Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL2381694 acm5_rat Rat No 9.7 EC50 = 0.2 Funct
Positive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced responsePositive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced response
351 5 0 7 3.7 C1=CC=C(C=C1)OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_rat Rat Yes 9.6 EC50 = 0.3 Funct
Positive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced responsePositive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced response
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL2022960 acm5_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL1223941 acm5_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223807 acm5_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 4 0 4 3.7 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=CC=CC=C4OC3=O
CHEMBL2022960 acm5_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL1223941 acm5_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223807 acm5_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 4 0 4 3.7 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=CC=CC=C4OC3=O
CHEMBL1602658 acm5_human Human Yes 5.0 EC50 = 10000 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 0 6 2.6 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCCO4
CHEMBL1602658 acm5_human Human Yes 5.0 EC50 = 10000 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 0 6 2.6 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCCO4
CHEMBL2381695 acm5_human Human No 6.0 EC50 = 1047.1 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
443 7 0 8 5.3 C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL305264 acm5_human Human No 7.0 EC50 = 110 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
196 2 1 4 1.1 CC(C)OC1=NOC2=C1CNCCC2
CHEMBL466253 acm5_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_human Human Yes 6.0 EC50 = 1100 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL3329738 acm5_human Human No 6.0 EC50 = 1110 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
443 6 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCC4
CHEMBL3329738 acm5_human Human No 6.0 EC50 = 1110 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
443 6 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCC4
CHEMBL3329738 acm5_human Human No 6.0 EC50 = 1122.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
443 6 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCC4
CHEMBL466253 acm5_human Human Yes 5.9 EC50 = 1160 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_human Human Yes 5.9 EC50 = 1160 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL1223754 acm5_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223754 acm5_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL3329765 acm5_human Human No 6.9 EC50 = 120 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 7 1 8 3.8 C1CC1CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329764 acm5_human Human No 6.9 EC50 = 120 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
537 7 1 8 4.8 CC(C)(C)CN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329765 acm5_human Human No 6.9 EC50 = 120 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 7 1 8 3.8 C1CC1CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329764 acm5_human Human No 6.9 EC50 = 120 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
537 7 1 8 4.8 CC(C)(C)CN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329765 acm5_human Human No 6.9 EC50 = 120.2 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 7 1 8 3.8 C1CC1CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL1242979 acm5_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
502 9 1 7 3.3 COC1=C(C=C(C=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F)OC
CHEMBL466253 acm5_human Human Yes 5.9 EC50 = 1200 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL1242979 acm5_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
502 9 1 7 3.3 COC1=C(C=C(C=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F)OC
CHEMBL466253 acm5_human Human Yes 5.9 EC50 = 1200 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL134641 acm5_human Human Yes 6.9 EC50 = 123 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL134641 acm5_human Human Yes 6.9 EC50 = 123 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL3329764 acm5_human Human No 6.9 EC50 = 123.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
537 7 1 8 4.8 CC(C)(C)CN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1223805 acm5_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223805 acm5_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223864 acm5_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL2146599 acm5_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL3329762 acm5_human Human No 5.9 EC50 = 1258.9 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
513 7 1 9 3.4 C1CN(CCC1C(=O)N(CCF)CC2=CC=CC=C2C(F)(F)F)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1223864 acm5_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL2146599 acm5_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL3329766 acm5_human Human No 6.9 EC50 = 128.8 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
535 7 1 8 4.3 C1CC(C1)CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329766 acm5_human Human No 6.9 EC50 = 130 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
535 7 1 8 4.3 C1CC(C1)CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329766 acm5_human Human No 6.9 EC50 = 130 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
535 7 1 8 4.3 C1CC(C1)CN(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329762 acm5_human Human No 5.9 EC50 = 1300 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
513 7 1 9 3.4 C1CN(CCC1C(=O)N(CCF)CC2=CC=CC=C2C(F)(F)F)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329762 acm5_human Human No 5.9 EC50 = 1300 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
513 7 1 9 3.4 C1CN(CCC1C(=O)N(CCF)CC2=CC=CC=C2C(F)(F)F)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL2381692 acm5_human Human No 5.9 EC50 = 1400 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
412 5 1 9 3.2 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(C2=O)(C[N+](=O)[O-])O
CHEMBL3329763 acm5_human Human No 6.8 EC50 = 150 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
523 7 1 8 4.4 CCC(C)N(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329763 acm5_human Human No 6.8 EC50 = 150 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
523 7 1 8 4.4 CCC(C)N(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1257975 acm5_human Human No 5.8 EC50 = 1500 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
432 5 0 9 4.8 C1=CC(=NC(=C1)F)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329743 acm5_human Human No 5.8 EC50 = 1500 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC(=CC=C1)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL1257975 acm5_human Human No 5.8 EC50 = 1500 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
432 5 0 9 4.8 C1=CC(=NC(=C1)F)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257975 acm5_human Human No 5.8 EC50 = 1500 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
432 5 0 9 4.8 C1=CC(=NC(=C1)F)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329743 acm5_human Human No 5.8 EC50 = 1500 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC(=CC=C1)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329763 acm5_human Human No 6.8 EC50 = 151.4 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
523 7 1 8 4.4 CCC(C)N(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329743 acm5_human Human No 5.8 EC50 = 1513.6 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC(=CC=C1)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329756 acm5_human Human No 6.8 EC50 = 154.9 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
509 7 1 8 3.9 CCCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329730 acm5_human Human No 5.8 EC50 = 1548.8 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1223861 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223862 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL1223940 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1223861 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223862 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL1223940 acm5_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1802360 acm5_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL1802360 acm5_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL3329756 acm5_human Human No 6.8 EC50 = 160 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
509 7 1 8 3.9 CCCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329756 acm5_human Human No 6.8 EC50 = 160 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
509 7 1 8 3.9 CCCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1257388 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.1 C1=CC(=CN=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL593506 acm5_human Human Yes 5.8 EC50 = 1600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329745 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC(=CC=C1)Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329730 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL1257388 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.1 C1=CC(=CN=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL593506 acm5_human Human Yes 5.8 EC50 = 1600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329745 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC(=CC=C1)Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329730 acm5_human Human No 5.8 EC50 = 1600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329745 acm5_human Human No 5.8 EC50 = 1621.8 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC(=CC=C1)Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329731 acm5_human Human No 5.8 EC50 = 1698.2 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL469144 acm5_human Human No 5.8 EC50 = 1700 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
351 4 0 7 3.5 COC1=CC=CC(=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL3329731 acm5_human Human No 5.8 EC50 = 1700 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL469144 acm5_human Human No 5.8 EC50 = 1700 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
351 4 0 7 3.5 COC1=CC=CC(=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL3329731 acm5_human Human No 5.8 EC50 = 1700 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 1 5 2.5 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329757 acm5_human Human No 5.8 EC50 = 1800 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
507 7 1 8 3.7 C=CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329760 acm5_human Human No 5.8 EC50 = 1800 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 6 1 8 3.9 C1CC(C1)N(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329757 acm5_human Human No 5.8 EC50 = 1800 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
507 7 1 8 3.7 C=CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329760 acm5_human Human No 5.8 EC50 = 1800 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 6 1 8 3.9 C1CC(C1)N(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL3329757 acm5_human Human No 5.7 EC50 = 1819.7 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
507 7 1 8 3.7 C=CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329760 acm5_human Human No 5.7 EC50 = 1819.7 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
521 6 1 8 3.9 C1CC(C1)N(CC2=CC=CC=C2C(F)(F)F)C(=O)C3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)NN=C5
CHEMBL447265 acm5_human Human No 5.7 EC50 = 1850 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
389 3 0 9 4.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C(F)(F)F
CHEMBL447265 acm5_human Human No 5.7 EC50 = 1850 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
389 3 0 9 4.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C(F)(F)F
CHEMBL494190 acm5_human Human No 5.7 EC50 = 1860 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
405 4 0 10 4.8 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)OC(F)(F)F
CHEMBL494190 acm5_human Human No 5.7 EC50 = 1860 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
405 4 0 10 4.8 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)OC(F)(F)F
CHEMBL1223803 acm5_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223804 acm5_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223803 acm5_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223804 acm5_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL3329755 acm5_human Human Yes 6.7 EC50 = 190 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329755 acm5_human Human Yes 6.7 EC50 = 190 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL604482 acm5_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
413 5 0 7 5.1 C1=CC=C(C=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL604482 acm5_human Human No 5.7 EC50 = 1900 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
413 5 0 7 5.1 C1=CC=C(C=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL604482 acm5_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
413 5 0 7 5.1 C1=CC=C(C=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL604482 acm5_human Human No 5.7 EC50 = 1900 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
413 5 0 7 5.1 C1=CC=C(C=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL604482 acm5_human Human No 5.7 EC50 = 1900 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
413 5 0 7 5.1 C1=CC=C(C=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL468925 acm5_human Human Yes 5.7 EC50 = 1930 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
334 2 0 3 3.2 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)Br
CHEMBL468925 acm5_human Human Yes 5.7 EC50 = 1930 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
334 2 0 3 3.2 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)Br
CHEMBL3329755 acm5_human Human Yes 6.7 EC50 = 195.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL503735 acm5_human Human Yes 5.7 EC50 = 2100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL1257498 acm5_human Human No 5.7 EC50 = 2100 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=CN=C4
CHEMBL3329744 acm5_human Human No 5.7 EC50 = 2100 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC=CC=C1F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL503735 acm5_human Human Yes 5.7 EC50 = 2100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL69305 acm5_human Human No 5.7 EC50 = 2100 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
182 2 1 4 0.7 CCOC1=NOC2=C1CNCCC2
CHEMBL1257498 acm5_human Human No 5.7 EC50 = 2100 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=CN=C4
CHEMBL3329744 acm5_human Human No 5.7 EC50 = 2100 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC=CC=C1F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL503735 acm5_human Human Yes 5.7 EC50 = 2110 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm5_human Human Yes 5.7 EC50 = 2110 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL3329744 acm5_human Human No 5.7 EC50 = 2138.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 1 6 2.6 CCN(CC1=CC=CC=C1F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL1258090 acm5_human Human No 5.7 EC50 = 2200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
444 6 0 9 4.7 COC1=CC=CC(=N1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL2381693 acm5_human Human No 5.7 EC50 = 2200 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
448 5 1 9 3.9 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(C2=O)(C4=CN=C(C=C4)F)O
CHEMBL1258090 acm5_human Human No 5.7 EC50 = 2200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
444 6 0 9 4.7 COC1=CC=CC(=N1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329729 acm5_human Human No 5.6 EC50 = 2344.2 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 0 5 3.3 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL1257499 acm5_human Human No 5.6 EC50 = 2400 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
357 3 0 7 3.5 C1=CC2=C(C=C1OC(F)(F)F)C(=O)C(=O)N2CC3=CN=C(C=C3)Cl
CHEMBL3329729 acm5_human Human No 5.6 EC50 = 2400 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 0 5 3.3 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL1257499 acm5_human Human No 5.6 EC50 = 2400 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
357 3 0 7 3.5 C1=CC2=C(C=C1OC(F)(F)F)C(=O)C(=O)N2CC3=CN=C(C=C3)Cl
CHEMBL3329729 acm5_human Human No 5.6 EC50 = 2400 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
427 6 0 5 3.3 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL3329746 acm5_human Human No 5.6 EC50 = 2600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC(=CC=C1)OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329746 acm5_human Human No 5.6 EC50 = 2600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC(=CC=C1)OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329746 acm5_human Human No 5.6 EC50 = 2630.3 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC(=CC=C1)OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL595628 acm5_human Human No 5.6 EC50 = 2700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=CC(=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL593506 acm5_human Human Yes 5.6 EC50 = 2700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL595628 acm5_human Human No 5.6 EC50 = 2700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=CC(=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL593506 acm5_human Human Yes 5.6 EC50 = 2700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
397 4 0 6 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL603445 acm5_human Human Yes 5.6 EC50 = 2800 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
403 4 0 7 4.9 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CSC=C4
CHEMBL3084447 acm5_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3
CHEMBL1257389 acm5_human Human No 5.6 EC50 = 2800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.1 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CC=NC=C4
CHEMBL1258091 acm5_human Human No 5.6 EC50 = 2800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
420 5 0 9 4.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)OC4=NC=CS4
CHEMBL603445 acm5_human Human Yes 5.6 EC50 = 2800 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
403 4 0 7 4.9 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CSC=C4
CHEMBL3084447 acm5_human Human No 5.6 EC50 = 2800 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3
CHEMBL1257389 acm5_human Human No 5.6 EC50 = 2800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.1 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CC=NC=C4
CHEMBL1258091 acm5_human Human No 5.6 EC50 = 2800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
420 5 0 9 4.5 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)OC4=NC=CS4
CHEMBL3329732 acm5_human Human No 5.5 EC50 = 2951.2 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 0 7 2.8 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=NSN=C4C=C3
CHEMBL3334989 acm5_human Human Yes 5.5 EC50 = 3000 Funct
Negative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerNegative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
268 5 0 4 3.2 COC1=CC=CC(=C1)C=NN=CC2=CC(=CC=C2)OC
CHEMBL3329732 acm5_human Human No 5.5 EC50 = 3000 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 0 7 2.8 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=NSN=C4C=C3
CHEMBL3334989 acm5_human Human Yes 5.5 EC50 = 3000 Funct
Negative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerNegative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
268 5 0 4 3.2 COC1=CC=CC(=C1)C=NN=CC2=CC(=CC=C2)OC
CHEMBL3329732 acm5_human Human No 5.5 EC50 = 3000 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
445 6 0 7 2.8 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=NSN=C4C=C3
CHEMBL3329717 acm5_human Human No 5.5 EC50 = 3090.3 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)OC
CHEMBL1257619 acm5_human Human No 5.5 EC50 = 3100 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.2 C1=CC=C(C=C1)C2=CN=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329717 acm5_human Human No 5.5 EC50 = 3100 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)OC
CHEMBL1257619 acm5_human Human No 5.5 EC50 = 3100 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.2 C1=CC=C(C=C1)C2=CN=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329717 acm5_human Human No 5.5 EC50 = 3100 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)OC
CHEMBL1223939 acm5_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223939 acm5_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL511206 acm5_human Human No 5.5 EC50 = 3190 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
305 2 0 5 3.0 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)C(F)(F)F
CHEMBL511206 acm5_human Human No 5.5 EC50 = 3190 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
305 2 0 5 3.0 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)C(F)(F)F
CHEMBL1257974 acm5_human Human No 5.5 EC50 = 3200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
414 5 0 8 4.4 C1=CC=NC(=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257151 acm5_human Human No 5.5 EC50 = 3200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
365 3 0 8 3.4 C1OC2=C(O1)C=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257974 acm5_human Human No 5.5 EC50 = 3200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
414 5 0 8 4.4 C1=CC=NC(=C1)OC2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257151 acm5_human Human No 5.5 EC50 = 3200 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
365 3 0 8 3.4 C1OC2=C(O1)C=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL468290 acm5_human Human No 5.5 EC50 = 3260 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL468290 acm5_human Human No 5.5 EC50 = 3260 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL506043 acm5_human Human No 5.5 EC50 = 3280 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
335 3 0 6 3.9 CC1=CC=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL506043 acm5_human Human No 5.5 EC50 = 3280 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
335 3 0 6 3.9 CC1=CC=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL2431187 acm5_human Human No 7.5 EC50 = 33 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerPositive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL3334991 acm5_human Human No 7.5 EC50 = 33 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerPositive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL2431187 acm5_human Human No 7.5 EC50 = 33 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerPositive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL3334991 acm5_human Human No 7.5 EC50 = 33 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerPositive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL596510 acm5_human Human No 5.5 EC50 = 3300 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
401 4 0 7 3.5 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329716 acm5_human Human No 5.5 EC50 = 3300 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL596510 acm5_human Human No 5.5 EC50 = 3300 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
401 4 0 7 3.5 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL3329716 acm5_human Human No 5.5 EC50 = 3300 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL3329716 acm5_human Human No 5.5 EC50 = 3311.3 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
417 7 0 5 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL485913 acm5_human Human No 7.5 EC50 = 34.3 Funct
Agonist activity at muscarinic M5 receptorAgonist activity at muscarinic M5 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm5_human Human No 7.5 EC50 = 34.3 Funct
Agonist activity at muscarinic M5 receptorAgonist activity at muscarinic M5 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL485913 acm5_human Human No 7.5 EC50 = 34.3 Funct
Agonist activity at muscarinic M5 receptorAgonist activity at muscarinic M5 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm5_human Human No 7.5 EC50 = 34.3 Funct
Agonist activity at muscarinic M5 receptorAgonist activity at muscarinic M5 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL3329754 acm5_human Human No 6.5 EC50 = 346.7 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329754 acm5_human Human No 6.5 EC50 = 350 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329754 acm5_human Human No 6.5 EC50 = 350 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL596509 acm5_human Human Yes 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
416 4 0 8 4.6 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=C(C=C4)F
CHEMBL596509 acm5_human Human Yes 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
416 4 0 8 4.6 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=C(C=C4)F
CHEMBL2024331 acm5_human Human No 5.4 EC50 = 3700 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024331 acm5_human Human No 5.4 EC50 = 3700 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL1257741 acm5_human Human No 5.4 EC50 = 3800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.2 C1=CC=C(C=C1)C2=NC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257741 acm5_human Human No 5.4 EC50 = 3800 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
398 4 0 7 4.2 C1=CC=C(C=C1)C2=NC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL595403 acm5_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
427 5 0 7 5.2 COC1=CC=CC=C1C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL595403 acm5_human Human No 5.4 EC50 = 3900 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
427 5 0 7 5.2 COC1=CC=CC=C1C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL511254 acm5_human Human Yes 5.4 EC50 = 3960 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
302 3 0 3 3.0 COC1=CC=C(C=C1)CN2C3=C(C=CC=C3Cl)C(=O)C2=O
CHEMBL511254 acm5_human Human Yes 5.4 EC50 = 3960 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
302 3 0 3 3.0 COC1=CC=C(C=C1)CN2C3=C(C=CC=C3Cl)C(=O)C2=O
CHEMBL1223806 acm5_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL1223863 acm5_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223806 acm5_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL1223863 acm5_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL2381694 acm5_rat Rat No 8.3 EC50 = 4.6 Funct
Positive allosteric modulation of rat muscarinic M5 receptorPositive allosteric modulation of rat muscarinic M5 receptor
351 5 0 7 3.7 C1=CC=C(C=C1)OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_rat Rat Yes 8.3 EC50 = 4.6 Funct
Positive allosteric modulation of rat muscarinic M5 receptorPositive allosteric modulation of rat muscarinic M5 receptor
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL2431187 acm5_human Human No 6.4 EC50 = 400 Funct
Allosteric agonist activity at human muscarinic acetylcholine receptor M5Allosteric agonist activity at human muscarinic acetylcholine receptor M5
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL3334991 acm5_human Human No 6.4 EC50 = 400 Funct
Allosteric agonist activity at human muscarinic acetylcholine receptor M5Allosteric agonist activity at human muscarinic acetylcholine receptor M5
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL2431187 acm5_human Human No 6.4 EC50 = 400 Funct
Allosteric agonist activity at human muscarinic acetylcholine receptor M5Allosteric agonist activity at human muscarinic acetylcholine receptor M5
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL3334991 acm5_human Human No 6.4 EC50 = 400 Funct
Allosteric agonist activity at human muscarinic acetylcholine receptor M5Allosteric agonist activity at human muscarinic acetylcholine receptor M5
310 4 2 4 2.5 C1C(CC1O)NC(=O)C2=NC=C(C=C2)C#CC3=CC(=CC=C3)F
CHEMBL1257862 acm5_human Human No 5.4 EC50 = 4000 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.1 C1=CC(=CN=C1)C2=NC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL1257862 acm5_human Human No 5.4 EC50 = 4000 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.1 C1=CC(=CN=C1)C2=NC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O
CHEMBL2381694 acm5_human Human No 6.4 EC50 = 407.4 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
351 5 0 7 3.7 C1=CC=C(C=C1)OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL513299 acm5_human Human No 5.4 EC50 = 4070 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
356 3 0 6 4.2 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)Cl
CHEMBL513299 acm5_human Human No 5.4 EC50 = 4070 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
356 3 0 6 4.2 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)Cl
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4080 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4080 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL467281 acm5_human Human No 5.4 EC50 = 4090 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL467281 acm5_human Human No 5.4 EC50 = 4090 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4100 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4100 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm5_human Human Yes 5.4 EC50 = 4100 Funct
Positive allosteric modulation activity at muscarinic M5 receptorPositive allosteric modulation activity at muscarinic M5 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL3084449 acm5_human Human No 5.4 EC50 = 4200 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
380 7 2 4 2.5 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL3084449 acm5_human Human No 5.4 EC50 = 4200 Funct
Agonist activity at human muscarinic M5 receptor by calcium mobilization assayAgonist activity at human muscarinic M5 receptor by calcium mobilization assay
380 7 2 4 2.5 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL2111051 acm5_human Human Yes 6.4 EC50 = 422 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL2111051 acm5_human Human Yes 6.4 EC50 = 422 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL1257863 acm5_human Human No 5.4 EC50 = 4400 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.1 C1=CC2=C(C=C1OC(F)(F)F)C(=O)C(=O)N2CC3=CN=C(C=C3)C4=CC=NC=C4
CHEMBL1257863 acm5_human Human No 5.4 EC50 = 4400 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
399 4 0 8 3.1 C1=CC2=C(C=C1OC(F)(F)F)C(=O)C(=O)N2CC3=CN=C(C=C3)C4=CC=NC=C4
CHEMBL2381696 acm5_human Human No 6.4 EC50 = 446.7 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
386 5 0 7 4.4 C1=CC(=CC=C1OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)Cl
CHEMBL523685 acm5_human Human Yes 5.3 EC50 = 4600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm5_human Human Yes 5.3 EC50 = 4600 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL494846 acm5_human Human Yes 5.3 EC50 = 4660 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
369 2 0 3 3.8 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=C(C=C(C=C3)Br)F
CHEMBL494846 acm5_human Human Yes 5.3 EC50 = 4660 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
369 2 0 3 3.8 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=C(C=C(C=C3)Br)F
CHEMBL304142 acm5_human Human Yes 5.3 EC50 = 4700 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
168 1 1 4 0.3 COC1=NOC2=C1CNCCC2
CHEMBL3329751 acm5_human Human No 6.3 EC50 = 478.6 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329751 acm5_human Human No 6.3 EC50 = 480 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329751 acm5_human Human No 6.3 EC50 = 480 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL596289 acm5_human Human Yes 5.3 EC50 = 4800 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
433 4 0 7 5.1 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=C(C=C4)Cl
CHEMBL596289 acm5_human Human Yes 5.3 EC50 = 4800 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
433 4 0 7 5.1 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O)C4=CN=C(C=C4)Cl
CHEMBL1223860 acm5_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL1223860 acm5_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL1223938 acm5_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL1223938 acm5_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL2381698 acm5_human Human No 6.3 EC50 = 524.8 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
365 5 0 7 4.1 CC1=CC(=CC=C1)OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL3329752 acm5_human Human No 5.3 EC50 = 5495.4 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC(=CC=C1)C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329752 acm5_human Human No 5.3 EC50 = 5600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC(=CC=C1)C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329752 acm5_human Human No 5.3 EC50 = 5600 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC(=CC=C1)C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL595404 acm5_human Human No 5.2 EC50 = 5700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=CC(=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL595404 acm5_human Human No 5.2 EC50 = 5700 Funct
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=CC(=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL2381697 acm5_human Human No 6.2 EC50 = 588.8 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
381 6 0 8 3.7 COC1=CC=C(C=C1)OCCN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL1255607 acm5_human Human No 5.2 EC50 = 5900 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
415 4 0 7 5.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O)F
CHEMBL1255607 acm5_human Human No 5.2 EC50 = 5900 Funct
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
415 4 0 7 5.3 C1=CC=C(C=C1)C2=CC(=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O)F
CHEMBL7303 acm5_human Human Yes 6.2 EC50 = 600 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1083203 acm5_human Human No 6.2 EC50 = 600 Funct
Positive allosteric modulation of human muscarinic M5 receptorPositive allosteric modulation of human muscarinic M5 receptor
335 3 0 4 2.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O)F
CHEMBL3329755 acm5_rat Rat Yes 6.2 EC50 = 610 Funct
Activity at rat muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329755 acm5_rat Rat Yes 6.2 EC50 = 610 Funct
Activity at rat muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329715 acm5_human Human Yes 5.2 EC50 = 6166.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
387 6 0 4 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3
CHEMBL3329715 acm5_human Human Yes 5.2 EC50 = 6200 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
387 6 0 4 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3
CHEMBL3329715 acm5_human Human Yes 5.2 EC50 = 6200 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
387 6 0 4 2.9 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3
CHEMBL216928 acm5_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human M5 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M5 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL216928 acm5_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human M5 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M5 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL3329750 acm5_human Human No 6.2 EC50 = 640 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329750 acm5_human Human No 6.2 EC50 = 640 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329750 acm5_human Human No 6.2 EC50 = 645.7 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
461 6 1 5 3.1 CCN(CC1=CC=CC=C1Cl)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL512977 acm5_human Human No 5.2 EC50 = 7130 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL512977 acm5_human Human No 5.2 EC50 = 7130 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC(=CC=C1CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL513311 acm5_human Human No 5.2 EC50 = 7150 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
336 3 0 3 3.6 COC1=CC=CC(=C1)CN2C3=C(C=CC(=C3C(=O)C2=O)Cl)Cl
CHEMBL513311 acm5_human Human No 5.2 EC50 = 7150 Funct
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
336 3 0 3 3.6 COC1=CC=CC(=C1)CN2C3=C(C=CC(=C3C(=O)C2=O)Cl)Cl
CHEMBL3329739 acm5_human Human No 6.1 EC50 = 724.4 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 4 4.1 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(CCC4)C=C3
CHEMBL3329739 acm5_human Human No 6.1 EC50 = 730 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 4 4.1 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(CCC4)C=C3
CHEMBL3329739 acm5_human Human No 6.1 EC50 = 730 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 4 4.1 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(CCC4)C=C3
CHEMBL3329741 acm5_human Human No 6.1 EC50 = 740 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329741 acm5_human Human No 6.1 EC50 = 740 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329734 acm5_human Human No 5.1 EC50 = 7400 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 6 0 6 2.7 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCO4
CHEMBL3329734 acm5_human Human No 5.1 EC50 = 7400 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 6 0 6 2.7 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCO4
CHEMBL3329741 acm5_human Human No 6.1 EC50 = 741.3 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL3329734 acm5_human Human No 5.1 EC50 = 7413.1 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 6 0 6 2.7 CCN(CC1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OCO4
CHEMBL3329749 acm5_human Human No 6.1 EC50 = 750 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC=CC=C1OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329749 acm5_human Human No 6.1 EC50 = 750 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC=CC=C1OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329740 acm5_human Human No 6.1 EC50 = 758.6 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329749 acm5_human Human No 6.1 EC50 = 758.6 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
457 7 1 6 2.5 CCN(CC1=CC=CC=C1OC)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329740 acm5_human Human No 6.1 EC50 = 760 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329740 acm5_human Human No 6.1 EC50 = 760 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3334990 acm5_human Human Yes 5.1 EC50 = 7600 Funct
Silent allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerSilent allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
277 3 0 2 4.6 C1=CC(=CC(=C1)Cl)C=NN=CC2=CC(=CC=C2)Cl
CHEMBL3334990 acm5_human Human Yes 5.1 EC50 = 7600 Funct
Silent allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate readerSilent allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
277 3 0 2 4.6 C1=CC(=CC(=C1)Cl)C=NN=CC2=CC(=CC=C2)Cl
CHEMBL1223753 acm5_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm5_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm5_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm5_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL3329747 acm5_human Human No 6.1 EC50 = 870 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC(=C1)C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329748 acm5_human Human No 6.1 EC50 = 870 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC=C1C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329747 acm5_human Human No 6.1 EC50 = 870 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC(=C1)C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329748 acm5_human Human No 6.1 EC50 = 870 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC=C1C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329747 acm5_human Human No 6.1 EC50 = 871.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC(=C1)C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329748 acm5_human Human No 6.1 EC50 = 871.0 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 1 5 2.9 CCN(CC1=CC=CC=C1C)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)C=NN4
CHEMBL3329737 acm5_human Human No 6.0 EC50 = 930 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 5 3.7 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL3329737 acm5_human Human No 6.0 EC50 = 930 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 5 3.7 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL3329737 acm5_human Human No 6.0 EC50 = 933.3 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
441 6 0 5 3.7 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)OC=C4
CHEMBL69306 acm5_human Human No 6.0 EC50 = 950 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)
192 2 1 4 0.4 C#CCOC1=NOC2=C1CNCCC2
CHEMBL3329736 acm5_human Human No 6.0 EC50 = 970 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 7 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL3329736 acm5_human Human No 6.0 EC50 = 970 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 7 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL3329736 acm5_human Human No 6.0 EC50 = 977.2 Funct
Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
431 7 0 5 3.3 CCN(C(C)C1=CC=CC=C1)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL2312346 acm5_rat Rat No 9.4 IC50 = 0.5 Funct
Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA releaseOrthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA release
381 8 0 5 3.6 CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3
CHEMBL3353274 acm5_human Human No 6.0 IC50 = 1000 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 2 0 7 3.6 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC5=C(C=C4)OCO5)C(=O)C6=CC(=C(C(=C6)F)F)F
CHEMBL3105212 acm5_human Human No 6.0 IC50 = 1000 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC(=C5)F)F
CHEMBL3353274 acm5_human Human No 6.0 IC50 = 1000 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 2 0 7 3.6 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC5=C(C=C4)OCO5)C(=O)C6=CC(=C(C(=C6)F)F)F
CHEMBL15936 acm5_human Human No 4.0 IC50 = 100000 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5
191 0 1 4 1.2 C1CNCC2=C1C=CC3=NSN=C23
CHEMBL279105 acm5_human Human No 4.0 IC50 = 100000 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5
241 2 0 5 1.4 CC1=C(CN(CC1)C)C2=NSN=C2SC
CHEMBL3105228 acm5_human Human Yes 6.0 IC50 = 1047.1 Funct
Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preincubated for 150 secs followed by acetyl choline addition by Fluo-4-AM dye based fluorescence assayNegative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preincubated for 150 secs followed by acetyl choline addition by Fluo-4-AM dye based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105208 acm5_human Human No 6.0 IC50 = 1047.1 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
390 2 0 4 3.7 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL75880 acm5_human Human Yes 6.0 IC50 = 1093.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 6.8 C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
CHEMBL75880 acm5_human Human Yes 6.0 IC50 = 1093.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 6.8 C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
CHEMBL255523 acm5_rat Rat No 6.0 IC50 = 1100 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL3353283 acm5_human Human No 6.0 IC50 = 1100 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
456 4 0 5 4.1 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC6=C(C=C5)OCO6
CHEMBL255523 acm5_rat Rat No 6.0 IC50 = 1100 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL3353283 acm5_human Human No 6.0 IC50 = 1100 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
456 4 0 5 4.1 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC6=C(C=C5)OCO6
CHEMBL3105213 acm5_rat Rat No 6.0 IC50 = 1100 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL30008 acm5_human Human Yes 6.0 IC50 = 1107 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL30008 acm5_human Human Yes 6.0 IC50 = 1107 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL3105228 acm5_human Human Yes 6.0 IC50 = 1110 Funct
Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preincubated for 150 secs followed by acetyl choline addition by Fluo-4-AM dye based fluorescence assayNegative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization preincubated for 150 secs followed by acetyl choline addition by Fluo-4-AM dye based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL333940 acm5_human Human No 6.0 IC50 = 1114.8 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
372 13 0 3 6.6 CCCCCCCCCCOC(=O)C1CN(CC=C1C2=CC=CC=C2)CC
CHEMBL936 acm5_human Human Yes 5.9 IC50 = 1191 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL936 acm5_human Human Yes 5.9 IC50 = 1191 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 2 4.2 C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
CHEMBL3353268 acm5_human Human No 5.9 IC50 = 1200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 3 0 5 4.0 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)OC
CHEMBL6528 acm5_rat Rat No 5.9 IC50 = 1200 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
280 3 0 2 3.3 CN1CC(C2=CC=CC=C2C1CN(C)C)C3=CC=CC=C3
CHEMBL3353268 acm5_human Human No 5.9 IC50 = 1200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 3 0 5 4.0 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)OC
CHEMBL480464 acm5_human Human No 5.9 IC50 = 1220 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in insect Sf9 cells
255 6 1 4 2.2 CCC(C)C(C(=O)OCC1CCN2C1CCC2)O
CHEMBL480464 acm5_human Human No 5.9 IC50 = 1220 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in insect Sf9 cellsDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in insect Sf9 cells
255 6 1 4 2.2 CCC(C)C(C(=O)OCC1CCN2C1CCC2)O
CHEMBL490 acm5_human Human Yes 6.9 IC50 = 123 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL490 acm5_human Human Yes 6.9 IC50 = 123 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL3105215 acm5_human Human No 5.9 IC50 = 1288.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
472 3 0 7 5.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)F)C(=O)C5=CC=C(C=C5)SC(F)(F)F
CHEMBL42 acm5_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 acm5_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL1092460 acm5_human Human Yes 5.9 IC50 = 1300 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
374 5 1 4 3.7 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3OC)Cl
CHEMBL3353286 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 5 0 4 4.6 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C)OC
CHEMBL3353265 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 2 0 6 3.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC5=C(C=C4)OCO5)C(=O)C6=CC(=C(C=C6)F)F
CHEMBL3361328 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353287 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
461 5 0 5 4.3 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)F)OC
CHEMBL3353271 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 3 0 5 4.0 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)OC
CHEMBL1092460 acm5_human Human Yes 5.9 IC50 = 1300 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
374 5 1 4 3.7 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3OC)Cl
CHEMBL6747 acm5_rat Rat No 5.9 IC50 = 1300 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
292 2 0 2 3.5 CCN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4
CHEMBL3353286 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 5 0 4 4.6 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C)OC
CHEMBL3353265 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 2 0 6 3.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC5=C(C=C4)OCO5)C(=O)C6=CC(=C(C=C6)F)F
CHEMBL3361328 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353287 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
461 5 0 5 4.3 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)F)OC
CHEMBL3353271 acm5_human Human No 5.9 IC50 = 1300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 3 0 5 4.0 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)OC
CHEMBL271704 acm5_rat Rat No 4.9 IC50 = 13000 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL271704 acm5_rat Rat No 4.9 IC50 = 13000 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL3361328 acm5_human Human No 5.9 IC50 = 1318.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL346389 acm5_human Human Yes 5.9 IC50 = 1340 Funct
Inhibition of [3H]- NMS binding against human recombinant Muscarinic acetylcholine receptor M5Inhibition of [3H]- NMS binding against human recombinant Muscarinic acetylcholine receptor M5
358 3 1 4 2.9 C1CN(CCN1CC2=CC3=C(C=C2)NC(=O)CO3)C4=CC=C(C=C4)Cl
CHEMBL41 acm5_human Human Yes 5.9 IC50 = 1358 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 5 4.0 CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
CHEMBL41 acm5_human Human Yes 5.9 IC50 = 1358 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 6 1 5 4.0 CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
CHEMBL3105203 acm5_human Human No 5.9 IC50 = 1380.4 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
454 3 0 6 5.2 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC=C(C=C5)SC(F)(F)F
CHEMBL3353276 acm5_human Human No 5.9 IC50 = 1400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
473 3 0 6 4.4 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)Cl
CHEMBL3353276 acm5_human Human No 5.9 IC50 = 1400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
473 3 0 6 4.4 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)Cl
CHEMBL633 acm5_human Human Yes 5.8 IC50 = 1499 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL1083618 acm5_human Human No 5.8 IC50 = 1584.9 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083618 acm5_human Human No 5.8 IC50 = 1584.9 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL21731 acm5_human Human Yes 6.8 IC50 = 160 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL21731 acm5_human Human Yes 6.8 IC50 = 160 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL3353279 acm5_human Human No 5.8 IC50 = 1600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
473 3 0 6 4.4 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)Cl
CHEMBL3361327 acm5_human Human No 5.8 IC50 = 1600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353279 acm5_human Human No 5.8 IC50 = 1600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
473 3 0 6 4.4 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)Cl
CHEMBL3361327 acm5_human Human No 5.8 IC50 = 1600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3361327 acm5_human Human No 5.8 IC50 = 1621.8 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL499519 acm5_human Human No 5.8 IC50 = 1640 Funct
Binding affinity to human muscarinic M5 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M5 receptor expressed in insect Sf9 cells
758 23 5 11 6.2 CCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL499519 acm5_human Human No 5.8 IC50 = 1640 Funct
Binding affinity to human muscarinic M5 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M5 receptor expressed in insect Sf9 cells
758 23 5 11 6.2 CCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL304036 acm5_human Human No 5.8 IC50 = 1731.8 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
376 3 1 4 4.3 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=CC=C5C)C
CHEMBL954 acm5_human Human Yes 5.8 IC50 = 1771 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL294726 acm5_human Human No 4.8 IC50 = 17980.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
320 1 1 3 3.7 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC
CHEMBL3361317 acm5_human Human No 5.8 IC50 = 1800 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3361317 acm5_human Human No 5.8 IC50 = 1800 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL6482 acm5_rat Rat No 4.8 IC50 = 18000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
320 4 0 2 4.3 CCCCN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4
CHEMBL3361317 acm5_human Human No 5.7 IC50 = 1819.7 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL120135 acm5_human Human No 5.7 IC50 = 1889.3 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
315 5 0 3 4.2 CCN1CCC(C(C1)C(=O)OC2CCCCC2)C3=CC=CC=C3
CHEMBL3353282 acm5_human Human No 5.7 IC50 = 1900 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
471 6 0 4 5.0 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)OC(C)C
CHEMBL3353282 acm5_human Human No 5.7 IC50 = 1900 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
471 6 0 4 5.0 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)OC(C)C
CHEMBL114379 acm5_human Human No 5.7 IC50 = 1910 Funct
Binding affinity against muscarinic acetylcholine receptor M5Binding affinity against muscarinic acetylcholine receptor M5
386 3 1 4 3.3 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC5=C(C=C4Cl)OCO5
CHEMBL3105204 acm5_human Human No 5.7 IC50 = 1949.8 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
422 2 0 5 4.4 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL284237 acm5_human Human Yes 8.7 IC50 = 2 Funct
Percent inhibition against Muscarinic acetylcholine receptor M5 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M5 at 1 uM
221 0 1 1 2.8 CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24
CHEMBL1123 acm5_human Human Yes 8.6 IC50 = 2.4 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL3353270 acm5_human Human No 5.7 IC50 = 2000 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
455 3 0 5 4.3 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)Cl
CHEMBL3353270 acm5_human Human No 5.7 IC50 = 2000 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
455 3 0 5 4.3 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)Cl
CHEMBL6638 acm5_rat Rat No 4.7 IC50 = 20000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
349 6 0 2 5.4 CCCCCCN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4
CHEMBL61700 acm5_human Human No 5.7 IC50 = 2033.9 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
455 5 1 5 5.4 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC6=CC=CC=C6)C
CHEMBL3102882 acm5_human Human No 5.7 IC50 = 2041.7 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
457 2 0 5 5.0 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL3105217 acm5_human Human No 5.7 IC50 = 2089.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
440 2 0 6 4.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)F)C(=O)C5=CC(=CC=C5)C(F)(F)F
CHEMBL3361330 acm5_human Human No 5.7 IC50 = 2100 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
396 2 0 4 4.4 C1CCC(CC1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL540195 acm5_rat Rat No 5.7 IC50 = 2100 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
294 1 1 3 2.7 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=C(C=C4)O
CHEMBL15944 acm5_human Human No 5.7 IC50 = 2100 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5
227 2 0 5 1.5 CN1CCC=C(C1)C2=NSN=C2SC
CHEMBL3105208 acm5_rat Rat No 5.7 IC50 = 2100 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
390 2 0 4 3.7 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3361330 acm5_human Human No 5.7 IC50 = 2138.0 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
396 2 0 4 4.4 C1CCC(CC1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3361330 acm5_human Human No 5.7 IC50 = 2138.0 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
396 2 0 4 4.4 C1CCC(CC1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL728 acm5_human Human Yes 6.7 IC50 = 220 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL728 acm5_human Human Yes 6.7 IC50 = 220 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3353289 acm5_human Human No 5.7 IC50 = 2200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 5 0 4 4.6 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C)OC
CHEMBL3353289 acm5_human Human No 5.7 IC50 = 2200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 5 0 4 4.6 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C)OC
CHEMBL1108 acm5_human Human Yes 5.6 IC50 = 2298 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1094003 acm5_human Human Yes 5.6 IC50 = 2300 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
378 4 1 3 4.3 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3Cl)Cl
CHEMBL1094003 acm5_human Human Yes 5.6 IC50 = 2300 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
378 4 1 3 4.3 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3Cl)Cl
CHEMBL15675 acm5_human Human No 4.6 IC50 = 23000 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5
225 0 0 5 0.6 CN1CCC2=C(C1)C3=NSN=C3SC2
CHEMBL3105226 acm5_human Human No 5.6 IC50 = 2344.2 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
404 2 0 4 4.1 CC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=CC(=C5)F)F
CHEMBL3105209 acm5_human Human No 5.6 IC50 = 2344.2 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
473 3 0 6 5.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)OC(F)(F)F
CHEMBL332320 acm5_human Human No 6.6 IC50 = 235.6 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
372 13 0 3 6.6 CCCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL1180285 acm5_human Human No 7.6 IC50 = 24.8 Funct
Binding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assay
349 7 0 3 4.4 CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)C)C3=CC=CC=C3
CHEMBL3353273 acm5_human Human No 5.6 IC50 = 2400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
466 4 0 6 4.6 CC(C)OC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F
CHEMBL3361331 acm5_human Human No 5.6 IC50 = 2400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
382 2 0 4 3.9 C1CCC(C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353273 acm5_human Human No 5.6 IC50 = 2400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
466 4 0 6 4.6 CC(C)OC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F
CHEMBL3361331 acm5_human Human No 5.6 IC50 = 2400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
382 2 0 4 3.9 C1CCC(C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3361331 acm5_human Human No 5.6 IC50 = 2454.7 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
382 2 0 4 3.9 C1CCC(C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL71 acm5_human Human Yes 7.6 IC50 = 25 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL71 acm5_human Human Yes 7.6 IC50 = 25 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL83 acm5_human Human Yes 5.6 IC50 = 2585 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL6649 acm5_rat Rat No 5.6 IC50 = 2600 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
252 3 2 2 2.4 CNCC1C2=CC=CC=C2C(CN1)C3=CC=CC=C3
CHEMBL2391353 acm5_human Human No 4.6 IC50 = 26000 Funct
Binding affinity to M5 receptor (unknown origin) by radioligand displacement assayBinding affinity to M5 receptor (unknown origin) by radioligand displacement assay
265 3 1 3 1.8 C1CCC(CC1)NC(=O)CN2CCN3CCCC3C2
CHEMBL1221 acm5_human Human Yes 5.6 IC50 = 2607 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL3353290 acm5_human Human No 6.6 IC50 = 263.0 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL1507034 acm5_human Human Yes 5.6 IC50 = 2630.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
403 2 0 2 4.5 CC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3105227 acm5_human Human No 5.6 IC50 = 2630.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
404 2 0 4 4.1 CC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353290 acm5_human Human No 6.6 IC50 = 264 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353290 acm5_human Human No 6.6 IC50 = 264 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL58228 acm5_human Human No 4.6 IC50 = 26644.8 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
422 5 1 6 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=CC(=C(C=C5CCN4C3)OC)OC)C
CHEMBL445 acm5_human Human Yes 7.6 IC50 = 27 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL445 acm5_human Human Yes 7.6 IC50 = 27 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3353269 acm5_human Human No 5.6 IC50 = 2700 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
438 3 0 6 3.8 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)F
CHEMBL3353269 acm5_human Human No 5.6 IC50 = 2700 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
438 3 0 6 3.8 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)F
CHEMBL900 acm5_human Human Yes 7.6 IC50 = 28 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL55 acm5_human Human Yes 5.5 IC50 = 2885 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL55 acm5_human Human Yes 5.5 IC50 = 2885 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL1172 acm5_human Human Yes 6.5 IC50 = 292 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL1172 acm5_human Human Yes 6.5 IC50 = 292 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL1231 acm5_human Human Yes 8.5 IC50 = 3.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL1231 acm5_human Human Yes 8.5 IC50 = 3.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL1770373 acm5_human Human Yes 6.5 IC50 = 300 Funct
Binding affinity to muscarinic M5 receptorBinding affinity to muscarinic M5 receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 acm5_human Human Yes 6.5 IC50 = 300 Funct
Binding affinity to muscarinic M5 receptorBinding affinity to muscarinic M5 receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL11 acm5_rat Rat Yes 6.5 IC50 = 300 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
280 4 0 2 4.8 CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3105228 acm5_human Human Yes 6.5 IC50 = 300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105205 acm5_human Human No 5.5 IC50 = 3020.0 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
422 2 0 5 4.4 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC(=CC=C5)C(F)(F)F
CHEMBL3105210 acm5_human Human No 5.5 IC50 = 3020.0 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
489 3 0 6 5.8 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)SC(F)(F)F
CHEMBL195437 acm5_human Human Yes 4.5 IC50 = 30764 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL195437 acm5_human Human Yes 4.5 IC50 = 30764 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL1909072 acm5_human Human Yes 5.5 IC50 = 3144 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1909072 acm5_human Human Yes 5.5 IC50 = 3144 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3353284 acm5_human Human No 5.5 IC50 = 3200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
461 5 0 5 4.3 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)OC)F
CHEMBL3361338 acm5_human Human No 5.5 IC50 = 3200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 4 0 5 4.0 CCOC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353284 acm5_human Human No 5.5 IC50 = 3200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
461 5 0 5 4.3 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)OC)F
CHEMBL3361338 acm5_human Human No 5.5 IC50 = 3200 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
434 4 0 5 4.0 CCOC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL1411979 acm5_human Human Yes 5.5 IC50 = 3265 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
261 6 0 4 2.6 CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2
CHEMBL1411979 acm5_human Human Yes 5.5 IC50 = 3265 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
261 6 0 4 2.6 CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2
CHEMBL120972 acm5_human Human No 6.5 IC50 = 328.6 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1CN(CC=C1C2=CC=CC=C2)CC
CHEMBL3353285 acm5_human Human No 5.5 IC50 = 3300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
477 5 0 4 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)OC)Cl
CHEMBL3353266 acm5_human Human No 5.5 IC50 = 3300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
438 3 0 6 3.8 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)F
CHEMBL3353285 acm5_human Human No 5.5 IC50 = 3300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
477 5 0 4 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)OC)Cl
CHEMBL3353266 acm5_human Human No 5.5 IC50 = 3300 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
438 3 0 6 3.8 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)F
CHEMBL305660 acm5_human Human Yes 6.5 IC50 = 337.8 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL9967 acm5_human Human Yes 6.5 IC50 = 340.6 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL56564 acm5_human Human Yes 5.5 IC50 = 3450 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 1 3 3.8 CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
CHEMBL56564 acm5_human Human Yes 5.5 IC50 = 3450 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 1 3 3.8 CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
CHEMBL3105221 acm5_human Human No 5.5 IC50 = 3467.4 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
452 3 0 6 5.0 CC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(F)(F)F
CHEMBL1459098 acm5_human Human Yes 5.5 IC50 = 3490 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
372 2 0 3 3.6 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC=C(C=C5)F
CHEMBL1093775 acm5_human Human Yes 5.5 IC50 = 3500 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
358 4 1 3 4.1 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C)Cl
CHEMBL1093775 acm5_human Human Yes 5.5 IC50 = 3500 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
358 4 1 3 4.1 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C)Cl
CHEMBL266801 acm5_rat Rat No 5.5 IC50 = 3500 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
323 1 0 4 2.9 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL7568 acm5_human Human Yes 5.4 IC50 = 3736 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL7568 acm5_human Human Yes 5.4 IC50 = 3736 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL3105207 acm5_human Human No 5.4 IC50 = 3801.9 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
390 2 0 4 3.7 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC(=CC(=C5)F)F
CHEMBL61412 acm5_human Human No 5.4 IC50 = 3807.6 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.4 CCCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL303758 acm5_human Human No 5.4 IC50 = 3884.2 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
376 3 1 4 4.3 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)C)C
CHEMBL54 acm5_human Human Yes 5.4 IC50 = 3890 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL54 acm5_human Human Yes 5.4 IC50 = 3890 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL643 acm5_human Human Yes 8.3 IC50 = 4.6 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL395110 acm5_human Human Yes 7.4 IC50 = 40 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL715 acm5_human Human Yes 7.4 IC50 = 40 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL395110 acm5_human Human Yes 7.4 IC50 = 40 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL414182 acm5_rat Rat No 5.4 IC50 = 4000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
266 3 1 2 2.9 CN(C)CC1C2=CC=CC=C2C(CN1)C3=CC=CC=C3
CHEMBL6455 acm5_rat Rat No 5.4 IC50 = 4000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
293 1 1 3 2.4 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=C(C=C4)N
CHEMBL3105222 acm5_human Human No 5.4 IC50 = 4073.8 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
468 3 0 6 5.6 CC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)SC(F)(F)F
CHEMBL59939 acm5_human Human No 5.4 IC50 = 4093 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 3 1 5 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC
CHEMBL1090097 acm5_human Human No 5.4 IC50 = 4100 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL1090096 acm5_human Human No 5.4 IC50 = 4100 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
412 4 1 6 4.6 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F)Cl
CHEMBL3353281 acm5_human Human No 5.4 IC50 = 4100 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 6 0 4 4.6 CCOC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C
CHEMBL1090097 acm5_human Human No 5.4 IC50 = 4100 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL1090096 acm5_human Human No 5.4 IC50 = 4100 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
412 4 1 6 4.6 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F)Cl
CHEMBL3353281 acm5_human Human No 5.4 IC50 = 4100 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
457 6 0 4 4.6 CCOC1=CC=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC=C(C=C5)OC(C)C
CHEMBL301041 acm5_human Human No 5.4 IC50 = 4187.1 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
362 3 1 4 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=CC=CC=C5CCN4C3)C
CHEMBL59347 acm5_human Human No 4.4 IC50 = 43462.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
350 2 1 4 3.6 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=CC(=C(C=C5C4O3)OC)OC
CHEMBL1306 acm5_human Human Yes 5.4 IC50 = 4362 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL3105202 acm5_human Human No 5.4 IC50 = 4466.8 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
438 3 0 6 4.7 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC=C(C=C5)OC(F)(F)F
CHEMBL588119 acm5_human Human Yes 5.4 IC50 = 4486.8 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
338 12 2 3 5.8 CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O
CHEMBL588119 acm5_human Human Yes 5.4 IC50 = 4486.8 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
338 12 2 3 5.8 CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O
CHEMBL6575 acm5_rat Rat No 4.4 IC50 = 45000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
368 1 0 6 2.7 CN1CCN2CC(C3=C(C2C1)C=C(C=C3)[N+](=O)[O-])C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL6627 acm5_rat Rat Yes 4.3 IC50 = 46000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
278 1 0 2 3.1 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4
CHEMBL61494 acm5_human Human No 4.3 IC50 = 47361.5 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
408 5 1 6 3.5 CCOC(=O)C1=CNC2=C1C3=C(C=C2)OC4C5=CC(=C(C=C5CCN4C3)OC)OC
CHEMBL62251 acm5_human Human No 5.3 IC50 = 4737 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 4 1 5 4.3 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC(C)C
CHEMBL3105213 acm5_human Human No 6.3 IC50 = 478.6 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105213 acm5_human Human No 6.3 IC50 = 478.6 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105213 acm5_human Human No 6.3 IC50 = 480 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105213 acm5_human Human No 6.3 IC50 = 480 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3105211 acm5_human Human No 5.3 IC50 = 4897.8 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
457 2 0 5 5.0 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=CC=C5)C(F)(F)F
CHEMBL2024407 acm5_human Human No 5.3 IC50 = 4900 Funct
Antagonist activity at human muscarinic M5 receptor by calcium mobilization assayAntagonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm5_human Human No 5.3 IC50 = 4900 Funct
Antagonist activity at human muscarinic M5 receptor by calcium mobilization assayAntagonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024407 acm5_human Human No 5.3 IC50 = 4900 Funct
Antagonist activity at human muscarinic M5 receptor by calcium mobilization assayAntagonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm5_human Human No 5.3 IC50 = 4900 Funct
Antagonist activity at human muscarinic M5 receptor by calcium mobilization assayAntagonist activity at human muscarinic M5 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL1083925 acm5_human Human No 6.3 IC50 = 501.2 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083925 acm5_human Human No 6.3 IC50 = 501.2 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083108 acm5_human Human No 5.3 IC50 = 5011.9 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL1083108 acm5_human Human No 5.3 IC50 = 5011.9 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL809 acm5_human Human Yes 6.3 IC50 = 507.3 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL809 acm5_human Human Yes 6.3 IC50 = 507.3 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL3353277 acm5_human Human No 6.3 IC50 = 510 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353277 acm5_human Human No 6.3 IC50 = 510 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353277 acm5_human Human No 6.3 IC50 = 512.9 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353290 acm5_rat Rat No 6.3 IC50 = 516 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353290 acm5_rat Rat No 6.3 IC50 = 516 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL415 acm5_human Human Yes 7.3 IC50 = 53 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL415 acm5_human Human Yes 7.3 IC50 = 53 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL3361326 acm5_human Human No 5.3 IC50 = 5500 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC=C1C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353267 acm5_human Human No 5.3 IC50 = 5500 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
455 3 0 5 4.3 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)Cl
CHEMBL3361326 acm5_human Human No 5.3 IC50 = 5500 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC=C1C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL3353267 acm5_human Human No 5.3 IC50 = 5500 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
455 3 0 5 4.3 COC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)Cl
CHEMBL6446 acm5_rat Rat No 5.3 IC50 = 5600 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
308 2 0 3 3.1 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=C(C=C4)OC
CHEMBL3361326 acm5_human Human No 5.3 IC50 = 5623.4 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
420 3 0 5 3.7 COC1=CC=CC=C1C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F
CHEMBL1459098 acm5_rat Rat Yes 5.3 IC50 = 5670 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
372 2 0 3 3.6 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC=C(C=C5)F
CHEMBL3105206 acm5_human Human No 5.2 IC50 = 5754.4 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
423 2 0 2 4.8 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=CC=C4)C(=O)C5=CC(=CC(=C5)Cl)Cl
CHEMBL61774 acm5_human Human No 5.2 IC50 = 5760.1 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
348 2 1 4 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=CC=CC=C5C4O3)C(=O)OC
CHEMBL3361323 acm5_human Human No 5.2 IC50 = 5800 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
408 2 0 4 3.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=NC=C5)F
CHEMBL3361323 acm5_human Human No 5.2 IC50 = 5800 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
408 2 0 4 3.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=NC=C5)F
CHEMBL3361323 acm5_human Human No 5.2 IC50 = 5888.4 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
408 2 0 4 3.5 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=NC=C5)F
CHEMBL60142 acm5_human Human No 5.2 IC50 = 5999.2 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 4 1 5 3.5 CCOC(=O)C1=CNC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC
CHEMBL3361320 acm5_human Human No 6.2 IC50 = 610 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
443 2 0 5 4.4 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C(=C5)F)F)F
CHEMBL3361320 acm5_human Human No 6.2 IC50 = 610 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
443 2 0 5 4.4 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C(=C5)F)F)F
CHEMBL3361320 acm5_human Human No 6.2 IC50 = 616.6 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
443 2 0 5 4.4 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C(=C5)F)F)F
CHEMBL7303 acm5_human Human Yes 4.2 IC50 = 62500 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL244946 acm5_human Human Yes 6.2 IC50 = 631.0 Funct
Antagonist activity at human muscarinic receptor M5Antagonist activity at human muscarinic receptor M5
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL244946 acm5_human Human Yes 6.2 IC50 = 631.0 Funct
Antagonist activity at human muscarinic receptor M5Antagonist activity at human muscarinic receptor M5
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL2391356 acm5_human Human Yes 4.2 IC50 = 63000 Funct
Binding affinity to M5 receptor (unknown origin) by radioligand displacement assayBinding affinity to M5 receptor (unknown origin) by radioligand displacement assay
185 3 2 3 -0.2 CC(C)NC(=O)CN1CCNCC1
CHEMBL1082365 acm5_human Human No 5.2 IC50 = 6309.6 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1082365 acm5_human Human No 5.2 IC50 = 6309.6 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL648 acm5_human Human Yes 6.2 IC50 = 633 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL564 acm5_human Human Yes 7.2 IC50 = 64 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL564 acm5_human Human Yes 7.2 IC50 = 64 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL3353288 acm5_human Human No 5.2 IC50 = 6400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
477 5 0 4 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)Cl)OC
CHEMBL3353288 acm5_human Human No 5.2 IC50 = 6400 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
477 5 0 4 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC(=C(C=C5)Cl)OC
CHEMBL3361316 acm5_human Human Yes 5.2 IC50 = 6600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=CC(=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL404992 acm5_rat Rat No 5.2 IC50 = 6600 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
306 3 0 2 4.0 CCCN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4
CHEMBL3361316 acm5_human Human Yes 5.2 IC50 = 6600 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=CC(=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3361316 acm5_human Human Yes 5.2 IC50 = 6606.9 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
419 3 0 3 4.1 COC1=CC=CC(=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3353278 acm5_human Human No 6.2 IC50 = 700 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
456 3 0 7 3.9 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)F
CHEMBL3353278 acm5_human Human No 6.2 IC50 = 700 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
456 3 0 7 3.9 COC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)F
CHEMBL6603 acm5_rat Rat No 5.2 IC50 = 7000 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
266 4 2 2 2.7 CCNCC1C2=CC=CC=C2C(CN1)C3=CC=CC=C3
CHEMBL296419 acm5_human Human Yes 6.2 IC50 = 703 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL296419 acm5_human Human Yes 6.2 IC50 = 703 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL1983100 acm5_human Human Yes 4.2 IC50 = 71000 Funct
Binding affinity to M5 receptor (unknown origin) by radioligand displacement assayBinding affinity to M5 receptor (unknown origin) by radioligand displacement assay
225 3 2 3 0.8 C1CCC(CC1)NC(=O)CN2CCNCC2
CHEMBL2391352 acm5_human Human No 4.1 IC50 = 74000 Funct
Binding affinity to M5 receptor (unknown origin) by radioligand displacement assayBinding affinity to M5 receptor (unknown origin) by radioligand displacement assay
265 3 1 3 1.8 C1CCC(CC1)NC(=O)CN2CCN3CCCC3C2
CHEMBL59898 acm5_human Human Yes 5.1 IC50 = 7411.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL43064 acm5_human Human Yes 6.1 IC50 = 759 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL43064 acm5_human Human Yes 6.1 IC50 = 759 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL255169 acm5_rat Rat Yes 5.1 IC50 = 7600 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
372 6 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3=CC=CC=C3)Cl
CHEMBL255169 acm5_rat Rat Yes 5.1 IC50 = 7600 Funct
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay
372 6 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3=CC=CC=C3)Cl
CHEMBL1201207 acm5_human Human Yes 5.1 IC50 = 7861 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
472 4 4 9 0.1 CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)(O)O)O)C)O)F)C
CHEMBL1201207 acm5_human Human Yes 5.1 IC50 = 7861 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
472 4 4 9 0.1 CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)(O)O)O)C)O)F)C
CHEMBL3361319 acm5_human Human No 6.1 IC50 = 790 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
447 4 0 3 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3361319 acm5_human Human No 6.1 IC50 = 790 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
447 4 0 3 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3105228 acm5_rat Rat Yes 6.1 IC50 = 790 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
425 2 0 4 4.3 C1CN(C2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F
CHEMBL1083723 acm5_human Human No 6.1 IC50 = 794.3 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL3361319 acm5_human Human No 6.1 IC50 = 794.3 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
447 4 0 3 4.9 CC(C)OC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL1083723 acm5_human Human No 6.1 IC50 = 794.3 Funct
Inhibition of human muscarinic M5 receptor expressed in CHO cellsInhibition of human muscarinic M5 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL1626 acm5_human Human Yes 8.1 IC50 = 8.4 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 acm5_human Human Yes 8.1 IC50 = 8.4 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL2164905 acm5_human Human No 7.1 IC50 = 82 Funct
Antagonist activity at human muscarinic M5 receptor by calcium mobilization assayAntagonist activity at human muscarinic M5 receptor by calcium mobilization assay
326 4 0 3 3.4 CN1CCN(CC1)C(=O)C(CC2=CC=CC=C2)(C3=CC=CC=C3)F
CHEMBL300987 acm5_human Human No 5.1 IC50 = 8211.3 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=CC(=C5)OC)C
CHEMBL1090094 acm5_human Human No 6.1 IC50 = 830 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
434 4 1 8 4.2 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C(=C(C(=C3F)F)F)F)F)Cl
CHEMBL1090094 acm5_human Human No 6.1 IC50 = 830 Funct
Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization
434 4 1 8 4.2 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C(=C(C(=C3F)F)F)F)F)Cl
CHEMBL121059 acm5_human Human No 7.1 IC50 = 85.4 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M5 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL3361318 acm5_human Human No 6.1 IC50 = 850 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
433 4 0 3 4.5 CCOC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3361318 acm5_human Human No 6.1 IC50 = 850 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
433 4 0 3 4.5 CCOC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3361318 acm5_human Human No 6.1 IC50 = 851.1 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
433 4 0 3 4.5 CCOC1=CC=C(C=C1)C(=O)N2CCN3C2(C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL1113 acm5_human Human Yes 6.1 IC50 = 856 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL6445 acm5_rat Rat No 6.1 IC50 = 860 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
264 1 1 2 2.6 C1CN2CC(C3=CC=CC=C3C2CN1)C4=CC=CC=C4
CHEMBL584 acm5_human Human Yes 4.1 IC50 = 86074 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
568 10 4 6 5.7 CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
CHEMBL62247 acm5_human Human No 5.1 IC50 = 8624 Funct
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.2 CCOC1=CC2=C(C=C1)C3N(CC2)CC4=C(O3)C=CC5=C4C(=C(N5)C)C(=O)OCC
CHEMBL1180343 acm5_human Human No 6.1 IC50 = 866 Funct
Binding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assay
365 8 0 4 4.0 CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL1200604 acm5_human Human Yes 7.1 IC50 = 89 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 6 1 3 1.5 CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
CHEMBL479 acm5_human Human Yes 8.0 IC50 = 9.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL479 acm5_human Human Yes 8.0 IC50 = 9.2 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL3353280 acm5_human Human No 6.1 IC50 = 900 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL6459 acm5_rat Rat No 6.1 IC50 = 900 Funct
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellumBinding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
313 1 0 2 3.7 CN1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=C(C=C4)Cl
CHEMBL3353280 acm5_human Human No 6.1 IC50 = 900 Funct
Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=C(C=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353277 acm5_rat Rat No 6.0 IC50 = 963 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL3353277 acm5_rat Rat No 6.0 IC50 = 963 Funct
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assayNegative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
452 3 0 6 4.1 CC1=C(C=CC(=C1)C23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C(=C5)F)F)F)OC
CHEMBL1180284 acm5_human Human No 6.0 IC50 = 977 Funct
Binding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M5 muscarinic receptor expressed in cell membranes by radioligand binding assay
245 4 0 3 2.1 CCN1CCC(=C(C1)C(=O)OC)C2=CC=CC=C2
CHEMBL1910856 acm5_human Human Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay
445 9 2 4 4.8 CC(C)(CCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)N)N3CC(C3)OC4=CC=CC(=C4)O
CHEMBL1910856 acm5_human Human Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay
445 9 2 4 4.8 CC(C)(CCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)N)N3CC(C3)OC4=CC=CC(=C4)O
CHEMBL3629360 acm5_human Human No 9.0 Ki = 1.1 Funct
Antagonist activity at muscarinic M5 receptor (unknown origin)Antagonist activity at muscarinic M5 receptor (unknown origin)
705 14 5 8 5.4 C1CCC(CC1)C(C2=CC=CC=C2)(C3=NN(C=N3)CC4CCN(CC4)CCC5=CC=C(C=C5)CCNCC(C6=C7C=CC(=O)NC7=C(C=C6)O)O)O
CHEMBL3629360 acm5_human Human No 9.0 Ki = 1.1 Funct
Antagonist activity at muscarinic M5 receptor (unknown origin)Antagonist activity at muscarinic M5 receptor (unknown origin)
705 14 5 8 5.4 C1CCC(CC1)C(C2=CC=CC=C2)(C3=NN(C=N3)CC4CCN(CC4)CCC5=CC=C(C=C5)CCNCC(C6=C7C=CC(=O)NC7=C(C=C6)O)O)O
CHEMBL219825 acm5_human Human No 8.9 Ki = 1.2 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL219825 acm5_human Human No 8.9 Ki = 1.2 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL1187846 acm5_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation counting
303 5 1 5 0.9 CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
CHEMBL1187846 acm5_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation counting
303 5 1 5 0.9 CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
CHEMBL385328 acm5_human Human No 8.9 Ki = 1.3 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL385328 acm5_human Human No 8.9 Ki = 1.3 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL71124 acm5_human Human No 8.8 Ki = 1.7 Funct
The compound was tested for the binding affinity against Muscarinic acetylcholine receptor M5The compound was tested for the binding affinity against Muscarinic acetylcholine receptor M5
426 6 0 4 5.9 CC(C1CCN(CC1)C2CCCCC2)C3=CC=C(C=C3)S(=O)C4=CC=C(C=C4)OC
CHEMBL1123 acm5_human Human Yes 8.8 Ki = 1.7 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL1123 acm5_human Human Yes 8.8 Ki = 1.7 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL376255 acm5_human Human No 8.7 Ki = 2.0 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL376870 acm5_human Human No 8.7 Ki = 2.0 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL376255 acm5_human Human No 8.7 Ki = 2.0 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL376870 acm5_human Human No 8.7 Ki = 2.0 Funct
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
332 3 0 3 5.0 CN1CCCC1C2CSC(O2)(C3CCCCC3)C4=CC=CC=C4
CHEMBL715 acm5_human Human Yes 8.0 Ki = 10 Funct
Binding affinity to M5 receptor (unknown origin) by PDSP assayBinding affinity to M5 receptor (unknown origin) by PDSP assay
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL376295 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cells
468 16 0 12 2.8 COC1=NSN=C1OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL386983 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cells
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL608151 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of muscarinic M5 receptorInhibition of muscarinic M5 receptor
286 4 1 2 3.1 CCOCC1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
CHEMBL42 acm5_human Human Yes 7.0 Ki = 100 Funct
Binding affinity to M5 receptor (unknown origin) by PDSP assayBinding affinity to M5 receptor (unknown origin) by PDSP assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL376295 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cells
468 16 0 12 2.8 COC1=NSN=C1OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL386983 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M5 receptor expressed in A9 L cells
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL608151 acm5_human Human No 7.0 Ki = 100 Funct
Inhibition of muscarinic M5 receptorInhibition of muscarinic M5 receptor
286 4 1 2 3.1 CCOCC1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
CHEMBL1834350 acm5_human Human No 5.0 Ki = 10000 Funct
Inhibition of human muscarinic M5 receptorInhibition of human muscarinic M5 receptor
384 5 2 5 1.2 CCN=C(NS(=O)(=O)C1=CC(=CC=C1)Cl)N2CC3(CCNCC3)C=N2
CHEMBL1834350 acm5_human Human No 5.0 Ki = 10000 Funct
Inhibition of human muscarinic M5 receptorInhibition of human muscarinic M5 receptor
384 5 2 5 1.2 CCN=C(NS(=O)(=O)C1=CC(=CC=C1)Cl)N2CC3(CCNCC3)C=N2
CHEMBL3354066 acm5_human Human No 7.0 Ki = 102.3 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
510 10 0 7 3.8 CN1CCC=C(C1)C2=NSN=C2OCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354066 acm5_human Human No 7.0 Ki = 102.3 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
510 10 0 7 3.8 CN1CCC=C(C1)C2=NSN=C2OCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL259344 acm5_human Human No 5.0 Ki = 10232.9 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
202 1 0 2 1.7 CC1OC(CS1)C2CCC[N+]2(C)C
CHEMBL259344 acm5_human Human No 5.0 Ki = 10232.9 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
202 1 0 2 1.7 CC1OC(CS1)C2CCC[N+]2(C)C
CHEMBL169680 acm5_human Human No 5.0 Ki = 10232.9 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
278 5 0 2 3.0 CN(C)CCC1=C(C2=CC=CC=C2C1)CC3=CC=NC=C3
CHEMBL571123 acm5_human Human No 7.0 Ki = 104.7 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting
317 4 0 2 4.8 CN1CCCC1C2=CC=C(O2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL571123 acm5_human Human No 7.0 Ki = 104.7 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting
317 4 0 2 4.8 CN1CCCC1C2=CC=C(O2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL278074 acm5_human Human No 6.0 Ki = 1047.1 Funct
Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.
358 4 0 4 3.4 C1CN2CCC1C(C2)OC(=O)C3=CC(=CC4=CC=NC=C4)C5=CC=CC=C53
CHEMBL353290 acm5_human Human No 6.0 Ki = 1047.1 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
310 5 0 3 2.8 CC(C1=CC=CC=N1)C2=C(CC3=C2C=C(C=C3)F)CCN(C)C
CHEMBL127273 acm5_human Human No 7.0 Ki = 105 Funct
Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells
687 17 0 6 8.8 COC1=CC=CC=C1CN2CCC(CC2)C3CCN(CC3)CCCCCCCCN4CCC(CC4)C5CCN(CC5)CC6=CC=CC=C6OC
CHEMBL258907 acm5_human Human No 5.0 Ki = 10715.2 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
202 1 0 2 1.7 CC1OC(CS1)C2CCC[N+]2(C)C
CHEMBL258907 acm5_human Human No 5.0 Ki = 10715.2 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
202 1 0 2 1.7 CC1OC(CS1)C2CCC[N+]2(C)C
CHEMBL633 acm5_human Human Yes 6.0 Ki = 1077 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL633 acm5_human Human Yes 6.0 Ki = 1077 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL2312368 acm5_human Human No 7.0 Ki = 110 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
400 7 0 5 2.9 CN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)S(=O)(=O)C)C3=CC=CC=C3
CHEMBL177040 acm5_human Human No 6.0 Ki = 1100 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
637 15 3 4 6.7 C1CCC(CC1)CN2CCCC(C2)CNC(=O)CCCNC(=O)CNC(=O)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL171216 acm5_human Human No 6.0 Ki = 1122.0 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
306 5 0 2 3.0 CC(C)N(C)CC1=C(C2=CC=CC=C2C1)C(C)C3=CC=CC=N3
CHEMBL104574 acm5_human Human No 6.0 Ki = 1122.0 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
455 5 1 5 5.0 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OCC6=CC=CC=C6
CHEMBL104804 acm5_human Human No 6.0 Ki = 1122.0 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
411 3 1 3 5.6 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)CC6=CC=CC=C6
CHEMBL326450 acm5_human Human No 5.0 Ki = 11220 Funct
Binding affinity to human M5 muscarinic receptorBinding affinity to human M5 muscarinic receptor
435 7 1 5 5.2 CCCCC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OCC
CHEMBL169594 acm5_human Human No 5.0 Ki = 11220.2 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
322 7 0 4 2.7 CN(C)CCOC(=O)C1=C(C2=CC=CC=C2C1)CC3=CN=CC=C3
CHEMBL326450 acm5_human Human No 5.0 Ki = 11220.2 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
435 7 1 5 5.2 CCCCC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OCC
CHEMBL2312344 acm5_human Human No 5.9 Ki = 1140 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
363 6 0 4 3.7 CN1CCC(=C(C1)C2=CC=CC=C2)C(=O)OCCC3=CC4=C(C=C3)OCC4
CHEMBL21731 acm5_human Human Yes 6.9 Ki = 115 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL2312364 acm5_human Human No 5.9 Ki = 1160 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
380 9 0 4 4.3 CN1CCC(=C(C1)C(=O)OCCCCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL1189234 acm5_human Human Yes 5.9 Ki = 1161 Funct
Binding affinity to M5 muscarinic receptorBinding affinity to M5 muscarinic receptor
265 2 1 2 2.4 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC=CC=C7)O
CHEMBL1189234 acm5_human Human Yes 5.9 Ki = 1161 Funct
Inhibition of muscarinic M5 receptor (unknown origin) by PDSP assayInhibition of muscarinic M5 receptor (unknown origin) by PDSP assay
265 2 1 2 2.4 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC=CC=C7)O
CHEMBL352375 acm5_human Human No 4.9 Ki = 11749.0 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
349 7 0 2 4.3 CC(C)N(CCC1=C(C2=CC=CC=C2C1)C(C)C3=CC=CC=N3)C(C)C
CHEMBL499519 acm5_human Human No 5.9 Ki = 1180 Funct
Binding affinity to human muscarinic M5 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M5 receptor expressed in insect Sf9 cells
758 23 5 11 6.2 CCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL519609 acm5_human Human No 6.9 Ki = 120 Funct
Antagonist activity at muscarinic M5 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M5 receptor (unknown origin) by PDSP assay
356 7 0 4 4.5 CCN(CC)CCCOC(=O)N1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL2312378 acm5_human Human No 6.9 Ki = 120 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
365 6 0 5 3.4 CCN1CCC(=C(C1)C(=O)OCC2=CC3=C(C=C2)OCO3)C4=CC=CC=C4
CHEMBL21321 acm5_human Human No 5.9 Ki = 1230.3 Funct
Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.
358 4 0 4 3.4 C1CN2CCC1C(C2)OC(=O)C3=CC(=CC4=CN=CC=C4)C5=CC=CC=C53
CHEMBL2312386 acm5_human Human No 5.9 Ki = 1250 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
365 8 0 4 4.0 CCN1CCC(=C(C1)C(=O)OCCC2=CC=CC=C2OC)C3=CC=CC=C3
CHEMBL9967 acm5_human Human Yes 6.9 Ki = 126 Funct
Binding affinity to human M5 muscarinic receptorBinding affinity to human M5 muscarinic receptor
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL954 acm5_human Human Yes 5.9 Ki = 1272 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL954 acm5_human Human Yes 5.9 Ki = 1272 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL320820 acm5_human Human No 4.9 Ki = 13182.6 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
176 2 0 2 1.2 CC1OC(CS1)C[N+](C)(C)C
CHEMBL320820 acm5_human Human No 4.9 Ki = 13182.6 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
176 2 0 2 1.2 CC1OC(CS1)C[N+](C)(C)C
CHEMBL1231 acm5_human Human Yes 7.9 Ki = 14.1 Funct
Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL1231 acm5_human Human Yes 7.9 Ki = 14.1 Funct
Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation counting
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL2312383 acm5_human Human No 6.9 Ki = 140 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
336 7 0 4 3.0 CCN1CCC(=C(C1)C(=O)OCCC2=CC=NC=C2)C3=CC=CC=C3
CHEMBL354841 acm5_human Human No 5.8 Ki = 1445.4 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
306 5 0 2 3.1 CC1=CC2=C(C=C1)C(=C(C2)CCN(C)C)C(C)C3=CC=CC=N3
CHEMBL3354072 acm5_human Human No 4.8 Ki = 14454.4 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
330 7 1 3 2.4 C1CN(CCC1CCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3354072 acm5_human Human No 4.8 Ki = 14454.4 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
330 7 1 3 2.4 C1CN(CCC1CCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL318995 acm5_human Human No 5.8 Ki = 1479.1 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
451 7 1 5 5.8 CCCCC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)SC)C(=O)OCC
CHEMBL2112957 acm5_human Human No 6.8 Ki = 150 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
689 11 1 4 7.8 C1CCC(CC1)CN2CCCC(C2)CNC(=O)C3CCCN3C(=O)C4CCCN4C(=O)CC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7
CHEMBL2312387 acm5_human Human No 6.8 Ki = 150 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
365 8 0 4 4.0 CCN1CCC(=C(C1)C(=O)OCCC2=CC(=CC=C2)OC)C3=CC=CC=C3
CHEMBL569953 acm5_human Human No 5.8 Ki = 1548.8 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting
339 4 1 3 4.4 CN1CCCC1C2=CC=C(O2)C(C3CCCCC3)(C4=CC=CC=C4)O
CHEMBL569953 acm5_human Human No 5.8 Ki = 1548.8 Funct
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells by scintillation counting
339 4 1 3 4.4 CN1CCCC1C2=CC=C(O2)C(C3CCCCC3)(C4=CC=CC=C4)O
CHEMBL2205829 acm5_human Human No 5.8 Ki = 1555 Funct
Binding affinity to M5 muscarinic receptorBinding affinity to M5 muscarinic receptor
309 2 1 4 2.2 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC8=C(C=C7)OCO8)O
CHEMBL2205829 acm5_human Human No 5.8 Ki = 1555 Funct
Inhibition of muscarinic M5 receptor (unknown origin) by PDSP assayInhibition of muscarinic M5 receptor (unknown origin) by PDSP assay
309 2 1 4 2.2 C1C2C3C4C1C5C2C6C3C4C5(N6CC7=CC8=C(C=C7)OCO8)O
CHEMBL728 acm5_human Human Yes 6.8 Ki = 158 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL136027 acm5_human Human No 6.8 Ki = 158.5 Funct
Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M5 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M5 expressed in A9 L cells
496 17 0 10 6.3 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCCCCOC3=NSN=C3OC
CHEMBL461089 acm5_human Human No 4.8 Ki = 15848.9 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
151 1 1 2 1.3 CC1=CC=C(O1)C2CCCN2
CHEMBL461089 acm5_human Human No 4.8 Ki = 15848.9 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
151 1 1 2 1.3 CC1=CC=C(O1)C2CCCN2
CHEMBL466253 acm5_human Human Yes 6.8 Ki = 159 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting in presence of acetylcholineDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting in presence of acetylcholine
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_human Human Yes 6.8 Ki = 159 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting in presence of acetylcholineDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting in presence of acetylcholine
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL378772 acm5_human Human No 5.8 Ki = 1600 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
717 11 2 8 5.5 C1CC(N(C1)C(=O)C2CC(CN2C(=O)CC(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)O)C(=O)NCC6CCN(CC6)CC7CC7
CHEMBL214342 acm5_human Human No 5.8 Ki = 1600 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
677 9 2 8 4.8 CN1CCC(CC1)CNC(=O)C2CCCN2C(=O)C3CC(CN3C(=O)CC(C4=CC=C(C=C4)F)(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F)O
CHEMBL378772 acm5_human Human No 5.8 Ki = 1600 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
717 11 2 8 5.5 C1CC(N(C1)C(=O)C2CC(CN2C(=O)CC(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)O)C(=O)NCC6CCN(CC6)CC7CC7
CHEMBL214342 acm5_human Human No 5.8 Ki = 1600 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
677 9 2 8 4.8 CN1CCC(CC1)CNC(=O)C2CCCN2C(=O)C3CC(CN3C(=O)CC(C4=CC=C(C=C4)F)(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F)O
CHEMBL466253 acm5_human Human Yes 5.8 Ki = 1610 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation countingDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL466253 acm5_human Human Yes 5.8 Ki = 1610 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation countingDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting
351 4 0 7 3.5 COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O
CHEMBL1108 acm5_human Human Yes 5.8 Ki = 1651 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1108 acm5_human Human Yes 5.8 Ki = 1651 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL461087 acm5_human Human Yes 4.8 Ki = 16595.9 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
137 1 1 2 0.9 C1CC(NC1)C2=CC=CO2
CHEMBL461087 acm5_human Human Yes 4.8 Ki = 16595.9 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
137 1 1 2 0.9 C1CC(NC1)C2=CC=CO2
CHEMBL242345 acm5_human Human No 6.8 Ki = 169.8 Funct
Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cells
635 23 2 6 7.8 COC1=CC=CC=C1CNCCCCCCN2CCC(CC2)CCC3CCN(CC3)CCCCCCNCC4=CC=CC=C4OC
CHEMBL242345 acm5_human Human No 6.8 Ki = 169.8 Funct
Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cells
635 23 2 6 7.8 COC1=CC=CC=C1CNCCCCCCN2CCC(CC2)CCC3CCN(CC3)CCCCCCNCC4=CC=CC=C4OC
CHEMBL280220 acm5_human Human No 5.8 Ki = 1698.2 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
451 6 0 5 5.2 CCCC1=C(C2=C(N1C)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)SC)C(=O)OCC
CHEMBL1187846 acm5_human Human No 7.8 Ki = 17.6 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
303 5 1 5 0.9 CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
CHEMBL438822 acm5_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
663 9 3 8 4.3 C1CC(CNC1)CNC(=O)C2CCCN2C(=O)C3CC(CN3C(=O)CC(C4=CC=C(C=C4)F)(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F)O
CHEMBL214029 acm5_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
677 10 3 8 4.7 C1CC(N(C1)C(=O)C2CC(CN2C(=O)CC(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)O)C(=O)NCCC6CCNCC6
CHEMBL2205812 acm5_human Human No 5.8 Ki = 1700 Funct
Binding affinity to M5 muscarinic receptorBinding affinity to M5 muscarinic receptor
309 4 1 3 2.8 COC1=CC=C(C=C1)CCN2C3C4C5CC6C4C2(C7C6C5C73)O
CHEMBL438822 acm5_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
663 9 3 8 4.3 C1CC(CNC1)CNC(=O)C2CCCN2C(=O)C3CC(CN3C(=O)CC(C4=CC=C(C=C4)F)(C5=CC=C(C=C5)F)C6=CC=C(C=C6)F)O
CHEMBL214029 acm5_human Human No 5.8 Ki = 1700 Funct
Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells
677 10 3 8 4.7 C1CC(N(C1)C(=O)C2CC(CN2C(=O)CC(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)O)C(=O)NCCC6CCNCC6
CHEMBL172234 acm5_human Human No 4.8 Ki = 17378.0 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
322 7 0 4 2.8 CN(C)CCOC(=O)C1=C(C2=CC=CC=C2C1)CC3=CC=CC=N3
CHEMBL20732 acm5_human Human No 4.8 Ki = 17782.8 Funct
Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.
320 6 0 4 2.9 CN(C)CCOC(=O)C1=CC(=CC2=CC=CC=N2)C3=CC=CC=C31
CHEMBL71 acm5_human Human Yes 7.8 Ki = 18 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL552338 acm5_human Human Yes 5.8 Ki = 1800 Funct
Binding affinity to human muscarinic M5 receptorBinding affinity to human muscarinic M5 receptor
326 4 1 5 3.3 C1CC(C1)CN(C2CCNC2)C(=O)C3=CC=CC=C3C(F)(F)F
CHEMBL552338 acm5_human Human Yes 5.8 Ki = 1800 Funct
Binding affinity to human muscarinic M5 receptorBinding affinity to human muscarinic M5 receptor
326 4 1 5 3.3 C1CC(C1)CN(C2CCNC2)C(=O)C3=CC=CC=C3C(F)(F)F
CHEMBL3627739 acm5_human Human No 5.7 Ki = 1810 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
367 7 1 3 3.7 CN1CCC(CC1)(CNC(=O)CCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL3627739 acm5_human Human No 5.7 Ki = 1810 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
367 7 1 3 3.7 CN1CCC(CC1)(CNC(=O)CCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL59898 acm5_human Human Yes 5.7 Ki = 1819.7 Funct
Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cells
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL59898 acm5_human Human Yes 5.7 Ki = 1819.7 Funct
Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO-K1 cells
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL1643900 acm5_human Human No 5.7 Ki = 1827 Funct
Inhibition of muscarinic M5 receptorInhibition of muscarinic M5 receptor
283 4 1 2 3.9 C1C2C3CC4C2C5C1C3C(C45)NCCC6=CC(=CC=C6)F
CHEMBL1643900 acm5_human Human No 5.7 Ki = 1827 Funct
Inhibition of muscarinic M5 receptorInhibition of muscarinic M5 receptor
283 4 1 2 3.9 C1C2C3CC4C2C5C1C3C(C45)NCCC6=CC(=CC=C6)F
CHEMBL1643900 acm5_human Human No 5.7 Ki = 1827 Funct
Inhibition of muscarinic M5 receptor (unknown origin) by PDSP assayInhibition of muscarinic M5 receptor (unknown origin) by PDSP assay
283 4 1 2 3.9 C1C2C3CC4C2C5C1C3C(C45)NCCC6=CC(=CC=C6)F
CHEMBL130835 acm5_human Human No 6.7 Ki = 183 Funct
Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells
715 15 0 6 6.9 COC1=CC=CC=C1CN2CCC(CC2)C3CCN(CC3)C(=O)CCCCCCC(=O)N4CCC(CC4)C5CCN(CC5)CC6=CC=CC=C6OC
CHEMBL83 acm5_human Human Yes 5.7 Ki = 1857 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL83 acm5_human Human Yes 5.7 Ki = 1857 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL1221 acm5_human Human Yes 5.7 Ki = 1873 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL1221 acm5_human Human Yes 5.7 Ki = 1873 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL2312367 acm5_human Human No 6.7 Ki = 190 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
368 7 0 4 4.2 CN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)SC)C3=CC=CC=C3
CHEMBL2312392 acm5_human Human No 6.7 Ki = 190 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
353 7 0 4 4.1 CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)F)C3=CC=CC=C3
CHEMBL2312384 acm5_human Human No 6.7 Ki = 190 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
341 7 0 4 3.7 CCN1CCC(=C(C1)C(=O)OCCC2=CSC=C2)C3=CC=CC=C3
CHEMBL505086 acm5_human Human Yes 4.7 Ki = 19054.6 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
151 1 1 2 1.3 CC1=CC=C(O1)C2CCCN2
CHEMBL21509 acm5_human Human No 4.7 Ki = 19054.6 Funct
Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.
276 4 0 2 3.1 CN(C)CCC1=CC(=CC2=CC=CC=N2)C3=CC=CC=C31
CHEMBL505086 acm5_human Human Yes 4.7 Ki = 19054.6 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
151 1 1 2 1.3 CC1=CC=C(O1)C2CCCN2
CHEMBL105122 acm5_human Human No 5.7 Ki = 1949.8 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
409 4 1 5 4.4 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)SC)C
CHEMBL106259 acm5_human Human No 4.7 Ki = 19498.5 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
405 3 1 4 3.5 CCN(C)C(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL2432040 acm5_human Human No 5.7 Ki = 1987 Funct
Inhibition of muscarinic M5 receptor (unknown origin) by PDSP assayInhibition of muscarinic M5 receptor (unknown origin) by PDSP assay
279 3 0 2 2.5 CN(CC1=CC=CC=C1)C2C3C4CC5C3C(=O)C6C5C4C62
CHEMBL172233 acm5_human Human No 5.7 Ki = 1995.3 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
324 7 0 3 3.0 CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)CCF
CHEMBL355455 acm5_human Human No 5.7 Ki = 1995.3 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
318 5 0 2 3.2 CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN4CCCC4
CHEMBL1535 acm5_human Human Yes 4.7 Ki = 19952.6 Funct
Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL1382 acm5_human Human Yes 8.7 Ki = 2.2 Funct
Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells
325 7 1 2 5.6 CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
CHEMBL1382 acm5_rat Rat Yes 8.7 Ki = 2.2 Funct
Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method
325 7 1 2 5.6 CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
CHEMBL1382 acm5_human Human Yes 8.7 Ki = 2.2 Funct
Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells
325 7 1 2 5.6 CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
CHEMBL3354068 acm5_human Human No 8.6 Ki = 2.3 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354068 acm5_human Human No 8.6 Ki = 2.3 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL1346 acm5_human Human Yes 8.6 Ki = 2.3 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
427 7 1 3 4.6 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
CHEMBL1231 acm5_human Human Yes 8.6 Ki = 2.3 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL3354069 acm5_human Human No 8.5 Ki = 3.0 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
594 16 0 7 7.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354069 acm5_human Human No 8.5 Ki = 3.0 Funct
Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay
594 16 0 7 7.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL445 acm5_human Human Yes 7.7 Ki = 20 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL900 acm5_human Human Yes 7.7 Ki = 20 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL900 acm5_human Human Yes 7.7 Ki = 20 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL369062 acm5_human Human No 6.7 Ki = 200 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
651 16 3 4 6.6 C1CCC(CC1)CN2CCCC(C2)CNC(=O)CCNC(=O)CCCNC(=O)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2112961 acm5_human Human No 5.7 Ki = 2000 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
649 12 2 4 7.1 C1CCC(CC1)CN2CCCC(C2)CNC(=O)CNC(=O)C3CCCN3C(=O)CC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6
CHEMBL2432048 acm5_human Human No 5.7 Ki = 2001 Funct
Inhibition of muscarinic M5 receptor (unknown origin) by PDSP assayInhibition of muscarinic M5 receptor (unknown origin) by PDSP assay
265 4 1 1 3.8 C1C2C3CC4C2C5C1C3C(C45)NCCC6=CC=CC=C6
CHEMBL3629537 acm5_human Human No 5.7 Ki = 2050 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
383 8 1 4 4.2 CN1CCC(CC1)(CNC(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL3629537 acm5_human Human No 5.7 Ki = 2050 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
383 8 1 4 4.2 CN1CCC(CC1)(CNC(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL55 acm5_human Human Yes 5.7 Ki = 2073 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL168704 acm5_human Human No 5.7 Ki = 2089.3 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
320 7 0 2 3.4 CCN(CC)CCC1=C(C2=CC=CC=C2C1)C(C)C3=CC=CC=N3
CHEMBL1172 acm5_human Human Yes 6.7 Ki = 210 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL2112956 acm5_human Human No 6.7 Ki = 210 Funct
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
608 15 2 3 8.0 C1CCC(CC1)CN2CCCC(C2)CNC(=O)CCCCCNC(=O)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3629533 acm5_human Human No 5.7 Ki = 2140 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
398 9 0 5 4.2 CN1CCC(CC1)(COC(=O)CCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3
CHEMBL3629533 acm5_human Human No 5.7 Ki = 2140 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysisDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis
398 9 0 5 4.2 CN1CCC(CC1)(COC(=O)CCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3
CHEMBL355769 acm5_human Human No 5.7 Ki = 2187.8 Funct
Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine
320 6 0 2 3.5 CC(C)N(C)CCC1=C(C2=CC=CC=C2C1)C(C)C3=CC=CC=N3
CHEMBL105457 acm5_human Human No 4.7 Ki = 21877.6 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
160 2 0 2 0.4 CC1OCC(O1)C[N+](C)(C)C
CHEMBL513277 acm5_human Human No 4.7 Ki = 21877.6 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
165 1 0 2 1.8 CC1=CC=C(O1)C2CCCN2C
CHEMBL105457 acm5_human Human No 4.7 Ki = 21877.6 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
160 2 0 2 0.4 CC1OCC(O1)C[N+](C)(C)C
CHEMBL513277 acm5_human Human No 4.7 Ki = 21877.6 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
165 1 0 2 1.8 CC1=CC=C(O1)C2CCCN2C
CHEMBL195437 acm5_human Human Yes 4.7 Ki = 22102 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL320465 acm5_human Human No 5.7 Ki = 2238.7 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
421 6 1 5 4.7 CCCC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OCC
CHEMBL420662 acm5_human Human No 5.7 Ki = 2238.7 Funct
Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
404 5 1 5 4.2 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OCC=C
CHEMBL2312346 acm5_human Human No 5.7 Ki = 2240 Funct
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
381 8 0 5 3.6 CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3
CHEMBL1909072 acm5_human Human Yes 5.7 Ki = 2259 Funct
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL493795 acm5_human Human No 6.6 Ki = 229.1 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells
341 3 0 4 2.8 CN1CCCC1C2CS(=O)C(O2)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL493795 acm5_human Human No 6.6 Ki = 229.1 Funct
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells
341 3 0 4 2.8 CN1CCCC1C2CS(=O)C(O2)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL402473 acm5_human Human No 4.6 Ki = 22908.7 Funct
Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
186 1 0 2 0.9 CC1OCC(O1)C2CCC[N+]2(C)C
CHEMBL402473 acm5_human Human No 4.6 Ki = 22908.7 Funct