GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44570962	183833	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480821	183833	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	145950336	162803	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172656	162803	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	156016416	177633	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177633	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94470	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251572	94470	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156014430	177199	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	177199	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016416	177633	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177633	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94470	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	CHEMBL251572	94470	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	44570963	183856	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481013	183856	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	156014430	177199	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	177199	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444563	154931	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401134	154931	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	156011926	177376	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	177376	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44571002	191074	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL518774	191074	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44449987	95864	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259166	95864	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	25010378	159374	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	CHEMBL410074	159374	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	44449955	159388	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410085	159388	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	156011926	177376	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	177376	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177782	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177782	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156015100	177548	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	177548	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177782	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177782	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44570960	183964	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481796	183964	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	24894012	176773	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL460680	176773	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	156015100	177548	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	177548	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437979	10295	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10295	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44437979	10295	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10295	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44454303	97541	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97541	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	156020725	178081	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	178081	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44570764	184025	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482220	184025	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	24803512	88978	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364468	88978	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	156020725	178081	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	178081	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	9917957	109691	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	CHEMBL322912	109691	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	44447855	194833	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL539929	194833	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	178024	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	156013414	177448	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	177448	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	177460	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	177460	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44452749	96186	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL260819	96186	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44570765	191416	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL519301	191416	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007047	88936	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364427	88936	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	178024	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1958	33	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	25022640	97773	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97773	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454337	155579	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155579	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44447839	94962	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254765	94962	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156013414	177448	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	177448	6	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	177460	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	177460	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44447857	166852	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL428592	166852	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156019724	177967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888474	63434	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL179823	63434	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	11306502	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63612	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888476	122792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	22888476	122792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	44454117	155532	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155532	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44444559	94407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251169	94407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	156011750	177266	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	177266	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156019724	177967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177967	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453123	97958	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL272753	97958	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	44570966	183545	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480037	183545	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007062	88938	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364429	88938	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	24803514	88983	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364472	88983	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	44447852	155538	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404354	155538	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156011750	177266	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	177266	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450016	160536	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411259	160536	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	44454367	95232	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95232	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	22867441	10283	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10283	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	16114096	79131	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	79131	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	22867441	10283	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10283	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447841	155054	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL401827	155054	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	69195371	88862	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364354	88862	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44450101	159436	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410135	159436	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	44391039	131762	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369329	131762	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44449988	161077	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411697	161077	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	44447843	94991	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254973	94991	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	10280020	63062	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178900	63062	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156021297	178065	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178065	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444571	93950	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248544	93950	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	10553921	104533	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104533	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	139250	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	139250	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	156012122	177357	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177357	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	178065	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178065	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11584048	98001	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	CHEMBL272993	98001	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	24755624	157276	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL407706	157276	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	24755624	157276	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	CHEMBL407706	157276	2	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	69197353	88916	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364408	88916	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44454060	155308	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155308	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10553921	104533	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104533	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	139250	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	139250	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	127047525	139742	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139742	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	156022162	178182	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	178182	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156012122	177357	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177357	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	20600693	63426	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179785	63426	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44560945	179078	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL471751	179078	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	216208	9695	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9695	33	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	44449891	96445	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL262358	96445	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	216208	9695	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9695	33	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	156021478	178031	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	178031	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437955	10293	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10293	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	9807597	182993	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL47938	182993	5	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	156018364	177889	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177889	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021478	178031	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	178031	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	178179	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	178179	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156022162	178182	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	178182	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	56926175	68984	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68984	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926356	68990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926461	69007	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	69007	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	69008	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	69008	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57399248	69015	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	69015	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	11664206	69024	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	69024	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926894	69035	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	69035	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	11526745	69039	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	69039	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11526696	71573	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71573	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71573	17	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	134130631	142348	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	142348	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134137202	142801	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142801	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	143112	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	143112	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133518	143428	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	143428	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134133352	143480	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	143480	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134286	143669	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143669	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135712	144113	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	144113	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	11512561	144344	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	144344	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144542	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144542	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132893	144838	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144838	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132152	144907	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144907	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	145262	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	145262	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	145301	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	145301	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	134142839	145361	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	145361	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143635	145549	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145549	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143366	145735	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145735	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134142204	145912	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145912	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	146166	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	146166	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	146348	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	146348	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134139279	146422	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	146422	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139286	146529	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146529	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	147093	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	147093	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	117812380	147727	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147727	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147730	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147730	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	148330	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	148330	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149306	148450	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	148450	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145791	148762	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148762	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145564	149066	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	149066	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147441	149465	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	149465	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134155239	150990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150990	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	151068	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	151068	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154079	152379	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	152379	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152696	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152696	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	44570763	190235	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517543	190235	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	9890504	89711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	CHEMBL237699	89711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	24969109	88846	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364338	88846	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11518200	88861	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364353	88861	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641108	88890	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364382	88890	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197887	88911	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364403	88911	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447856	161790	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL414394	161790	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156018364	177889	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177889	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	178179	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	178179	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10323604	10277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10323604	10277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10277	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447853	94935	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254565	94935	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	25022503	155539	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404355	155539	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44269035	27301	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13675	27301	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44269039	98313	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL275093	98313	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	145956061	162669	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162669	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44570965	189813	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL516602	189813	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	69194933	88933	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364424	88933	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	69198297	88942	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364432	88942	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447850	94906	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254363	94906	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450015	96289	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261358	96289	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	178024	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	178024	1958	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	5867	1958	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	CHEMBL13817	1958	33	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	178024	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	145956061	162669	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162669	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44450104	95772	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258761	95772	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	214092	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	214092	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	22888475	63795	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180246	63795	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL500468	214092	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.040
	162653916	180521	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	180521	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	214092	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.02.021
	CHEMBL500468	214092	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.05.100
	178024	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1958	33	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	156012849	177274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390996	64274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181063	64274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64586	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64586	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64586	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64586	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44347919	16341	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122939	16341	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	16133832	213308	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	213308	18	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	145957574	162277	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162277	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	9875705	205278	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	205278	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	156012849	177274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177274	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013219	177465	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177465	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11648350	88889	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364381	88889	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007043	88892	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364384	88892	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	69197106	88935	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364426	88935	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	24803348	88940	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364430	88940	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197228	88986	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364475	88986	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	16114291	191270	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL5190973	191270	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	16114292	96905	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96905	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	9875705	205278	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	205278	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	44436850	91520	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91520	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44447840	94963	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254766	94963	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44447854	94936	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254566	94936	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL105462	208445	38	None	12	2	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm980197u
	44447844	94848	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253965	94848	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450017	96317	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261544	96317	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	10118326	24061	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	24061	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10458218	27456	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13687	27456	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	10745618	112960	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	CHEMBL331093	112960	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	10118326	24061	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	24061	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	156010457	177030	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	177030	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	23649669	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL398372	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	23649669	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	CHEMBL398372	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	23649669	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL398372	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	23649669	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL398372	153943	9	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44437955	10293	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10293	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	10626337	101198	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	101198	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156010457	177030	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	177030	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	156012445	177311	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177311	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	177557	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177557	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452750	96228	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL261030	96228	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44452932	97559	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	CHEMBL270790	97559	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	44570700	183935	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	CHEMBL481620	183935	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	69197169	88907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364399	88907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641478	88915	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364407	88915	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	24803350	88951	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364441	88951	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	11547664	88991	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364480	88991	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	44579802	186744	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488965	186744	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44444572	93990	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248745	93990	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145962494	162050	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	162050	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145951150	162752	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162752	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44434120	89878	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89878	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	9827234	5304	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL106841	5304	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	44411718	10274	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161825	10274	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10292	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10292	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	44293557	101061	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL294923	101061	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL540001	101061	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	127046473	139755	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139755	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	156012203	177310	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	177310	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	156016696	177606	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177606	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11525404	95352	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL256808	95352	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44571004	184022	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482203	184022	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL105462	208445	38	None	12	2	Rat	8.0	pEC50	=	8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(97)10199-8
	24969294	88851	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364343	88851	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	69194607	88866	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364358	88866	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	69197049	88867	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364359	88867	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	69195141	88885	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364377	88885	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	11682686	88898	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364390	88898	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198021	88941	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	CHEMBL2364431	88941	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	11655608	88954	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364444	88954	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194649	88988	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364477	88988	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196750	88990	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364479	88990	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	23730339	148095	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL393531	148095	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	156016696	177606	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177606	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145993528	167294	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	167294	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	156012203	177310	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	177310	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	145950201	162918	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162918	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44281466	169358	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	169358	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44452806	96654	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL263916	96654	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44452885	97786	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271948	97786	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	11633712	159311	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410013	159311	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	57390496	69026	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69026	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	56926782	69028	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	69028	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	69031	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	69031	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	69033	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	69033	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926893	69034	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	69034	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	134131183	142443	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	142443	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133488	143211	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	143211	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134870	144367	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	144367	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144636	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144636	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132265	144946	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144946	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	76460236	145435	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	145435	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134141159	146704	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146704	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	148429	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	148429	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134146570	148756	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148756	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145820	149010	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	149010	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155024	150988	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150988	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	151318	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	151318	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152627	151524	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151524	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150696	152055	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	152055	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150029	152091	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	152091	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	152346	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	152346	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154022	152801	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152801	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151899	153295	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	153295	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134156625	153627	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153627	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	16040587	179360	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	179360	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	44576247	214199	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	214199	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	214199	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	214199	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL3578015	211743	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	211746	0	None	-15	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69198097	88872	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364364	88872	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	69198438	88874	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364366	88874	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	69196473	88883	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364375	88883	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197657	88884	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364376	88884	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	69195983	88905	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364397	88905	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196844	88922	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364414	88922	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647817	88926	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	CHEMBL2364418	88926	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	69196864	88944	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364434	88944	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	69198407	88973	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364463	88973	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	44579958	191318	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519171	191318	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	156020713	178064	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	178064	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	134139753	146011	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	146011	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44449923	96309	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL261497	96309	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	156020713	178064	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	178064	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	44434110	88483	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88483	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578018	211746	0	None	-15	2	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44450102	95742	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL258550	95742	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	16114290	137183	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	137183	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11664206	69024	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	69024	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	71453489	209345	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	9870965	64284	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181092	64284	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44434051	89386	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	89386	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	44434053	146833	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	CHEMBL392522	146833	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	145988557	167236	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	167236	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL2170775	209340	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434083	90002	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	90002	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44436884	91523	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91523	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114098	141586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113246	94648	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94648	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	22888486	64288	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL181108	64288	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	71453489	209345	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	CHEMBL2170781	209345	15	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	156018539	177785	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177785	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145949755	162910	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162910	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	156013970	177216	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	177216	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156018539	177785	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177785	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	69197178	88844	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364336	88844	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	69194396	88895	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364387	88895	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	69195258	88927	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364419	88927	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11604627	88943	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364433	88943	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197381	88961	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364451	88961	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	11576185	88968	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364458	88968	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	11633856	88994	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364483	88994	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	59007104	88997	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364486	88997	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2170779	209343	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579824	184086	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482623	184086	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44579883	186813	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489403	186813	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579861	194177	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL528332	194177	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	44579906	192595	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL521612	192595	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	145992125	166726	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166726	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016682	177742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170776	209341	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	16752689	188344	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	188344	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44444557	154662	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL399704	154662	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	145957404	162025	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	162025	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	162500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	162500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	145950261	162705	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162705	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156014569	177208	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	177208	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452776	96299	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL261466	96299	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	69196695	88857	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364349	88857	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007058	88865	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	CHEMBL2364357	88865	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	156016682	177742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177742	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44579842	184727	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL485091	184727	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	145986461	167189	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	167189	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145950261	162705	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162705	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	10602593	112815	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330860	112815	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391038	64555	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181627	64555	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170783	209347	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm300414b
	CHEMBL2170779	209343	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013970	177216	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	177216	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156014569	177208	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	177208	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	56926173	68983	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68983	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	134138625	148006	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	148006	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	155526063	171012	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	171012	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145957404	162025	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	162025	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	162500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	162500	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	44454060	155308	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155308	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	57399248	69015	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	69015	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	145949755	162910	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162910	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44434109	146256	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	146256	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9890375	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44436876	146994	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146994	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9890375	98242	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL274599	98242	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL558802	98242	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	9890375	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	98242	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44281466	169358	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	169358	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	162672839	182998	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182998	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	22888428	64320	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181247	64320	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	23730227	147849	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	CHEMBL393330	147849	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	44450133	160369	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL411122	160369	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44579821	184204	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL483455	184204	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	44579879	186971	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490627	186971	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44450071	96556	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263141	96556	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	16113906	137198	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	137198	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44579752	186936	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490390	186936	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	44436887	90930	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90930	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44434076	89748	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89748	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	145952740	162477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	23648250	79134	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	79134	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16113577	84907	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84907	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	162657465	181017	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	181017	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	44444574	93991	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248746	93991	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145952740	162477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162477	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	11532288	96891	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL265950	96891	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	11576186	155201	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	CHEMBL402632	155201	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	44570964	183857	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481014	183857	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44570921	183931	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481601	183931	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	59007073	88845	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364337	88845	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	69197749	88854	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364346	88854	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11682796	88856	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364348	88856	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198460	88868	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	CHEMBL2364360	88868	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	69198360	88876	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364368	88876	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11683967	88888	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364380	88888	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	69195261	88896	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364388	88896	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11516766	88900	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364392	88900	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11525161	88957	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364447	88957	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194533	88987	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364476	88987	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197165	88999	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364488	88999	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44579777	186960	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490601	186960	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44454432	155234	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155234	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44434112	168836	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168836	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44579908	186850	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489610	186850	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145954311	162462	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162462	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44434124	88629	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235817	88629	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	162659161	181367	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	181367	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44444556	94373	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	CHEMBL250973	94373	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	145950963	162782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952396	162979	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162979	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	156011695	177331	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	177331	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452887	159554	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL410282	159554	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	46882522	5680	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5680	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	69195349	88879	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	CHEMBL2364371	88879	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	69198352	89000	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364489	89000	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	44446188	155367	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	155367	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145954311	162462	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162462	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882521	5679	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5679	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	44445620	154654	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154654	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	22862453	98431	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL275795	98431	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	10675061	96514	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL262889	96514	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	10026738	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	56926464	69010	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	69010	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	155540883	172933	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	10210658	10294	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10294	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	145952396	162979	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162979	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL2170784	209348	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134139080	147658	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147658	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	156011695	177331	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	177331	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170697	209334	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434080	89882	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434080	89882	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89882	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89882	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10210658	10294	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10294	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10026738	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162745	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	10530983	168361	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL434609	168361	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391003	123295	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL361612	123295	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170780	209344	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145950963	162782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	127047409	139606	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139606	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	10745533	140095	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	140095	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	202497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	202497	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	16113693	137991	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137991	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	11692516	69019	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	69019	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	155557019	174563	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	9810101	99221	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL281764	99221	17	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10745533	140095	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	140095	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	202497	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	202497	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44579909	186879	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186879	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44436882	145991	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145991	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2170698	209335	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434122	89482	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237302	89482	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	145992142	166747	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166747	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL3578006	211737	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	145953016	162563	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162563	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	44454304	97575	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97575	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97621	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97621	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454338	97807	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97807	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	22867310	30010	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	CHEMBL13891	30010	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	162653802	180507	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	180507	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44436886	161931	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161931	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9987037	12000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	12000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	12000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	44391008	64837	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182137	64837	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	22888379	168289	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL434152	168289	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	44444564	94443	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251366	94443	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	145961213	162139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	162139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145953016	162563	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162563	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949595	162700	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162700	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	163000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44452929	97515	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL270573	97515	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	46882396	5812	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	5812	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570698	183934	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481619	183934	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	24969292	88848	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364340	88848	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	69194665	88881	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364373	88881	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	11524465	88901	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364393	88901	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11576404	88912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364404	88912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194865	88931	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364422	88931	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	11712498	88945	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364435	88945	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	69195296	88950	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364440	88950	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11518242	88953	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364443	88953	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	69197366	88958	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364448	88958	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11503413	88975	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	CHEMBL2364465	88975	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	11647900	88981	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364470	88981	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	11669734	88982	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364471	88982	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	44391007	64836	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182136	64836	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	145994050	167321	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	167321	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016392	177622	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177622	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578006	211737	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	25098836	191434	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	191434	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957574	162277	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162277	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10276	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10276	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	10626337	101198	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	101198	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156013219	177465	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177465	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888352	63907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888352	63907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63907	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	10649999	17074	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL125498	17074	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156015928	177557	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177557	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012445	177311	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177311	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44411634	10273	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10273	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44411634	10273	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10273	1	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44390986	64639	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181832	64639	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170695	209332	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156011766	177284	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	177284	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44281449	113367	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	113367	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	44281449	113367	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	113367	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	23648249	79133	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	79133	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	10166594	64606	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181786	64606	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391010	64844	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL182158	64844	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	23648244	91985	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91985	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	155557019	174563	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44444565	94471	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251573	94471	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145957075	162255	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162255	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10276	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10276	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	156013684	177241	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	177241	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156011766	177284	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	177284	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	11539642	97900	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL272540	97900	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	44570702	183812	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480639	183812	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	11683968	88887	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364379	88887	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197883	88910	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364402	88910	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69195597	88923	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	CHEMBL2364415	88923	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	59007081	88937	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364428	88937	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	11648834	88992	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364481	88992	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	44411753	10278	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10278	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411753	10278	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10278	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	10415000	168043	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	168043	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	71453489	209345	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013684	177241	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	177241	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10415000	168043	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	168043	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	156019457	177918	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177918	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449922	96192	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL260849	96192	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44269019	98198	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL274340	98198	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44579840	184725	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL485090	184725	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579907	187024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	187024	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579805	187042	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491221	187042	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434113	88620	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88620	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127048060	139836	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139836	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	57399248	69015	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	69015	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44268965	24030	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13383	24030	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	10675800	113767	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL332414	113767	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391002	123884	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL362798	123884	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44579857	186900	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490009	186900	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44434018	88463	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235012	88463	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44579641	186873	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489794	186873	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579996	187112	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491835	187112	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	44579919	191325	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	CHEMBL519196	191325	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	44454092	97621	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97621	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44450070	158627	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL409258	158627	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	156016392	177622	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177622	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145961213	162139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	162139	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145949595	162700	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162700	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	163000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163000	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44390905	64427	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181337	64427	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391040	64431	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181352	64431	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10579444	114216	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL332987	114216	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	162645413	179702	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179702	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44293091	188162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	188162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	16114011	138113	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	138113	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	145981343	166685	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166685	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44391048	62918	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178502	62918	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44454399	155115	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	155115	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44293091	188162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	188162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	155540883	172933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44579801	187137	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL492028	187137	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	168276220	190397	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5177954	190397	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	145958774	162242	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162242	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145950877	162971	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162971	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44450135	158679	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL409327	158679	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44454302	159356	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	159356	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	16203237	96922	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96922	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	56926462	69008	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	69008	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162660604	181195	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	181195	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956753	162133	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	162133	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	71453489	209345	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44446190	94527	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94527	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446189	155350	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	155350	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	10744738	16172	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122420	16172	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL2170699	209336	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44454432	155234	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155234	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44454397	155500	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL404227	155500	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145949381	162691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	22862431	30454	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13930	30454	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	162653781	180458	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	180458	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	156013764	177247	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	177247	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145958317	162289	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162289	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949381	162691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950877	162971	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162971	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	156013764	177247	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	177247	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156020452	178010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	178010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	24969201	88852	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364344	88852	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	69197403	88877	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	CHEMBL2364369	88877	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	59007071	88891	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364383	88891	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11547135	88904	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364396	88904	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11567764	88908	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364400	88908	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11511157	88918	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	CHEMBL2364410	88918	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	11547599	88920	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364412	88920	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197133	88930	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	CHEMBL2364421	88930	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	69197849	88955	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364445	88955	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198350	88962	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364452	88962	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	156020452	178010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	178010	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44579860	188877	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL507551	188877	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145956415	162039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956415	162039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162039	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956753	162133	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	162133	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145958774	162242	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162242	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145955718	162511	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	162511	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952404	162712	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162712	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	211742	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44436816	91776	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91776	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44391028	64268	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181051	64268	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44390906	132077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369571	132077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44434052	89387	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237059	89387	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	44450169	159726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	CHEMBL410499	159726	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	56926894	69035	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	69035	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	44391027	128777	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL366916	128777	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579803	186745	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488966	186745	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145952404	162712	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162712	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	211742	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11526696	71573	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1923502	71573	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1963249	71573	17	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	44450045	159213	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL409894	159213	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	44434012	89045	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	89045	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44454398	97570	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97570	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	11526745	69039	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	69039	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44391020	63834	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180337	63834	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	162643920	181756	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181756	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145955718	162511	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	162511	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	23648236	79123	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	79123	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	145958317	162289	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162289	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	162649014	179917	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179917	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	44434123	145525	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145525	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	11526696	71573	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71573	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71573	17	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	122178179	121237	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	121237	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	145980382	166619	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166619	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71453489	209345	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134149793	148581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	145980333	166557	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166557	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44579823	184057	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	184057	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957075	162255	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162255	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145951150	162752	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162752	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44449864	158806	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL409462	158806	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	10005618	10291	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10291	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77715	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77715	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	99221	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	99221	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	141185	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	141185	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	208664	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	16114292	96905	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96905	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16114292	96905	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96905	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	23730225	154152	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	CHEMBL398570	154152	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	10530781	15546	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122108	15546	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10005618	10291	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10291	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77715	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77715	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	99221	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	99221	17	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	141185	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	141185	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	208664	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	156011385	177354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	177354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449956	96586	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263389	96586	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44447846	94870	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254166	94870	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44444566	154743	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400124	154743	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156011385	177354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	177354	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156019457	177918	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177918	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570961	192537	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521246	192537	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	69195095	88934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364425	88934	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194503	88970	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364460	88970	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	59007103	88996	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	CHEMBL2364485	88996	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	69197358	89002	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364491	89002	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	44450046	95827	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	CHEMBL259016	95827	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	23730341	89713	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL237701	89713	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	71453489	209345	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44390914	63608	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180093	63608	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888424	122972	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360877	122972	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	71453489	209345	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	162671996	182807	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182807	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	23730228	89563	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237492	89563	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	71453489	209345	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444568	93949	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248542	93949	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	15481185	77232	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	77232	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	156011736	177399	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	177399	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	25022506	95238	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL256263	95238	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	24803347	155004	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401548	155004	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	46882394	5810	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	5810	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882395	5811	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	5811	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570699	191281	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL519121	191281	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196498	88882	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364374	88882	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	69197028	88921	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364413	88921	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198238	88932	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364423	88932	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11712867	88969	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364459	88969	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	69194471	88984	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364473	88984	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	11698505	88993	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364482	88993	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	9950632	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL236038	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	44579880	186811	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186811	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579841	192530	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL521176	192530	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434010	88744	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL236311	88744	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	9950632	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	9950632	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88677	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44434010	88744	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88744	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44437966	202070	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	202070	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	202496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	202496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437966	202070	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	202070	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	202496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	202496	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44454368	95233	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL256236	95233	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145987684	167253	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	167253	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44444560	154930	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401133	154930	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	145953855	162491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44570923	183932	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481602	183932	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44570761	189948	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517081	189948	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	122178179	121237	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	121237	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	24969112	88847	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364339	88847	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11540248	88853	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364345	88853	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647560	88855	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364347	88855	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196005	88886	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	CHEMBL2364378	88886	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	69198434	88894	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	CHEMBL2364386	88894	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	69198286	88902	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364394	88902	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11562181	88913	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364405	88913	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196132	88924	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	CHEMBL2364416	88924	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	69197703	88925	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364417	88925	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	69194443	88946	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364436	88946	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	11503069	88949	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364439	88949	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11647941	88956	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364446	88956	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	11576203	88963	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	CHEMBL2364453	88963	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	11683891	88977	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364467	88977	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	69194380	89001	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364490	89001	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	56926783	69029	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	69029	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	156021183	178100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	178100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177626	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177626	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021183	178100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	178100	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453070	95064	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL255401	95064	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	44453097	155069	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401891	155069	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	44570762	183404	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL479865	183404	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578013	211741	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156017268	177626	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177626	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44434114	89389	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237060	89389	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	44450134	161868	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL415095	161868	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44446177	94618	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94618	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500468	214092	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	44450105	95773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL258762	95773	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44447848	94871	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254167	94871	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44580031	193046	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL522446	193046	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL3578013	211741	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44447845	94849	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253966	94849	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44434119	89877	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89877	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	145953855	162491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44434121	89879	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89879	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	162646324	179712	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179712	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	10721075	15521	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121960	15521	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	145959787	162261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114289	98637	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98637	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	56926892	69033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	69033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145984632	166367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	166367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	155551597	173925	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173925	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	22862448	97149	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL268231	97149	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	22867465	97190	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	CHEMBL268518	97190	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	44301387	11232	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11232	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11232	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56926356	68990	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68990	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	10143731	64298	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181156	64298	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44444558	167753	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL430398	167753	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	145959007	162233	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162233	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	162261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156021766	178103	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178103	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452826	95353	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL256809	95353	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452777	96191	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL260831	96191	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	11554351	96510	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL262879	96510	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	11605061	96685	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL264170	96685	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452825	155226	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL402772	155226	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL3578017	211745	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69197033	88878	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364370	88878	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197513	88893	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364385	88893	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196509	88897	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364389	88897	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11669948	88909	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364401	88909	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196071	88967	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364457	88967	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	69194899	88971	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364461	88971	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	44434055	89276	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	89276	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44436889	153033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	153033	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44570922	192539	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521264	192539	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196838	88858	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364350	88858	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	25211977	186878	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186878	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	16113580	137854	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137854	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	44434111	146258	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	146258	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	15481185	77232	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	77232	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	127048059	139541	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139541	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	16113580	137854	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137854	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44450103	95743	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258551	95743	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44391032	64815	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182050	64815	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156011736	177399	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	177399	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450132	95983	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259712	95983	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	145948725	167473	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	167473	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	44281450	99617	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99617	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44281450	99617	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99617	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44411584	10271	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10271	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	156015766	177544	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	177544	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44411584	10271	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10271	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888433	64583	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181735	64583	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579775	187156	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL492230	187156	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	11258291	189080	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL510195	189080	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579882	193042	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL522426	193042	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44450044	161078	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411699	161078	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	56926463	69009	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	69009	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145981687	166553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166553	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44579640	186872	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489793	186872	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579686	186967	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490614	186967	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	16203238	137084	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	137084	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	44390997	122975	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360891	122975	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL3578017	211745	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	23661656	169020	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	169020	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434074	154649	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154649	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434009	167429	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	167429	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	22867312	23838	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	CHEMBL13366	23838	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	162665952	182355	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	182355	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44434056	144970	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391088	144970	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434007	88546	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88546	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	156021766	178103	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178103	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44391035	122582	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360247	122582	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	44301512	11990	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11990	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11990	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	145979268	166640	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166640	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145959007	162233	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162233	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44580030	186946	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490422	186946	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	118718706	115353	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	115353	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	44301462	11230	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11230	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11230	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113800	137787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44391015	123529	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL361802	123529	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	162677268	183549	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	183549	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	10507433	16435	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL123430	16435	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	23730458	146547	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	CHEMBL392296	146547	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	44576247	214199	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL506986	214199	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	168285897	191633	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5196194	191633	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	155529391	171416	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	171416	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145956659	162031	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162031	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	155537651	172292	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	172292	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145981196	166512	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	166512	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	145979819	166449	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	166449	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434016	90164	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	90164	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	16113692	137211	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	137211	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	24970113	69027	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	69027	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170777	209342	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm300414b
	145956026	162638	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162638	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	138164	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	138164	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139511	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139511	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	169260	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	169260	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	11526696	71573	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71573	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71573	17	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	10649323	15498	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121803	15498	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10841400	16819	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL124831	16819	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156009875	177099	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177099	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444562	94442	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251365	94442	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	145956026	162638	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162638	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10282	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	138164	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	138164	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	139511	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	139511	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	169260	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	169260	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	156009875	177099	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177099	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015766	177544	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	177544	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44570967	190145	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL517391	190145	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	24969114	88850	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364342	88850	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	59007076	88873	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364365	88873	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	69197196	88875	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364367	88875	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	69197071	88914	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364406	88914	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194482	88929	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364420	88929	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	11719784	88966	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364456	88966	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	59007054	88998	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	CHEMBL2364487	88998	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	16114097	79128	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	79128	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	16113710	79132	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	79132	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	23730226	147847	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	CHEMBL393329	147847	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	71453489	209345	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	209345	15	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	44411632	10272	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10272	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888425	62494	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178216	62494	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44411632	10272	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10272	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL2170782	209346	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579858	186901	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490010	186901	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579778	186995	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490801	186995	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162657606	181093	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	181093	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956659	162031	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162031	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950987	162816	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162816	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	69198313	88869	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	CHEMBL2364361	88869	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	69195692	88870	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	CHEMBL2364362	88870	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	69196612	88871	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364363	88871	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	11511158	88919	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364411	88919	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198054	88972	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364462	88972	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	69195074	88985	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364474	88985	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	69195546	88995	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364484	88995	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	44580028	193226	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL523786	193226	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	44434011	147839	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147839	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	57390496	69026	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69026	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	145988894	167120	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	167120	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434086	148831	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL394130	148831	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	145950987	162816	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162816	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	44449924	159921	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	CHEMBL410730	159921	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	56926785	69031	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	69031	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434078	89881	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237932	89881	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434008	146509	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	146509	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44411913	10281	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10281	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44268939	30416	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13926	30416	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44411913	10281	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10281	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44434015	88462	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88462	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44411905	10280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10506325	101214	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	101214	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	16113371	79124	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	79124	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	162676229	183280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	183280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL3578005	211736	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	44348031	113062	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL331303	113062	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44411905	10280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10280	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10292	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10292	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	10506325	101214	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	101214	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	44436857	145631	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145631	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	156021787	178119	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	178119	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	10006735	116987	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116987	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	10006735	116987	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116987	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	156021787	178119	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	178119	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	11712108	161284	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL412303	161284	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	44571003	192564	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL521439	192564	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578005	211736	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	69196876	88860	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364352	88860	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11562329	88899	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364391	88899	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	69196868	88903	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364395	88903	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196990	88959	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364449	88959	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	69195880	88976	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364466	88976	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	11518463	88979	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364469	88979	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	69195024	89003	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364492	89003	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44390922	122120	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL359686	122120	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	23631026	167432	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL429817	167432	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL2170779	209343	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44447842	94990	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254972	94990	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44579804	187041	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491220	187041	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145948708	167472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	167472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	121879	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	5868	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	CHEMBL308716	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	44268996	166439	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL427806	166439	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	122178180	121238	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	121238	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	44579959	184248	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL483865	184248	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44454117	155532	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155532	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	162677361	183485	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	183485	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170700	209337	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444570	154744	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400125	154744	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156017532	177884	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177884	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11662746	97785	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271947	97785	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	122178180	121238	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	121238	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578007	211738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	16750162	88849	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364341	88849	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	11568467	88859	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364351	88859	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197136	88960	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	CHEMBL2364450	88960	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	69195304	88974	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	CHEMBL2364464	88974	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	145949880	162767	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162767	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16114099	137199	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	137199	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44269018	97319	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL269447	97319	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	145949880	162767	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162767	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	156015598	177553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	44452827	95397	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL257019	95397	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	46882582	5723	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	5723	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	145988647	167048	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	167048	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44454367	95232	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95232	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	16113691	136694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	16113691	136694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136694	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	22867380	29389	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13841	29389	1	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	2098	3668	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	36511	3668	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3805	3668	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3835	3668	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	CHEMBL235363	3668	36	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	155561671	175640	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175640	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44434073	89571	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89571	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	145981794	166672	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166672	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56926173	68983	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	CHEMBL1923501	68983	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	44301389	11243	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11243	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11243	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	156015598	177553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	177553	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	156017532	177884	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177884	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10100708	12002	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	12002	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	12002	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44579756	186799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145958487	162160	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	162160	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156016840	177607	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177607	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170779	209343	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453489	209345	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10209618	63469	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179978	63469	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391041	64291	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181123	64291	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10600702	141311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	141311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10600702	141311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	141311	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	9868878	96512	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL262884	96512	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	11306502	63612	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63612	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888395	63875	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180540	63875	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	156021942	178199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16113248	79135	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	79135	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	23730342	89873	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	CHEMBL237916	89873	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	145958487	162160	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	162160	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156010733	177056	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177056	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013130	177478	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177478	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016840	177607	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177607	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156021942	178199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570920	183909	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481408	183909	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44571005	184023	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL482204	184023	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	11539144	88864	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364356	88864	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	69197315	88880	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364372	88880	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11683663	88906	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364398	88906	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	11583902	88947	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364437	88947	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	69198030	88952	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364442	88952	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197149	88964	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364454	88964	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	69196669	88989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364478	88989	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	10032659	12019	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	12019	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	12019	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44450137	96272	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL261234	96272	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	127046472	139669	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139669	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127046472	139669	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139669	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	145988286	167182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	167182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL3578007	211738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	CHEMBL61663	215816	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	24180592	96984	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96984	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	162663868	181964	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181964	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	145986080	166428	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	166428	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	168274297	190555	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5180310	190555	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	127047523	140038	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	140038	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	44434118	148154	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL393570	148154	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44446187	94592	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94592	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145959787	162261	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	155557019	174563	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926893	69034	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	69034	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	44437963	202069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	202069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44437963	202069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	202069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44579881	186812	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL489402	186812	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	24180646	148158	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	148158	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	24180646	148158	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148158	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	145959787	162261	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882520	5824	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5824	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	46882458	5946	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5946	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL3578016	211744	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	59007057	88863	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364355	88863	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11597905	88917	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364409	88917	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198135	88948	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364438	88948	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	11711997	88965	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	CHEMBL2364455	88965	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	44452778	159754	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410527	159754	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	10437444	112854	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330989	112854	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	24969603	69025	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	69025	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	162649450	180030	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	180030	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	156013130	177478	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177478	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44450100	160631	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL411330	160631	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	44411720	10275	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10275	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411720	10275	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10275	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10279	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	162656896	180836	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180836	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44436883	146128	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	146128	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	156010733	177056	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177056	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10745674	167930	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167930	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44579776	193227	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL523795	193227	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	127048061	139711	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139711	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	23730340	89712	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237700	89712	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	56926175	68984	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68984	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	145992835	166810	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166810	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56925343	69037	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	69037	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	145986870	167116	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	167116	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44434054	89275	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL236857	89275	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	44446178	155099	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	155099	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3578016	211744	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	162648837	179814	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179814	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44391024	64255	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180992	64255	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10745674	167930	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167930	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391021	19421	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL129637	19421	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL2170696	209333	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	23730343	89874	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	CHEMBL237917	89874	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	22888359	63886	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180591	63886	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	16114514	79129	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	79129	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	44579843	184729	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL485092	184729	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44579643	186747	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488971	186747	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579822	192500	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL520953	192500	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44579755	186919	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490186	186919	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44580032	186810	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489398	186810	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	145991945	166791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	145992253	166904	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166904	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL2170702	209339	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145993313	166868	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166868	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16114008	84817	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84817	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL501261	214112	23	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	9848305	145427	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391429	145427	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	44434050	145425	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	145425	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578015	211743	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL369482	212140	0	None	-	0	Rat	8.0	pED50	=	8	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/S0960-894X(01)80239-0
	44269087	98199	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	CHEMBL274341	98199	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	70691550	73171	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011825	73171	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	16114292	96905	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96905	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL509976	215557	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	25260901	113453	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319405	113453	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	71456897	81821	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81821	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70691551	73172	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011826	73172	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	25261382	113414	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319215	113414	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11431274	77315	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	77315	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11577349	65201	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	65201	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	11351838	77621	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	CHEMBL208842	77621	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	11712151	75964	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75964	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11713497	123211	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	123211	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409757	141299	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383454	141299	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	127046807	139915	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139915	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	3676358	5502	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1076586	5502	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	122182047	121976	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121976	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122178603	121313	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	121313	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	11649248	66640	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66640	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44395020	124006	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	124006	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	44389262	122006	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	122006	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	145993628	167367	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4295148	167367	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11211892	80187	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	80187	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122178611	121322	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	121322	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	11846624	77887	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77887	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11846463	139217	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	139217	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11430392	76695	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76695	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57797614	73163	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011817	73163	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44409801	76704	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206638	76704	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11523411	75526	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75526	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	11537800	75538	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75538	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	71453392	81818	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164504	81818	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71456910	81872	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81872	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	71460578	81879	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164830	81879	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	122178612	121323	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	121323	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL507636	214410	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	56942387	139637	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139637	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145991822	166935	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287267	166935	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11676995	66132	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	66132	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	127048038	139947	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139947	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	71458746	81808	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164493	81808	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	145992142	166747	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166747	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	71460565	81810	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164495	81810	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	11538533	74972	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74972	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	46880462	6235	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081648	6235	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	70693641	73174	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011828	73174	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	44409756	76738	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76738	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46865987	7565	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087908	7565	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880772	5879	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079624	5879	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11538534	74985	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74985	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	145986870	167116	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	167116	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	127046806	139908	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139908	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178613	121324	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	121324	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	145981196	166512	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	166512	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	46880814	6345	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082190	6345	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178616	121326	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	121326	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	145986461	167189	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	167189	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71451551	81822	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81822	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	46880727	6113	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080939	6113	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122182190	121983	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121983	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409840	76313	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205896	76313	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127047362	139694	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139694	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145989916	166722	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4283454	166722	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	127048038	139947	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139947	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880673	6073	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080755	6073	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11455251	161290	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	161290	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409611	74658	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203019	74658	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11221946	140821	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140821	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409839	76229	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	76229	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71460576	81876	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164828	81876	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL509976	215557	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11692087	62962	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62962	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409758	75945	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75945	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409661	75967	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205484	75967	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880724	6226	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081611	6226	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	71455105	81875	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164827	81875	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	11221946	140821	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140821	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	44410003	76152	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	76152	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880811	5966	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080162	5966	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687379	73169	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011823	73169	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	44394974	66982	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66982	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	211778	6	None	-	1	Rat	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	46880567	6355	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082210	6355	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71460564	81807	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164492	81807	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	145992854	166842	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4285747	166842	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	44394833	126799	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126799	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL509976	215557	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	215557	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	215557	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	127047654	139952	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139952	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	145993758	167292	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294024	167292	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145993528	167294	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	167294	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL444131	213906	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	11476589	75959	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75959	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11329138	64430	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL181350	64430	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	70681022	73178	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011833	73178	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL509976	215557	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178611	121322	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	121322	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	46880675	6111	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080927	6111	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11612155	140984	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140984	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	328912	62546	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62546	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	70685218	73166	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011820	73166	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145981794	166672	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166672	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11649239	66310	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	66310	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL501261	214112	23	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	1744826	62968	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62968	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	11282247	165902	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165902	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11282247	165902	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165902	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62968	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62968	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409831	75669	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204776	75669	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145979268	166640	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166640	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44409678	141192	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	141192	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11349789	78744	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78744	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11692087	62962	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62962	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11677781	125032	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	125032	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	11538533	74972	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74972	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	11154823	76000	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	76000	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942244	125171	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	125171	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44409994	76153	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205796	76153	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214199	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44395002	66156	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	66156	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	11646276	75905	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75905	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	127046807	139915	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139915	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113695	137002	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	137002	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	145987684	167253	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	167253	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	122178602	121312	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	121312	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	70681020	73175	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011829	73175	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	56942098	125167	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	125167	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	125169	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	125169	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139932	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139932	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	66788278	125166	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	125166	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139932	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139932	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	57797640	73197	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011892	73197	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880628	6000	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	6000	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	121316	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	121316	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880629	6026	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080556	6026	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	121316	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	121316	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	70681021	73177	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011832	73177	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70691552	73179	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011834	73179	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44576247	214199	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	122178607	121318	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	121318	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	46880631	6103	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080907	6103	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	46880726	6112	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080938	6112	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70689441	73196	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011891	73196	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145988582	167267	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4293608	167267	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	122178610	121321	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	121321	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409666	75858	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204897	75858	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214199	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL500703	214097	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	44409802	76715	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76715	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178613	121324	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	121324	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	71458747	81809	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81809	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	56942244	125171	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	125171	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11537683	75498	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75498	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	71449740	81811	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164497	81811	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	122178601	121311	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	121311	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	11337482	76611	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76611	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122178614	121325	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	121325	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	44389168	64843	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64843	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	145991389	166980	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4288108	166980	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145990051	166931	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287218	166931	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44410012	138374	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	138374	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71462272	81816	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164502	81816	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	71451563	81881	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164832	81881	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	145988286	167182	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	167182	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	46880813	6344	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082189	6344	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	44409761	75837	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75837	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11846625	77855	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77855	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	122178610	121321	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	121321	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880461	6203	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081483	6203	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	71453391	81817	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164503	81817	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	1221269	122008	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	122008	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389151	62475	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62475	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	71451564	81883	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164834	81883	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	71449753	81873	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164825	81873	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44409871	75367	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75367	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880569	6157	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081212	6157	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	70693640	73168	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011822	73168	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL449590	213939	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	44576247	214199	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145994299	167372	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4295212	167372	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71460577	81877	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164829	81877	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	16113902	137651	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137651	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	71462274	81820	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL2164506	81820	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL509976	215557	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	70683143	73167	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011821	73167	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880495	6337	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082162	6337	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	11697618	62569	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62569	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145988557	167236	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	167236	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44409771	141228	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383073	141228	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145980333	166557	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166557	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11329138	64430	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64430	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	44576247	214199	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11568561	169530	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	169530	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	145991945	166791	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166791	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	44394982	66108	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	66108	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	66788278	125166	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	125166	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942099	125168	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	125168	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942243	125170	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	125170	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139837	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139837	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	70681018	73165	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011819	73165	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	70685225	73199	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011894	73199	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11410373	138510	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	138510	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	11339816	75978	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75978	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992253	166904	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166904	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11503585	65174	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	65174	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	44409762	75857	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75857	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180026	121561	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121561	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	46880846	7580	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088038	7580	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44389248	122142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	122142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	70695749	73181	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011836	73181	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178614	121325	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	121325	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	70695748	73173	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011827	73173	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	145981687	166553	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166553	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11508639	76506	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76506	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409683	76230	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	76230	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11626181	124355	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	124355	2	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11690097	76643	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76643	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409775	75996	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75996	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214199	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11655355	74392	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74392	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	127047654	139952	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139952	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113799	168689	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168689	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145986080	166428	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	166428	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56942385	125172	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	125172	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880771	5878	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079623	5878	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11654867	76172	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	76172	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	122178600	121310	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	121310	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	46880844	7564	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087907	7564	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11248021	139230	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378989	139230	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122182189	121982	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121982	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	44409865	140693	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381759	140693	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11751384	141481	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	141481	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409679	75479	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75479	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409868	76713	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76713	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409667	75940	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205294	75940	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	214199	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	56942388	139918	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139918	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	11166495	75521	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75521	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	145994050	167321	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	167321	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11538533	74972	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74972	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880770	5877	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079622	5877	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71453390	81814	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81814	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	44409763	141340	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383757	141340	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165802	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165802	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44410008	141226	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	141226	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11178309	79872	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79872	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	168314	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	168314	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	127047655	139589	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139589	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139682	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139682	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139837	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139837	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	56942098	125167	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	125167	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139682	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139682	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	46880630	6066	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080735	6066	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70685219	73180	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011835	73180	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	121308	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	121308	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	122178607	121318	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	121318	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	11452801	139273	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	139273	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	46882763	5596	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5596	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409776	77114	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	77114	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145991797	166892	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286597	166892	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	122178616	121326	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	121326	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	11430583	80188	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	80188	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL509976	215557	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11669486	64584	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64584	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409946	139790	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL379887	139790	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127046806	139908	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139908	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178600	121310	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	121310	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	11605333	76696	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76696	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	46880845	7579	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088037	7579	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880773	6175	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081301	6175	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178604	121314	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	121314	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	56942387	139637	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139637	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	214199	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11683469	76677	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76677	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	44389216	123828	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123828	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	145979819	166449	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	166449	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880498	5963	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080155	5963	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71462273	81819	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164505	81819	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71453404	81874	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81874	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44389283	62915	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62915	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11179347	77324	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	77324	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44409764	77120	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	77120	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11606121	64546	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64546	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	11539587	67047	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	67047	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	211778	6	None	-	1	Rat	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122178608	121319	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	121319	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409821	76008	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	76008	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11340044	141310	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	141310	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70683149	73194	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011887	73194	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	71452183	83500	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83500	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	122178602	121312	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	121312	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	11582836	62883	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62883	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389192	168622	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168622	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	71455106	81884	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164835	81884	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	44409998	138511	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	138511	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145984632	166367	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	166367	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	10415364	126741	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126741	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	15949382	74819	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203158	74819	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145993313	166868	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166868	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11605822	124362	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	124362	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11154001	79859	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL212354	79859	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	44394930	66302	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	66302	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11699004	66173	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	66173	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11618705	166914	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166914	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44409785	75774	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204852	75774	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409990	76488	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76488	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145992125	166726	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166726	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880568	6356	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082211	6356	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687383	73195	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011890	73195	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	121308	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	121308	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL509976	215557	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	57422817	113422	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319223	113422	18	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11190594	75956	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75956	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	56942385	125172	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	125172	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	214199	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	16113904	137011	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	137011	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44389215	63048	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	63048	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44576247	214199	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409809	75036	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	75036	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113468	141775	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141775	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11531313	62474	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62474	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389167	123832	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123832	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880674	6110	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080926	6110	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71455085	81815	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164501	81815	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	46880463	6236	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081649	6236	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	46880812	5989	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080320	5989	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880497	6339	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082164	6339	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	44409770	141343	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383766	141343	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	121314	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	121314	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	46880496	6338	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082163	6338	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL502208	214127	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	145980382	166619	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166619	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44389186	64585	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64585	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409864	75470	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75470	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409975	75761	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75761	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409455	75939	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75939	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	11441554	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	5871	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	CHEMBL212761	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	11340329	79573	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211454	79573	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178605	121315	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	121315	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	127047655	139589	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139589	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	46880672	6164	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081254	6164	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	66601728	81812	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81812	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70689440	73164	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011818	73164	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	70693644	73198	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011893	73198	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70695747	73162	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	73162	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11225576	166013	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	166013	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11225576	166013	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	166013	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122178608	121319	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	121319	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	121320	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	121320	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	56942388	139918	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139918	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139736	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139736	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11176805	77305	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	77305	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	71453405	81882	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164833	81882	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	44394913	127147	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	127147	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	44409832	76381	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76381	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25190383	81880	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81880	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	122178615	121278	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	121278	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44410013	77024	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	77024	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44389243	64553	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64553	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	753168	123213	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	123213	40	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880566	6354	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082209	6354	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178603	121313	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	121313	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	44409979	140534	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140534	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11256439	75350	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75350	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	11655578	170009	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	170009	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70681019	73170	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011824	73170	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	122178612	121323	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	121323	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	11617435	75968	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75968	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	145988647	167048	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	167048	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11663710	124441	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	124441	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	56942099	125168	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	125168	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	125169	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	125169	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	11663710	124441	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL363995	124441	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	70695747	73162	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	73162	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70687380	73176	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011831	73176	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178605	121315	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	121315	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	145988894	167120	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	167120	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16203569	141708	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141708	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145981343	166685	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166685	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL509976	215557	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178615	121278	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	121278	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44409810	140875	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382138	140875	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113124	121309	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	121309	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44576247	214199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409536	75480	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75480	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992835	166810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11327400	75343	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75343	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11539588	66883	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66883	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	16113796	84652	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84652	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	11442040	78522	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211211	78522	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178601	121311	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	121311	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	56942243	125170	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	125170	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	46880725	6227	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	CHEMBL1081612	6227	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	122178609	121320	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	121320	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	11454617	141294	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	141294	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	46880628	6000	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	6000	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44409684	140860	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140860	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409672	140462	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	140462	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409673	76721	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76721	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	11453509	76149	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	76149	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	127047362	139694	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139694	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139736	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139736	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145990956	166997	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4288441	166997	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44394947	169199	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	169199	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	44410007	76398	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76398	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75958	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75958	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11576960	67085	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	67085	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11281346	75989	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75989	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL499371	214072	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	155540883	172933	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155540883	172933	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174563	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174563	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57399248	69015	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	69015	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	71452183	83500	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83500	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	44454117	155532	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155532	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44454060	155308	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155308	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	95232	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95232	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454338	97807	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97807	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44434080	89882	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89882	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454302	159356	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	159356	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454092	97621	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97621	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454432	155234	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155234	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	9950632	88677	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88677	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44454399	155115	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	155115	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454432	155234	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	155234	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	25022640	97773	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97773	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97621	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97621	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454303	97541	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97541	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454304	97575	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97575	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	56926461	69007	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923609	69007	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	44454398	97570	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97570	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	44454060	155308	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	155308	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	95232	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	95232	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454337	155579	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155579	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454117	155532	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155532	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	1099	1773	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.	Guide to Pharmacology		None	None	None		None	29233536
	121879	2222	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2222	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2222	24	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5869	4049	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	121879	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	5868	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	CHEMBL308716	2222	24	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	1099	1773	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10628755
	1099	1773	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	121879	2222	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2222	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2222	24	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	1093	1781	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1781	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1781	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1781	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	178024	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	178024	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	5867	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	CHEMBL13817	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1958	33	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	1099	1773	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1773	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	5866	3597	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9804743	3597	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	CHEMBL360227	3597	4	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9734	2316	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.	Guide to Pharmacology		None	None	None		None	29233536
	11441554	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5871	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	CHEMBL212761	220	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5872	2111	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	74015851	2111	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	25124566	1861	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5870	1861	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	CHEMBL3358452	1861	8	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5866	3597	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	9804743	3597	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	CHEMBL360227	3597	4	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	25124566	1861	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	5870	1861	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	CHEMBL3358452	1861	8	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2713	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-	0	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	156419	935	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3308	935	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	647	935	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1201284	935	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB01012	935	74	None	-	1	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	5920	47245	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	7048703	47245	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1544	47245	83	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	651	5	3	4	4.0	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	148192	10388	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1163	10388	81	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704	14	5	9	4.2	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	10.1038/s41467-023-40064-9
	154257	178595	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	2600	3750	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	47319	26433	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	26433	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	242	469	124	None	-	52	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-	52	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-	52	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-	52	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-	52	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	39186	85906	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL23	85906	54	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	414	6	0	6	3.4	COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1	10.1038/s41467-023-40064-9
	16362	3103	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3042	1402	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1402	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1402	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1402	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1402	35	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	10184665	3960	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	3191	102831	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102831	97	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	3926	207218	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207218	40	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	11626560	200914	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200914	94	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	2267	557	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	557	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	557	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	557	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	557	71	None	-	7	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	135564886	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	14461	5	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	2585	800	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-	22	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	1353	1898	93	None	-	86	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-	86	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-	86	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-	86	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-	86	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	100	3776	58	None	-	56	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-	56	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-	56	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-	56	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-	56	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	202	1496	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-	33	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	11976	917	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	917	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	917	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	917	59	None	-	24	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	2218	15251	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15251	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	41684	31191	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31191	105	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	3025	7243	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
	CHEMBL1086	7243	86	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	10	1	4	3.5	CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1	10.1038/s41467-023-40064-9
	44112	121264	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121264	48	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	68617	205504	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-	26	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	2726	916	68	None	-	73	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-	73	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-	73	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-	73	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-	73	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	16363	593	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-	7	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2291	3162	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3162	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3162	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3162	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3162	58	None	-	12	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2274	3151	58	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2398	951	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-	29	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	3074	17926	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL126075	17926	26	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	4413	98045	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98045	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	25382	9125	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	2375	158370	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL409	158370	106	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	2351	4269	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4269	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4269	49	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	448537	160226	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-	25	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3393	207901	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL968	207901	24	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	0	3	4.0	CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	441243	9804	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	CHEMBL114	9804	58	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	214	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-	30	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-	54	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-	54	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-	54	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-	54	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	6436173	55086	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1617	55086	45	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	8550	14392	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
	CHEMBL1200515	14392	57	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
	31101	726	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-	36	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	104850	3305	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3305	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3305	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3305	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3305	96	None	-	6	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	392622	56282	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56282	95	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	2995	204382	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204382	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204382	53	None	-	23	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	3947	206372	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL87708	206372	53	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	212	3777	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL3039583	210926	0	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
	60065	84340	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2218858	84340	6	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	3081361	93905	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93905	123	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	107771	120222	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120222	49	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	3151	1450	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1450	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1450	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1450	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1450	97	None	-	27	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3949	100586	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100586	50	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	2435	3563	83	None	-	49	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3563	83	None	-	49	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3563	83	None	-	49	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3563	83	None	-	49	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3563	83	None	-	49	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	25181577	78190	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2105695	78190	56	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	2318	154832	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	2407	3347	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3347	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3347	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3347	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3347	76	None	-	7	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	3380	22758	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
	CHEMBL13280	22758	34	None	-	1	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
	2202	3110	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3110	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3110	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3110	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3110	96	None	-	21	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4495	196512	92	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56367	196512	92	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	10.1038/s41467-023-40064-9
	9801	91556	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL24072	91556	35	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	6729	14453	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201271	14453	41	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	432	5	0	2	6.5	CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1	10.1038/s41467-023-40064-9
	1016	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2561	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2733526	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	5384	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL83	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	DB00675	3720	78	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	9915743	63512	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL180022	63512	93	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	556	11	2	8	5.9	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C	10.1038/s41467-023-40064-9
	275196	125647	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	CHEMBL364713	125647	52	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	26987	946	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-	21	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	11980903	14460	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14460	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14460	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14460	19	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	25077405	2696	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	3902	2696	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL1201309	2696	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB00666	2696	0	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	102	4096	48	None	-	50	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-	50	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-	50	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-	50	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-	50	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	4034	55792	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-	1	Human	4.4	pAC50	=	4.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	5328940	100188	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100188	107	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	10531	1408	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-	24	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	118422671	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2737	65	None	-	4	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	30323	62455	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL1563	62455	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL178	62455	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	10096344	89565	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
	CHEMBL237500	89565	85	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	10	1.1	CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C	10.1038/s41467-023-40064-9
	216416	111554	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	319	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1312	44	None	-	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	3149	12582	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	4746	204868	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204868	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204868	31	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	65709	59851	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1729803	59851	39	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	11643449	89926	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
	CHEMBL238071	89926	3	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	753	6	5	10	2.7	CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1	10.1038/s41467-023-40064-9
	2448	99295	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99295	70	None	-	18	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	4452	2742	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2742	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2742	19	None	-	19	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	176	397	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157	397	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2566	397	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	CHEMBL633	397	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	DB01118	397	66	None	-	31	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	1222	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	72093	35031	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	42890	9393	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	CHEMBL1117	9393	59	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	1164	1617	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	1626	1617	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	3345	1617	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL596	1617	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	DB00813	1617	26	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	2247	504	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-	42	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	5482	14388	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14388	80	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	1385580	29245	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29245	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29245	76	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16722836	18953	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL1287853	18953	99	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	524	10	3	8	4.8	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1	10.1038/s41467-023-40064-9
	2794	19348	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1292	19348	85	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	3883	183511	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL480	183511	112	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GHSR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	369	5	1	4	3.5	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1	10.1038/s41467-023-40064-9
	178024	1958	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	5867	1958	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	CHEMBL13817	1958	33	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	22867441	10283	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10283	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	67457995	91804	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	CHEMBL2413152	91804	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	22867441	10283	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10283	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	71716660	85973	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85973	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	139250	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	139250	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	71716660	85973	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85973	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	139250	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	139250	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	9807597	182993	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL47938	182993	5	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10323604	10277	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10277	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10323604	10277	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10277	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411920	77849	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77849	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	162662316	181499	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	CHEMBL4765101	181499	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	90666017	109273	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	109273	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44411920	77849	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77849	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	10625750	168130	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	168130	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10625750	168130	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	168130	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10626337	101198	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	101198	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411718	10274	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161825	10274	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44293557	101061	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL294923	101061	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL540001	101061	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	16040587	179360	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	CHEMBL473921	179360	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	16040587	179360	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL473921	179360	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	16752689	188344	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	CHEMBL501315	188344	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	9890375	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	9890375	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	98242	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162745	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10745533	140095	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	140095	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10745533	140095	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	140095	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411745	10276	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10276	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	10626337	101198	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	101198	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411634	10273	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10273	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411634	10273	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10273	1	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411745	10276	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10276	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411753	10278	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10278	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411753	10278	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10278	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44293091	188162	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	188162	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	44293091	188162	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	188162	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	46905972	10377	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10377	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77715	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77715	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	99221	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	99221	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	141185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	141185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	208905	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	216208	9695	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	CHEMBL113313	9695	33	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	46905972	10377	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10377	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77715	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77715	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	99221	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	99221	17	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	141185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	141185	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	208905	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	15481185	77232	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	77232	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	15481185	77232	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	77232	1	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	44411584	10271	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10271	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411584	10271	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10271	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	22862436	10282	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10282	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	138164	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	138164	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	139511	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	139511	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	169260	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	169260	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	22862436	10282	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10282	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	138164	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	138164	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	139511	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	139511	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	169260	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	169260	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411632	10272	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10272	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411632	10272	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10272	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	23529194	102164	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	CHEMBL302810	102164	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	16041292	183587	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL480219	183587	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44411913	10281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411913	10281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411905	10280	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10280	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	101214	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	101214	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	44411905	10280	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10280	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	101214	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	101214	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10600702	141311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	141311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10600702	141311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	141311	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL335799	211541	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmc.2013.06.006
	44411720	10275	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10275	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10279	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10279	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411720	10275	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10275	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10279	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10279	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44390849	62885	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL178475	62885	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	25227441	113416	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319217	113416	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL501253	214110	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	44582528	193392	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	91935097	193392	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL525994	193392	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL2310891	209472	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	90665845	109245	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218645	109245	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL500468	214092	0	None	-	1	Human	9.9	pIC50	=	9.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.042
	57422686	113420	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319221	113420	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310888	209470	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C	10.1021/jm0001727
	11340044	141310	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	141310	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44336274	108543	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	CHEMBL320289	108543	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	122180027	121562	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121562	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	118709502	113445	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319398	113445	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390862	63837	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180349	63837	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	16133832	213308	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL425281	213308	18	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL500468	214092	0	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	90665847	109247	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218647	109247	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	122182190	121983	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121983	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422687	113421	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319222	113421	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16114292	96905	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96905	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114292	96905	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96905	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11225576	166013	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	166013	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122182047	121976	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121976	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	11225576	166013	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	166013	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25260749	113419	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319220	113419	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	57422792	113444	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319397	113444	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422692	113418	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319219	113418	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL500468	214092	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	122182043	121972	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121972	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	118709506	113455	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319407	113455	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	178024	1958	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	5867	1958	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	CHEMBL13817	1958	33	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	11431274	77315	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	77315	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11410373	138510	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	138510	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	44582531	188698	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	91935100	188698	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL504776	188698	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122182046	121975	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121975	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260745	113448	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319400	113448	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	122182190	121983	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121983	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422768	113427	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	CHEMBL3319228	113427	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	16114096	79131	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	79131	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	178024	1958	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	5867	1958	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	CHEMBL13817	1958	33	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	57422690	113426	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319227	113426	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	118709503	113446	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319399	113446	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	66788278	125166	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645254	125166	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	16114292	96905	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96905	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	44436850	91520	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91520	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	57422793	113443	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	CHEMBL3319396	113443	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	178024	1958	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1958	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1958	33	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	57422688	113424	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319225	113424	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57785733	113423	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319224	113423	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16113245	121308	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	121308	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	44445600	154764	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL400175	154764	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL437713	213708	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm020424z
	178024	1958	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1958	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1958	33	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL412799	213002	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(N)=O)C(C)C	10.1021/jm0001727
	57422817	113422	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319223	113422	18	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	11476589	75959	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75959	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL526723	215674	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44436857	145631	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145631	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	90666039	109295	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218912	109295	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	118709505	113454	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319406	113454	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310887	209469	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCC(CCC)C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122180026	121561	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121561	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121972	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121972	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL2310890	209471	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		C/C=C/C=C/C=C/C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44409536	75480	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75480	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44445595	94374	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL250974	94374	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90665850	109250	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218650	109250	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	90665851	109251	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218651	109251	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11134880	99403	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	99403	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	5866	3597	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	9804743	3597	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	CHEMBL360227	3597	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	11712151	75964	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75964	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942098	125167	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645255	125167	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	25261382	113414	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319215	113414	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422789	113428	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319229	113428	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	56942244	125171	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645259	125171	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	90665846	109246	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218646	109246	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11339816	75978	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75978	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409756	76738	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76738	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666012	109268	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218885	109268	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666031	109287	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218904	109287	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44390840	123530	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL361804	123530	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	90666017	109273	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	109273	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666027	109283	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218900	109283	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	44445594	154618	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399447	154618	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666013	109269	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218886	109269	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44445599	94155	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249639	94155	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44446187	94592	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94592	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	178024	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	23648244	91985	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91985	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	44409776	77114	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	77114	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178616	121326	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	121326	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	16113471	84692	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL222789	84692	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	156021766	178103	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178103	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145959787	162261	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145953855	162491	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162491	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	16113585	137210	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL375161	137210	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	145958774	162242	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162242	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	156016073	177631	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4641503	177631	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	162646061	179507	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	CHEMBL4741413	179507	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	70692600	75845	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75845	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2310886	209468	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCNC(=O)CCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	156021766	178103	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	178103	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445601	94156	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249640	94156	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	44390901	64049	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180755	64049	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	145959787	162261	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	70694648	75843	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75843	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	44445591	154617	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399446	154617	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113468	141775	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL386218	141775	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16113468	141775	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141775	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	46882103	5922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079872	5922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	72190450	92246	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426679	92246	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	11441978	130429	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL368034	130429	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL2310894	209474	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)c1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm0001727
	122180017	121552	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121552	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44445592	94154	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249638	94154	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113577	84907	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84907	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	16113902	137651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375859	137651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666041	109297	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218914	109297	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	16113902	137651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137651	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	15945877	146914	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392593	146914	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	11337482	76611	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76611	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	44409775	75996	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75996	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121983	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121983	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44445620	154654	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154654	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	11676995	66132	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	66132	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	16203930	84306	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL221674	84306	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	11537683	75498	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75498	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	122180020	121555	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121555	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44338247	7895	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109035	7895	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	44445622	154655	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399653	154655	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	59446139	81572	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163449	81572	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436812	91735	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241033	91735	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11731384	162696	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162696	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	44390888	64386	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181312	64386	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	60195112	81577	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163466	81577	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2370788	209898	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	16113904	137011	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374655	137011	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90665852	109252	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218652	109252	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666032	109288	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218905	109288	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113904	137011	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	137011	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500703	214097	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	10415364	126741	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126741	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	53390181	92242	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426675	92242	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	145957075	162255	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162255	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162638	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162638	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162669	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162669	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	145951150	162752	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162752	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	11328064	160288	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL411055	160288	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	44445607	166706	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL428314	166706	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113581	85108	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL224921	85108	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	90666022	109278	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218895	109278	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666028	109284	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218901	109284	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	70682036	75849	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75849	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	16113796	84652	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84652	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	57422697	113434	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319276	113434	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL499371	214072	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	59446101	81587	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163477	81587	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446101	81587	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163477	81587	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389262	122006	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	122006	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	16113796	84652	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222518	84652	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11576960	67085	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	67085	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11124146	99125	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	99125	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	122178600	121310	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	121310	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	44409679	75479	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75479	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	9745	2437	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2437	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2437	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2437	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113579	84908	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL223726	84908	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL3578015	211743	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145954311	162462	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162462	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578015	211743	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11373823	78474	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211188	78474	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	145954311	162462	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	162462	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44301389	11243	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11243	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11243	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	46882236	5740	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078608	5740	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114514	79129	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	79129	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	11523411	75526	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75526	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	57422730	113411	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319212	113411	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	46882763	5596	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5596	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44576247	214199	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	214199	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145951150	162752	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162752	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL433540	213619	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020424z
	1744826	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	CHEMBL178668	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	1744826	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	122178603	121313	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	121313	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	16114009	137169	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374921	137169	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	23648246	161764	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL414132	161764	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	11655578	170009	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	170009	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62968	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	156021336	178143	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4649089	178143	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44446190	94527	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94527	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44389167	123832	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123832	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338240	109112	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL321403	109112	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	11539587	67047	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	67047	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11503585	65174	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	65174	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	23656300	148742	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL394054	148742	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	59446107	81590	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163480	81590	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446107	81590	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163480	81590	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436807	148287	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL393692	148287	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	46882237	5748	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078677	5748	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44395002	66156	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	66156	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	44445627	154916	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401084	154916	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113906	137198	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	137198	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	70692601	75846	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75846	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	145957075	162255	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	162255	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162638	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162638	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162669	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162669	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	46882271	5777	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078899	5777	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156018364	177889	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177889	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445624	154882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400879	154882	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203238	137084	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	137084	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	16113694	137168	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374920	137168	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16114181	141915	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL387109	141915	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44446137	155393	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403682	155393	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	122180017	121552	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121552	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44379072	12766	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188124	12766	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL535353	12766	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	16113905	84668	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222622	84668	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11626181	124355	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	124355	2	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	42624369	188839	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582535	188839	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935102	188839	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506930	188839	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	16113691	136694	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136694	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	90666023	109279	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218896	109279	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113691	136694	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136694	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	57422696	113451	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319403	113451	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	156012849	177274	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177274	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390860	63614	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180096	63614	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	73347725	92241	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426674	92241	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	156012849	177274	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	177274	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	177557	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177557	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156018364	177889	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177889	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145949595	162700	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162700	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	1100	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	6918297	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	CHEMBL108335	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	11539588	66883	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66883	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	122180015	121550	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121550	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178615	121278	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	121278	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	16113798	84304	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221662	84304	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	16113797	138112	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL376735	138112	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	16113903	168353	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL434573	168353	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	44338241	6509	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL108287	6509	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	44410012	138374	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	138374	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113122	148144	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393565	148144	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	11556937	81593	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163484	81593	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556937	81593	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163484	81593	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	9956908	13064	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190326	13064	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540604	13064	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11329138	64430	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64430	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	90665848	109248	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218648	109248	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	23648245	91986	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241776	91986	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	145949595	162700	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162700	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	11846625	77855	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77855	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	44409683	76230	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	76230	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882305	5796	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079091	5796	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11124146	99125	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	99125	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	56942855	125173	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	CHEMBL3645261	125173	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	11016748	98322	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	98322	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44445602	94157	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249659	94157	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	11256439	75350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	44390881	66073	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL183916	66073	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44338151	109722	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL323026	109722	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	46882238	5751	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078699	5751	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446133	175010	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567432	175010	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195284	81581	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163471	81581	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394930	66302	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	66302	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11016748	98322	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	98322	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	59446115	174286	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4550305	174286	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195379	81585	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163475	81585	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	46882155	5676	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078114	5676	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11145720	67310	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	CHEMBL18853	67310	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	11846628	77683	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL208930	77683	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	156015928	177557	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	177557	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16114012	168375	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL434738	168375	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180018	121553	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121553	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113582	136614	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL373995	136614	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	46882807	5732	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078533	5732	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114184	150467	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	CHEMBL395441	150467	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	44446188	155367	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	155367	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	44436817	166745	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL428383	166745	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445618	161874	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415134	161874	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44436887	90930	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90930	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10907396	99122	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	99122	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11649239	66310	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	66310	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	1100	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	6918297	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	CHEMBL108335	1595	45	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	16113580	137854	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137854	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	16113580	137854	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137854	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44436883	146128	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	146128	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	44436889	153033	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	153033	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11452801	139273	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	139273	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44445625	154795	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400381	154795	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	122180019	121554	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121554	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	145957443	162065	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	162065	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	10864048	98360	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	98360	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44389187	63992	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL180722	63992	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409871	75367	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75367	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145959007	162233	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162233	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145956659	162031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145959787	162261	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16113248	79135	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	79135	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11282247	165902	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165902	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11282247	165902	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165902	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409802	76715	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76715	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156019457	177918	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177918	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	216208	9695	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9695	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	90666037	109293	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218910	109293	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	23648236	79123	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	79123	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	44383343	120316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	CHEMBL353007	120316	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	156014693	177168	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4635089	177168	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44389151	62475	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62475	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409979	140534	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140534	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44395020	124006	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	124006	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	16114530	84711	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222912	84711	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	59446130	81589	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163479	81589	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446130	81589	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163479	81589	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409761	75837	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75837	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145956659	162031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	162031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145957443	162065	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	162065	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145959007	162233	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	162233	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	162261	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	162261	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11328920	144017	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	CHEMBL390308	144017	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	122178606	121316	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	121316	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	121320	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	121320	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	178024	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1958	33	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	44409821	76008	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	76008	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882307	5798	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079108	5798	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121973	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121973	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	5866	3597	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	9804743	3597	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL360227	3597	4	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL500468	214092	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	CHEMBL500468	214092	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	11683469	76677	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76677	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	11454617	141294	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	141294	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	90666029	109285	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218902	109285	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44409672	140462	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	140462	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11154823	76000	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	76000	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11190594	75956	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75956	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75958	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75958	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	25260900	113450	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319402	113450	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	10918326	98944	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98944	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	44378981	13938	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1196773	13938	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL558181	13938	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	90666033	109289	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218906	109289	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113472	168982	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL439251	168982	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	66813470	76803	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	CHEMBL2069411	76803	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	122180022	121557	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121557	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	70694649	75855	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75855	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	10100708	12002	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	12002	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	12002	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	11577349	65201	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	65201	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	16114098	141586	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141586	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11327400	75343	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75343	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409455	75939	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75939	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	156019457	177918	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177918	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882306	5797	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079107	5797	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11731384	162696	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162696	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	118709470	113432	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319274	113432	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL507636	214410	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	156021885	178191	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4649741	178191	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	70688404	75838	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75838	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	11114279	98221	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	98221	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	70688404	75838	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048807	75838	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	16113693	137991	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137991	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	216208	9695	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9695	33	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	11827047	99192	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	99192	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	9745	2437	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2437	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2437	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2437	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113124	121309	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	121309	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44445605	154957	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401260	154957	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113578	137167	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374919	137167	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16113584	137569	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	CHEMBL375568	137569	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	44389168	64843	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64843	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	11314908	141787	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL386290	141787	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	11846627	79695	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL211581	79695	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	10929048	68778	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68778	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	90666020	109276	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218893	109276	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16114403	147162	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392805	147162	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	57422673	113439	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319282	113439	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	70684154	75840	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75840	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	122180020	121555	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121555	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113710	79132	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	79132	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	122178611	121322	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	121322	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	122178614	121325	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	121325	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	16114531	84646	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222498	84646	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	145974293	163000	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163000	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882197	5710	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078403	5710	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409980	76151	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205790	76151	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145952740	162477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	44409868	76713	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76713	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156017532	177884	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177884	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11605822	124362	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	124362	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	162651761	180185	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4749698	180185	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	70686292	75851	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75851	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	10186158	98414	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	98414	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	122178602	121312	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	121312	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3586019	211778	6	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122180025	121560	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121560	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	156017532	177884	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177884	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145952740	162477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	162477	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	145974293	163000	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	163000	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436881	91559	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	CHEMBL240746	91559	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	122182189	121982	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121982	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122180016	121551	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121551	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	46882199	5729	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078498	5729	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44301462	11230	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11230	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11230	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	90666042	109298	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218915	109298	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	25262771	113437	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319280	113437	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	42624370	188813	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582537	188813	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935104	188813	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506624	188813	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44445617	154652	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399649	154652	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11163070	65538	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL183123	65538	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	156012428	177286	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4636832	177286	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	46882766	5640	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077839	5640	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44436813	147282	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL392902	147282	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44410013	77024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	77024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44235473	81588	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163478	81588	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	44235473	81588	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163478	81588	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409839	76229	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	76229	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16114099	137199	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	137199	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113372	79125	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113319	79125	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	46882273	5786	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078982	5786	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121973	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121973	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	121879	2222	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2222	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2222	24	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL2370788	209898	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	145950261	162705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44394974	66982	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66982	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	44445615	161845	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414929	161845	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113370	79130	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL2113323	79130	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	145953016	162563	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162563	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	156012445	177311	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177311	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10186158	98414	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	98414	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	11617435	75968	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75968	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	70696689	75853	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75853	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	70694647	75839	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048808	75839	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	56942242	125169	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	CHEMBL3645257	125169	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	122178605	121315	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	121315	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	44445611	154651	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399648	154651	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	122182189	121982	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121982	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	56942385	125172	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645260	125172	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL501261	214112	23	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	56942099	125168	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645256	125168	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	56942243	125170	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	CHEMBL3645258	125170	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	122178608	121319	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	121319	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409673	76721	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76721	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	208445	38	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11690097	76643	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76643	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	57422695	113449	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319401	113449	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	25124566	1861	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	5870	1861	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	CHEMBL3358452	1861	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	156013219	177465	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177465	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	162277	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162277	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	46882805	5792	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079046	5792	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	53390538	92248	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426681	92248	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	178024	1958	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	5867	1958	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	CHEMBL13817	1958	33	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	44445629	161876	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL415136	161876	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16204239	136259	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL373393	136259	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	11508639	76506	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76506	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	216208	9695	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL113313	9695	33	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	11846630	138910	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378438	138910	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156012445	177311	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	177311	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145953016	162563	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162563	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949755	162910	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162910	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	16204241	84399	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL221996	84399	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	11221946	140821	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140821	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	11221946	140821	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140821	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	46882104	5923	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079873	5923	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145956415	162039	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162039	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950261	162705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11654867	76172	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	76172	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	10415364	126741	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126741	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	178024	1958	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1958	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1958	33	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	16114404	154873	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL400814	154873	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	90666014	109270	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218887	109270	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	44436885	146404	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	CHEMBL392191	146404	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	44436829	152454	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397109	152454	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114404	154873	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL400814	154873	24	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	122182047	121976	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121976	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70684155	75856	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75856	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2163483	209302	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163483	209302	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409872	75037	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203581	75037	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445596	154619	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399448	154619	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113692	137211	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	137211	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	118709504	113452	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319404	113452	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	10907396	99122	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	99122	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11677781	125032	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	125032	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	44445606	154990	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401467	154990	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	44379034	12892	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189120	12892	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL538068	12892	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44378986	13063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190325	13063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540603	13063	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11697618	62569	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62569	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145956415	162039	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	162039	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436886	161931	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161931	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	145949755	162910	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162910	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	23648242	79127	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113320	79127	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11606121	64546	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64546	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	122180023	121558	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121558	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	44379301	13028	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190091	13028	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540093	13028	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44338300	167819	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL430882	167819	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44338239	167874	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL431245	167874	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44409762	75857	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75857	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180018	121553	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121553	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122182189	121982	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121982	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	10032659	12019	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	12019	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	12019	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	60195019	81575	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163464	81575	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	156009875	177099	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177099	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11430583	80188	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	80188	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	168314	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	168314	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409975	75761	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75761	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	53391301	92245	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426678	92245	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90666019	109275	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218892	109275	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	11669486	64584	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64584	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	59446141	81591	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163481	81591	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446141	81591	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163481	81591	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436917	90620	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239007	90620	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	60165265	116172	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	CHEMBL3358453	116172	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	16113002	148289	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393693	148289	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	44409678	141192	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	141192	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	121314	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	121314	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	10929048	68778	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68778	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	60195018	81574	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163463	81574	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394913	127147	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	127147	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	11649248	66640	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66640	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44394833	126799	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126799	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	11827047	99192	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	99192	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	42624359	193377	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582536	193377	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935103	193377	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL525751	193377	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	156009875	177099	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	177099	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021942	178199	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178199	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180021	121556	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121556	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11134880	99403	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	99403	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	11846629	138794	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378118	138794	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11114279	98221	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	98221	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	145952396	162979	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162979	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	122178607	121318	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	121318	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	156013219	177465	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	177465	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	162277	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	162277	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	11846463	139217	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	139217	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	9890863	131966	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL369533	131966	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44409864	75470	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75470	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180027	121562	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121562	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	11430392	76695	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76695	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57785737	113415	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319216	113415	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390871	64812	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL182035	64812	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	70682037	75852	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75852	20	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	156021297	178065	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178065	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666040	109296	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218913	109296	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666026	109282	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218899	109282	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	16204021	84678	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL222710	84678	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180014	121549	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121549	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	90666016	109272	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	CHEMBL3218889	109272	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	44389186	64585	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64585	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338266	110306	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	CHEMBL323974	110306	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	70692602	75847	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75847	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	11455251	161290	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	161290	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156021942	178199	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	178199	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16204037	137208	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL375150	137208	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	11582836	62883	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62883	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389131	63432	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL179812	63432	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	122180025	121560	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121560	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	122178612	121323	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	121323	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	16203237	96922	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96922	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	59446148	175025	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567800	175025	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	46882152	5823	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079302	5823	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	11655355	74392	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74392	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145952396	162979	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162979	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	46882764	5599	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077716	5599	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	16114290	137183	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	137183	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666015	109271	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218888	109271	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	44436831	151972	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL396681	151972	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	25262608	113436	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	CHEMBL3319279	113436	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	10918326	98944	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98944	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	16203918	84758	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL223239	84758	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	70696687	75844	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75844	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	46882105	6319	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1082044	6319	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44446189	155350	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	155350	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446157	94623	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252501	94623	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44446148	155394	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL403683	155394	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44410008	141226	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	141226	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	59446143	81571	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163448	81571	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446143	81571	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163448	81571	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	44338221	8016	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109094	8016	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	60195113	81578	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	CHEMBL2163467	81578	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	46882804	5791	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079045	5791	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	10864048	98360	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	98360	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	156016110	177674	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4642043	177674	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	156017268	177626	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177626	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	59446118	174676	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4559602	174676	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195285	81583	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163473	81583	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436868	146058	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391922	146058	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	44394947	169199	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	169199	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	122180022	121557	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121557	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	11751384	141481	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	141481	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122180026	121561	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121561	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121972	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121972	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	16204226	84770	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223323	84770	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	118709472	113435	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	CHEMBL3319277	113435	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	46882196	5709	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078402	5709	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44379303	12807	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188529	12807	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536706	12807	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL2310893	209473	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44445614	169285	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL441567	169285	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44445598	94347	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL250807	94347	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145949381	162691	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162691	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44436832	151974	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL396682	151974	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445626	97037	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL267197	97037	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666025	109281	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218898	109281	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	156012122	177357	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177357	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012122	177357	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	177357	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	178065	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	178065	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666024	109280	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218897	109280	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	57422776	113417	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319218	113417	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	162657463	181016	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4759415	181016	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	44409990	76488	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76488	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180024	121559	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121559	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	44409758	75945	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75945	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121983	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121983	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409684	140860	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140860	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113003	94718	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	CHEMBL253126	94718	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	16113003	94718	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL253126	94718	2	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	122182047	121976	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121976	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	90666030	109286	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218903	109286	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11605333	76696	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76696	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	122182046	121975	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121975	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	11281346	75989	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75989	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145949381	162691	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162691	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16204145	136527	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL373772	136527	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	90666036	109292	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218909	109292	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44338235	109635	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL322499	109635	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	156016392	177622	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177622	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177626	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177626	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145958317	162289	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162289	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949880	162767	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162767	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950963	162782	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162782	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156016392	177622	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177622	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445608	154991	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401468	154991	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	59446116	81569	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163439	81569	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	23631387	93237	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL244936	93237	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666038	109294	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218911	109294	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	44421230	84762	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223269	84762	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	156018460	177853	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4644587	177853	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	145950963	162782	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162782	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11618705	166914	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166914	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44436842	146913	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392592	146913	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL509976	215557	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL450217	213940	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrsDisplacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrs	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300414b
	CHEMBL450217	213940	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1074/jbc.m609796200
	10984270	98479	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98479	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44436884	91523	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91523	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL444131	213906	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	60195020	81576	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163465	81576	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446112	172950	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4517723	172950	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL422461	213263	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm0001727
	16114010	136258	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL373392	136258	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16203349	166266	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL427076	166266	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11531313	62474	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62474	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389283	62915	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62915	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	122180019	121554	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121554	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL447282	213926	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm8014519
	145958317	162289	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	162289	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114008	84817	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84817	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	16112910	136352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL373507	136352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16112910	136352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL373507	136352	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44436882	145991	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145991	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	145949880	162767	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162767	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	122180024	121559	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121559	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	46882154	5829	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079323	5829	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446145	81570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163444	81570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446145	81570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163444	81570	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	11699004	66173	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	66173	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11537800	75538	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75538	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	16203236	166238	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	CHEMBL426905	166238	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	10207327	67041	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	67041	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	44445603	154956	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401259	154956	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL502208	214127	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	16113583	161727	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL413856	161727	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	90665849	109249	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218649	109249	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	70696688	75850	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75850	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	44436816	91776	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91776	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10984270	98479	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98479	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44301387	11232	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11232	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11232	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	11692087	62962	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62962	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	122178610	121321	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	121321	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	16113695	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	CHEMBL374643	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	16113695	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374643	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113695	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	16113695	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	CHEMBL374643	137002	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	44436888	153032	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397593	153032	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11692087	62962	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62962	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409809	75036	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	75036	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165802	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165802	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	208445	38	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	90666018	109274	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218891	109274	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	11612155	140984	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140984	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	118722878	116171	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	CHEMBL3358451	116171	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	16114097	79128	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	79128	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	122182189	121982	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121982	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260901	113453	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319405	113453	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	122180021	121556	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121556	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11179347	77324	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	77324	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445593	154763	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400174	154763	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203569	141708	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL385803	141708	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	90666034	109290	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218907	109290	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL449590	213939	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	121879	2222	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2222	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2222	24	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	11568561	169530	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	169530	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	44338246	98826	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL278909	98826	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL105462	208445	38	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(99)00584-3
	44409767	157218	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL407647	157218	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445612	97011	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	CHEMBL266964	97011	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	44410003	76152	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	76152	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16203569	141708	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141708	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL18872	209035	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(C)(C)N)C(N)=O	10.1021/jm300557t
	46882106	5830	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079340	5830	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	44436876	146994	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146994	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	121879	2222	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2222	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2222	24	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	156010733	177056	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177056	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145962494	162050	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	162050	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950201	162918	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162918	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44409832	76381	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76381	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16204237	84868	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223638	84868	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16204343	137166	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	CHEMBL374918	137166	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	122178613	121324	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	121324	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	57422749	113412	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319213	113412	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44410007	76398	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76398	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	118718706	115353	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	115353	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	89768546	148993	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	CHEMBL3942511	148993	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	16114011	138113	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	138113	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	11349789	78744	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78744	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	16112909	144256	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL390503	144256	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44378837	12989	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189851	12989	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL539575	12989	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44445597	94487	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL251640	94487	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11176805	77305	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	77305	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	156010733	177056	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	177056	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882153	5828	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079322	5828	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145950201	162918	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162918	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882239	5752	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078700	5752	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	1221269	122008	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	122008	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44446177	94618	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94618	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114289	98637	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98637	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	11538533	74972	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74972	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	10415364	126741	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126741	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL263544	210552	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O	10.1021/jm0001727
	122180023	121558	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121558	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	118709507	113456	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319408	113456	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	90666011	109267	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218884	109267	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	11538533	74972	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74972	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409998	138511	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	138511	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666021	109277	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218894	109277	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11453509	76149	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	76149	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445610	161699	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL413608	161699	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	23648249	79133	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	79133	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	11178309	79872	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79872	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL3578018	211746	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	211746	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44445613	94158	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	CHEMBL249662	94158	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	16204229	84288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221569	84288	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44409867	76712	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206672	76712	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145962494	162050	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	162050	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44389215	63048	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	63048	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11211892	80187	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	80187	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122180015	121550	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121550	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	59446138	81592	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163482	81592	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446138	81592	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163482	81592	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446127	173012	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4518972	173012	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195286	81584	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163474	81584	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	10207327	67041	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	67041	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	16112911	84700	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL222835	84700	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	5311280	81580	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163470	81580	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389243	64553	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64553	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	23648232	91214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL240179	91214	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	44445616	161846	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414930	161846	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	118709471	113433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319275	113433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	44390889	64393	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181313	64393	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	46882270	5785	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078960	5785	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156016696	177606	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177606	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578016	211744	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL2163348	209301	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163348	209301	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	16113800	137787	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137787	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL3578016	211744	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156013130	177478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016696	177606	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177606	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145950877	162971	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162971	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44358041	161307	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	91931457	161307	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL412565	161307	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	57422810	177637	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	CHEMBL4641579	177637	4	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	16113246	94648	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94648	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	11846624	77887	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77887	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	46882272	5778	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078900	5778	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	9987037	12000	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	12000	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	12000	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56942537	125174	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	CHEMBL3645262	125174	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	57422761	113413	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319214	113413	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422760	113410	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319211	113410	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422791	113425	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319226	113425	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	44445619	154653	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399650	154653	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113469	137477	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL375408	137477	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	122182045	121974	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121974	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	44446175	94958	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL254741	94958	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	10994861	67241	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL18815	67241	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	10984260	168329	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	CHEMBL434391	168329	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	59446135	81586	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163476	81586	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446135	81586	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163476	81586	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	59446154	81573	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	CHEMBL2163453	81573	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	59446154	81573	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	CHEMBL2163453	81573	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	44446178	155099	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	155099	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	753168	123213	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	123213	40	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338253	9255	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL110900	9255	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44301512	11990	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11990	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11990	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113799	168689	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168689	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11166495	75521	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75521	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	25262772	113438	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319281	113438	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390869	122316	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL359922	122316	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	156013130	177478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	177478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180014	121549	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121549	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178601	121311	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	121311	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	16202767	84967	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL223810	84967	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	46882156	5677	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078115	5677	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16113474	136608	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL373993	136608	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	59446105	172797	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4514053	172797	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556936	81582	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163472	81582	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	60195114	81579	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	CHEMBL2163468	81579	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	70690449	75842	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75842	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	70692603	75848	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75848	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	44389192	168622	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168622	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	44394982	66108	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	66108	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL335799	211541	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm0001727
	CHEMBL61663	215816	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	44445628	161875	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415135	161875	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145950877	162971	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162971	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	11663710	124441	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	124441	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	16113371	79124	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	79124	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	16113371	79124	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113318	79124	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11713497	123211	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	123211	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	122182045	121974	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121974	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	11646276	75905	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75905	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122182046	121975	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121975	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	44436828	91971	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241664	91971	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL410108	212776	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	11538533	74972	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74972	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL500468	214092	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	11538534	74985	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74985	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	122182047	121976	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121976	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70686293	75854	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75854	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	122180016	121551	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121551	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44389216	123828	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123828	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	44389248	122142	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	122142	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145958774	162242	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	162242	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44445609	97010	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL266961	97010	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16114532	84667	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222610	84667	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	23648250	79134	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	79134	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	44409764	77120	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	77120	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44378979	12812	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188586	12812	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536779	12812	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11197	1061	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	154699458	1061	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL4632411	1061	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL498956	214065	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm8014519
	46882198	5728	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078497	5728	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL3578017	211745	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578017	211745	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145953855	162491	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	162491	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	90666035	109291	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218908	109291	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	328912	62546	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62546	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	178024	1958	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	5867	1958	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	CHEMBL13817	1958	33	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	57398340	71247	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956993	71247	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57400002	71248	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956994	71248	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57394881	71264	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957010	71264	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57393073	71255	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957001	71255	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926461	69007	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	69007	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	69008	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	69008	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926680	69021	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923623	69021	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926682	69023	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923625	69023	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11664206	69024	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	69024	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926893	69034	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	69034	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	11526745	69039	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	69039	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137202	142801	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142801	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	143112	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	143112	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133352	143480	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	143480	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	11527086	144025	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903118	144025	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11512561	144344	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	144344	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144542	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144542	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132670	144589	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907891	144589	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132152	144907	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144907	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142839	145361	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	145361	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142553	145422	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3914259	145422	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143635	145549	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145549	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143096	145908	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918009	145908	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134142204	145912	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145912	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	146166	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	146166	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139279	146422	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	146422	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134138445	147352	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929593	147352	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138218	147985	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934367	147985	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148686	148147	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3935670	148147	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149719	148663	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	CHEMBL3939872	148663	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	134145791	148762	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148762	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134143746	150576	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3955179	150576	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	134145221	150608	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955437	150608	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155656	151170	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959816	151170	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	151318	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	151318	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153496	152261	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969367	152261	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153654	152742	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973513	152742	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157569	154012	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3984338	154012	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57345600	71244	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956990	71244	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57345599	71245	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956991	71245	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398341	71253	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956999	71253	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	178024	1958	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	5867	1958	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	CHEMBL13817	1958	33	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	57398342	71261	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957007	71261	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401803	71263	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957009	71263	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401799	71254	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957000	71254	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57399248	69015	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	69015	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	44340008	113361	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL331801	113361	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57399248	69015	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	69015	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24970113	69027	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	69027	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	57391293	71251	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956997	71251	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162659411	181201	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761419	181201	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	44340268	110494	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL325062	110494	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57401800	71257	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957003	71257	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162657606	181093	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	181093	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401801	71259	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957005	71259	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162672839	182998	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182998	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	214092	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	56942242	125169	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	125169	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	56925343	69037	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	69037	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57398339	71246	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956992	71246	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162645413	179702	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179702	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172933	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172933	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	16133832	213308	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	213308	18	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	162653781	180458	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	180458	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401802	71260	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957006	71260	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401797	71240	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956987	71240	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398343	71262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957008	71262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926175	68984	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68984	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926360	69006	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923608	69006	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926582	69014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923616	69014	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926681	69022	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923624	69022	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926891	69032	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923635	69032	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	69033	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	69033	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926894	69035	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	69035	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	56925345	69040	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923643	69040	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134130631	142348	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	142348	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134131442	142371	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3889678	142371	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134131183	142443	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	142443	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134136433	142482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890602	142482	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137008	142518	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890889	142518	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137012	142577	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3891381	142577	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137398	142851	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893476	142851	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134136665	142874	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	CHEMBL3893697	142874	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	134133488	143211	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	143211	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134248	143326	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3897510	143326	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134556	143327	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3897527	143327	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133518	143428	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	143428	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134134286	143669	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143669	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135296	143986	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902856	143986	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144636	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144636	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132137	144788	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3909431	144788	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	134132893	144838	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144838	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	24969783	144839	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	CHEMBL3909838	144839	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	130334810	145135	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	CHEMBL3912211	145135	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	134132394	145159	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912375	145159	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	145262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	145262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	145301	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	145301	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	59778970	145350	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913763	145350	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143366	145735	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145735	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	117812386	145833	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3917385	145833	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139489	146037	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3919021	146037	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	146348	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	146348	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140007	146379	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3921750	146379	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139286	146529	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146529	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139113	146628	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	CHEMBL3923633	146628	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	134141159	146704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140968	146765	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3924635	146765	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	134141782	146969	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3926434	146969	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	147093	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	147093	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134138234	147388	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929852	147388	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	117812380	147727	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147727	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147730	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147730	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	148330	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	148330	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	148429	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	148429	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134149306	148450	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	148450	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134149407	148496	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938452	148496	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148639	148519	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	CHEMBL3938683	148519	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	134146570	148756	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148756	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145552	148995	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	CHEMBL3942528	148995	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	134145564	149066	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	149066	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	72574018	149080	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943159	149080	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134146319	149102	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943294	149102	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147809	149425	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3946007	149425	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147441	149465	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	149465	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134146888	149739	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948268	149739	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147381	149761	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948472	149761	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147802	150067	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3950904	150067	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145064	150126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951476	150126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144205	150250	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952596	150250	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144429	150262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952699	150262	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144211	150307	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953033	150307	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144606	150311	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953053	150311	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134155024	150988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155239	150990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	151068	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	151068	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155178	151355	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3961456	151355	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	134150646	151622	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963865	151622	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150029	152091	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	152091	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150729	152132	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3968175	152132	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154254	152275	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969506	152275	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154486	152418	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3970827	152418	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134154392	152508	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3971540	152508	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152696	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152696	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134153772	152875	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3974701	152875	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	52911621	153037	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3975975	153037	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134151758	153080	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3976294	153080	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152984	153144	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3976853	153144	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134151899	153295	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	153295	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134152339	153435	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979468	153435	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152133	153499	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979911	153499	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157813	153648	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981238	153648	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134156963	153834	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3982825	153834	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528321	153933	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	CHEMBL3983626	153933	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	134156579	154030	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3984464	154030	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134156405	154238	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	CHEMBL3986375	154238	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	134156453	154276	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3986628	154276	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56942098	125167	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	125167	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162646324	179712	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179712	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	162665018	182111	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782214	182111	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	58438451	92256	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426689	92256	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90644553	111708	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287214	111708	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	56926177	68986	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923506	68986	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926268	68988	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	CHEMBL1923510	68988	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	56926269	68989	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL1923511	68989	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	56926356	68990	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68990	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926465	69011	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL1923613	69011	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	56926782	69028	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	69028	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926784	69030	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923633	69030	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	69031	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	69031	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	71452183	83500	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	CHEMBL2203623	83500	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	134131439	142370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	CHEMBL3889672	142370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	134137460	142610	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3891657	142610	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134136637	142695	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	CHEMBL3892319	142695	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	134136946	142729	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3892517	142729	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134136405	142894	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893850	142894	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134133771	143316	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL3897387	143316	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	134133353	143494	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	CHEMBL3898864	143494	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	134134505	143643	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900035	143643	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134605	143652	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900122	143652	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134099	143706	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900636	143706	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135897	143969	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902804	143969	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134825	144054	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903351	144054	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	72989837	144090	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	CHEMBL3903647	144090	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	134135712	144113	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	144113	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	134136025	144307	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3905495	144307	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134134870	144367	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	144367	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135261	144460	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	CHEMBL3906788	144460	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	134134893	144486	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3907031	144486	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134132666	144540	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907480	144540	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132519	144624	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908156	144624	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132427	144676	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908583	144676	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134131971	144903	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3910288	144903	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132265	144946	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144946	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	134131903	145113	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912034	145113	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132099	145185	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3912534	145185	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	134142223	145318	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	CHEMBL3913486	145318	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	134142139	145377	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	CHEMBL3913981	145377	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	76460236	145435	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	145435	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134143044	145448	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3914467	145448	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143657	145711	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3916501	145711	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143398	145909	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918022	145909	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139992	146314	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	CHEMBL3921227	146314	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	134140213	146595	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	CHEMBL3923324	146595	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	134140762	146640	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	CHEMBL3923718	146640	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	134141057	146670	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923918	146670	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134140844	147200	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3928367	147200	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	68186750	147362	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	CHEMBL3929656	147362	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	134138656	147529	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3930811	147529	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134138764	147611	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	CHEMBL3931402	147611	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	134138160	147640	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3931716	147640	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137758	147949	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3934093	147949	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134137945	147961	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	CHEMBL3934184	147961	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	134149048	148052	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	CHEMBL3934901	148052	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	134149058	148110	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	CHEMBL3935422	148110	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	134149451	148141	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3935626	148141	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134148804	148294	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	CHEMBL3936957	148294	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	58012657	148341	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3937314	148341	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134149772	148455	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938132	148455	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149793	148581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	134148754	148675	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	CHEMBL3939993	148675	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	134145258	148778	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940860	148778	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145652	148999	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942543	148999	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145920	149002	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942554	149002	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134146710	149006	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	CHEMBL3942610	149006	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	134145820	149010	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	149010	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134146617	149091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943228	149091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145420	149289	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	CHEMBL3944936	149289	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	134147617	149411	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3945918	149411	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134147244	149422	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3945984	149422	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148131	149674	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3947758	149674	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147387	149793	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948746	149793	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147861	149833	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949023	149833	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	134147972	149914	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3949704	149914	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147412	149942	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3949926	149942	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148083	150088	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	CHEMBL3951110	150088	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	134144491	150117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951362	150117	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143693	150133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951593	150133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145200	150428	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3954124	150428	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134144043	150465	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	CHEMBL3954394	150465	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	134144941	150503	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3954620	150503	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144060	150633	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955632	150633	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155541	151013	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3958657	151013	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134155247	151026	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	CHEMBL3958739	151026	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	117812381	151327	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3961160	151327	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134155292	151378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961641	151378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154704	151386	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961696	151386	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	134152627	151524	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151524	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150950	151581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3963523	151581	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	57528212	151799	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	CHEMBL3965338	151799	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	134150767	151802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3965351	151802	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134150369	151832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3965516	151832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134150388	151901	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3966251	151901	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134150696	152055	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	152055	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	152346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	152346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154369	152370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970414	152370	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153972	152378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3970491	152378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154079	152379	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	152379	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153529	152424	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970856	152424	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134154612	152487	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	CHEMBL3971356	152487	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	134153232	152555	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	CHEMBL3971845	152555	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	134154534	152720	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973254	152720	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154022	152801	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152801	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151581	153184	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3977241	153184	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528347	153188	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3977265	153188	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134152388	153194	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	CHEMBL3977294	153194	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	134151706	153330	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3978455	153330	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134151524	153356	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3978661	153356	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134152209	153378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3978864	153378	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152547	153459	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3979606	153459	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11421086	153542	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	CHEMBL3980276	153542	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	134157913	153607	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3980873	153607	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156625	153627	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153627	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134157438	153724	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981843	153724	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134157625	153737	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981960	153737	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	59834193	154128	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	CHEMBL3985477	154128	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	134156443	154322	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	CHEMBL3986906	154322	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	56926176	68985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923505	68985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926266	68987	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	CHEMBL1923508	68987	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	134133634	143609	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3899825	143609	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57722117	143659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3900193	143659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57722068	143908	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3902231	143908	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	134135595	143939	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902597	143939	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139160	146184	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	CHEMBL3920156	146184	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	134140250	146221	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3920479	146221	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57951693	146252	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3920711	146252	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	134140177	146345	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3921493	146345	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139639	146614	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3923467	146614	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134140216	146619	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923508	146619	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134141155	146703	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3924187	146703	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	134137626	147458	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3930400	147458	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134148332	148257	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3936664	148257	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528213	148460	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3938163	148460	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134149424	148612	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3939431	148612	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	57951672	149570	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3946954	149570	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134147008	149912	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949653	149912	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134155726	150994	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3958492	150994	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	134155844	151064	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3959055	151064	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	57528307	151103	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3959346	151103	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134156186	151326	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961157	151326	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134150525	151540	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	CHEMBL3963236	151540	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	134149894	151810	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3965402	151810	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	134150119	152023	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	CHEMBL3967266	152023	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	134150914	152056	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	CHEMBL3967522	152056	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	57722047	152843	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3974323	152843	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57951687	152848	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3974356	152848	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	57528291	152892	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3974776	152892	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134152485	153152	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3976941	153152	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134151873	153176	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	CHEMBL3977166	153176	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	76556607	153531	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	CHEMBL3980176	153531	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	134157812	153646	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3981235	153646	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156737	153675	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981446	153675	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	134156806	154070	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	CHEMBL3984892	154070	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	134157124	154182	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	CHEMBL3985913	154182	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	11706547	69017	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923619	69017	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	134138625	148006	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	148006	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44434011	147839	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147839	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	70692601	75846	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75846	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046957	139682	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139682	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127046472	139669	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139669	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	56926266	68987	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	CHEMBL1923508	68987	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	73352329	92236	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426669	92236	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70692602	75847	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75847	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	162665974	182211	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4783347	182211	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	44396381	67501	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL189625	67501	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	44396377	66913	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL186647	66913	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	44396269	67326	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	CHEMBL188586	67326	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	56926895	69036	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923639	69036	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56942244	125171	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	125171	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162648546	179854	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745666	179854	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	58438460	111711	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111711	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926356	68990	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68990	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926176	68985	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923505	68985	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	71453390	81814	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81814	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162663952	182128	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782383	182128	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	118725963	117168	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394203	117168	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	44434112	168836	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168836	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	3174463	66738	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185876	66738	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	56926464	69010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	69010	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	118725960	117164	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394199	117164	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162657547	180959	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4758721	180959	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162658148	181124	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760746	181124	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	162662164	181386	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763700	181386	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	127047362	139694	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139694	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	3154000	124244	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	CHEMBL363467	124244	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	162651277	180172	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4749525	180172	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	3180629	67323	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL188582	67323	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	44434016	90164	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	90164	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	72190452	92249	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426682	92249	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	118725964	117169	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394204	117169	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	70692600	75845	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75845	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	70682036	75849	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75849	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	70686293	75854	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75854	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	58438460	111711	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3287217	111711	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	162660604	181195	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	181195	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162671996	182807	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182807	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	25032438	116170	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	CHEMBL3358450	116170	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	11692516	69019	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	69019	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	67407161	92255	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426688	92255	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67410074	111710	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111710	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926782	69028	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923631	69028	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70696687	75844	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75844	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046806	139908	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139908	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127048038	139947	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139947	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44434076	89748	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89748	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	56926463	69009	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	69009	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	11526696	71573	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71573	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71573	17	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	72191051	92233	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426666	92233	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	58438460	111711	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111711	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926783	69029	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	69029	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	162658631	181059	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759983	181059	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	118725958	117163	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394197	117163	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	162659337	181292	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4762631	181292	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	73355325	92238	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426671	92238	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70696688	75850	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75850	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	127048060	139836	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139836	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	56942388	139918	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139918	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162677361	183485	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	183485	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	92244	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	92244	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	44434109	146256	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	146256	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	134139080	147658	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147658	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	44434010	88744	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88744	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127047655	139589	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139589	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	44340007	9282	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL111026	9282	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56925344	69038	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923641	69038	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44434083	90002	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	90002	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44434050	145425	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	145425	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	44396306	67247	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL188173	67247	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	145948725	167473	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	167473	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	57345597	71241	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956988	71241	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56942243	125170	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	125170	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162648837	179814	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179814	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	127048059	139541	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139541	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	11526745	69039	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	69039	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57400003	71250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956996	71250	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155529391	171416	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	171416	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	70690449	75842	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75842	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	118725965	117170	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	CHEMBL3394205	117170	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	44434080	89882	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89882	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	162647450	179847	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745548	179847	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	71456910	81872	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81872	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	3154005	66743	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185887	66743	5	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	70696689	75853	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75853	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	56926681	69022	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923624	69022	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	127047409	139606	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139606	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56926785	69031	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	69031	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75838	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75838	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	44434009	167429	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	167429	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	53248756	61151	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL1765654	61151	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL2170701	209338	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10253999	123767	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL362303	123767	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	127048061	139711	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139711	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	162662593	181946	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780100	181946	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	44579909	186879	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186879	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44434073	89571	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89571	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	70694649	75855	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75855	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	162659161	181367	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	181367	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162652815	180352	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4751674	180352	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170779	209343	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434008	146509	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	146509	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434110	88483	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88483	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44577060	188028	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	188028	0	None	-69	8	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL2170780	209344	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453404	81874	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81874	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	70692603	75848	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75848	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	56926360	69006	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923608	69006	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	72190451	92247	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	92247	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	44579907	187024	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	187024	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	73350846	92237	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426670	92237	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	44576247	214199	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	214199	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	214199	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	214199	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	44579880	186811	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186811	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	118725962	117167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	CHEMBL3394202	117167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	44396384	67378	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	CHEMBL188839	67378	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	44434074	154649	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154649	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	70684155	75856	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75856	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	72191050	92234	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426667	92234	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190449	92243	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426676	92243	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	118725966	117171	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	CHEMBL3394206	117171	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	162675268	183334	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797685	183334	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	3153999	126805	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL365489	126805	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	71451551	81822	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81822	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	72190451	92247	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426680	92247	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190451	92247	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	92247	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	9950632	88677	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88677	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	127046472	139669	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139669	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139674	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798095	139674	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139674	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798095	139674	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	127047523	140038	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	140038	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	71456897	81821	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81821	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162653916	180521	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	180521	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162643920	181756	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181756	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155537651	172292	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	172292	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57391292	71249	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956995	71249	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	57345598	71258	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957004	71258	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	53373577	92253	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426686	92253	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	57391294	71252	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956998	71252	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155526063	171012	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	171012	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	162663004	182025	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4781141	182025	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	155557019	174563	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174563	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	71453489	209345	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	209345	15	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	67405379	92250	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426683	92250	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	25211977	186878	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186878	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	25098836	191434	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	191434	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	127047525	139742	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139742	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162653309	180449	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4752936	180449	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44579756	186799	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186799	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162666964	182486	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4787023	182486	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170693	209330	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434121	89879	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89879	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	56926584	69018	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923620	69018	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434120	89878	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89878	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434007	88546	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88546	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	11541143	69016	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923618	69016	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24969520	69020	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923622	69020	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170694	209331	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926580	69012	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	CHEMBL1923614	69012	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	162653802	180507	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	180507	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	73346226	92235	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426668	92235	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	162674738	183363	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797988	183363	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926177	68986	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923506	68986	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926581	69013	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	CHEMBL1923615	69013	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	71458747	81809	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81809	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	23631116	4081	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	3538	4081	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	CHEMBL243001	4081	23	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	127046956	139932	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139932	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	118725961	117165	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394200	117165	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162663407	182006	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780843	182006	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	56926462	69008	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	69008	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	70695747	73162	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	73162	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	67406334	111707	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111707	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57390496	69026	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69026	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	71453489	209345	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	209345	15	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926269	68989	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	CHEMBL1923511	68989	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	56926784	69030	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923633	69030	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	70688404	75838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75838	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434123	145525	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145525	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	56926582	69014	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923616	69014	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	16114404	154873	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL400814	154873	24	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	25190383	81880	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81880	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	11683187	199909	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	CHEMBL594828	199909	44	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	70684154	75840	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75840	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434055	89276	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	89276	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	56942385	125172	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	125172	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139736	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139736	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	24180592	96984	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96984	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	44434113	88620	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88620	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434051	89386	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	89386	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	118725954	117161	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3394193	117161	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	24969603	69025	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	69025	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	57394882	71265	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957011	71265	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	9876514	9108	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL109980	9108	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	70682037	75852	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048820	75852	20	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	145948708	167472	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	167472	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	67410074	111710	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111710	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926465	69011	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	CHEMBL1923613	69011	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	44434119	89877	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89877	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	70694648	75843	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75843	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	155561671	175640	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175640	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926894	69035	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	69035	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	162672372	183062	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4794448	183062	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	56925345	69040	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923643	69040	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56926464	69010	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923612	69010	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	56942387	139637	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139637	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL105462	208445	38	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm960054c
	56926680	69021	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923623	69021	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162649014	179917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179917	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	162666112	182290	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4784240	182290	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	162676229	183280	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	183280	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426677	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	58438475	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	56926461	69007	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923609	69007	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	118725956	117162	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394195	117162	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	155551597	173925	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173925	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57394797	71256	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957002	71256	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162649450	180030	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	180030	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	58438464	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	58438464	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3043	35	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	67406334	111707	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111707	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57401798	71242	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956989	71242	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	58438475	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	CHEMBL2426677	92244	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	11541319	69041	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	CHEMBL1923644	69041	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	162659375	181327	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763077	181327	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	127046807	139915	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139915	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127047654	139952	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139952	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	121879	2222	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	5868	2222	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	CHEMBL308716	2222	24	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	162665952	182355	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	182355	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	134139753	146011	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	146011	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	162663868	181964	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181964	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926268	68988	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	CHEMBL1923510	68988	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	56926175	68984	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68984	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	23635235	166477	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL427860	166477	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	70686292	75851	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75851	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	90644554	111709	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287215	111709	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	70682037	75852	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75852	20	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	11664206	69024	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	69024	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	216208	9695	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL113313	9695	33	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56926682	69023	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923625	69023	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	67408128	92251	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426684	92251	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	24180646	148158	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	148158	0	None	-1023	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	57390496	69026	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	69026	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL501261	214112	23	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	56926892	69033	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	69033	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434012	89045	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	89045	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	127046473	139755	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139755	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56942099	125168	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	125168	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	66601728	81812	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81812	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162657465	181017	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	181017	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	56926891	69032	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923635	69032	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434015	88462	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88462	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	67407808	92254	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	92254	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	56926173	68983	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68983	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	3153998	67491	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL189561	67491	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	56926893	69034	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	69034	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	66788278	125166	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	125166	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139837	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139837	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162677268	183549	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	183549	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	58438487	92252	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426685	92252	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	67407808	92254	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426687	92254	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67407808	92254	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	92254	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	67406727	117166	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394201	117166	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	162656896	180836	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180836	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44579823	184057	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	184057	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44396320	66787	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	CHEMBL186045	66787	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	162674996	183365	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4798018	183365	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	44434111	146258	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	146258	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9745	2437	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9804938	2437	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	CHEMBL278623	2437	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	DB13074	2437	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9745	2437	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	9804938	2437	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	CHEMBL278623	2437	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	DB13074	2437	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	1102	1309	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1093	1781	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1781	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1781	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1781	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	1100	1595	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	6918297	1595	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	CHEMBL108335	1595	45	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	1099	1773	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1773	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1092	3136	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	134715446	3136	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	2232	3136	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	6918245	3136	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL106593	3136	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	58438464	3043	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3043	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3043	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3043	35	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3043	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3043	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3043	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3043	35	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3043	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3043	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3043	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3043	35	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	12413	3048	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3048	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	12413	3048	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3048	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	23631116	4081	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	3538	4081	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	CHEMBL243001	4081	23	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	1098	1379	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1098	1379	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14763915
	1101	654	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15339248
	10740	1925	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	146170991	1925	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	1092	3136	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	134715446	3136	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	2232	3136	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	6918245	3136	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	CHEMBL106593	3136	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	178024	1958	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1958	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1958	33	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	1099	1773	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1093	1781	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1781	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)