GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2583	205871	51	None	6	4	Human	9.0	pAC50	=	9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	CHEMBL839	205871	51	None	6	4	Human	9.0	pAC50	=	9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	1978	250	60	None	28	2	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	40	250	60	None	28	2	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	7107	250	60	None	28	2	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	CHEMBL642	250	60	None	28	2	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	DB01193	250	60	None	28	2	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	336	10	3	5	3.0	CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O	10.1038/s41467-023-40064-9
	10184665	3960	51	None	-173	10	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	-173	10	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	-173	10	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	-173	10	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	-173	10	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	216416	111554	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-117	23	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	11823027	192592	37	None	-5	3	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	4411	192592	37	None	-5	3	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	CHEMBL521606	192592	37	None	-5	3	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	72093	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4418	34192	85	None	-19	18	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34192	85	None	-19	18	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	12582	947	45	None	-1	7	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783	947	45	None	-1	7	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	CHEMBL49080	947	45	None	-1	7	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	DB01407	947	45	None	-1	7	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	3083544	26778	51	None	-199	6	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200811	26778	51	None	-199	6	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1363	26778	51	None	-199	6	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1951071	26778	51	None	-199	6	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL605993	26778	51	None	-199	6	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	100	3776	58	None	-2754	38	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-2754	38	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-2754	38	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-2754	38	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-2754	38	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	11980903	14460	19	None	-354	25	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14460	19	None	-354	25	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14460	19	None	-354	25	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14460	19	None	-354	25	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	2713	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-2	27	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	6436135	99544	43	None	-1	2	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	9	2	4	5.8	CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL283754	99544	43	None	-1	2	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	9	2	4	5.8	CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O	10.1038/s41467-023-40064-9
	5906	14463	23	None	-1	4	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14463	23	None	-1	4	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	202	1496	77	None	-10	17	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-10	17	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-10	17	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-10	17	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-10	17	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3191	102831	97	None	-831	33	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102831	97	None	-831	33	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	1786	2503	85	None	-10	7	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	4171	2503	85	None	-10	7	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	553	2503	85	None	-10	7	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL13	2503	85	None	-10	7	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00264	2503	85	None	-10	7	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	267	9	2	4	1.6	COCCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	6436173	55086	45	None	-4	22	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1617	55086	45	None	-4	22	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	2274	3151	58	None	-1047	37	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-1047	37	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-1047	37	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-1047	37	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-1047	37	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3464	3150	28	None	-616	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	4916	3150	28	None	-616	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	CHEMBL160519	3150	28	None	-616	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	DB01366	3150	28	None	-616	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	290	5	4	4	2.0	CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C	10.1038/s41467-023-40064-9
	31729	205761	10	None	-707	7	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL83063	205761	10	None	-707	7	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3926	207218	40	None	-27	18	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207218	40	None	-27	18	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	1016	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2561	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2733526	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	5384	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL83	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	DB00675	3720	78	None	-2344	40	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2267	557	71	None	-741	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	557	71	None	-741	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	557	71	None	-741	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	557	71	None	-741	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	557	71	None	-741	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2435	3563	83	None	-4365	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3563	83	None	-4365	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3563	83	None	-4365	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3563	83	None	-4365	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3563	83	None	-4365	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2540	4369	111	None	-2570	28	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4369	111	None	-2570	28	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	64139	84756	96	None	-3	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	CHEMBL223228	84756	96	None	-3	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	0	1	2	4.1	O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1	10.1038/s41467-023-40064-9
	451668	14425	110	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	228	2	3	8	-2.1	Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1	10.1038/s41467-023-40064-9
	CHEMBL1201129	14425	110	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	228	2	3	8	-2.1	Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1	10.1038/s41467-023-40064-9
	33624	3792	34	None	-3	6	Human	8.6	pAC50	=	8.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	4061	3792	34	None	-3	6	Human	8.6	pAC50	=	8.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	565	3792	34	None	-3	6	Human	8.6	pAC50	=	8.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL499	3792	34	None	-3	6	Human	8.6	pAC50	=	8.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	DB00373	3792	34	None	-3	6	Human	8.6	pAC50	=	8.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	1222	1651	49	None	-467	25	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1651	49	None	-467	25	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1651	49	None	-467	25	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1651	49	None	-467	25	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1651	49	None	-467	25	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	1836	2574	59	None	-39810	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	3340	2574	59	None	-39810	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	5281040	2574	59	None	-39810	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	CHEMBL787	2574	59	None	-39810	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	DB00471	2574	59	None	-39810	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1038/s41467-023-40064-9
	5591	157507	90	None	-12	17	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	-12	17	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	3151	1450	97	None	-7585	24	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1450	97	None	-7585	24	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1450	97	None	-7585	24	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1450	97	None	-7585	24	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1450	97	None	-7585	24	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	165193	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	2303	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	62882	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	66366	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3165	68	None	-6	20	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	5282219	35839	63	None	-3	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1441961	35839	63	None	-3	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	105	3435	91	None	-28	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	2083	3435	91	None	-28	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	558	3435	91	None	-28	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL714	3435	91	None	-28	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	DB01001	3435	91	None	-28	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	11976	917	59	None	-7244	16	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	917	59	None	-7244	16	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	917	59	None	-7244	16	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	917	59	None	-7244	16	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	155774	4065	40	None	42	3	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	2848	4065	40	None	42	3	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	538	4065	40	None	42	3	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL75753	4065	40	None	42	3	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	DB13781	4065	40	None	42	3	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1038/s41467-023-40064-9
	180	400	56	None	-48977	38	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-48977	38	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-48977	38	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-48977	38	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-48977	38	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3689	102744	55	None	-3311	16	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102744	55	None	-3311	16	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102744	55	None	-3311	16	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	1971	2846	38	None	-33113	32	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-33113	32	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-33113	32	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-33113	32	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-33113	32	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	5482	14388	80	None	-13	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14388	80	None	-13	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2419	3437	84	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3437	84	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3437	84	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3437	84	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3437	84	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	129211	3722	78	None	-5495	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3722	78	None	-5495	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3722	78	None	-5495	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3722	78	None	-5495	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3722	78	None	-5495	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	26987	946	33	None	-21877	34	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-21877	34	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-21877	34	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-21877	34	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-21877	34	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	4640	78237	30	None	-218	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78237	30	None	-218	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	4486	122957	25	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	11	2	9	0.3	Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O	10.1038/s41467-023-40064-9
	CHEMBL360861	122957	25	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	11	2	9	0.3	Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O	10.1038/s41467-023-40064-9
	1549120	196463	85	None	-17	19	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56337	196463	85	None	-17	19	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	2372	106441	40	None	12	6	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106441	40	None	12	6	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	5606	10161	67	None	-3	2	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1159717	10161	67	None	-3	2	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	65948	18524	109	None	-12	6	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	CHEMBL1275868	18524	109	None	-12	6	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	4908	188782	78	None	-5	7	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	CHEMBL506	188782	78	None	-5	7	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	4452	2742	19	None	-8912	21	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2742	19	None	-8912	21	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2742	19	None	-8912	21	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	2470	3626	50	None	-46773	23	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-46773	23	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-46773	23	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-46773	23	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-46773	23	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	216239	23763	118	None	-15	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23763	118	None	-15	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23763	118	None	-15	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	3760	50270	37	None	-3	5	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	414	6	0	3	6.5	Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1571863	50270	37	None	-3	5	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	414	6	0	3	6.5	Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	30323	62455	57	None	-14	21	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL1563	62455	57	None	-14	21	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL178	62455	57	None	-14	21	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	135398735	136943	32	None	-12	27	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	136262914	136943	32	None	-12	27	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL374478	136943	32	None	-12	27	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	176	397	66	None	-4	40	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157	397	66	None	-4	40	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2566	397	66	None	-4	40	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	CHEMBL633	397	66	None	-4	40	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	DB01118	397	66	None	-4	40	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2333	142310	97	None	-25	14	Human	4.5	pAC50	=	4.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142310	97	None	-25	14	Human	4.5	pAC50	=	4.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	118422671	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2737	65	None	22	23	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	2585	800	103	None	1	34	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	1	34	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	1	34	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	1	34	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	1	34	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	3149	12582	15	None	-8	26	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-8	26	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2601	3751	33	None	-1023	17	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-1023	17	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-1023	17	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-1023	17	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-1023	17	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	5311064	1354	46	None	3	7	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	534	1354	46	None	3	7	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	806	1354	46	None	3	7	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL493682	1354	46	None	3	7	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	150	2492	21	None	-1445	17	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	-1445	17	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	-1445	17	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	-1445	17	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	-1445	17	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	2291	3162	58	None	-6	13	Human	6.4	pAC50	=	6.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3162	58	None	-6	13	Human	6.4	pAC50	=	6.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3162	58	None	-6	13	Human	6.4	pAC50	=	6.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3162	58	None	-6	13	Human	6.4	pAC50	=	6.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3162	58	None	-6	13	Human	6.4	pAC50	=	6.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2464	3613	58	None	-7	3	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	5253	3613	58	None	-7	3	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	7297	3613	58	None	-7	3	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL471	3613	58	None	-7	3	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	DB00489	3613	58	None	-7	3	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	272	6	3	4	1.1	CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C	10.1038/s41467-023-40064-9
	4567	9916	34	None	-72	12	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9916	34	None	-72	12	Human	5.4	pAC50	=	5.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	2176	3104	68	None	-1	8	Human	8.4	pAC50	=	8.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828	3104	68	None	-1	8	Human	8.4	pAC50	=	8.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	91	3104	68	None	-1	8	Human	8.4	pAC50	=	8.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL500	3104	68	None	-1	8	Human	8.4	pAC50	=	8.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00960	3104	68	None	-1	8	Human	8.4	pAC50	=	8.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	44112	121264	48	None	-1	12	Human	8.3	pAC50	=	8.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121264	48	None	-1	12	Human	8.3	pAC50	=	8.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	9931954	10902	76	None	-3	2	Human	4.4	pAC50	=	4.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	323	3	3	2	3.0	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1173055	10902	76	None	-3	2	Human	4.4	pAC50	=	4.4	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	323	3	3	2	3.0	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	10.1038/s41467-023-40064-9
	3486	3135	56	None	-1	2	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	4883	3135	56	None	-1	2	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	555	3135	56	None	-1	2	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL6995	3135	56	None	-1	2	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	DB01297	3135	56	None	-1	2	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	7	3	4	1.4	OC(COc1ccc(cc1)NC(=O)C)CNC(C)C	10.1038/s41467-023-40064-9
	25382	9125	37	None	-141	21	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-141	21	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	36811	1442	37	None	-11	17	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	1442	37	None	-11	17	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	1442	37	None	-11	17	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	1442	37	None	-11	17	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	1442	37	None	-11	17	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	16362	3103	71	None	-616	35	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-616	35	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-616	35	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-616	35	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-616	35	Human	5.3	pAC50	=	5.3	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2318	154832	29	None	-8	15	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	-8	15	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	11504295	2902	47	None	-954	8	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2902	47	None	-954	8	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2902	47	None	-954	8	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2902	47	None	-954	8	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2902	47	None	-954	8	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2398	951	62	None	-4265	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-4265	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-4265	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-4265	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-4265	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1499	2078	47	None	-58	38	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779	2078	47	None	-58	38	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	536	2078	47	None	-58	38	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	CHEMBL434	2078	47	None	-58	38	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	DB01064	2078	47	None	-58	38	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	137	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	369	52	None	-3	8	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	4631	194949	29	None	-1	5	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL546	194949	29	None	-1	5	Human	8.2	pAC50	=	8.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	2169	44817	35	None	1	12	Human	7.2	pAC50	=	7.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44817	35	None	1	12	Human	7.2	pAC50	=	7.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	1155	1616	53	None	-17	11	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1616	53	None	-17	11	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1616	53	None	-17	11	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1616	53	None	-17	11	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1616	53	None	-17	11	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-54	37	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-54	37	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2249	511	111	None	-38	5	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	255	511	111	None	-38	5	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	548	511	111	None	-38	5	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL24	511	111	None	-38	5	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	DB00335	511	111	None	-38	5	Human	6.2	pAC50	=	6.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	266	8	3	4	0.5	OC(COc1ccc(cc1)CC(=O)N)CNC(C)C	10.1038/s41467-023-40064-9
	9801	91556	35	None	-17	16	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL24072	91556	35	None	-17	16	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-2398	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-2398	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-2398	36	Human	5.2	pAC50	=	5.2	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	242	469	124	None	-213	33	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-213	33	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-213	33	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-213	33	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-213	33	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2663	98734	34	None	60	2	Human	7.1	pAC50	=	7.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL27810	98734	34	None	60	2	Human	7.1	pAC50	=	7.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	379	9	3	5	2.9	CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-57	34	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-57	34	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-57	34	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-57	34	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	56959	31526	103	None	-5	9	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31526	103	None	-5	9	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31526	103	None	-5	9	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	5639	98867	75	None	-15	13	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98867	75	None	-15	13	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	2351	4269	49	None	-3	22	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4269	49	None	-3	22	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4269	49	None	-3	22	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	11658860	2329	51	None	-724	11	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2329	51	None	-724	11	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2329	51	None	-724	11	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2329	51	None	-724	11	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2329	51	None	-724	11	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	119607	206180	113	None	1	6	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL865	206180	113	None	1	6	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	10.1038/s41467-023-40064-9
	68617	205504	62	None	-23	30	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-23	30	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-23	30	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	16363	593	53	None	-1621	21	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-1621	21	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-1621	21	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-1621	21	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-1621	21	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	1054	1573	54	None	66	2	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	59768	1573	54	None	66	2	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	7178	1573	54	None	66	2	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL768	1573	54	None	66	2	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00187	1573	54	None	66	2	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	295	9	2	5	1.5	COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	275196	125647	52	None	-26	5	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	CHEMBL364713	125647	52	None	-26	5	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	413	4	0	8	2.9	COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C	10.1038/s41467-023-40064-9
	156419	935	74	None	-138	15	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3308	935	74	None	-138	15	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	647	935	74	None	-138	15	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1201284	935	74	None	-138	15	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB01012	935	74	None	-138	15	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	41684	31191	105	None	-19	32	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31191	105	None	-19	32	Human	5.1	pAC50	=	5.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	1673	959	24	None	-1	3	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	5284371	959	24	None	-1	3	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	725	959	24	None	-1	3	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	CHEMBL485	959	24	None	-1	3	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	DB00318	959	24	None	-1	3	Human	6.1	pAC50	=	6.1	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	299	1	1	4	1.5	COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C	10.1038/s41467-023-40064-9
	31101	726	40	None	-1659	29	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-1659	29	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-1659	29	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-1659	29	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-1659	29	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	135564886	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	14461	5	None	-3	25	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	1028	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	289	71	None	-10	19	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2405	662	76	None	-6	4	Human	7.0	pAC50	=	7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	380	662	76	None	-6	4	Human	7.0	pAC50	=	7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	7129	662	76	None	-6	4	Human	7.0	pAC50	=	7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL645	662	76	None	-6	4	Human	7.0	pAC50	=	7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	DB00612	662	76	None	-6	4	Human	7.0	pAC50	=	7	Functional	Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method	ChEMBL	325	12	2	5	2.4	OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C	10.1038/s41467-023-40064-9
	9849126	12407	0	None	3	4	Guinea pig	10.4	pEC50	=	10.4	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL1185969	12407	0	None	3	4	Guinea pig	10.4	pEC50	=	10.4	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL443435	12407	0	None	3	4	Guinea pig	10.4	pEC50	=	10.4	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	1499	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	3779	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	536	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	CHEMBL434	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	DB01064	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm701324c
	1499	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	3779	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	536	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	CHEMBL434	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	DB01064	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2008.08.009
	1499	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	3779	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	536	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	CHEMBL434	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	DB01064	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm800222k
	1499	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	3779	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	536	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	CHEMBL434	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	DB01064	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm8000345
	1499	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	3779	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	536	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	CHEMBL434	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	DB01064	2078	47	None	-58	38	Human	10.1	pEC50	=	10.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmcl.2004.11.001
	11268355	96367	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	CHEMBL26183	96367	0	None	1	3	Human	9.9	pEC50	=	9.9	Functional	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	358	7	3	3	4.1	COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12	10.1016/s0960-894x(03)00073-8
	1239	1664	55	None	1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3410	1664	55	None	1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	3465	1664	55	None	1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	CHEMBL1256786	1664	55	None	1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	DB00983	1664	55	None	1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1021/jm801016j
	24936881	17485	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	476	8	3	8	4.1	Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	CHEMBL1257913	17485	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	476	8	3	8	4.1	Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1	10.1016/j.bmcl.2010.08.039
	12065	625	26	None	-6	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	45483813	625	26	None	-6	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	CHEMBL579394	625	26	None	-6	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	164622827	188540	0	None	-26	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868585	188540	0	None	-26	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028721	188540	0	None	-26	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	9891927	184173	9	None	-5	4	Guinea pig	9.1	pEC50	=	9.1	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL446840	184173	9	None	-5	4	Guinea pig	9.1	pEC50	=	9.1	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483200	184173	9	None	-5	4	Guinea pig	9.1	pEC50	=	9.1	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483201	184173	9	None	-5	4	Guinea pig	9.1	pEC50	=	9.1	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	45483810	197121	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL567863	197121	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	123686	1968	51	None	74	3	Human	9.1	pEC50	=	9.1	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	12581	1968	51	None	74	3	Human	9.1	pEC50	=	9.1	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	CHEMBL11268	1968	51	None	74	3	Human	9.1	pEC50	=	9.1	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	354	9	4	5	1.7	C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O	10.1021/jm400348g
	1499	2078	47	None	-58	38	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	3779	2078	47	None	-58	38	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	536	2078	47	None	-58	38	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	CHEMBL434	2078	47	None	-58	38	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	DB01064	2078	47	None	-58	38	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm9000709
	164623105	188544	0	None	-47	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4862449	188544	0	None	-47	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028738	188544	0	None	-47	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	13345218	197198	0	None	-8	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568272	197198	0	None	-8	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	44392175	131768	0	None	1	2	Human	9.1	pEC50	=	9.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	480	12	5	7	3.2	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1	10.1016/j.bmcl.2004.11.001
	CHEMBL369346	131768	0	None	1	2	Human	9.1	pEC50	=	9.1	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	480	12	5	7	3.2	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1	10.1016/j.bmcl.2004.11.001
	1499	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	3779	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	536	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	CHEMBL434	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	DB01064	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	1499	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	3779	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	536	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	CHEMBL434	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	DB01064	2078	47	None	-58	38	Human	9.0	pEC50	=	9	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	1499	2078	47	None	-58	38	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	3779	2078	47	None	-58	38	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	536	2078	47	None	-58	38	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	CHEMBL434	2078	47	None	-58	38	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	DB01064	2078	47	None	-58	38	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	44392230	65567	1	None	1	2	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	479	12	6	6	3.0	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/j.bmcl.2004.11.001
	CHEMBL183283	65567	1	None	1	2	Human	8.9	pEC50	=	8.9	Functional	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	ChEMBL	479	12	6	6	3.0	O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/j.bmcl.2004.11.001
	24822304	97836	0	None	6	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	412	9	3	5	4.1	O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	CHEMBL272234	97836	0	None	6	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	ChEMBL	412	9	3	5	4.1	O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1	10.1021/jm701324c
	105	3435	91	None	-28	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	2083	3435	91	None	-28	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	558	3435	91	None	-28	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	CHEMBL714	3435	91	None	-28	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	DB01001	3435	91	None	-28	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	164615126	188480	0	None	-104	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854569	188480	0	None	-104	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028293	188480	0	None	-104	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	90645347	112486	0	None	-7	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298987	112486	0	None	-7	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	164618895	188511	0	None	-95	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868938	188511	0	None	-95	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028525	188511	0	None	-95	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	45101519	198500	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	CHEMBL577917	198500	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level	ChEMBL	498	11	8	7	1.6	CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.06.104
	24936492	17517	0	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	482	8	3	9	4.1	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	CHEMBL1258026	17517	0	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay	ChEMBL	482	8	3	9	4.1	Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1	10.1016/j.bmcl.2010.08.039
	164612078	188454	0	None	-64	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848617	188454	0	None	-64	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028119	188454	0	None	-64	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	9927453	96658	0	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	CHEMBL26393	96658	0	None	-1	3	Human	8.7	pEC50	=	8.7	Functional	Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR	ChEMBL	328	6	3	2	4.1	C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1	10.1016/s0960-894x(03)00073-8
	42625513	12527	0	None	-3	4	Guinea pig	8.7	pEC50	=	8.7	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL1186722	12527	0	None	-3	4	Guinea pig	8.7	pEC50	=	8.7	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	CHEMBL475389	12527	0	None	-3	4	Guinea pig	8.7	pEC50	=	8.7	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm801016j
	90645346	112468	0	None	-2	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	13	6	7	4.7	O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298762	112468	0	None	-2	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	13	6	7	4.7	O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2014.04.095
	42625517	12689	0	None	-19	4	Guinea pig	8.0	pEC50	=	8	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187654	12689	0	None	-19	4	Guinea pig	8.0	pEC50	=	8	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL514032	12689	0	None	-19	4	Guinea pig	8.0	pEC50	=	8	Functional	Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	11180293	112481	0	None	-22	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298897	112481	0	None	-22	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	56668796	66572	0	None	-31	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1835860	66572	0	None	-31	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	CHEMBL1852632	66572	0	None	-31	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	598	20	7	7	4.3	O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1	10.1016/j.bmc.2011.08.043
	45273268	195606	0	None	194	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204004	195606	0	None	194	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL556274	195606	0	None	194	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	362	10	3	4	4.0	O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	10217757	112243	0	None	-31	4	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290998	112243	0	None	-31	4	Human	8.0	pEC50	=	8	Functional	Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	164614147	188468	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4856990	188468	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028233	188468	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164618813	188510	0	None	-275	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865833	188510	0	None	-275	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028523	188510	0	None	-275	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164619360	188514	0	None	-371	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868763	188514	0	None	-371	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028547	188514	0	None	-371	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	155774	4065	40	None	42	3	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	2848	4065	40	None	42	3	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	538	4065	40	None	42	3	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	CHEMBL75753	4065	40	None	42	3	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	DB13781	4065	40	None	42	3	Human	8.0	pEC50	=	8.0	Functional	Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs	ChEMBL	339	8	4	6	-0.2	OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1	10.1021/jm400348g
	10863093	50297	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	439	10	4	6	2.1	C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	CHEMBL157210	50297	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration	ChEMBL	439	10	4	6	2.1	C[C@H](CNc1ccc(CC(=O)NS(C)(=O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1021/jm0101500
	16049450	64063	0	None	-125	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807827	64063	0	None	-125	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	16049234	64064	0	None	-177	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807828	64064	0	None	-177	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3ccccc3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	16049448	64065	0	None	-56	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807829	64065	0	None	-56	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	515	13	5	7	4.2	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCNCCc3cccc(Cl)c3Cl)c2s1	10.1016/j.bmcl.2011.05.097
	16049374	64069	0	None	-89	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807869	64069	0	None	-89	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor	ChEMBL	481	13	5	7	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	1499	2078	47	None	-58	38	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	3779	2078	47	None	-58	38	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	536	2078	47	None	-58	38	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	CHEMBL434	2078	47	None	-58	38	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	DB01064	2078	47	None	-58	38	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2009.03.044
	9888047	93352	0	None	-398	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL245673	93352	0	None	-398	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	414	9	4	5	4.4	C[C@H](CNc1cccc(-c2occc2C(=O)O)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441231	148030	0	None	-50	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL393470	148030	0	None	-50	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	431	9	4	6	4.3	C[C@H](CNc1cccc(-c2csc(C(=O)O)n2)c1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	44441235	150968	0	None	-251	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	CHEMBL395834	150968	0	None	-251	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	430	9	4	5	4.9	C[C@H](CNc1ccc(-c2sccc2C(=O)O)cc1)NC[C@H](O)c1cccc(Cl)c1	10.1016/j.bmcl.2007.05.069
	45271523	195105	0	None	-10	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL1204000	195105	0	None	-10	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	CHEMBL550096	195105	0	None	-10	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	435	10	4	4	4.4	Cc1ccc(NC(=S)Nc2ccc(CCNC[C@H](O)COc3ccccc3)cc2)cc1	10.1016/j.bmc.2009.06.031
	45272417	195418	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL2448074	195418	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	CHEMBL552368	195418	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	ChEMBL	455	10	4	4	4.7	O[C@@H](CNCCc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1)COc1ccccc1	10.1016/j.bmc.2009.06.031
	42625823	12647	0	None	-501	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187371	12647	0	None	-501	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL500782	12647	0	None	-501	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	46832804	6954	0	None	-50	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm100326d
	CHEMBL1084655	6954	0	None	-50	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	496	17	5	8	1.9	NS(=O)(=O)c1ccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1	10.1021/jm100326d
	10553603	99670	0	None	1	3	Human	7.0	pEC50	=	7	Functional	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	1.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	CHEMBL284612	99670	0	None	1	3	Human	7.0	pEC50	=	7	Functional	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor	ChEMBL	506	10	6	8	1.5	CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(NC(=O)CC(=O)O)cc3)CC2)ccc1O	10.1021/jm000544b
	42625517	12689	0	None	-1995	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187654	12689	0	None	-1995	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL514032	12689	0	None	-1995	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	536	19	5	7	3.8	CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	42625588	180402	0	None	-630	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	2.9	NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL475237	180402	0	None	-630	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	508	18	5	7	2.9	NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	10121328	4406	0	None	-100	3	Human	6.0	pEC50	=	6	Functional	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	593	11	5	10	1.4	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	CHEMBL101606	4406	0	None	-100	3	Human	6.0	pEC50	=	6	Functional	Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor	ChEMBL	593	11	5	10	1.4	CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(S(=O)(=O)c3ccc(-n4cc(C(=O)O)cn4)cc3)CC2)ccc1O	10.1016/s0960-894x(02)00608-x
	11575154	77186	0	None	-100000	2	Human	5.0	pEC50	=	5	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	CHEMBL207943	77186	0	None	-100000	2	Human	5.0	pEC50	=	5	Functional	Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	411	9	4	5	3.8	O=C(O)c1ccncc1-c1cccc(NCCNC[C@H](O)c2cccc(Cl)c2)c1	10.1021/jm0509445
	44237766	58209	0	None	-10000	2	Rat	5.0	pEC50	=	5	Functional	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	550	10	6	6	5.5	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682221	58209	0	None	-10000	2	Rat	5.0	pEC50	=	5	Functional	Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect	ChEMBL	550	10	6	6	5.5	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)Nc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2010.12.096
	155517986	170183	0	None	-478630	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	170183	0	None	-478630	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164622775	188539	0	None	-120226	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4867311	188539	0	None	-120226	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028718	188539	0	None	-120226	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	44313150	103750	0	None	-6	3	Human	5.0	pEC50	=	5	Functional	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	CHEMBL308868	103750	0	None	-6	3	Human	5.0	pEC50	=	5	Functional	Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)	ChEMBL	628	12	6	6	6.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(-c3cccc(CC4NCCc5cc(O)c(O)cc54)c3)c2)cc1	10.1016/s0960-894x(00)00459-5
	1960	2838	67	None	-38	19	Guinea pig	5.0	pEC50	=	5	Functional	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	439260	2838	67	None	-38	19	Guinea pig	5.0	pEC50	=	5	Functional	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	505	2838	67	None	-38	19	Guinea pig	5.0	pEC50	=	5	Functional	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	CHEMBL1437	2838	67	None	-38	19	Guinea pig	5.0	pEC50	=	5	Functional	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	DB00368	2838	67	None	-38	19	Guinea pig	5.0	pEC50	=	5	Functional	Effective dose required to stimulate contractions in isolated guinea pig atrium.Effective dose required to stimulate contractions in isolated guinea pig atrium.	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00019a001
	10301101	102933	0	None	-1659	2	Human	4.0	pEC50	=	4	Functional	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	509	9	3	6	3.5	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL306423	102933	0	None	-1659	2	Human	4.0	pEC50	=	4	Functional	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	509	9	3	6	3.5	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1	10.1016/s0960-894x(03)00387-1
	145984792	165705	0	None	-12882	3	Human	4.0	pEC50	=	4	Functional	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	461	12	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	CHEMBL4246134	165705	0	None	-12882	3	Human	4.0	pEC50	=	4	Functional	Antagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assayAntagonist activity at human beta1 adrenergic receptor expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of isoproterenol-induced intercellular calcium mobilization pre-incubated for 10 mins before isoproterenol addition by Fluo-4AM dye-based fluorescence assay	ChEMBL	461	12	4	5	3.1	CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NC(=O)c3ccccc3)cc2)c1	10.1016/j.ejmech.2018.03.032
	45483848	197117	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	394	7	3	3	5.3	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	CHEMBL567843	197117	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	394	7	3	3	5.3	CC(C)c1ccc(CC(C)(C)NCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1	10.1016/j.bmcl.2009.10.013
	11567751	200736	0	None	-29	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	374	6	4	5	2.5	CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600401	200736	0	None	-29	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	374	6	4	5	2.5	CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	10145482	4139	0	None	-34	2	Human	6.0	pEC50	=	6	Functional	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	604	12	5	7	3.4	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	CHEMBL100057	4139	0	None	-34	2	Human	6.0	pEC50	=	6	Functional	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	604	12	5	7	3.4	O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(02)00607-8
	10281165	4381	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	560	11	5	7	3.3	O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1	10.1016/s0960-894x(02)00607-8
	CHEMBL101485	4381	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor	ChEMBL	560	11	5	7	3.3	O=C(Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)cc3)CC2)cc1)NC1CCCCC1	10.1016/s0960-894x(02)00607-8
	11539348	200764	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	434	6	4	5	3.1	CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	CHEMBL600616	200764	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	434	6	4	5	3.1	CC(C)(Cc1ccc(Br)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmcl.2009.12.087
	44309649	204269	0	None	-186	2	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	436	9	3	7	1.6	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	CHEMBL71348	204269	0	None	-186	2	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells	ChEMBL	436	9	3	7	1.6	COc1ccc(S(=O)(=O)N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1	10.1016/s0960-894x(03)00387-1
	3083544	26778	51	None	-199	6	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1021/acs.jmedchem.0c01195
	CHEMBL1200811	26778	51	None	-199	6	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technologyAgonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology	ChEMBL	344	9	4

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