 118179218 | 180121 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 565 | 5 | 1 | 4 | 5.1 | CC(=O)N1CCC2(CC1)c1cc(NC(=O)c3cccc(F)c3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4747248 | 180121 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 565 | 5 | 1 | 4 | 5.1 | CC(=O)N1CCC2(CC1)c1cc(NC(=O)c3cccc(F)c3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| 44573110 | 187300 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 442 | 4 | 1 | 5 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL492327 | 187300 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 442 | 4 | 1 | 5 | 4.9 | Cc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1C | 10.1016/j.bmcl.2009.02.043 | |||
| 44573113 | 193347 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nc1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL523711 | 193347 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 456 | 5 | 1 | 5 | 5.4 | CCn1cc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)nc1C | 10.1016/j.bmcl.2009.02.043 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44577104 | 178851 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 456 | 5 | 2 | 4 | 5.4 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL468565 | 178851 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 456 | 5 | 2 | 4 | 5.4 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c(C)[nH]1 | 10.1016/j.bmcl.2010.02.099 | |||
| 67143054 | 170392 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 581 | 8 | 1 | 7 | 3.9 | Cc1c(N2CCN(Cc3cccc(F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4446360 | 170392 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 581 | 8 | 1 | 7 | 3.9 | Cc1c(N2CCN(Cc3cccc(F)c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 53239181 | 172607 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 570 | 8 | 1 | 8 | 3.5 | Cc1c(N2CCN(Cc3ccc(C#N)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4483419 | 172607 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 570 | 8 | 1 | 8 | 3.5 | Cc1c(N2CCN(Cc3ccc(C#N)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 44305605 | 205789 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 613 | 11 | 1 | 8 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/s0960-894x(02)00372-4 | |||
| CHEMBL64920 | 205789 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 613 | 11 | 1 | 8 | 5.6 | CCOC(=O)c1cn(Cc2c(F)cccc2F)c2nc(-c3ccc(NC(=O)CC)cc3)c(CN(C)Cc3ccccc3)n2c1=O | 10.1016/s0960-894x(02)00372-4 | |||
| 11214294 | 122261 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 505 | 6 | 1 | 7 | 3.8 | Cc1c(-c2ccc3c(c2)OCCO3)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/jm049218c | |||
| CHEMBL359754 | 122261 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 505 | 6 | 1 | 7 | 3.8 | Cc1c(-c2ccc3c(c2)OCCO3)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/jm049218c | |||
| CHEMBL438652 | 216246 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(N)=O | 10.1021/jm0512894 | |||||
| 44293111 | 101272 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)c4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| CHEMBL295917 | 101272 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 531 | 7 | 3 | 7 | 5.8 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(NC(=O)c4cnccn4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00318-8 | |||
| 11980076 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| 36523 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| 36523.0 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| 638793 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| 638793.0 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| CHEMBL1007 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| CHEMBL1981292 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| DB00644 | 210912 | None | 21 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1021/jm9803673 | |||||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| CHEMBL448249 | 216417 | None | 13 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.ejmech.2019.01.041 | |||||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44359456 | 12208 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1184286 | 12208 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL342908 | 12208 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 572 | 8 | 3 | 6 | 7.1 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccc(N(C)C)cc4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 10930638 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL280212 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 11599857 | 76906 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 597 | 11 | 0 | 9 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2[N+](=O)[O-])c2sc(-c3ccc(OC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL206964 | 76906 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 597 | 11 | 0 | 9 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2[N+](=O)[O-])c2sc(-c3ccc(OC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 11520078 | 79756 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 577 | 10 | 0 | 8 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2C#N)c2sc(-c3ccc(OC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL211588 | 79756 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 577 | 10 | 0 | 8 | 6.5 | CCOC(=O)c1cn(Cc2ccccc2C#N)c2sc(-c3ccc(OC)cc3)c(CN(C)Cc3ccccc3)c2c1=O | 10.1021/jm0512894 | |||
| 10837806 | 78055 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 463 | 7 | 0 | 7 | 5.3 | CCOC(=O)c1cn(Cc2ccccc2OC)c2sc(-c3ccc(OC)cc3)c(C)c2c1=O | 10.1021/jm0512894 | |||
| CHEMBL209836 | 78055 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 463 | 7 | 0 | 7 | 5.3 | CCOC(=O)c1cn(Cc2ccccc2OC)c2sc(-c3ccc(OC)cc3)c(C)c2c1=O | 10.1021/jm0512894 | |||
| 162653870 | 180649 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 489 | 4 | 1 | 4 | 3.3 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(C)(=O)=O)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4753775 | 180649 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 489 | 4 | 1 | 4 | 3.3 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(C)(=O)=O)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 67142732 | 169726 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 640 | 9 | 1 | 9 | 4.5 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4436854 | 169726 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 640 | 9 | 1 | 9 | 4.5 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44417615 | 142010 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 662 | 9 | 2 | 9 | 6.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC3=NCCN3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL387006 | 142010 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 662 | 9 | 2 | 9 | 6.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC3=NCCN3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 67143815 | 171643 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 651 | 8 | 1 | 8 | 5.8 | Cc1c(N2CCN(Cc3cccc4ccsc34)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4464440 | 171643 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 651 | 8 | 1 | 8 | 5.8 | Cc1c(N2CCN(Cc3cccc4ccsc34)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67143102 | 173035 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 610 | 8 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C#N)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4516712 | 173035 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 610 | 8 | 1 | 9 | 4.0 | Cc1c(N2CCN(Cc3ccc(C#N)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 71623059 | 180931 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 603 | 6 | 1 | 6 | 4.2 | O=C(NCc1ncccc1Cl)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4756920 | 180931 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 603 | 6 | 1 | 6 | 4.2 | O=C(NCc1ncccc1Cl)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 162673323 | 183222 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 621 | 6 | 1 | 4 | 5.8 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NC3(c4ccccc4Cl)CC3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4794864 | 183222 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 621 | 6 | 1 | 4 | 5.8 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NC3(c4ccccc4Cl)CC3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| 86274853 | 116251 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 662 | 6 | 1 | 7 | 4.5 | N#Cc1cccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ncc(C(F)(F)F)cc4F)cc3C3(CCS(=O)(=O)CC3)C2C2CC2)c1 | 10.1021/ml5004469 | |||
| CHEMBL3358414 | 116251 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 662 | 6 | 1 | 7 | 4.5 | N#Cc1cccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ncc(C(F)(F)F)cc4F)cc3C3(CCS(=O)(=O)CC3)C2C2CC2)c1 | 10.1021/ml5004469 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 67143030 | 173219 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 638 | 8 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccc(F)c3C#N)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4520639 | 173219 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 638 | 8 | 1 | 8 | 4.6 | Cc1c(N2CCN(Cc3cccc(F)c3C#N)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 67143633 | 173414 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 612 | 8 | 2 | 8 | 3.2 | Cc1c(N2CCN(Cc3ccc(=O)[nH]c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4526188 | 173414 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 612 | 8 | 2 | 8 | 3.2 | Cc1c(N2CCN(Cc3ccc(=O)[nH]c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 44573275 | 187521 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.6 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1CC | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL493730 | 187521 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.6 | CCc1nc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)cn1CC | 10.1016/j.bmcl.2009.02.043 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44293151 | 101228 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 510 | 12 | 2 | 3 | 6.9 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C(C)C | 10.1016/s0960-894x(01)00275-x | |||
| CHEMBL295595 | 101228 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 510 | 12 | 2 | 3 | 6.9 | CCN(C(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3cccnc3)c2c1)C(C)C | 10.1016/s0960-894x(01)00275-x | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 145973124 | 163117 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 595 | 8 | 1 | 6 | 5.2 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)Cc3ccc(C(F)(F)F)cc3F)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4175801 | 163117 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 595 | 8 | 1 | 6 | 5.2 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)Cc3ccc(C(F)(F)F)cc3F)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44346397 | 114562 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 639 | 10 | 0 | 9 | 6.2 | CN(CCc1ccccn1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL333518 | 114562 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 639 | 10 | 0 | 9 | 6.2 | CN(CCc1ccccn1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 44359193 | 11642 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180764 | 11642 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL141750 | 11642 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 587 | 8 | 3 | 7 | 6.4 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)NCc4ccc5c(c4)OCO5)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 70697569 | 78003 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 551 | 10 | 3 | 5 | 4.6 | CC(C)(C)CNC(=O)NCCc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| CHEMBL2096778 | 78003 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 551 | 10 | 3 | 5 | 4.6 | CC(C)(C)CNC(=O)NCCc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| 44346398 | 14544 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 638 | 10 | 0 | 8 | 6.8 | CN(CCc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL120260 | 14544 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 638 | 10 | 0 | 8 | 6.8 | CN(CCc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44417614 | 141705 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL385175 | 141705 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44346667 | 113807 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 636 | 9 | 1 | 7 | 6.8 | CC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| CHEMBL332355 | 113807 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 636 | 9 | 1 | 7 | 6.8 | CC(=O)Nc1ccc(-c2sc3c(c2CN(C)Cc2ccccc2)c(=O)n(-c2ccccc2)c(=O)n3Cc2c(F)cccc2F)cc1 | 10.1021/jm060580w | |||
| 15462666 | 96555 | None | 2 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 624 | 9 | 0 | 8 | 6.7 | CN(Cc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL262557 | 96555 | None | 2 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 624 | 9 | 0 | 8 | 6.7 | CN(Cc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44391541 | 65612 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 482 | 9 | 1 | 7 | 4.6 | CCSc1nc2cc(S(=O)(=O)NCc3ccc([N+](=O)[O-])cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| CHEMBL183237 | 65612 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 482 | 9 | 1 | 7 | 4.6 | CCSc1nc2cc(S(=O)(=O)NCc3ccc([N+](=O)[O-])cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| 44391525 | 166461 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 9 | 1 | 6 | 4.7 | CCSc1nc2cc(S(=O)(=O)NCc3ccc(OC)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| CHEMBL427500 | 166461 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 467 | 9 | 1 | 6 | 4.7 | CCSc1nc2cc(S(=O)(=O)NCc3ccc(OC)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| 11619758 | 173317 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 470 | 6 | 3 | 5 | 5.0 | S=c1[nH]c2cccc(OCCN3CCN(c4cccc5[nH]c(-c6ccccc6)nc45)CC3)c2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL452293 | 173317 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 470 | 6 | 3 | 5 | 5.0 | S=c1[nH]c2cccc(OCCN3CCN(c4cccc5[nH]c(-c6ccccc6)nc45)CC3)c2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 67144335 | 169941 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 658 | 9 | 1 | 9 | 4.6 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4439926 | 169941 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 658 | 9 | 1 | 9 | 4.6 | Cc1c(N2CCN(Cc3cccc([N+](=O)[O-])c3F)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 118179127 | 183320 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 599 | 7 | 2 | 5 | 4.2 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2CCO | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4795998 | 183320 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 599 | 7 | 2 | 5 | 4.2 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2CCO | 10.1021/acs.jmedchem.0c01076 | |||
| 67143413 | 169720 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 610 | 8 | 1 | 8 | 4.3 | Cc1cncc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4436711 | 169720 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 610 | 8 | 1 | 8 | 4.3 | Cc1cncc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| 44573789 | 187446 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.8 | CCCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| CHEMBL493167 | 187446 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 470 | 6 | 1 | 5 | 5.8 | CCCn1cnc(CN2CCN(c3cccc4[nH]c(-c5ccc(C(C)(C)C)cc5)nc34)CC2)c1C | 10.1016/j.bmcl.2009.02.043 | |||
| 11496610 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| 5582 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| CHEMBL474991 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1016/j.bmcl.2010.02.099 | |||
| 53238728 | 170777 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 8 | 1 | 7 | 3.7 | Cc1c(N2CCN(Cc3ccccc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4451627 | 170777 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 8 | 1 | 7 | 3.7 | Cc1c(N2CCN(Cc3ccccc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 11496610 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| 5582 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| CHEMBL474991 | 4075 | None | 10 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 2 | ChEMBL | 476 | 4 | 1 | 5 | 5.8 | CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C | 10.1021/jm801572m | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 87285476 | 171570 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 653 | 8 | 1 | 8 | 5.2 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4463476 | 171570 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 653 | 8 | 1 | 8 | 5.2 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 25194091 | 189118 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 7 | 3 | 5 | 5.5 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL508898 | 189118 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 7 | 3 | 5 | 5.5 | CCc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 25193797 | 189774 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 548 | 7 | 2 | 5 | 6.4 | CC(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL515200 | 189774 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 548 | 7 | 2 | 5 | 6.4 | CC(C)c1ccc(-c2nc3c(N4CCN(CCOc5cccc6nc(C(F)(F)F)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm060580w | |||
| 44402647 | 69851 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 11 | 3 | 8 | 6.5 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NCc3ccccc3)c21 | 10.1016/j.bmcl.2005.03.030 | |||
| CHEMBL193740 | 69851 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 11 | 3 | 8 | 6.5 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NCc3ccccc3)c21 | 10.1016/j.bmcl.2005.03.030 | |||
| 11237922 | 65541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| 11237922 | 65541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| CHEMBL183066 | 65541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1016/j.bmcl.2004.10.089 | |||
| CHEMBL183066 | 65541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 532 | 10 | 1 | 6 | 5.4 | O=S(=O)(NCc1ccc(F)cc1)c1ccc2c(c1)nc(SCCc1cccnc1)n2Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| 25194092 | 189985 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 498 | 6 | 3 | 5 | 5.6 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)c(C)c1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL516934 | 189985 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 498 | 6 | 3 | 5 | 5.6 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)c(C)c1 | 10.1016/j.bmc.2008.05.024 | |||
| 44417614 | 141705 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL385175 | 141705 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 87285767 | 174981 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 775 | 13 | 2 | 10 | 5.1 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCS(=O)(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4563686 | 174981 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 775 | 13 | 2 | 10 | 5.1 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCS(=O)(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 162652474 | 180557 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 519 | 5 | 1 | 3 | 5.7 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(Cc1ccc(F)cc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4752711 | 180557 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 519 | 5 | 1 | 3 | 5.7 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(Cc1ccc(F)cc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| 67144367 | 169965 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 454 | 6 | 1 | 6 | 3.3 | Cc1c(N2CCCCC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4440296 | 169965 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 454 | 6 | 1 | 6 | 3.3 | Cc1c(N2CCCCC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 87285768 | 170598 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4449332 | 170598 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 739 | 13 | 2 | 9 | 5.7 | Cc1c(N2CCN(Cc3ccc(C(F)(F)F)o3)CC2)c(=O)n(C[C@H](NCCCC(=O)O)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 162650892 | 180335 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 554 | 5 | 2 | 6 | 4.5 | N=S1(=O)CCC2(CC1)c1cc(NC(=O)c3cccnc3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4749974 | 180335 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 554 | 5 | 2 | 6 | 4.5 | N=S1(=O)CCC2(CC1)c1cc(NC(=O)c3cccnc3)ccc1N(S(=O)(=O)c1ccc(F)cc1)C2C1CC1 | 10.1021/acs.jmedchem.0c01076 | |||
| 10930638 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL280212 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 67144085 | 171273 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 590 | 9 | 1 | 9 | 3.6 | Cc1c(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4458877 | 171273 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 590 | 9 | 1 | 9 | 3.6 | Cc1c(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 67144307 | 173130 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 546 | 8 | 1 | 8 | 3.1 | Cc1c(N2CCN(Cc3cccnc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4518726 | 173130 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 546 | 8 | 1 | 8 | 3.1 | Cc1c(N2CCN(Cc3cccnc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 44402467 | 170759 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 619 | 12 | 3 | 9 | 5.9 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NCCc3ccncc3)c21 | 10.1016/j.bmcl.2005.03.030 | |||
| CHEMBL445143 | 170759 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 619 | 12 | 3 | 9 | 5.9 | CCCn1c(SCc2cc([N+](=O)[O-])ccc2OC)nc2cc(NC(=O)NC(C)(C)C)cc(C(=O)NCCc3ccncc3)c21 | 10.1016/j.bmcl.2005.03.030 | |||
| 25194090 | 189036 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 484 | 6 | 3 | 5 | 5.3 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL507973 | 189036 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 484 | 6 | 3 | 5 | 5.3 | Cc1ccc(-c2nc3c(N4CCN(CCOc5cccc6[nH]c(=S)[nH]c56)CC4)cccc3[nH]2)cc1 | 10.1016/j.bmc.2008.05.024 | |||
| 44346398 | 14544 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 638 | 10 | 0 | 8 | 6.8 | CN(CCc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL120260 | 14544 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 638 | 10 | 0 | 8 | 6.8 | CN(CCc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 123549935 | 179540 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 551 | 5 | 1 | 4 | 4.7 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccccc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4740379 | 179540 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 551 | 5 | 1 | 4 | 4.7 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccccc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| 162647697 | 179965 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 523 | 5 | 1 | 5 | 5.2 | O=C(Nc1ccc2c(c1)C1(CCSCC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1)c1cccnc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4745391 | 179965 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 523 | 5 | 1 | 5 | 5.2 | O=C(Nc1ccc2c(c1)C1(CCSCC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1)c1cccnc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 44444665 | 94254 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL249772 | 94254 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 630 | 8 | 1 | 5 | 6.4 | Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN2CCC(CC(=O)N3CCOCC3)CC2)c1 | 10.1016/j.bmcl.2007.09.099 | |||
| CHEMBL2430899 | 212919 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(=O)CCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O | 10.1016/j.bmcl.2013.08.075 | |||||
| 118179265 | 180619 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 619 | 5 | 1 | 4 | 5.8 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4753358 | 180619 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 619 | 5 | 1 | 4 | 5.8 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| 118178983 | 183537 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 552 | 5 | 1 | 5 | 4.1 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1cccnc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4798682 | 183537 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 552 | 5 | 1 | 5 | 4.1 | CC(=O)N1CCC2(CC1)c1cc(C(=O)NCc3ccccc3Cl)ccc1N(S(=O)(=O)c1cccnc1)C2C | 10.1021/acs.jmedchem.0c01076 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 53238731 | 171079 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 579 | 8 | 1 | 7 | 4.3 | Cc1c(N2CCN(Cc3ccc(Cl)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4456075 | 171079 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 579 | 8 | 1 | 7 | 4.3 | Cc1c(N2CCN(Cc3ccc(Cl)cc3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F | 10.1021/acs.jmedchem.6b01071 | |||
| 67144408 | 176013 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 586 | 8 | 1 | 9 | 3.5 | Cc1c(N2CCN(Cc3ccon3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4587044 | 176013 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 586 | 8 | 1 | 9 | 3.5 | Cc1c(N2CCN(Cc3ccon3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 67144409 | 171208 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 610 | 8 | 1 | 8 | 4.3 | Cc1ccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)cn1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4457786 | 171208 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 610 | 8 | 1 | 8 | 4.3 | Cc1ccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4C(F)(F)F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)cn1 | 10.1021/acs.jmedchem.6b01071 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 67144509 | 174233 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 575 | 9 | 1 | 8 | 3.7 | COc1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4546034 | 174233 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 575 | 9 | 1 | 8 | 3.7 | COc1cccc(CN2CCN(c3c(C)n(Cc4c(F)cccc4F)c(=O)n(C[C@H](N)c4ccccc4)c3=O)CC2)c1 | 10.1021/acs.jmedchem.6b01071 | |||
| 162672599 | 183113 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 481 | 4 | 1 | 5 | 4.1 | CC1N(S(=O)(=O)c2ccc(F)cc2)c2ccc(NC(=O)c3cccnc3)cc2C12CCOCC2 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4793643 | 183113 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 481 | 4 | 1 | 5 | 4.1 | CC1N(S(=O)(=O)c2ccc(F)cc2)c2ccc(NC(=O)c3cccnc3)cc2C12CCOCC2 | 10.1021/acs.jmedchem.0c01076 | |||
| 15462666 | 96555 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 624 | 9 | 0 | 8 | 6.7 | CN(Cc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL262557 | 96555 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 624 | 9 | 0 | 8 | 6.7 | CN(Cc1ccccc1)Cc1c(-c2ccc([N+](=O)[O-])cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44417614 | 141705 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL385175 | 141705 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 727 | 11 | 2 | 7 | 8.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)NCc3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44417615 | 142010 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 662 | 9 | 2 | 9 | 6.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC3=NCCN3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL387006 | 142010 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 662 | 9 | 2 | 9 | 6.2 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC3=NCCN3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44391574 | 66111 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 445 | 8 | 1 | 6 | 4.2 | CCOc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccsc1 | 10.1016/j.bmcl.2004.10.089 | |||
| CHEMBL183847 | 66111 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 445 | 8 | 1 | 6 | 4.2 | CCOc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccsc1 | 10.1016/j.bmcl.2004.10.089 | |||
| 162667361 | 182631 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 3 | 5.1 | CC1N(S(=O)(=O)c2ccccc2)c2ccc(C(=O)NCc3ccccc3Cl)cc2C1(C)C | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4787218 | 182631 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 468 | 5 | 1 | 3 | 5.1 | CC1N(S(=O)(=O)c2ccccc2)c2ccc(C(=O)NCc3ccccc3Cl)cc2C1(C)C | 10.1021/acs.jmedchem.0c01076 | |||
| 71666542 | 180453 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 621 | 6 | 1 | 6 | 4.4 | O=C(NCc1ncc(F)cc1Cl)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4751345 | 180453 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 621 | 6 | 1 | 6 | 4.4 | O=C(NCc1ncc(F)cc1Cl)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 67143761 | 171464 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 710 | 12 | 3 | 9 | 3.8 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4461692 | 171464 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 710 | 12 | 3 | 9 | 3.8 | Cc1c(N2CCN(Cc3cccc(C(=O)NCCC(=O)O)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 1185 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 3038517 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| CHEMBL22055 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| DB06494 | 3701 | None | 34 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 667 | 10 | 2 | 8 | 6.5 | CONC(=O)Nc1ccc(cc1)c1sc2c(c1CN(Cc1ccccc1)C)c(=O)n(c(=O)n2Cc1c(F)cccc1F)c1ccccc1 | 10.1021/jm0506928 | |||
| 118179051 | 180324 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 581 | 6 | 1 | 5 | 4.8 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C3(CCN(C(C)=O)CC3)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4749790 | 180324 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 581 | 6 | 1 | 5 | 4.8 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C3(CCN(C(C)=O)CC3)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL436874 | 216150 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0506928 | |||||
| 10930638 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL280212 | 99083 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44359252 | 11635 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL1180715 | 11635 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| CHEMBL139291 | 11635 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 571 | 8 | 3 | 7 | 6.7 | Cc1cc(C)cc(-c2c(O)nc3cc(Cl)c(C(=O)Nc4ccnc(C5CC5)n4)cc3c2OCCC2CCCCN2)c1 | 10.1016/s0960-894x(00)00024-x | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 11167850 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1178 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 1187 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| CHEMBL179691 | 2741 | None | 28 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 7 | 1 | 6 | 4.2 | COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)N)c(=O)n(c1C)Cc1c(F)cccc1F | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL3085508 | 213448 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1NCCC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O | 10.1021/jm0506928 | |||||
| 44380192 | 57464 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| CHEMBL165534 | 57464 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 584 | 8 | 2 | 3 | 8.3 | Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CNCc2cccc3ncccc23)c1 | 10.1016/s0960-894x(02)00026-4 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 70691931 | 74214 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1924 | 45 | 22 | 28 | -1.5 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(/C(C)=N/OCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1016/j.ejmech.2012.08.014 | |||
| CHEMBL2023088 | 74214 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1924 | 45 | 22 | 28 | -1.5 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(/C(C)=N/OCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | 10.1016/j.ejmech.2012.08.014 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 44391718 | 65626 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 523 | 10 | 3 | 5 | 4.0 | CC(C)NC(=O)NCCc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| CHEMBL183325 | 65626 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 523 | 10 | 3 | 5 | 4.0 | CC(C)NC(=O)NCCc1nc2cc(S(=O)(=O)NCc3ccc(F)cc3)ccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2004.10.090 | |||
| 162645007 | 179567 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 4 | 5.2 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C(C)(C)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4740709 | 179567 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 4 | 5.2 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C(C)(C)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 44560995 | 179259 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 3 | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| CHEMBL472117 | 179259 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 3 | ChEMBL | 498 | 5 | 2 | 5 | 4.7 | FC(F)(F)c1nc2c(N3CCN(CCOc4cccc5nc(C(F)(F)F)[nH]c45)CC3)cccc2[nH]1 | 10.1016/j.bmc.2008.05.024 | |||
| 10919052 | 113583 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 594 | 8 | 1 | 7 | 6.4 | CN(Cc1ccccc1)Cc1c(-c2ccc(N)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL332138 | 113583 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 594 | 8 | 1 | 7 | 6.4 | CN(Cc1ccccc1)Cc1c(-c2ccc(N)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 10930638 | 99083 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| CHEMBL280212 | 99083 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 698 | 10 | 1 | 7 | 8.1 | CN(Cc1ccccc1)Cc1c(-c2ccc(NC(=O)c3ccccc3)cc2)sc2c1c(=O)n(-c1ccccc1)c(=O)n2Cc1c(F)cccc1F | 10.1021/jm060580w | |||
| 44402232 | 71435 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 454 | 8 | 1 | 7 | 5.6 | COc1ccc([N+](=O)[O-])cc1CSc1nc2cc(NC(=O)C3CCC3)ccc2n1C(C)C | 10.1016/j.bmcl.2005.03.030 | |||
| CHEMBL195920 | 71435 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 454 | 8 | 1 | 7 | 5.6 | COc1ccc([N+](=O)[O-])cc1CSc1nc2cc(NC(=O)C3CCC3)ccc2n1C(C)C | 10.1016/j.bmcl.2005.03.030 | |||
| 67143374 | 171844 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 614 | 8 | 1 | 8 | 4.1 | Cc1c(N2CCN(Cc3cncc(F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| CHEMBL4467261 | 171844 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 614 | 8 | 1 | 8 | 4.1 | Cc1c(N2CCN(Cc3cncc(F)c3)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F | 10.1021/acs.jmedchem.6b01071 | |||
| 162645007 | 179567 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 4 | 5.2 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C(C)(C)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4740709 | 179567 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 4 | 5.2 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3C(C)(C)C2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 162675445 | 183514 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 470 | 6 | 1 | 4 | 4.4 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3CC2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4798298 | 183514 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 470 | 6 | 1 | 4 | 4.4 | COc1ccc(S(=O)(=O)N2c3ccc(C(=O)NCc4ccccc4Cl)cc3CC2C)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 71668147 | 180096 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 637 | 6 | 1 | 6 | 4.6 | O=C(NCc1ccc(C(F)(F)F)cn1)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL4746969 | 180096 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 637 | 6 | 1 | 6 | 4.6 | O=C(NCc1ccc(C(F)(F)F)cn1)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 86275342 | 116250 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 671 | 6 | 1 | 6 | 5.3 | O=C(NCc1ncc(Cl)cc1C(F)(F)F)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| CHEMBL3358413 | 116250 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 671 | 6 | 1 | 6 | 5.3 | O=C(NCc1ncc(Cl)cc1C(F)(F)F)c1ccc2c(c1)C1(CCS(=O)(=O)CC1)C(C1CC1)N2S(=O)(=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c01076 | |||
| 145957339 | 162403 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 561 | 8 | 1 | 6 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)Cc3c(F)cccc3Cl)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| CHEMBL4164508 | 162403 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 561 | 8 | 1 | 6 | 4.8 | COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(CC(N)Cc3c(F)cccc3Cl)c2=O)c1F | 10.1016/j.ejmech.2017.12.095 | |||
| 44572286 | 180907 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 494 | 4 | 3 | 5 | 5.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6c(c5)NCC(=O)N6)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| CHEMBL475650 | 180907 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 494 | 4 | 3 | 5 | 5.2 | CC(C)(C)c1ccc(-c2nc3c(N4CCN(Cc5ccc6c(c5)NCC(=O)N6)CC4)cccc3[nH]2)cc1 | 10.1021/jm801572m | |||
| 44406776 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| CHEMBL371722 | 134411 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 609 | 14 | 2 | 3 | 8.8 | COc1c(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N(CC(C)C)CC(C)C)cc3c2[C@H](C)CNCCc2ccccc2)cc1C | 10.1021/jm0506928 | |||
| 67143780 | 172355 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | |||||||||||||