Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL414185 ada1b_human Human No 9.4 EC50 = 0.4 Funct
Effective concentration showing agonistic activity towards Human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells was determined
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL414185 ada1b_human Human No 9.4 EC50 = 0.4 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL414185 ada1b_human Human No 9.4 EC50 = 0.4 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL72441 ada1b_human Human No 9.4 EC50 = 0.4 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
235 4 2 3 1.8 CC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL611 ada1b_human Human Yes 9.3 EC50 = 0.5 Funct
Antagonist activity at alpha-1B adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1B adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_human Human Yes 9.3 EC50 = 0.5 Funct
Antagonist activity at alpha-1B adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1B adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL70751 ada1b_human Human No 9.3 EC50 = 0.5 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
256 4 2 3 2.1 CSC1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL357129 ada1b_human Human No 9.0 EC50 = 1 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL95523 ada1b_human Human No 8.8 EC50 = 1.6 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL155326 ada1b_human Human No 8.8 EC50 = 1.6 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL72768 ada1b_human Human No 8.7 EC50 = 1.9 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
239 4 2 4 1.5 CSC1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL117248 ada1b_human Human No 8.7 EC50 = 2.0 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL279136 ada1b_human Human No 8.0 EC50 = 10 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 1 3 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CO3
CHEMBL327005 ada1b_human Human No 7.0 EC50 = 100 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
243 4 1 4 1.0 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NO3
CHEMBL449284 ada1b_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL449284 ada1b_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL152693 ada1b_human Human No 7.0 EC50 = 112.2 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
271 4 2 3 2.6 CC1=C(SC=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL142387 ada1b_human Human No 7.9 EC50 = 12.6 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NS3
CHEMBL95565 ada1b_human Human No 7.9 EC50 = 12.6 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
274 6 3 3 2.1 CC(C)CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL98016 ada1b_human Human No 6.9 EC50 = 125.9 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
260 5 3 3 1.6 CC(C)NC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL71479 ada1b_human Human No 6.9 EC50 = 141.3 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
267 4 2 4 1.1 CC1=CC(=C(C=C1)S(=O)(=O)C)NCC2=NCCN2
CHEMBL111537 ada1b_rat Rat No 4.9 EC50 = 14125.4 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
319 4 2 4 2.5 CC(C)S(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL109848 ada1b_rat Rat No 4.8 EC50 = 14454.4 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
255 2 2 2 1.9 CC(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL422477 ada1b_human Human No 7.8 EC50 = 15.9 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.2 C1CN=C(N1)COC2=CC=CC=C2C3=CSC=C3
CHEMBL329928 ada1b_human Human No 6.8 EC50 = 158.5 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
247 6 2 4 1.7 CCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL511411 ada1b_human Human No 5.8 EC50 = 1770 Funct
Agonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL511411 ada1b_human Human No 5.8 EC50 = 1770 Funct
Agonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL336161 ada1b_rat Rat No 6.7 EC50 = 186.2 Funct
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleenIn vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL142871 ada1b_human Human No 7.7 EC50 = 20.0 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CS3
CHEMBL18436 ada1b_human Human No 6.7 EC50 = 199.5 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
298 7 2 4 1.9 CCCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL99362 ada1b_human Human Yes 6.7 EC50 = 199.5 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
246 5 3 3 1.1 CCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL421011 ada1b_human Human No 5.7 EC50 = 1995.3 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL421011 ada1b_human Human No 5.7 EC50 = 1995.3 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL421011 ada1b_human Human No 5.7 EC50 = 1995.3 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL108804 ada1b_rat Rat No 6.6 EC50 = 229.1 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
307 3 3 5 1.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=CN=CN3)O
CHEMBL118055 ada1b_human Human Yes 7.6 EC50 = 25.1 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL99559 ada1b_human Human No 7.6 EC50 = 25.1 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
275 8 2 4 2.6 CCCCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL450018 ada1b_human Human No 6.6 EC50 = 251.2 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL97044 ada1b_human Human No 6.6 EC50 = 251.2 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
258 5 3 3 1.3 C1CC1NC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL70691 ada1b_human Human No 8.4 EC50 = 3.6 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
251 5 2 4 1.4 COC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL155327 ada1b_human Human No 8.4 EC50 = 3.7 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL143801 ada1b_human Human No 8.4 EC50 = 4.0 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.3 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CS3
CHEMBL154298 ada1b_human Human No 7.5 EC50 = 30.2 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
252 4 2 3 1.5 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=N3
CHEMBL325745 ada1b_human Human No 6.5 EC50 = 316.2 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
258 6 3 3 2.3 CCCNC(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL17776 ada1b_human Human No 6.5 EC50 = 316.2 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
284 6 2 4 1.5 CCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL109783 ada1b_rat Rat Yes 6.5 EC50 = 316.2 Funct
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleenIn vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL95245 ada1b_human Human Yes 6.5 EC50 = 316.2 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
272 4 2 3 1.4 C1CCN(C1)C(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL109783 ada1b_rat Rat Yes 6.5 EC50 = 320 Funct
Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uM
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL349082 ada1b_human Human No 6.5 EC50 = 338.8 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.5 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CN=C3
CHEMBL2261355 ada1b_rat Rat No 5.4 EC50 = 3801.9 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
305 4 2 4 2.1 CCS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL18069 ada1b_human Human No 7.4 EC50 = 39.8 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
256 4 2 4 0.7 CN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL18256 ada1b_human Human No 7.4 EC50 = 39.8 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.7 CN1C=CN=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL152725 ada1b_human Human No 7.3 EC50 = 46.8 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
255 4 2 3 2.1 CC1=CC=C(O1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL142784 ada1b_human Human No 8.3 EC50 = 5.0 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 1 3 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=COC=C3
CHEMBL17491 ada1b_human Human No 8.3 EC50 = 5.0 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
242 4 3 4 0.7 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=NN3
CHEMBL277375 ada1b_human Human No 8.3 EC50 = 5.0 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL346380 ada1b_human Human No 8.2 EC50 = 5.8 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 3 2.3 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CS3
CHEMBL17856 ada1b_human Human No 7.3 EC50 = 50.1 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C=CC(=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL111554 ada1b_rat Rat No 5.3 EC50 = 5128.6 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL72724 ada1b_human Human No 8.2 EC50 = 6.0 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
289 4 2 6 2.3 CSC1=C(C=C(C=C1)C(F)(F)F)NCC2=NCCN2
CHEMBL306792 ada1b_human Human No 8.2 EC50 = 6.0 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
239 4 2 4 1.5 CSC1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL152155 ada1b_human Human No 8.2 EC50 = 6.3 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
241 4 2 3 1.7 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CO3
CHEMBL256983 ada1b_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL256983 ada1b_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL70634 ada1b_human Human No 7.2 EC50 = 61.7 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
288 4 2 4 1.4 CS(=O)(=O)C1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL13852 ada1b_human Human Yes 7.2 EC50 = 63.1 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL13852 ada1b_human Human Yes 7.2 EC50 = 63.1 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL273316 ada1b_human Human No 7.2 EC50 = 63.1 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
270 5 2 4 1.0 CCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL13852 ada1b_human Human Yes 7.2 EC50 = 63.1 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL13852 ada1b_human Human Yes 7.2 EC50 = 63.1 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL98243 ada1b_human Human No 7.2 EC50 = 63.1 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
275 6 2 4 2.3 CC(C)(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL143973 ada1b_human Human No 6.2 EC50 = 631.0 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
254 4 1 4 0.4 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CN=C3
CHEMBL358685 ada1b_human Human No 6.2 EC50 = 676.1 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 5 1.2 CC1=NC(=NO1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL434074 ada1b_human Human No 7.2 EC50 = 69.2 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
272 4 2 4 2.0 CC1=NC(=CS1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL326702 ada1b_rat Rat No 6.2 EC50 = 691.8 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL468711 ada1b_human Human No 6.1 EC50 = 760 Funct
Agonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL468711 ada1b_human Human No 6.1 EC50 = 760 Funct
Agonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL156661 ada1b_human Human No 7.1 EC50 = 77.6 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL318544 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsActivation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL344551 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 2 3 0.9 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NN3
CHEMBL356605 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL275844 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CNN=C3
CHEMBL100198 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
246 4 2 3 0.9 CN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL318544 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL95398 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
275 7 2 4 2.7 CC(C)COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL95333 ada1b_human Human No 7.1 EC50 = 79.4 Funct
Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.
286 4 2 3 1.8 C1CCN(CC1)C(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL258007 ada1b_human Human No 6.1 EC50 = 791 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL258007 ada1b_human Human No 6.1 EC50 = 791 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL70692 ada1b_human Human No 7.1 EC50 = 85.1 Funct
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsAgonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
239 4 2 4 1.5 CSC1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL1076 ada1b_rat Rat Yes 4.1 EC50 = 85000 Funct
Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uM
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL1076 ada1b_rat Rat Yes 4.1 EC50 = 85113.8 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL260720 ada1b_human Human No 6.0 EC50 = 902 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL260720 ada1b_human Human No 6.1 EC50 = 902 Funct
Agonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL347268 ada1b_human Human No 7.0 EC50 = 95.5 Funct
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
256 4 2 4 1.4 CC1=NOC(=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL323402 ada1b_rat Rat No 6.0 EC50 = 977.2 Funct
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleenAgonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen
213 1 2 2 2.1 C1CC(C2=C(C1)C(=CC=C2)N)C3=CN=CN3
CHEMBL466634 ada1b_human Human No 6.0 EC50 = 990 Funct
Agonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL466634 ada1b_human Human No 6.0 EC50 = 990 Funct
Agonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1B receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL707 ada1b_rat Rat Yes 9.1 IC50 = 0.8 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL3582270 ada1b_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL430717 ada1b_human Human No 8.9 IC50 = 1.2 Funct
Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptorBinding affinity was tested on cloned hamster Alpha-1B adrenergic receptor
496 8 1 9 3.8 CC(C)C1=C(C(=CC=C1)OC)OCC(=O)N2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL85 ada1b_rat Rat Yes 8.7 IC50 = 1.9 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL85 ada1b_rat Rat Yes 8.7 IC50 = 1.9 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL3741318 ada1b_human Human No 7.0 IC50 = 100.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3741318 ada1b_human Human No 7.0 IC50 = 100.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL137487 ada1b_human Human No 5.0 IC50 = 10000 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
482 9 5 5 4.1 C1=CC=C(C=C1)CNC2=C(C(=C(C=C2)C3=CC(=CC=C3)N)CC(=O)NCC4=CC=C(C=C4)C(=N)N)F
CHEMBL3741079 ada1b_human Human No 6.0 IC50 = 1003 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL3741079 ada1b_human Human No 6.0 IC50 = 1003 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL3739900 ada1b_human Human No 6.0 IC50 = 1007 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL3739900 ada1b_human Human No 6.0 IC50 = 1007 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL584606 ada1b_rat Rat No 7.0 IC50 = 102 Funct
Displacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 minsDisplacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 mins
367 6 1 5 2.4 CC1=CC=C(C=C1)N2CCN(CC2)CCCN3C(=O)C(=C(C(=N3)C)C=C)N
CHEMBL584606 ada1b_rat Rat No 7.0 IC50 = 102 Funct
Displacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 minsDisplacement of [3H]prazosin from adrenergic Alpha-1B receptor in Wistar rat liver membrane after 60 mins
367 6 1 5 2.4 CC1=CC=C(C=C1)N2CCN(CC2)CCCN3C(=O)C(=C(C(=N3)C)C=C)N
CHEMBL450018 ada1b_human Human No 5.0 IC50 = 10471.3 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL25098 ada1b_rat Rat No 7.0 IC50 = 108 Funct
Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorBinding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptor
540 9 1 6 5.6 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC(C)C)C5=CC=CC=C5
CHEMBL1113 ada1b_rat Rat Yes 7.0 IC50 = 109 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL1113 ada1b_rat Rat Yes 7.0 IC50 = 109 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL30008 ada1b_rat Rat Yes 6.0 IC50 = 1096 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL621 ada1b_rat Rat Yes 7.0 IC50 = 111 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL621 ada1b_rat Rat Yes 7.0 IC50 = 111 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL3739533 ada1b_human Human No 7.9 IC50 = 12.6 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL3739533 ada1b_human Human No 7.9 IC50 = 12.6 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL3810005 ada1b_human Human No 5.9 IC50 = 1206 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810005 ada1b_human Human No 5.9 IC50 = 1206 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3740558 ada1b_human Human No 6.9 IC50 = 121.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740558 ada1b_human Human No 6.9 IC50 = 121.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809600 ada1b_human Human No 5.9 IC50 = 1284 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3809600 ada1b_human Human No 5.9 IC50 = 1284 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL356605 ada1b_human Human No 5.9 IC50 = 1288.3 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL3809093 ada1b_human Human No 6.9 IC50 = 130.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3809093 ada1b_human Human No 6.9 IC50 = 130.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL155327 ada1b_human Human No 6.9 IC50 = 131.8 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL415 ada1b_rat Rat Yes 6.9 IC50 = 132 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL415 ada1b_rat Rat Yes 6.9 IC50 = 132 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL3808595 ada1b_human Human No 5.9 IC50 = 1361 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 11 3 6 3.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808595 ada1b_human Human No 5.9 IC50 = 1361 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 11 3 6 3.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL1403281 ada1b_rat Rat Yes 7.9 IC50 = 14 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL19826 ada1b_rat Rat No 7.9 IC50 = 14 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtypeCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype
483 6 2 9 2.4 CC(C)(C)NC(=O)C1CN(CCN1C(=O)C2=CC=CO2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL1403281 ada1b_rat Rat Yes 7.9 IC50 = 14 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL346389 ada1b_rat Rat Yes 5.9 IC50 = 1425 Funct
Inhibition of [3H]- prazosin binding against Alpha-1B adrenergic receptor from rat liverInhibition of [3H]- prazosin binding against Alpha-1B adrenergic receptor from rat liver
358 3 1 4 2.9 C1CN(CCN1CC2=CC3=C(C=C2)NC(=O)CO3)C4=CC=C(C=C4)Cl
CHEMBL1306 ada1b_rat Rat Yes 4.8 IC50 = 14299 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL470432 ada1b_human Human No 6.8 IC50 = 144.5 Funct
Displacement of [3H]prazosin form human recombinant Alpha-1B adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1B adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL470432 ada1b_human Human No 6.8 IC50 = 144.5 Funct
Displacement of [3H]prazosin form human recombinant Alpha-1B adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1B adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL192 ada1b_rat Rat Yes 5.8 IC50 = 1457 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
475 7 1 7 1.5 CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C
CHEMBL19826 ada1b_rat Rat No 7.8 IC50 = 15 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptor
483 6 2 9 2.4 CC(C)(C)NC(=O)C1CN(CCN1C(=O)C2=CC=CO2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL19376 ada1b_rat Rat No 5.8 IC50 = 1500 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.
388 5 3 8 1.3 CC(C)(C)NC(=O)C1CN(CCN1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL134792 ada1b_human Human No 5.8 IC50 = 1560 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
422 9 4 5 3.7 C1=CC=C(C=C1)CCNC2=C(C(=C(C=C2)F)CC(=O)NCC3=CC=C(C=C3)C(=N)N)F
CHEMBL219916 ada1b_rat Rat Yes 6.8 IC50 = 158 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL219916 ada1b_rat Rat Yes 6.8 IC50 = 158 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL277375 ada1b_human Human No 6.8 IC50 = 158.5 Funct
Inhibitory concentration against radioligand binding to human Alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL3809630 ada1b_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL3809630 ada1b_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL1358628 ada1b_rat Rat Yes 7.8 IC50 = 16 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada1b_rat Rat Yes 7.8 IC50 = 16 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada1b_rat Rat Yes 7.8 IC50 = 16 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL3582271 ada1b_human Human No 7.8 IC50 = 16.3 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
679 6 4 12 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=S)NC4=CC(=C(C=C4)C5=C6C=CC(=O)C=C6OC7=C5C=CC(=C7)O)C(=O)O)N)OC
CHEMBL3582271 ada1b_human Human No 7.8 IC50 = 16.3 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
679 6 4 12 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=S)NC4=CC(=C(C=C4)C5=C6C=CC(=O)C=C6OC7=C5C=CC(=C7)O)C(=O)O)N)OC
CHEMBL351542 ada1b_human Human No 6.8 IC50 = 162.2 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
232 5 2 4 1.0 CON=CC1=CC=CC=C1NCC2=NCCN2
CHEMBL21731 ada1b_rat Rat Yes 6.8 IC50 = 163 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL3808896 ada1b_human Human No 6.8 IC50 = 168.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3808896 ada1b_human Human No 6.8 IC50 = 168.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3809794 ada1b_human Human No 6.8 IC50 = 169.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809794 ada1b_human Human No 6.8 IC50 = 169.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL6966 ada1b_rat Rat Yes 5.8 IC50 = 1698 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
455 13 0 6 3.8 CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
CHEMBL318544 ada1b_human Human No 5.8 IC50 = 1698.2 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL296419 ada1b_rat Rat Yes 6.8 IC50 = 172 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL3810346 ada1b_human Human No 5.8 IC50 = 1736 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810346 ada1b_human Human No 5.8 IC50 = 1736 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL319553 ada1b_human Human No 5.8 IC50 = 1778.3 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
261 6 2 4 2.1 CC(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL1108 ada1b_rat Rat Yes 7.8 IC50 = 18 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1108 ada1b_rat Rat Yes 7.8 IC50 = 18 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL3739762 ada1b_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3739762 ada1b_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3808572 ada1b_human Human No 6.7 IC50 = 180.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3808572 ada1b_human Human No 6.7 IC50 = 180.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL2203713 ada1b_human Human No 5.8 IC50 = 1800 Funct
Inhibition of alpha1B adrenergic receptorInhibition of alpha1B adrenergic receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL3739505 ada1b_human Human No 5.7 IC50 = 1876 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5F
CHEMBL3739505 ada1b_human Human No 5.7 IC50 = 1876 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5F
CHEMBL3742253 ada1b_human Human No 7.7 IC50 = 19.7 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL3742253 ada1b_human Human No 7.7 IC50 = 19.7 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL50588 ada1b_rat Rat Yes 5.7 IC50 = 1934 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
481 7 1 6 4.7 CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC
CHEMBL50588 ada1b_rat Rat Yes 5.7 IC50 = 1934 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
481 7 1 6 4.7 CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC
CHEMBL320419 ada1b_human Human No 5.7 IC50 = 1949.8 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
274 7 3 3 2.0 CCCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL3742276 ada1b_human Human No 6.7 IC50 = 199 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742276 ada1b_human Human No 6.7 IC50 = 199 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL1909072 ada1b_rat Rat Yes 8.6 IC50 = 2.6 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL420683 ada1b_human Human No 5.7 IC50 = 2041.7 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=N3
CHEMBL24619 ada1b_human Human No 6.7 IC50 = 206 Funct
Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptorBinding affinity was tested on cloned hamster Alpha-1B adrenergic receptor
547 9 1 10 5.0 COC1=C(C=C(C=C1)CC2C3=CC(=C(C=C3CCN2C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC)OC)OC)OC
CHEMBL445 ada1b_rat Rat Yes 6.7 IC50 = 207 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL454246 ada1b_human Human No 6.7 IC50 = 215 Funct
Inhibition of adrenergic receptor 1b receptor expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetryInhibition of adrenergic receptor 1b receptor expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetry
795 6 5 13 3.8 CC1CC2C34C(C5C6(C(C3C7C(O7)(C(C2(C1OC(=O)C=CC=CC(C8CCC(C8C)CC6(C)O)OC(=O)CC(C)C)O)O)CO)OC(O5)(O4)C9=CC=CC=C9)O)C
CHEMBL3808417 ada1b_human Human No 5.7 IC50 = 2162 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
462 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3808417 ada1b_human Human No 5.7 IC50 = 2162 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
462 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL117248 ada1b_human Human No 6.7 IC50 = 218.8 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL156661 ada1b_human Human No 5.7 IC50 = 2187.8 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL3809840 ada1b_human Human No 5.7 IC50 = 2197 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809840 ada1b_human Human No 5.7 IC50 = 2197 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL97044 ada1b_human Human No 5.7 IC50 = 2238.7 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
258 5 3 3 1.3 C1CC1NC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL3809032 ada1b_human Human No 5.7 IC50 = 2248 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3809032 ada1b_human Human No 5.7 IC50 = 2248 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL117381 ada1b_human Human No 6.6 IC50 = 229.1 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CN=CO3
CHEMBL295698 ada1b_rat Rat Yes 4.6 IC50 = 22910 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
531 7 0 6 4.3 CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL13789 ada1b_human Human No 5.6 IC50 = 2398.8 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL27341 ada1b_rat Rat No 7.6 IC50 = 24 Funct
Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorBinding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptor
497 8 0 6 5.1 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)CCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL344294 ada1b_human Human No 5.6 IC50 = 2454.7 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
267 4 1 3 1.9 CC1=CC(=NC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL648 ada1b_rat Rat Yes 5.6 IC50 = 2492 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL648 ada1b_rat Rat Yes 5.6 IC50 = 2492 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL1631540 ada1b_rat Rat Yes 7.6 IC50 = 25.1 Funct
Inhibition of rat adrenergic Alpha-1B receptorInhibition of rat adrenergic Alpha-1B receptor
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL1631540 ada1b_rat Rat Yes 7.6 IC50 = 25.1 Funct
Inhibition of rat adrenergic Alpha-1B receptorInhibition of rat adrenergic Alpha-1B receptor
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL3739542 ada1b_human Human No 6.6 IC50 = 250.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL3739542 ada1b_human Human No 6.6 IC50 = 250.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL631 ada1b_rat Rat Yes 5.6 IC50 = 2558 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
341 11 2 4 3.3 CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
CHEMBL631 ada1b_rat Rat Yes 5.6 IC50 = 2558 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
341 11 2 4 3.3 CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
CHEMBL3809319 ada1b_human Human No 6.6 IC50 = 262.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3809319 ada1b_human Human No 6.6 IC50 = 262.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3187195 ada1b_human Human Yes 6.6 IC50 = 263.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3187195 ada1b_human Human Yes 6.6 IC50 = 263.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL357129 ada1b_human Human No 6.6 IC50 = 269.2 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL137483 ada1b_human Human No 4.6 IC50 = 26900 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
473 9 4 7 2.3 C1=CC=C(C=C1)CS(=O)(=O)NC2=C(C(=C(C=C2)F)CC(=O)NCC3=CC=C(C=C3)C(=N)N)F
CHEMBL81 ada1b_rat Rat Yes 5.6 IC50 = 2693 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL81 ada1b_rat Rat Yes 5.6 IC50 = 2693 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL19376 ada1b_rat Rat No 5.6 IC50 = 2700 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptor
388 5 3 8 1.3 CC(C)(C)NC(=O)C1CN(CCN1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL3809781 ada1b_human Human No 5.6 IC50 = 2768 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL3809781 ada1b_human Human No 5.6 IC50 = 2768 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL3740019 ada1b_human Human No 7.5 IC50 = 28.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740019 ada1b_human Human No 7.5 IC50 = 28.9 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809490 ada1b_human Human No 5.5 IC50 = 2862 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809490 ada1b_human Human No 5.5 IC50 = 2862 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3810145 ada1b_human Human No 6.5 IC50 = 287.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810145 ada1b_human Human No 6.5 IC50 = 287.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL278518 ada1b_rat Rat No 7.5 IC50 = 29 Funct
Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorBinding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptor
530 7 1 5 5.8 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCCNC(=O)C3=CC=CC4=C3OC(=C(C4=O)C)C5=CC=CC=C5
CHEMBL3808981 ada1b_human Human No 5.5 IC50 = 2959 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3808981 ada1b_human Human No 5.5 IC50 = 2959 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL19826 ada1b_human Human No 8.5 IC50 = 3.2 Funct
Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtypeCompound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype
483 6 2 9 2.4 CC(C)(C)NC(=O)C1CN(CCN1C(=O)C2=CC=CO2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL325745 ada1b_human Human No 5.5 IC50 = 3020.0 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
258 6 3 3 2.3 CCCNC(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL19376 ada1b_human Human No 7.5 IC50 = 31 Funct
Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.
388 5 3 8 1.3 CC(C)(C)NC(=O)C1CN(CCN1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL3742103 ada1b_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742103 ada1b_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809500 ada1b_human Human No 5.5 IC50 = 3139 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809500 ada1b_human Human No 5.5 IC50 = 3139 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3808726 ada1b_human Human No 7.5 IC50 = 32.7 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL3808726 ada1b_human Human No 7.5 IC50 = 32.7 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL154023 ada1b_human Human No 6.5 IC50 = 323.6 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
256 4 2 4 1.4 CC1=C(OC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL3809532 ada1b_human Human No 5.5 IC50 = 3266 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809532 ada1b_human Human No 5.5 IC50 = 3266 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL549 ada1b_rat Rat Yes 5.5 IC50 = 3288 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL549 ada1b_rat Rat Yes 5.5 IC50 = 3288 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL3740874 ada1b_human Human No 7.5 IC50 = 34.8 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL3740874 ada1b_human Human No 7.5 IC50 = 34.8 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL7568 ada1b_rat Rat Yes 5.5 IC50 = 3414 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL3809248 ada1b_human Human No 7.5 IC50 = 35.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809248 ada1b_human Human No 7.5 IC50 = 35.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL1172 ada1b_rat Rat Yes 5.4 IC50 = 3623 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL715 ada1b_rat Rat Yes 7.4 IC50 = 37 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL643 ada1b_rat Rat Yes 7.4 IC50 = 39 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL24629 ada1b_rat Rat No 7.4 IC50 = 39 Funct
Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorBinding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptor
499 9 0 6 5.8 CC1=C(OC2=C(C1=O)C=CC=C2OCCCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL17851 ada1b_human Human No 6.4 IC50 = 398.1 Funct
Inhibitory concentration against radioligand binding to human Alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL479 ada1b_rat Rat Yes 8.3 IC50 = 4.7 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL3739513 ada1b_human Human No 6.4 IC50 = 406.2 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3739513 ada1b_human Human No 6.4 IC50 = 406.2 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL384790 ada1b_rat Rat No 4.4 IC50 = 41686.9 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from ratAntagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=C(C=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=C(C=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL305660 ada1b_rat Rat Yes 6.4 IC50 = 420.7 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3808999 ada1b_human Human No 5.4 IC50 = 4320 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808999 ada1b_human Human No 5.4 IC50 = 4320 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3740351 ada1b_human Human No 6.4 IC50 = 433.3 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740351 ada1b_human Human No 6.4 IC50 = 433.3 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL155326 ada1b_human Human No 6.4 IC50 = 446.7 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL954 ada1b_rat Rat Yes 5.3 IC50 = 4569 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL954 ada1b_rat Rat Yes 5.3 IC50 = 4569 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL1909065 ada1b_rat Rat No 5.3 IC50 = 4726 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL936 ada1b_rat Rat Yes 5.3 IC50 = 4760 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL936 ada1b_rat Rat Yes 5.3 IC50 = 4760 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL3809543 ada1b_human Human No 5.3 IC50 = 4807 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809543 ada1b_human Human No 5.3 IC50 = 4807 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL263289 ada1b_rat Rat No 5.3 IC50 = 5128.6 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from ratAntagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CC=C4CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC=C5C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL3582272 ada1b_human Human No 7.3 IC50 = 52.4 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
586 9 1 12 3.4 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)CN4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3582272 ada1b_human Human No 7.3 IC50 = 52.4 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
586 9 1 12 3.4 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)CN4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3810198 ada1b_human Human No 5.3 IC50 = 5320 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810198 ada1b_human Human No 5.3 IC50 = 5320 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL216443 ada1b_rat Rat No 4.3 IC50 = 54954.1 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from ratAntagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=CC=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC(=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL1201216 ada1b_rat Rat Yes 7.3 IC50 = 55 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL1201216 ada1b_rat Rat Yes 7.3 IC50 = 55 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL3609360 ada1b_human Human No 6.3 IC50 = 560 Funct
Antagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assayAntagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assay
392 5 1 3 4.7 C1CN(CCC1C2=CNC3=C2C=CC(=C3)F)CCCN4CCC5=CC=CC=C5C4
CHEMBL3609360 ada1b_human Human No 6.3 IC50 = 560 Funct
Antagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assayAntagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assay
392 5 1 3 4.7 C1CN(CCC1C2=CNC3=C2C=CC(=C3)F)CCCN4CCC5=CC=CC=C5C4
CHEMBL19476 ada1b_human Human Yes 5.2 IC50 = 5800 Funct
Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptorCompound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL154298 ada1b_human Human No 6.2 IC50 = 588.8 Funct
In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
252 4 2 3 1.5 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=N3
CHEMBL421011 ada1b_human Human No 5.2 IC50 = 5888.4 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL116700 ada1b_human Human No 5.2 IC50 = 5888.4 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
250 4 1 2 3.2 C1=CC=C(C=C1)C2=CC=CC=C2OCC3=CN=CN3
CHEMBL3808878 ada1b_human Human No 5.2 IC50 = 5992 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3808878 ada1b_human Human No 5.2 IC50 = 5992 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL611 ada1b_rat Rat Yes 8.2 IC50 = 6.0 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.2 IC50 = 6.0 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL42 ada1b_rat Rat Yes 8.2 IC50 = 6.5 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 ada1b_rat Rat Yes 8.2 IC50 = 6.5 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL809 ada1b_rat Rat Yes 6.2 IC50 = 605 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL809 ada1b_rat Rat Yes 6.2 IC50 = 605 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL395110 ada1b_rat Rat Yes 7.2 IC50 = 61 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL395110 ada1b_rat Rat Yes 7.2 IC50 = 61 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL3808408 ada1b_human Human No 6.2 IC50 = 610.2 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL3808408 ada1b_human Human No 6.2 IC50 = 610.2 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL3810220 ada1b_human Human No 6.2 IC50 = 617.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 12 3 6 2.9 CC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3810220 ada1b_human Human No 6.2 IC50 = 617.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 12 3 6 2.9 CC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL142635 ada1b_human Human Yes 6.2 IC50 = 634 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1b_human Human Yes 6.2 IC50 = 634 Funct
Antagonist activity at alpha 1B adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1B adrenergic receptor (unknown origin) by luciferase reporter gene assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1b_human Human Yes 6.2 IC50 = 634 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL3808632 ada1b_human Human No 6.2 IC50 = 640.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 14 3 6 4.0 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3808632 ada1b_human Human No 6.2 IC50 = 640.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 14 3 6 4.0 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL122621 ada1b_rat Rat No 4.2 IC50 = 67608.3 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from ratAntagonist affinity [non competitive (irreversible)] at alpha-1B-adrenoceptors on isolated spleen from rat
591 27 4 8 5.0 COC1=CC=CC(=C1)CNCCCCCCNCCSSCCNCCCCCCNCC2=CC=CC=C2OC
CHEMBL138119 ada1b_human Human No 5.2 IC50 = 6800 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
479 10 5 4 4.8 C1=CC=C(C=C1)CCNC2=C(C(=C(C=C2)C3=CC=CC=C3)CC(=O)NCC4=CC=C(C=C4)C(=N)N)O
CHEMBL3740847 ada1b_human Human No 6.2 IC50 = 684 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL3740847 ada1b_human Human No 6.2 IC50 = 684 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL95523 ada1b_human Human No 6.2 IC50 = 691.8 Funct
Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL3810110 ada1b_human Human No 7.2 IC50 = 70.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3810110 ada1b_human Human No 7.2 IC50 = 70.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL343173 ada1b_human Human No 5.2 IC50 = 7000 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
481 10 4 4 5.3 C1=CC=C(C=C1)CCNC2=C(C(=C(C=C2)C3=CC=CC=C3)CC(=O)NCC4=CC=C(C=C4)C(=N)N)F
CHEMBL1626 ada1b_rat Rat Yes 7.1 IC50 = 74 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 ada1b_rat Rat Yes 7.1 IC50 = 74 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL13789 ada1b_human Human No 6.1 IC50 = 741.3 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL3808717 ada1b_human Human No 5.1 IC50 = 7583 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808717 ada1b_human Human No 5.1 IC50 = 7583 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3741260 ada1b_human Human No 6.1 IC50 = 769.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C#N
CHEMBL3741260 ada1b_human Human No 6.1 IC50 = 769.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C#N
CHEMBL143562 ada1b_human Human No 6.1 IC50 = 776.3 Funct
Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesBinding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
256 4 1 3 2.0 CC1=C(OC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL3742198 ada1b_human Human No 6.1 IC50 = 781.5 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3742198 ada1b_human Human No 6.1 IC50 = 781.5 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3741161 ada1b_human Human No 6.1 IC50 = 787.5 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
462 6 0 6 4.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)F)F
CHEMBL3741161 ada1b_human Human No 6.1 IC50 = 787.5 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
462 6 0 6 4.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)F)F
CHEMBL25012 ada1b_rat Rat No 7.1 IC50 = 79 Funct
Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorBinding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptor
498 7 1 6 4.4 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)NCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL333980 ada1b_human Human No 5.1 IC50 = 7900 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
431 9 4 4 4.0 CC(C)NC1=C(C(=C(C=C1)C2=CC=CC=C2)CC(=O)NCC3=CC=C(C=C3)C(=N)N)OC
CHEMBL3741483 ada1b_human Human No 6.1 IC50 = 794.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3741483 ada1b_human Human No 6.1 IC50 = 794.4 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL564 ada1b_rat Rat Yes 8.1 IC50 = 8.2 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL564 ada1b_rat Rat Yes 8.1 IC50 = 8.2 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL19476 ada1b_human Human Yes 8.1 IC50 = 8.8 Funct
Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL54 ada1b_rat Rat Yes 8.1 IC50 = 8.9 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL71 ada1b_rat Rat Yes 8.1 IC50 = 9.0 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL3810401 ada1b_human Human No 6.1 IC50 = 835.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3810401 ada1b_human Human No 6.1 IC50 = 835.9 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3810187 ada1b_human Human No 5.1 IC50 = 8488 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810187 ada1b_human Human No 5.1 IC50 = 8488 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809175 ada1b_human Human No 6.1 IC50 = 866.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809175 ada1b_human Human No 6.1 IC50 = 866.1 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3741658 ada1b_human Human No 6.1 IC50 = 875.3 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL3741658 ada1b_human Human No 6.1 IC50 = 875.3 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL728 ada1b_rat Rat Yes 7.1 IC50 = 89 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL728 ada1b_rat Rat Yes 7.1 IC50 = 89 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL118055 ada1b_human Human Yes 6.1 IC50 = 891.3 Funct
In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL19476 ada1b_rat Rat Yes 8.0 IC50 = 9.3 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptor
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL19476 ada1b_rat Rat Yes 8.0 IC50 = 9.3 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL43064 ada1b_rat Rat Yes 6.0 IC50 = 906 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3809676 ada1b_human Human No 6.0 IC50 = 936.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3809676 ada1b_human Human No 6.0 IC50 = 936.6 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3740042 ada1b_human Human No 6.0 IC50 = 948.8 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740042 ada1b_human Human No 6.0 IC50 = 948.8 Funct
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL125781 ada1b_human Human No 6.0 IC50 = 950 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
434 8 5 5 3.4 CC(C)NC1=C(C(=C(C=C1)C2=CC(=CC=C2)N)CC(=O)NCC3=CC=C(C=C3)C(=N)N)F
CHEMBL137444 ada1b_human Human No 5.0 IC50 = 9500 Funct
Inhibitory activity against thrombin was determinedInhibitory activity against thrombin was determined
493 11 4 4 5.1 COC1=C(C=CC(=C1CC(=O)NCC2=CC=C(C=C2)C(=N)N)C3=CC=CC=C3)NCCC4=CC=CC=C4
CHEMBL841 ada1b_rat Rat Yes 6.0 IC50 = 965 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
477 7 1 3 5.0 CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL841 ada1b_rat Rat Yes 6.0 IC50 = 965 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
477 7 1 3 5.0 CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL55 ada1b_rat Rat Yes 6.0 IC50 = 967 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL55 ada1b_rat Rat Yes 6.0 IC50 = 967 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL3808511 ada1b_human Human No 6.0 IC50 = 980.5 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808511 ada1b_human Human No 6.0 IC50 = 980.5 Funct
Antagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1B adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL1214185 ada1b_rat Rat Yes 6.0 IC50 = 989 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
837 13 5 17 3.1 CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
CHEMBL1214185 ada1b_rat Rat Yes 6.0 IC50 = 989 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
837 13 5 17 3.1 CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
CHEMBL27013 ada1b_rat Rat No 9.8 Kd = 0.1 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL27013 ada1b_rat Rat No 9.8 Kd = 0.1 Funct
Antagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from ratAntagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from rat
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL707 ada1b_rat Rat Yes 9.5 Kd = 0.3 Funct
Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleenAntagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_rat Rat Yes 9.5 Kd = 0.3 Funct
Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleenAntagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_rat Rat Yes 9.5 Kd = 0.3 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL144224 ada1b_rat Rat No 9.4 Kd = 0.4 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
452 11 1 7 4.2 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL138681 ada1b_rat Rat No 9.2 Kd = 0.6 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
608 20 2 9 5.0 CNCCCCCCN(C)CC1=CC=C(C=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL423294 ada1b_rat Rat Yes 9.2 Kd = 0.7 Funct
Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleenAntagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1b_rat Rat Yes 9.2 Kd = 0.7 Funct
Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleenAntagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL144776 ada1b_rat Rat No 9.2 Kd = 0.7 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
580 19 3 9 4.0 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1CNCCCCCCN)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL423294 ada1b_rat Rat Yes 9.2 Kd = 0.7 Funct
Antagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from ratAntagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from rat
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL358060 ada1b_rat Rat No 9.2 Kd = 0.7 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC=C(C=C1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL178673 ada1b_rat Rat No 9.0 Kd = 1.0 Funct
Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)
436 5 1 9 1.8 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CC4CCSS4)N)OC
CHEMBL144238 ada1b_rat Rat No 9.0 Kd = 1.1 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
490 12 1 8 4.0 CN(CCCCCCN(C)C(=O)C1=CC=C(O1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1630940 ada1b_rat Rat No 9.0 Kd = 1.1 Funct
Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsAntagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 mins
462 11 2 10 3.5 CC(CC1=CC(=C(C=C1)OC)S(=O)(=O)N)NCCOC2=CC=CC=C2OCC(F)(F)F
CHEMBL1630940 ada1b_rat Rat No 9.0 Kd = 1.1 Funct
Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsAntagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 mins
462 11 2 10 3.5 CC(CC1=CC(=C(C=C1)OC)S(=O)(=O)N)NCCOC2=CC=CC=C2OCC(F)(F)F
CHEMBL175934 ada1b_rat Rat No 8.8 Kd = 1.7 Funct
Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)
422 4 1 9 1.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCSS4)N)OC
CHEMBL13856 ada1b_rat Rat Yes 8.8 Kd = 1.7 Funct
In vitro functional activity at Alpha-1B adrenergic receptor in rat spleenIn vitro functional activity at Alpha-1B adrenergic receptor in rat spleen
477 6 1 6 4.2 CC1=CC=CC(=C1)C2=CSC3=C2C(=O)N(C(=O)N3)CCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL144677 ada1b_rat Rat No 8.7 Kd = 1.9 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL42231 ada1b_rat Rat No 7.0 Kd = 109.7 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
418 9 1 4 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2)C4=CC=CC=C4
CHEMBL1256344 ada1b_human Human No 6.0 Kd = 1096.5 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
601 12 1 8 4.2 CCOC(=O)C(C)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1256344 ada1b_human Human No 6.0 Kd = 1096.5 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
601 12 1 8 4.2 CCOC(=O)C(C)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL29907 ada1b_rat Rat No 6.9 Kd = 114.8 Funct
Antagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from ratAntagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from rat
450 11 3 10 2.6 COC1=C(C=C2C(=C1)C(=NC(=N2)NCCSSCCNC(=O)C3=CC=CO3)N)OC
CHEMBL40650 ada1b_rat Rat Yes 7.9 Kd = 12.9 Funct
In vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleenIn vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleen
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL3415011 ada1b_rat Rat No 6.9 Kd = 123.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
393 7 2 4 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(C=C3)NC=C4
CHEMBL3415011 ada1b_rat Rat No 6.9 Kd = 123.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
393 7 2 4 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(C=C3)NC=C4
CHEMBL503007 ada1b_human Human No 5.9 Kd = 1258.9 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
573 11 1 8 3.4 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)CC(=O)OC)O
CHEMBL503007 ada1b_human Human No 5.9 Kd = 1258.9 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
573 11 1 8 3.4 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)CC(=O)OC)O
CHEMBL146724 ada1b_rat Rat No 7.9 Kd = 13.2 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
509 13 1 8 4.0 CN(C)CC1=CC=CC=C1C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL2261355 ada1b_rat Rat No 4.9 Kd = 13803.8 Funct
Antagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contraction
305 4 2 4 2.1 CCS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL3415020 ada1b_rat Rat No 6.9 Kd = 141.3 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
483 9 1 4 5.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=CC=CC=C4N3CC5=CC=CC=C5
CHEMBL3415020 ada1b_rat Rat No 6.9 Kd = 141.3 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
483 9 1 4 5.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=CC=CC=C4N3CC5=CC=CC=C5
CHEMBL3414578 ada1b_rat Rat No 5.8 Kd = 1445.4 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
423 8 2 5 3.6 COC1=CC2=C(C=C1)NC(=C2)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL3414578 ada1b_rat Rat No 5.8 Kd = 1445.4 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
423 8 2 5 3.6 COC1=CC2=C(C=C1)NC(=C2)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL111734 ada1b_rat Rat Yes 4.8 Kd = 15135.6 Funct
Antagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contraction
279 5 2 4 1.7 CCS(=O)(=O)NC1=CC=CC(=C1C)CC2=CN=CN2
CHEMBL3415015 ada1b_rat Rat No 6.8 Kd = 154.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
409 7 3 5 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)O
CHEMBL3415015 ada1b_rat Rat No 6.8 Kd = 154.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
409 7 3 5 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)O
CHEMBL43905 ada1b_rat Rat No 6.8 Kd = 154.9 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
436 9 1 5 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3S2)C4=CC=CC=C4
CHEMBL2419765 ada1b_rat Rat No 7.8 Kd = 17.0 Funct
Antagonist activity at alpha-1B adrenoreceptor in Sprague-Dawley rat spleen assessed as inhibition of phenylephrine-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1B adrenoreceptor in Sprague-Dawley rat spleen assessed as inhibition of phenylephrine-induced tissue contraction after 30 mins by Schild plot analysis
354 7 2 5 3.0 COC1=C(C2=C(C=C1)C=CN2)OCCNCC3COC4=CC=CC=C4O3
CHEMBL3415019 ada1b_rat Rat No 6.8 Kd = 166.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
407 7 1 4 3.2 CN1C=C(C2=CC=CC=C21)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL3415019 ada1b_rat Rat No 6.8 Kd = 166.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
407 7 1 4 3.2 CN1C=C(C2=CC=CC=C21)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL142635 ada1b_rat Rat Yes 6.8 Kd = 177.8 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1b_rat Rat Yes 6.8 Kd = 177.8 Funct
Antagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of (-)-noradrenaline-induced contractile response
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1b_rat Rat Yes 6.8 Kd = 177.8 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL62033 ada1b_rat Rat No 7.7 Kd = 18.6 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
416 4 1 5 2.5 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=C(C=C5)C#N)NC4=O
CHEMBL1257883 ada1b_human Human No 5.7 Kd = 1819.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
503 7 1 6 3.6 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3F)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1257883 ada1b_human Human No 5.7 Kd = 1819.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
503 7 1 6 3.6 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3F)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL144000 ada1b_rat Rat No 7.7 Kd = 19.5 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
608 20 2 9 5.0 CNCCCCCCN(C)CC1=CC=CC(=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL444648 ada1b_human Human No 5.7 Kd = 1949.8 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
587 12 1 8 3.8 CCOC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL444648 ada1b_human Human No 5.7 Kd = 1949.8 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
587 12 1 8 3.8 CCOC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL268758 ada1b_rat Rat Yes 8.7 Kd = 2.0 Funct
In vitro functional activity at Alpha-1B adrenergic receptor in rat spleenIn vitro functional activity at Alpha-1B adrenergic receptor in rat spleen
463 6 1 6 3.9 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC=C4C5=CC=CC=C5
CHEMBL242507 ada1b_rat Rat No 8.7 Kd = 2.2 Funct
Antagonist activity against adrenergic Alpha-1B receptor in rat spleen assessed as inhibition of phenylephrine-induced responseAntagonist activity against adrenergic Alpha-1B receptor in rat spleen assessed as inhibition of phenylephrine-induced response
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242507 ada1b_rat Rat No 8.7 Kd = 2.2 Funct
Antagonist activity against adrenergic Alpha-1B receptor in rat spleen assessed as inhibition of phenylephrine-induced responseAntagonist activity against adrenergic Alpha-1B receptor in rat spleen assessed as inhibition of phenylephrine-induced response
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL342997 ada1b_rat Rat No 8.6 Kd = 2.4 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
499 13 1 9 3.4 CN(C)CC1=CC=C(O1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL357669 ada1b_rat Rat No 8.6 Kd = 2.5 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
481 12 2 8 3.0 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CN)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.5 Funct
Antagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of phenylephrine-induced contractile response
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.5 Funct
In vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleenIn vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleen
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.5 Funct
In vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleenIn vitro antagonism against Alpha-1B adrenergic receptor using phenylephrine (PE) challenge in rat spleen
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.5 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.6 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.6 Funct
Antagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1B-adrenoreceptor in Sprague-Dawley rat spleen assessed as relaxation of (-)-noradrenaline-induced contractile response
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.6 Kd = 2.6 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL144263 ada1b_rat Rat No 8.5 Kd = 3.0 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
509 13 1 8 4.0 CN(C)CC1=CC=C(C=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL3415017 ada1b_rat Rat No 6.7 Kd = 208.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
471 7 2 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=C(C=C4)Br
CHEMBL3415017 ada1b_rat Rat No 6.7 Kd = 208.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
471 7 2 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=C(C=C4)Br
CHEMBL3415013 ada1b_rat Rat No 6.7 Kd = 218.8 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
421 9 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCC3=CNC4=CC=CC=C43
CHEMBL3415013 ada1b_rat Rat No 6.7 Kd = 218.8 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
421 9 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCC3=CNC4=CC=CC=C43
CHEMBL297106 ada1b_rat Rat No 5.6 Kd = 2511.9 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
421 9 1 6 4.4 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL3415018 ada1b_rat Rat No 6.6 Kd = 257.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
427 7 2 4 4.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)Cl
CHEMBL3415018 ada1b_rat Rat No 6.6 Kd = 257.0 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
427 7 2 4 4.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)Cl
CHEMBL44403 ada1b_rat Rat No 7.6 Kd = 26.3 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
432 9 1 5 5.2 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2=O)C4=CC=CC=C4
CHEMBL13647 ada1b_rat Rat Yes 7.6 Kd = 28.2 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL42472 ada1b_rat Rat No 7.5 Kd = 28.8 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
420 9 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL179743 ada1b_rat Rat No 8.5 Kd = 3.1 Funct
Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)
445 4 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C4=CC(=O)C5=CC=CC=C5C4=O)N)OC
CHEMBL291303 ada1b_rat Rat No 7.5 Kd = 30.2 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
452 6 1 6 2.7 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=CC(=C(C=C5NC4=O)OC)OC
CHEMBL1630941 ada1b_rat Rat No 7.5 Kd = 30.9 Funct
Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsAntagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL1630941 ada1b_rat Rat No 7.5 Kd = 30.9 Funct
Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsAntagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL40325 ada1b_rat Rat No 6.5 Kd = 302 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
436 9 1 5 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3S2)C4=CC=CC=C4
CHEMBL29591 ada1b_rat Rat Yes 7.5 Kd = 32.4 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
478 11 1 10 2.9 CN(CCSSCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL29591 ada1b_rat Rat Yes 7.5 Kd = 32.4 Funct
Antagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from ratAntagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from rat
478 11 1 10 2.9 CN(CCSSCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL13647 ada1b_rat Rat Yes 7.5 Kd = 33.1 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL1258228 ada1b_human Human No 5.4 Kd = 3630.8 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
543 10 1 7 3.4 COC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1258228 ada1b_human Human No 5.4 Kd = 3630.8 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
543 10 1 7 3.4 COC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL341665 ada1b_rat Rat No 7.4 Kd = 37.2 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
509 13 1 8 4.0 CN(C)CC1=CC=CC(=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL326702 ada1b_rat Rat No 5.4 Kd = 3981.1 Funct
Antagonistic activity against Alpha-1B adrenergic receptor determined using phenylephrine challenge in rat spleen isolated tissues.Antagonistic activity against Alpha-1B adrenergic receptor determined using phenylephrine challenge in rat spleen isolated tissues.
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL709 ada1b_rat Rat Yes 8.3 Kd = 4.9 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
389 8 2 8 1.7 CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL178923 ada1b_rat Rat No 7.4 Kd = 40.7 Funct
Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)
478 8 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CCCCC4CCSS4)N)OC
CHEMBL326702 ada1b_rat Rat No 5.4 Kd = 4073.8 Funct
Antagonist activity at rat spleen adrenergic Alpha-1B receptorAntagonist activity at rat spleen adrenergic Alpha-1B receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1b_rat Rat No 5.4 Kd = 4073.8 Funct
Antagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contraction
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1b_rat Rat No 5.4 Kd = 4073.8 Funct
Antagonist activity at rat spleen adrenergic Alpha-1B receptorAntagonist activity at rat spleen adrenergic Alpha-1B receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL145181 ada1b_rat Rat No 7.4 Kd = 42.7 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
526 12 1 10 3.3 CN(CCSSCCN(C)C(=O)C1=CC=C(O1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL13647 ada1b_rat Rat Yes 7.4 Kd = 42.7 Funct
In vitro functional activity at Alpha-1B adrenergic receptor in rat spleenIn vitro functional activity at Alpha-1B adrenergic receptor in rat spleen
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL321644 ada1b_rat Rat No 4.4 Kd = 42658.0 Funct
Antagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen assessed as inhibition of phenylephrine-indued contraction
359 4 2 7 2.8 C1CC(C2=C(C1)C(=CC=C2)NS(=O)(=O)CC(F)(F)F)C3=CN=CN3
CHEMBL1258457 ada1b_human Human No 7.3 Kd = 45.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
515 9 2 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL1258457 ada1b_human Human No 7.3 Kd = 45.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
515 9 2 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL1258344 ada1b_human Human No 6.3 Kd = 457.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
471 7 2 5 3.3 C1CN(CCN1CC(CN2C(=O)NC(=O)C2(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=CC=C5
CHEMBL1258344 ada1b_human Human No 6.3 Kd = 457.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
471 7 2 5 3.3 C1CN(CCN1CC(CN2C(=O)NC(=O)C2(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=CC=C5
CHEMBL3415012 ada1b_rat Rat No 6.3 Kd = 512.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
407 8 2 4 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CC3=CNC4=CC=CC=C43
CHEMBL3415012 ada1b_rat Rat No 6.3 Kd = 512.9 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
407 8 2 4 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CC3=CNC4=CC=CC=C43
CHEMBL1258345 ada1b_human Human No 7.3 Kd = 53.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
501 8 2 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL146601 ada1b_rat Rat No 7.3 Kd = 53.7 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
535 13 1 11 2.7 CN(C)CC1=CC=C(O1)C(=O)N(C)CCSSCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1258345 ada1b_human Human No 7.3 Kd = 53.7 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
501 8 2 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL3415016 ada1b_rat Rat No 6.2 Kd = 645.7 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
438 7 2 6 3.4 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C(=CC=C4)[N+](=O)[O-]
CHEMBL3415016 ada1b_rat Rat No 6.2 Kd = 645.7 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
438 7 2 6 3.4 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C(=CC=C4)[N+](=O)[O-]
CHEMBL145384 ada1b_rat Rat No 7.2 Kd = 66.1 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL42558 ada1b_rat Rat No 7.2 Kd = 67.6 Funct
Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorAntagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor
408 12 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2CC3=CC=CC=C3
CHEMBL293695 ada1b_rat Rat No 8.2 Kd = 7.1 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
452 6 1 6 2.7 COC1=C(C2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC)OC
CHEMBL445325 ada1b_rat Rat No 7.1 Kd = 85.1 Funct
In vitro antagonistic activity against alpha-1B receptor in rat spleen.In vitro antagonistic activity against alpha-1B receptor in rat spleen.
436 6 0 6 3.0 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C=NC5=CC(=C(C=C5C4=O)OC)OC
CHEMBL500266 ada1b_human Human No 6.1 Kd = 851.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
587 11 1 8 3.8 CC(C(=O)OC)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL490865 ada1b_human Human No 6.1 Kd = 851.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
529 9 1 6 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C)O
CHEMBL500266 ada1b_human Human No 6.1 Kd = 851.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
587 11 1 8 3.8 CC(C(=O)OC)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL490865 ada1b_human Human No 6.1 Kd = 851.1 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
529 9 1 6 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C)O
CHEMBL148061 ada1b_rat Rat No 8.0 Kd = 9.3 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
553 13 1 9 4.5 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CN2CCSC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL144768 ada1b_rat Rat No 8.0 Kd = 9.8 Funct
Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.
553 13 1 9 4.5 CN(CCCCCCN(C)C(=O)C1=CC=C(C=C1)CN2CCSC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL448198 ada1b_human Human No 6.0 Kd = 933.3 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
601 12 1 8 4.2 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C(C)C(=O)OC)O
CHEMBL448198 ada1b_human Human No 6.0 Kd = 933.3 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
601 12 1 8 4.2 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C(C)C(=O)OC)O
CHEMBL3415014 ada1b_rat Rat No 7.0 Kd = 95.5 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
435 10 2 4 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCCC3=CNC4=CC=CC=C43
CHEMBL3415014 ada1b_rat Rat No 7.0 Kd = 95.5 Funct
Antagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 minsAntagonist activity at Sprague-Dawley rat spleen adrenergic alpha-1B receptor after 20 mins
435 10 2 4 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCCC3=CNC4=CC=CC=C43
CHEMBL484102 ada1b_human Human No 6.0 Kd = 955.0 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
515 8 1 6 3.5 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL484102 ada1b_human Human No 6.0 Kd = 955.0 Funct
Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenAntagonist activity at adrenergic Alpha-1B receptor in guinea pig spleen
515 8 1 6 3.5 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1259113 ada1b_mesau Golden hamster No 10.4 Ki = 0.0 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
340 2 1 4 2.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CN
CHEMBL1259113 ada1b_mesau Golden hamster No 10.4 Ki = 0.0 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
340 2 1 4 2.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CN
CHEMBL42472 ada1b_human Human No 10.4 Ki = 0.0 Funct
Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor
420 9 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL342062 ada1b_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL324090 ada1b_human Human Yes 10.1 Ki = 0.1 Funct
Binding affinity against Alpha-1B adrenergic receptor from human cloneBinding affinity against Alpha-1B adrenergic receptor from human clone
395 5 1 7 3.4 COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC
CHEMBL1259144 ada1b_mesau Golden hamster No 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259144 ada1b_mesau Golden hamster No 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259112 ada1b_mesau Golden hamster Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
335 1 0 4 3.4 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C#N
CHEMBL1259112 ada1b_mesau Golden hamster Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
335 1 0 4 3.4 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C#N
CHEMBL3582270 ada1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL1259128 ada1b_rat Rat No 10.0 Ki = 0.1 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
407 3 0 6 3.9 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CC5=NN(N=N5)C
CHEMBL3582270 ada1b_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1B adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL1259128 ada1b_rat Rat No 10.0 Ki = 0.1 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
407 3 0 6 3.9 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CC5=NN(N=N5)C
CHEMBL324090 ada1b_human Human Yes 10.0 Ki = 0.1 Funct
Binding affinity against Alpha-1B adrenergic receptor from hamster clones.Binding affinity against Alpha-1B adrenergic receptor from hamster clones.
395 5 1 7 3.4 COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC
CHEMBL27013 ada1b_human Human No 10.0 Ki = 0.1 Funct
Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL423294 ada1b_human Human Yes 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1b_human Human Yes 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL342062 ada1b_human Human No 9.9 Ki = 0.1 Funct
Compound was tested for binding affinity against human hippocampus Alpha-1B adrenergic receptor using radioligand ([3H]-prazosin) binding assayCompound was tested for binding affinity against human hippocampus Alpha-1B adrenergic receptor using radioligand ([3H]-prazosin) binding assay
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL2261604 ada1b_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from Homo sapiens (human) alpha1B adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1B adrenergic receptor
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1b_human Human Yes 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL1259216 ada1b_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
393 2 0 6 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(N=N5)C
CHEMBL1259129 ada1b_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
407 3 0 6 3.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CC5=NN=NN5C
CHEMBL1259216 ada1b_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
393 2 0 6 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(N=N5)C
CHEMBL1259129 ada1b_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortexDisplacement of [3H]prozosin from alpha-1b receptor in rat cerebral cortex
407 3 0 6 3.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CC5=NN=NN5C
CHEMBL198860 ada1b_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)Cl
CHEMBL198860 ada1b_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)Cl
CHEMBL341665 ada1b_human Human No 9.8 Ki = 0.2 Funct
Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
509 13 1 8 4.0 CN(C)CC1=CC=CC(=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1259042 ada1b_mesau Golden hamster No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
389 2 0 5 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CN=C5
CHEMBL1259042 ada1b_mesau Golden hamster No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
389 2 0 5 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CN=C5
CHEMBL1258987 ada1b_mesau Golden hamster No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN(N=C5)C
CHEMBL1259190 ada1b_mesau Golden hamster No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL423294 ada1b_human Human Yes 9.7 Ki = 0.2 Funct
Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptorBinding affinity was tested on cloned hamster Alpha-1B adrenergic receptor
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL1258987 ada1b_mesau Golden hamster No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN(N=C5)C
CHEMBL1259190 ada1b_mesau Golden hamster No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL2261604 ada1b_rat Rat No 9.7 Ki = 0.2 Funct
Binding affinity to alpha1B adrenoreceptor in Rattus norvegicus (rat) liverBinding affinity to alpha1B adrenoreceptor in Rattus norvegicus (rat) liver
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL303313 ada1b_mesau Golden hamster Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL242724 ada1b_human Human No 9.6 Ki = 0.2 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
454 4 1 8 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CS5)N)OC
CHEMBL242724 ada1b_human Human No 9.6 Ki = 0.2 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
454 4 1 8 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CS5)N)OC
CHEMBL1259232 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.7 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(C=C5)C
CHEMBL1259232 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.7 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(C=C5)C
CHEMBL200366 ada1b_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL199080 ada1b_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC(=CC=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL200366 ada1b_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL199080 ada1b_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC(=CC=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL1259023 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CC=C5
CHEMBL1259023 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CC=C5
CHEMBL1259189 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259189 ada1b_mesau Golden hamster No 9.6 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL423294 ada1b_human Human Yes 9.5 Ki = 0.3 Funct
Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL388884 ada1b_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
516 4 1 8 4.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=C(O5)Br)N)OC
CHEMBL388884 ada1b_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
516 4 1 8 4.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=C(O5)Br)N)OC
CHEMBL178673 ada1b_human Human No 9.5 Ki = 0.3 Funct
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cells
436 5 1 9 1.8 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CC4CCSS4)N)OC
CHEMBL1259145 ada1b_mesau Golden hamster No 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259145 ada1b_mesau Golden hamster No 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259231 ada1b_mesau Golden hamster No 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.7 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=NN5C
CHEMBL1259231 ada1b_mesau Golden hamster No 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
391 2 0 4 3.7 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=NN5C
CHEMBL423294 ada1b_human Human Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1b_human Human Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL12713 ada1b_mesau Golden hamster Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL61483 ada1b_human Human No 9.5 Ki = 0.3 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
474 5 1 5 4.4 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C(=CS5)C6=CC=CC=C6)NC4=O
CHEMBL12713 ada1b_mesau Golden hamster Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL12713 ada1b_mesau Golden hamster Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysis
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL12713 ada1b_mesau Golden hamster Yes 9.5 Ki = 0.3 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL1259216 ada1b_mesau Golden hamster No 9.5 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
393 2 0 6 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(N=N5)C
CHEMBL1259216 ada1b_mesau Golden hamster No 9.5 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
393 2 0 6 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(N=N5)C
CHEMBL1259217 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
393 2 0 6 3.0 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN=NN5C
CHEMBL1259217 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
393 2 0 6 3.0 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN=NN5C
CHEMBL318901 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
564 6 1 6 4.5 CN1C=NC(=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5C(=O)C6=CC=CC=C6NC5=O)C7=CC=C(C=C7)F
CHEMBL196817 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL200580 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
454 14 1 7 4.5 COC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL196817 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL200580 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
454 14 1 7 4.5 COC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL1259043 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
387 2 0 3 5.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=CC=C5
CHEMBL1259043 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
387 2 0 3 5.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=CC=C5
CHEMBL707 ada1b_rat Rat Yes 9.4 Ki = 0.4 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_rat Rat Yes 9.4 Ki = 0.4 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL564481 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL564481 ada1b_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL1259174 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL64875 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1788222 ada1b_rat Rat No 9.4 Ki = 0.4 Funct
Displacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membraneDisplacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membrane
391 4 1 5 2.0 COC1=CC=CC=C1N2CCN(CC2)CC3CN=C4N3C(=O)NC5=CC=CC=C54
CHEMBL1259174 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL64875 ada1b_mesau Golden hamster No 9.4 Ki = 0.4 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL430717 ada1b_human Human No 9.4 Ki = 0.5 Funct
The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.
496 8 1 9 3.8 CC(C)C1=C(C(=CC=C1)OC)OCC(=O)N2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL97698 ada1b_mesau Golden hamster Yes 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL137598 ada1b_human Human Yes 9.3 Ki = 0.5 Funct
The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.
355 4 1 8 2.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C4=CC=CO4)N)OC
CHEMBL242934 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
448 4 1 7 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CC=C5)N)OC
CHEMBL242934 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
448 4 1 7 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CC=C5)N)OC
CHEMBL1254582 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
440 13 1 6 5.1 COC1=C(C(=CC=C1)OC)SCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL1254582 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
440 13 1 6 5.1 COC1=C(C(=CC=C1)OC)SCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL1259158 ada1b_mesau Golden hamster No 9.3 Ki = 0.5 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
424 4 1 4 4.2 CC(C)(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259158 ada1b_mesau Golden hamster No 9.3 Ki = 0.5 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
424 4 1 4 4.2 CC(C)(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL43116 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1b_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL175934 ada1b_human Human No 9.3 Ki = 0.5 Funct
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cells
422 4 1 9 1.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCSS4)N)OC
CHEMBL64249 ada1b_mesau Golden hamster Yes 9.3 Ki = 0.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1259188 ada1b_mesau Golden hamster No 9.3 Ki = 0.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
503 7 1 6 3.6 CN1N=C(N=N1)CC2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL64249 ada1b_mesau Golden hamster Yes 9.3 Ki = 0.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1259188 ada1b_mesau Golden hamster No 9.3 Ki = 0.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
503 7 1 6 3.6 CN1N=C(N=N1)CC2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL200839 ada1b_human Human No 9.3 Ki = 0.6 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3Cl
CHEMBL200839 ada1b_human Human No 9.3 Ki = 0.6 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3Cl
CHEMBL97698 ada1b_human Human Yes 9.2 Ki = 0.6 Funct
Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL3609360 ada1b_rat Rat No 9.2 Ki = 0.6 Funct
Displacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranesDisplacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranes
392 5 1 3 4.7 C1CN(CCC1C2=CNC3=C2C=CC(=C3)F)CCCN4CCC5=CC=CC=C5C4
CHEMBL3609360 ada1b_rat Rat No 9.2 Ki = 0.6 Funct
Displacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranesDisplacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranes
392 5 1 3 4.7 C1CN(CCC1C2=CNC3=C2C=CC(=C3)F)CCCN4CCC5=CC=CC=C5C4
CHEMBL707 ada1b_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]prazosin from human alpha1B adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1B adrenoceptor expressed in CHO cell membranes after 30 mins
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL80730 ada1b_human Human No 9.2 Ki = 0.6 Funct
Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand
490 9 1 7 4.7 CC(C)C(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL293695 ada1b_human Human No 9.2 Ki = 0.7 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
452 6 1 6 2.7 COC1=C(C2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC)OC
CHEMBL58956 ada1b_human Human No 9.2 Ki = 0.7 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
421 5 1 5 2.8 COC1=CC2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC
CHEMBL106737 ada1b_rat Rat Yes 9.2 Ki = 0.7 Funct
Displacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membraneDisplacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membrane
391 4 1 5 2.0 COC1=CC=CC=C1N2CCN(CC2)CC3CN=C4N3C(=O)NC5=CC=CC=C54
CHEMBL179743 ada1b_human Human No 9.2 Ki = 0.7 Funct
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cells
445 4 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C4=CC(=O)C5=CC=CC=C5C4=O)N)OC
CHEMBL97242 ada1b_mesau Golden hamster No 9.2 Ki = 0.7 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
490 6 0 7 3.9 CN1N=C(N=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCOC5=O)C6=CC=C(C=C6)F
CHEMBL611 ada1b_mesau Golden hamster Yes 9.2 Ki = 0.7 Funct
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1b expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1b expressed in LTK cell
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL423294 ada1b_human Human Yes 9.2 Ki = 0.7 Funct
Binding affinity to human alpha1B adrenergic receptorBinding affinity to human alpha1B adrenergic receptor
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL2261604 ada1b_human Human No 9.2 Ki = 0.7 Funct
Binding affinity to alpha1B adrenoreceptor (unknown origin) by radioligand binding assayBinding affinity to alpha1B adrenoreceptor (unknown origin) by radioligand binding assay
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL342062 ada1b_human Human No 9.2 Ki = 0.7 Funct
Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL1259005 ada1b_mesau Golden hamster No 9.1 Ki = 0.7 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
407 2 0 4 5.4 CC1=CC=C(S1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL1259005 ada1b_mesau Golden hamster No 9.1 Ki = 0.7 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
407 2 0 4 5.4 CC1=CC=C(S1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL707 ada1b_human Human Yes 9.1 Ki = 0.7 Funct
Binding affinity against Alpha-1B adrenergic receptor from human cloneBinding affinity against Alpha-1B adrenergic receptor from human clone
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL62028 ada1b_human Human No 9.1 Ki = 0.7 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
428 5 1 6 3.1 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=C(S5)OC)NC4=O
CHEMBL310599 ada1b_human Human No 9.1 Ki = 0.8 Funct
Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand
466 7 1 6 4.3 CC(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCN3CCN(CC3)C4=CC=CC=C4Cl
CHEMBL197442 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL382972 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC=CC=C1COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL1254742 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
452 15 1 6 5.3 CCOC1=C(C(=CC=C1)OCC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL197442 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL382972 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
438 13 1 6 4.9 CC1=CC=CC=C1COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL1254742 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
452 15 1 6 5.3 CCOC1=C(C(=CC=C1)OCC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL707 ada1b_human Human Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_human Human Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_human Human Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1b_human Human Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL1259079 ada1b_mesau Golden hamster No 9.1 Ki = 0.8 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
401 2 0 3 5.7 CC1=CC=C(C=C1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL1259079 ada1b_mesau Golden hamster No 9.1 Ki = 0.8 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
401 2 0 3 5.7 CC1=CC=C(C=C1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL3298750 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
655 12 3 8 3.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)CCCC(=O)NCC6=CC=CC=C6)NC3=O
CHEMBL3298750 ada1b_human Human No 9.1 Ki = 0.8 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
655 12 3 8 3.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)CCCC(=O)NCC6=CC=CC=C6)NC3=O
CHEMBL61598 ada1b_human Human No 9.1 Ki = 0.8 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
449 5 2 5 2.0 CC(=O)NC1=CC2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC
CHEMBL291073 ada1b_mesau Golden hamster No 9.1 Ki = 0.9 Funct
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell
491 5 2 6 3.0 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=C(C=C6)C(=O)N)NC4=O
CHEMBL242508 ada1b_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
468 5 1 9 3.6 COC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242507 ada1b_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242508 ada1b_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
468 5 1 9 3.6 COC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242507 ada1b_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL1259173 ada1b_mesau Golden hamster No 9.1 Ki = 0.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1259173 ada1b_mesau Golden hamster No 9.1 Ki = 0.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL440865 ada1b_human Human No 9.0 Ki = 0.9 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
426 4 1 4 3.4 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=CC=C5Cl)NC4=O
CHEMBL64875 ada1b_mesau Golden hamster No 9.0 Ki = 0.9 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL561851 ada1b_human Human No 9.0 Ki = 0.9 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
510 11 1 9 4.0 CN(CCCCCCN(C)C(=O)C1COC2=CC=CC=C2O1)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL561851 ada1b_human Human No 9.0 Ki = 0.9 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
510 11 1 9 4.0 CN(CCCCCCN(C)C(=O)C1COC2=CC=CC=C2O1)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL1259063 ada1b_mesau Golden hamster No 9.0 Ki = 1.0 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
401 2 0 3 5.7 CC1=CC=CC(=C1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL1259063 ada1b_mesau Golden hamster No 9.0 Ki = 1.0 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
401 2 0 3 5.7 CC1=CC=CC(=C1)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL8618 ada1b_human Human Yes 9.0 Ki = 1.0 Funct
Displacement of [125]HEAT from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1b receptor expressed in CHO cells
393 7 0 5 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL8618 ada1b_human Human Yes 9.0 Ki = 1.0 Funct
Displacement of [125]HEAT from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1b receptor expressed in CHO cells
393 7 0 5 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL200446 ada1b_human Human No 9.0 Ki = 1 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)Cl
CHEMBL707 ada1b_human Human Yes 9.0 Ki = 1 Funct
Binding affinity was tested on human Alpha-1B adrenergic receptorBinding affinity was tested on human Alpha-1B adrenergic receptor
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL200446 ada1b_human Human No 9.0 Ki = 1 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)Cl
CHEMBL445071 ada1b_human Human No 9.0 Ki = 1.0 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
397 4 1 5 2.5 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=CSC=C5NC4=O
CHEMBL62110 ada1b_human Human No 9.0 Ki = 1.0 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
405 4 1 4 3.2 CC1=C2C(=CC=C1)NC(=O)N(C2=O)CCN3CC4CCC5=C(C4C3)C=CC=C5OC
CHEMBL1256414 ada1b_human Human No 9.0 Ki = 1.0 Funct
Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation countingDisplacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL29591 ada1b_human Human Yes 9.0 Ki = 1.1 Funct
Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
478 11 1 10 2.9 CN(CCSSCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL85 ada1b_rat Rat Yes 9.0 Ki = 1.1 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL1259172 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
436 6 2 4 2.3 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)CN)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL319352 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
489 6 1 6 3.3 CN1N=C(N=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL319352 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
489 6 1 6 3.3 CN1N=C(N=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL51433 ada1b_rat Rat Yes 9.0 Ki = 1.1 Funct
Displacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membraneDisplacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membrane
380 5 1 5 2.2 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=CC=CC=C4NC3=O
CHEMBL319352 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysis
489 6 1 6 3.3 CN1N=C(N=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL1259172 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
436 6 2 4 2.3 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)CN)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL319352 ada1b_mesau Golden hamster No 9.0 Ki = 1.1 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
489 6 1 6 3.3 CN1N=C(N=N1)C2=CC3=C(C=C2)N(C=C3C4CCN(CC4)CCN5CCNC5=O)C6=CC=C(C=C6)F
CHEMBL43905 ada1b_human Human No 8.9 Ki = 1.1 Funct
Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor
436 9 1 5 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3S2)C4=CC=CC=C4
CHEMBL61491 ada1b_human Human No 8.9 Ki = 1.2 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
391 4 1 4 2.8 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=CC=CC=C5NC4=O
CHEMBL1259080 ada1b_mesau Golden hamster No 8.9 Ki = 1.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
415 2 0 3 6.1 CC1=CC=CC(=C1C)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL1258988 ada1b_mesau Golden hamster No 8.9 Ki = 1.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
392 2 0 5 3.5 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(C=N5)C
CHEMBL611 ada1b_human Human Yes 8.9 Ki = 1.2 Funct
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylaminomethyl tetralone from human cloned Alpha-1b adrenergic receptor stably expressed in LM cellsAbility to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylaminomethyl tetralone from human cloned Alpha-1b adrenergic receptor stably expressed in LM cells
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_human Human Yes 8.9 Ki = 1.2 Funct
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adrenergic receptor
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL1259080 ada1b_mesau Golden hamster No 8.9 Ki = 1.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
415 2 0 3 6.1 CC1=CC=CC(=C1C)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C
CHEMBL1258988 ada1b_mesau Golden hamster No 8.9 Ki = 1.2 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
392 2 0 5 3.5 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=NN(C=N5)C
CHEMBL338029 ada1b_human Human No 8.9 Ki = 1.2 Funct
Inhibition of [3H]-prazosin binding to cloned human Alpha-1B adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1B adrenergic receptor in CHO cells (chinese hamster ovary cells)
601 12 1 9 5.4 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OCCCO[N+](=O)[O-])C5=CC=CC=C5
CHEMBL13735 ada1b_human Human No 8.9 Ki = 1.2 Funct
Binding affinity towards human Alpha-1B adrenergic receptorBinding affinity towards human Alpha-1B adrenergic receptor
386 5 1 6 2.2 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC=C4
CHEMBL44403 ada1b_human Human No 8.9 Ki = 1.2 Funct
Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor
432 9 1 5 5.2 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2=O)C4=CC=CC=C4
CHEMBL25300 ada1b_human Human Yes 8.9 Ki = 1.3 Funct
Binding affinity was tested on human Alpha-1B adrenergic receptorBinding affinity was tested on human Alpha-1B adrenergic receptor
402 8 2 5 5.1 CC1=CC(=C(C=C1O)C(C)C)OCCN(C)CC2=C(C(=C(C(=C2C)O)C)C)OC
CHEMBL178923 ada1b_human Human No 8.9 Ki = 1.3 Funct
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1b expressed in CHO cells
478 8 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CCCCC4CCSS4)N)OC
CHEMBL60721 ada1b_human Human No 8.9 Ki = 1.3 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
412 4 1 5 3.2 CC1=CSC2=C1NC(=O)N(C2=O)CCN3CC4CCC5=C(C4C3)C=CC=C5OC
CHEMBL430706 ada1b_human Human No 8.9 Ki = 1.3 Funct
Binding affinity towards Alpha-1B adrenergic receptorBinding affinity towards Alpha-1B adrenergic receptor
477 6 2 4 4.5 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL1256414 ada1b_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation countingDisplacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation counting
196 1 1 1 2.1 C1C2C1(CC3=CC=CC=C23)C4=CN=CN4
CHEMBL431720 ada1b_human Human No 8.9 Ki = 1.3 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
420 4 1 4 3.5 CC1=C(C2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC)C
CHEMBL242723 ada1b_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
480 5 1 9 3.3 CC(=O)C1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242723 ada1b_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells
480 5 1 9 3.3 CC(=O)C1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL1788223 ada1b_rat Rat No 8.9 Ki = 1.4 Funct
Displacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membraneDisplacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membrane
422 5 0 6 3.2 COC1=CC=CC=C1N2CCN(CC2)CC3CN=C4N3C(=NC5=CC=CC=C54)SC
CHEMBL564481 ada1b_human Human No 8.9 Ki = 1.4 Funct
Binding affinity to alpha1B adrenergic receptor (unknown origin)Binding affinity to alpha1B adrenergic receptor (unknown origin)
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL558890 ada1b_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL558890 ada1b_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL1909072 ada1b_rat Rat Yes 8.9 Ki = 1.4 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1909072 ada1b_rat Rat Yes 8.9 Ki = 1.4 Funct
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL77618 ada1b_human Human No 8.8 Ki = 1.4 Funct
Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand
510 9 1 7 4.7 CC(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCCN3CCN(CC3)C4=C(C=CC(=C4)Cl)OC
CHEMBL78874 ada1b_human Human No 8.8 Ki = 1.5 Funct
Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand
476 9 1 7 4.2 CCC(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL62033 ada1b_human Human No 8.8 Ki = 1.6 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
416 4 1 5 2.5 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=C(C=C5)C#N)NC4=O
CHEMBL137903 ada1b_human Human No 8.8 Ki = 1.6 Funct
The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line.
498 7 1 7 4.3 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5)N)OC
CHEMBL76168 ada1b_human Human Yes 8.8 Ki = 1.6 Funct
Binding affinity towards Alpha-1B adrenergic receptor hamster smooth muscle using [3H]prazosin as radioligandBinding affinity towards Alpha-1B adrenergic receptor hamster smooth muscle using [3H]prazosin as radioligand
402 7 1 6 1.9 CC1=CC(=C(C=C1)OC)N2CCN(CC2)CCCNC3=CC(=O)N(C(=O)N3C)C
CHEMBL1259006 ada1b_mesau Golden hamster No 8.8 Ki = 1.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=CC=N5
CHEMBL1259006 ada1b_mesau Golden hamster No 8.8 Ki = 1.6 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=CC=N5
CHEMBL2115086 ada1b_human Human No 8.8 Ki = 1.6 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
397 4 1 5 2.8 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=CS5)NC4=O
CHEMBL291839 ada1b_human Human No 8.8 Ki = 1.6 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
397 4 1 5 2.8 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=CS5)NC4=O
CHEMBL369154 ada1b_human Human No 8.8 Ki = 1.6 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
450 6 1 6 2.7 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=C(C=C5)C(=O)OC)NC4=O
CHEMBL3298019 ada1b_human Human No 8.8 Ki = 1.7 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
565 10 2 8 3.1 CN(C)CCCC(=O)NC1=CC2=C(C=C1)SC3=C2NC(=O)N(C3=O)CCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL3298019 ada1b_human Human No 8.8 Ki = 1.7 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
565 10 2 8 3.1 CN(C)CCCC(=O)NC1=CC2=C(C=C1)SC3=C2NC(=O)N(C3=O)CCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL290519 ada1b_mesau Golden hamster No 8.8 Ki = 1.7 Funct
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell
519 5 1 6 3.6 CN(C)C(=O)C1=CC2=C(C=C1)SC3=C2NC(=O)N(C3=O)CCN4CC5CCC6=C(C5C4)C=CC=C6OC
CHEMBL81486 ada1b_human Human No 8.8 Ki = 1.8 Funct
Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligand
454 7 1 6 3.9 CN1C(=O)C(=CC(=N1)C2=CC=CC=C2)NCCN3CCN(CC3)C4=C(C=CC(=C4)Cl)OC
CHEMBL1259098 ada1b_mesau Golden hamster No 8.7 Ki = 1.8 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
429 2 0 3 6.4 CC1=CC(=C(C(=C1)C)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C)C
CHEMBL95175 ada1b_mesau Golden hamster No 8.8 Ki = 1.8 Funct
Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsDisplacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cells
486 6 0 6 4.0 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)C4=NC=CC=N4)C5=CC=C(C=C5)F)CCN6CCOC6=O
CHEMBL1259098 ada1b_mesau Golden hamster No 8.8 Ki = 1.8 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
429 2 0 3 6.4 CC1=CC(=C(C(=C1)C)C2=CC3=C(C=C2)SC4=CC=CC=C4CC3N5CCN(CC5)C)C
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Binding affinity to adrenergic Alpha-1B receptorBinding affinity to adrenergic Alpha-1B receptor
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cells
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Binding affinity to adrenergic Alpha-1B receptorBinding affinity to adrenergic Alpha-1B receptor
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cells
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL301707 ada1b_human Human Yes 8.7 Ki = 1.8 Funct
In vitro binding affinity at human Alpha-1B adrenergic receptor.In vitro binding affinity at human Alpha-1B adrenergic receptor.
419 5 2 5 2.7 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL13903 ada1b_human Human No 8.7 Ki = 1.9 Funct
Binding affinity towards human Alpha-1B adrenergic receptorBinding affinity towards human Alpha-1B adrenergic receptor
463 6 1 6 3.9 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC(=C4)C5=CC=CC=C5
CHEMBL1259024 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=NC=C5
CHEMBL1259203 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
386 3 0 4 4.2 CN1CCC(CC1)C2=CN(C3=C2C=C(C=C3)C4=CN=CN=C4)C5=CC=C(C=C5)F
CHEMBL611 ada1b_human Human Yes 8.7 Ki = 1.9 Funct
In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1b_rat Rat Yes 8.7 Ki = 1.9 Funct
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1B adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1B adrenergic receptor
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL1259203 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysis
386 3 0 4 4.2 CN1CCC(CC1)C2=CN(C3=C2C=C(C=C3)C4=CN=CN=C4)C5=CC=C(C=C5)F
CHEMBL1259024 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
388 2 0 4 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CC=NC=C5
CHEMBL1259203 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
Displacement of [3H]prozosin from hamster cloned alpha-1b receptorDisplacement of [3H]prozosin from hamster cloned alpha-1b receptor
386 3 0 4 4.2 CN1CCC(CC1)C2=CN(C3=C2C=C(C=C3)C4=CN=CN=C4)C5=CC=C(C=C5)F
CHEMBL611 ada1b_human Human Yes 8.7 Ki = 1.9 Funct
In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL3297829 ada1b_human Human No 8.7 Ki = 1.9 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
669 12 2 8 4.0 CN(CC1=CC=CC=C1)C(=O)CCCC(=O)NC2=CC3=C(C=C2)SC4=C3NC(=O)N(C4=O)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL3297829 ada1b_human Human No 8.7 Ki = 1.9 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
669 12 2 8 4.0 CN(CC1=CC=CC=C1)C(=O)CCCC(=O)NC2=CC3=C(C=C2)SC4=C3NC(=O)N(C4=O)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL1630938 ada1b_human Human No 8.7 Ki = 1.9 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
423 11 2 7 3.2 CC(C)OC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N
CHEMBL1630938 ada1b_human Human No 8.7 Ki = 1.9 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
423 11 2 7 3.2 CC(C)OC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N
CHEMBL41444 ada1b_mesau Golden hamster No 8.7 Ki = 1.9 Funct
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell
482 4 1 5 4.8 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC(=C6)Cl)NC4=O
CHEMBL611 ada1b_human Human Yes 8.7 Ki = 2.0 Funct
Binding affinity determined by displacement of [3H]prazosin from alpha-1B adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1B adrenergic receptor
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL427552 ada1b_human Human No 8.7 Ki = 2.0 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
454 14 1 7 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)OC
CHEMBL427552 ada1b_human Human No 8.7 Ki = 2.0 Funct
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
454 14 1 7 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)OC
CHEMBL2146801 ada1b_human Human No 8.0 Ki = 10 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
413 7 0 5 2.8 COCCN1CCCC1CN2C(=O)C3=C(C=NC=C3)C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL1767136 ada1b_human Human No 8.0 Ki = 10 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
368 4 0 3 4.0 CN1CCCC1CN2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL1241557 ada1b_human Human No 8.0 Ki = 10 Funct
Displacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration technique
534 7 0 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CC3COC(O3)(CN4C(=O)CC5(CCCC5)CC4=O)C6=CC=CC=C6
CHEMBL3298745 ada1b_human Human No 8.0 Ki = 10 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
556 7 2 7 4.4 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)C6=CC=CC=C6)NC3=O
CHEMBL309518 ada1b_human Human No 8.0 Ki = 10 Funct
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1b adrenergic receptor stably expressed in LM cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1b adrenergic receptor stably expressed in LM cells.
502 7 0 7 3.5 CSC1=CC2=C(C=C1)S(=O)(=O)N(C2=O)CCCCN3CCC(CC3)N4C5=CC=CC=C5OC4=O
CHEMBL2146801 ada1b_human Human No 8.0 Ki = 10 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
413 7 0 5 2.8 COCCN1CCCC1CN2C(=O)C3=C(C=NC=C3)C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL1767136 ada1b_human Human No 8.0 Ki = 10 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
368 4 0 3 4.0 CN1CCCC1CN2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL42 ada1b_human Human Yes 8.0 Ki = 10 Funct
Binding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL85 ada1b_human Human Yes 8.0 Ki = 10 Funct
Binding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL709 ada1b_human Human Yes 8.0 Ki = 10 Funct
Binding affinity was tested on human Alpha-1B adrenergic receptorBinding affinity was tested on human Alpha-1B adrenergic receptor
389 8 2 8 1.7 CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1241557 ada1b_human Human No 8.0 Ki = 10 Funct
Displacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration technique
534 7 0 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CC3COC(O3)(CN4C(=O)CC5(CCCC5)CC4=O)C6=CC=CC=C6
CHEMBL3298745 ada1b_human Human No 8.0 Ki = 10 Funct
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells
556 7 2 7 4.4 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)C6=CC=CC=C6)NC3=O
CHEMBL55695 ada1b_human Human No 8.0 Ki = 10 Funct
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor
458 8 1 9 3.1 CC1=CNC(=O)N(C1=O)CCCCN2CCN(CC2)C3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL293539 ada1b_human Human No 8.0 Ki = 10.1 Funct
Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleenBinding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen
408 4 0 5 3.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)F)Cl
CHEMBL291588 ada1b_human Human No 8.0 Ki = 10.6 Funct
Binding affinity to hamster alpha-1B adrenergic receptorBinding affinity to hamster alpha-1B adrenergic receptor
392 4 1 5 1.7 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=CN=C5)NC4=O
CHEMBL386005 ada1b_human Human No 8.0 Ki = 10.7 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells
454 5 2 5 3.3 COC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL386005 ada1b_human Human No 8.0 Ki = 10.7 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells
454 5 2 5 3.3 COC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O
CHEMBL2146807 ada1b_human Human No 7.0 Ki = 100 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
411 7 0 4 4.5 CCCCN1CCCC1CN2C(=O)C3=C(C=CC=N3)C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL1767161 ada1b_human Human No 7.0 Ki = 100 Funct
Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblastsBinding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts
655 13 0 5 8.6 C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCCCN3CCCC(CC3)N4C(=O)C5=CC=CC=C5C(=N4)CC6=CC=C(C=C6)Cl
CHEMBL1083182 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells
422 9 1 5 4.9 COC1=CC=CC=C1OCCNCC2CSC(O2)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1255003 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
392 11 1 4 5.3 CC1=C(C(=CC=C1)C)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL1255085 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
395 11 3 6 3.9 C1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3O)O
CHEMBL1255086 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
363 11 1 4 4.6 C1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=CC=CC=C3
CHEMBL2146807 ada1b_human Human No 7.0 Ki = 100 Funct
Antagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imagingAntagonist activity at human adrenergic alpha1B receptor expressed in rat fibroblasts by by plate-based calcium imaging
411 7 0 4 4.5 CCCCN1CCCC1CN2C(=O)C3=C(C=CC=N3)C(=N2)CC4=CC=C(C=C4)Cl
CHEMBL145746 ada1b_human Human No 7.0 Ki = 100 Funct
Binding affinity against Alpha-1B adrenergic receptor (recombinant human receptor) using [3H]prazosin.Binding affinity against Alpha-1B adrenergic receptor (recombinant human receptor) using [3H]prazosin.
586 11 0 6 6.7 CC1=C(C(N(C(=N1)C)CCCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=C(C=C5)F)F)C(=O)OC
CHEMBL1767161 ada1b_human Human No 7.0 Ki = 100 Funct
Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblastsBinding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts
655 13 0 5 8.6 C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCCCN3CCCC(CC3)N4C(=O)C5=CC=CC=C5C(=N4)CC6=CC=C(C=C6)Cl
CHEMBL1083182 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells
422 9 1 5 4.9 COC1=CC=CC=C1OCCNCC2CSC(O2)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1255003 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
392 11 1 4 5.3 CC1=C(C(=CC=C1)C)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL1255085 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
395 11 3 6 3.9 C1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3O)O
CHEMBL1255086 ada1b_human Human No 7.0 Ki = 100 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells
363 11 1 4 4.6 C1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=CC=CC=C3
CHEMBL43491 ada1b_human Human No 7.0 Ki = 100 Funct
In vitro antagonism at Alpha-1B adrenergic receptorIn vitro antagonism at Alpha-1B adrenergic receptor
511 7 2 7 3.4 CC1=C(C(CC(=O)N1)C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC(CC3)C4=C(C=C(C=C4)F)C#N
CHEMBL145334 ada1b_human Human No 7.0 Ki = 100 Funct
In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.
593 9 3 8 2.8 CC1=C(C(N(C(=O)N1)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C(=O)OC)C4=CC=C(C=C4)[N+](=O)[O-])C(=O)NC
CHEMBL145562 ada1b_human Human Yes 7.0 Ki = 100 Funct
In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.
579 9 3 8 2.4 CC1=C(C(N(C(=O)N1)C(=O)NCCCN2CCC(CC2)(C3=CC=CC=C3)C(=O)OC)C4=CC=C(C=C4)[N+](=O)[O-])C(=O)N
CHEMBL142236 ada1b_human Human No 7.0 Ki = 100 Funct
In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1B adrenergic receptor of human liver microsomes.
601 11 3 10 1.7 COCC1=C(C(N(C(=O)N1)C(=O)NCCCN2CCN(CC2)C3=CC=CC=C3C(=O)N)C4=CC(=C(C=C4)F)F)C(=O)OC
CHEMBL292403 ada1b_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor
426 7 1 8 2.7 CC1=CN(C(=O)NC1=O)CCCN2CCN(CC2)C3=CC=CC=C3OCC(F)(F)F
CHEMBL299452 ada1b_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor
430 7 1 9 2.4 C1CN(CCN1CCCN2C(=O)C=CNC2=O)C3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL417954 ada1b_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor
448 7 1 10 2.7 C1CN(CCN1CCCN2C(=O)C(=CNC2=O)F)C3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL57740 ada1b_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptor
472 8 1 9 3.5 CC(C)C1=CNC(=O)N(C1=O)CCCN2CCN(CC2)C3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL425190 ada1b_human Human Yes 6.0 Ki = 1000 Funct
Binding affinity for human alpha-1B adrenergic receptor Binding affinity for human alpha-1B adrenergic receptor
413 6 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC=CC5=C4N=CC=C5
CHEMBL1767153 ada1b_human Human No 6.0 Ki = 1000 Funct
Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblastsBinding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts
313 6 0 3 3.7 CCCCCC1=NN(C(=O)C2=CC=CC=C21)CC3CCCN3C
CHEMBL3342865 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
443 4 0 9 2.5 COC1=CC=CC=C1N2CCN(CC2)CC3COC4(O3)CCN(CC4)C(=O)C(F)(F)F
CHEMBL3342858 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
425 5 0 7 2.9 COC1=CC=CC=C1N2CCN(CC2)CC3COC4(O3)CCN(CC4)C5=CC=CC=N5
CHEMBL3342864 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
389 4 0 6 1.3 CC(=O)N1CCC2(CC1)OCC(O2)CN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL74071 ada1b_human Human No 6.0 Ki = 1000 Funct
Affinity to human Alpha-1B adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1B adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
281 5 2 4 1.5 CC(C)S(=O)(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL425190 ada1b_human Human Yes 6.0 Ki = 1000 Funct
Binding affinity for human alpha-1B adrenergic receptor Binding affinity for human alpha-1B adrenergic receptor
413 6 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC=CC5=C4N=CC=C5
CHEMBL715 ada1b_human Human Yes 6.0 Ki = 1000 Funct
Binding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assay
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL1767153 ada1b_human Human No 6.0 Ki = 1000 Funct
Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblastsBinding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts
313 6 0 3 3.7 CCCCCC1=NN(C(=O)C2=CC=CC=C21)CC3CCCN3C
CHEMBL414628 ada1b_human Human No 6.0 Ki = 1000 Funct
Compound was evaluated for binding affinity against Alpha-1B adrenergic receptorCompound was evaluated for binding affinity against Alpha-1B adrenergic receptor
499 4 1 6 2.8 COC1=C(C=C(C=C1)S(=O)(=O)N2CCC3=C2C=C(C=C3)I)N4CCNCC4
CHEMBL3342865 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
443 4 0 9 2.5 COC1=CC=CC=C1N2CCN(CC2)CC3COC4(O3)CCN(CC4)C(=O)C(F)(F)F
CHEMBL3342858 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
425 5 0 7 2.9 COC1=CC=CC=C1N2CCN(CC2)CC3COC4(O3)CCN(CC4)C5=CC=CC=N5
CHEMBL3342864 ada1b_human Human No 6.0 Ki = 1000 Funct
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
389 4 0 6 1.3 CC(=O)N1CCC2(CC1)OCC(O2)CN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL282971 ada1b_human Human No 6.0 Ki = 1000 Funct
The compound was tested for the binding affinity towards Alpha-1B adrenergic receptorThe compound was tested for the binding affinity towards Alpha-1B adrenergic receptor
492 5 1 7 5.2 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCN5CCCC5C4
CHEMBL1796038 ada1b_human Human No 5.0 Ki = 10000 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cells
446 5 0 4 3.8 C1CN(CCN1CCN2C(=O)CC(CC2=O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4Cl
CHEMBL274529 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
416 9 0 6 2.2 CC(C)OC1=CC=CC=C1N2CCN(CC2)CC(=O)CC(=O)CN3CCCCC3=O
CHEMBL11828 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
418 9 1 6 1.6 CC(C)OC1=CC=CC=C1N2CCN(CC2)CC(CC(=O)CN3CCCCC3=O)O
CHEMBL268030 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
417 8 0 5 2.1 CC(C)OC1=CC=CC=C1N2CCN(CC2)CCN(C)C(=O)CN3CCCCC3=O
CHEMBL12062 ada1b_human Human Yes 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
417 9 1 5 2.2 CC(C)OC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CN3CCCCC3=O
CHEMBL12501 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
389 8 1 5 1.4 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CN3CCCCC3=O
CHEMBL12364 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
460 8 1 9 2.3 C1CCN(C(=O)C1)CC(=O)NCCN2CCN(CC2)C3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL418531 ada1b_human Human No 5.0 Ki = 10000 Funct
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
421 8 1 6 2.0 CC(C)OC1=C(C=CC(=C1)F)N2CCN(CC2)CCNC(=O)CN3CCCCC3=O
CHEMBL109827 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
Binding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assayBinding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assay
271 3 2 3 2.3 COC(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL2261351 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
Binding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assayBinding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assay
289 3 3 4 1.0 COC(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL322492 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
Binding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assayBinding affinity to Cricetinae (hamster) alpha1B adrenoreceptor by radioligand displacement assay
305 3 2 4 2.3 CS(=O)(=O)NC1=CC=CC2=C1CCCCC2C3=CN=CN3
CHEMBL1796038 ada1b_human Human No 5.0 Ki = 10000 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cells
446 5 0 4 3.8 C1CN(CCN1CCN2C(=O)CC(CC2=O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4Cl
CHEMBL111412 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
In vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assayIn vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assay
267 5 2 4 0.6 CCS(=O)(=O)NC1=CC=CC(=C1)CC2CN=CN2
CHEMBL109827 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
In vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assayIn vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assay
271 3 2 3 2.3 COC(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL322492 ada1b_mesau Golden hamster No 5.0 Ki = 10000 Funct
In vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assayIn vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assay
305 3 2 4 2.3 CS(=O)(=O)NC1=CC=CC2=C1CCCCC2C3=CN=CN3
CHEMBL95986 ada1b_human Human No 4.0 Ki = 100000 Funct
In vitro binding affinity at human Alpha-1B adrenergic receptor.In vitro binding affinity at human Alpha-1B adrenergic receptor.
449 5 1 5 4.7 CC(C)C1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5S4)NC3=O
CHEMBL233410 ada1b_human Human No 7.0 Ki = 101 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
510 7 1 7 5.4 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=C(C=C(C=C4)Cl)F
CHEMBL233582 ada1b_human Human No 7.0 Ki = 101 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
510 7 1 7 5.4 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=C(C=C(C=C4)Cl)F
CHEMBL233410 ada1b_human Human No 7.0 Ki = 101 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
510 7 1 7 5.4 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=C(C=C(C=C4)Cl)F
CHEMBL233582 ada1b_human Human No 7.0 Ki = 101 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
510 7 1 7 5.4 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=C(C=C(C=C4)Cl)F
CHEMBL1256503 ada1b_human Human No 7.0 Ki = 102.3 Funct
Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation countingDisplacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation counting
226 2 1 2 1.5 COC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL1256503 ada1b_human Human No 7.0 Ki = 102.3 Funct
Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation countingDisplacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed in CHO cells after 120 mins by liquid scintillation counting
226 2 1 2 1.5 COC1C2=CC=CC=C2C3C1(C3)C4=CN=CN4
CHEMBL150161 ada1b_human Human Yes 7.0 Ki = 102.4 Funct
Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assay
362 6 1 4 2.9 C1CN(CC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL362954 ada1b_human Human No 7.0 Ki = 102.8 Funct
Binding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
296 5 2 3 3.0 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)OC)NC3=NCCN3
CHEMBL362954 ada1b_human Human No 7.0 Ki = 102.8 Funct
Binding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
296 5 2 3 3.0 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)OC)NC3=NCCN3
CHEMBL42539 ada1b_rat Rat No 7.0 Ki = 102.9 Funct
Binding affinity towards Alpha-1B adrenergic receptor in rat liver using [3H]prazosin as radioligandBinding affinity towards Alpha-1B adrenergic receptor in rat liver using [3H]prazosin as radioligand
436 9 1 6 4.8 CC1=CC=C(C=C1)C2C(OC3=CC=CC=C3O2)CNCCOC4=C(C=CC=C4OC)OC
CHEMBL347559 ada1b_human Human No 6.0 Ki = 1020 Funct
Binding affinity was determined for the alpha-1B adrenergic receptorBinding affinity was determined for the alpha-1B adrenergic receptor
543 8 3 7 2.9 CC1=C(C(C(=C(N1)C)C(=O)NCCCN2CCC(CC2)(C#N)C3=CC=CC=C3)C4=CC=C(C=C4)[N+](=O)[O-])C(=O)N
CHEMBL234681 ada1b_human Human No 7.0 Ki = 103 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
476 7 1 7 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC=CC=C4F
CHEMBL399195 ada1b_human Human No 7.0 Ki = 103 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
476 7 1 7 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC=CC=C4F
CHEMBL234681 ada1b_human Human No 7.0 Ki = 103 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
476 7 1 7 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC=CC=C4F
CHEMBL399195 ada1b_human Human No 7.0 Ki = 103 Funct
Binding affinity to human cloned adrenergic alpha-1B receptorBinding affinity to human cloned adrenergic alpha-1B receptor
476 7 1 7 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC=CC=C4F